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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32090

FusionGeneSummary for RPS23_RPS24

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS23_RPS24
Fusion gene ID: 32090
HgeneTgene
Gene symbol

RPS23

RPS24

Gene ID

6228

6229

Gene nameribosomal protein S23ribosomal protein S24
SynonymsBTDD|MABAS|MCINS|PAMAS|S23|uS12DBA3|S24|eS24
Cytomap

5q14.2

10q22.3

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S23homolog of yeast ribosomal protein S28small ribosomal subunit protein uS1240S ribosomal protein S24small ribosomal subunit protein eS24
Modification date2018052320180522
UniProtAcc

P62266

P62847

Ensembl transtripts involved in fusion geneENST00000296674, ENST00000510210, 
ENST00000512493, ENST00000510019, 
ENST00000507980, ENST00000503605, 
ENST00000511844, 		ENST00000435275, 
ENST00000440692, ENST00000372360, 
ENST00000476545, ENST00000360830, 
Fusion gene scores* DoF score3 X 3 X 1=96 X 6 X 1=36
# samples 36
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS23 [Title/Abstract] AND RPS24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS23

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI908980RPS23chr5

81573514

-RPS24chr10

79799960

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000296674ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000296674ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000296674ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000296674ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000296674ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+
Frame-shiftENST00000510210ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510210ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510210ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510210ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510210ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+
In-frameENST00000512493ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000512493ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000512493ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000512493ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000512493ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+
In-frameENST00000510019ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510019ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510019ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510019ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000510019ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+
In-frameENST00000507980ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000507980ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000507980ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000507980ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
5CDS-intronENST00000507980ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+
5UTR-3CDSENST00000503605ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
5UTR-intronENST00000503605ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
5UTR-intronENST00000503605ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
5UTR-intronENST00000503605ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
5UTR-intronENST00000503605ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+
intron-3CDSENST00000511844ENST00000435275RPS23chr5

81573514

-RPS24chr10

79799960

+
intron-intronENST00000511844ENST00000440692RPS23chr5

81573514

-RPS24chr10

79799960

+
intron-intronENST00000511844ENST00000372360RPS23chr5

81573514

-RPS24chr10

79799960

+
intron-intronENST00000511844ENST00000476545RPS23chr5

81573514

-RPS24chr10

79799960

+
intron-intronENST00000511844ENST00000360830RPS23chr5

81573514

-RPS24chr10

79799960

+

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FusionProtFeatures for RPS23_RPS24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS23

P62266

RPS24

P62847

Component of the ribosome, a large ribonucleoproteincomplex responsible for the synthesis of proteins in the cell(PubMed:28257692, PubMed:23636399, PubMed:25957688,PubMed:25901680). The small ribosomal subunit (SSU) bindsmessenger RNAs (mRNAs) and translates the encoded message byselecting cognate aminoacyl-transfer RNA (tRNA) molecules. Thelarge subunit (LSU) contains the ribosomal catalytic site termedthe peptidyl transferase center (PTC), which catalyzes theformation of peptide bonds, thereby polymerizing the amino acidsdelivered by tRNAs into a polypeptide chain. The nascentpolypeptides leave the ribosome through a tunnel in the LSU andinteract with protein factors that function in enzymaticprocessing, targeting, and the membrane insertion of nascentchains at the exit of the ribosomal tunnel (PubMed:23636399,PubMed:25957688, PubMed:25901680). Plays an important role intranslational accuracy (PubMed:28257692).{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:28257692}. Required for processing of pre-rRNA and maturation of40S ribosomal subunits. {ECO:0000269|PubMed:18230666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS23_RPS24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RPS23_ENST00000296674_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_49aa

>In-frame_RPS23_ENST00000512493_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_49aa

>In-frame_RPS23_ENST00000510019_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_49aa

>In-frame_RPS23_ENST00000507980_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_49aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RPS23_ENST00000296674_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_147nt
TTTGTGTATTGCCAAGTCTGTTGTGAGCCCTTCCACAAGTTTTGTTTAGAGGAGAACGAGCGCCCTCTGGAGGACCAGCTGGAAAATTGG

>In-frame_RPS23_ENST00000512493_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_147nt
TTTGTGTATTGCCAAGTCTGTTGTGAGCCCTTCCACAAGTTTTGTTTAGAGGAGAACGAGCGCCCTCTGGAGGACCAGCTGGAAAATTGG

>In-frame_RPS23_ENST00000510019_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_147nt
TTTGTGTATTGCCAAGTCTGTTGTGAGCCCTTCCACAAGTTTTGTTTAGAGGAGAACGAGCGCCCTCTGGAGGACCAGCTGGAAAATTGG

>In-frame_RPS23_ENST00000507980_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_147nt
TTTGTGTATTGCCAAGTCTGTTGTGAGCCCTTCCACAAGTTTTGTTTAGAGGAGAACGAGCGCCCTCTGGAGGACCAGCTGGAAAATTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RPS23_ENST00000296674_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_542nt
TCAAAAGAAAAAGGGGGAAAAAAAACCATGCAAATTAGATATCTCTGAATTTCTTGCAAATTAAATAAGACGCAGATTCTGGCTCAGGAA
AGTGATGCAAACGCGTCGTTTTCAAAGGAGAGACCCCAGCCTCGGGTCAGGCGCGGCGCAGACAGCGGCGCGGGGTCCTTGGCTGGGCGG
GGCTTGCTCGCGGTGGCTTGTGGCTCCTTCCTGCGGTGCTTCTCTCTTTCGCTCAGGCCCGTGGCGCCGACAGGATGGGCAAGTGTCGTG
GACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCC
TAAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTCAGTGAGCTGGAGATTGGATCACAGCCGAAGG
AGTAAAGGTGCTGCAATGATGTTAGCTGTGGCCACTGTGGATTTTTCGCAAGAACATTAATAAACTAAAAACTTCATGTGTCTGGTTGTT

>In-frame_RPS23_ENST00000512493_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_316nt
TTTCGCTCAGGCCCGTGGCGCCGACAGGATGGGCAAGTGTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAA
GTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGT
GCTGGAAAAAGTCAGTGAGCTGGAGATTGGATCACAGCCGAAGGAGTAAAGGTGCTGCAATGATGTTAGCTGTGGCCACTGTGGATTTTT

>In-frame_RPS23_ENST00000510019_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_361nt
GCTTGCTCGCGGTGGCTTGTGGCTCCTTCCTGCGGTGCTTCTCTCTTTCGCTCAGGCCCGTGGCGCCGACAGGATGGGCAAGTGTCGTGG
ACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCT
AAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTCAGTGAGCTGGAGATTGGATCACAGCCGAAGGA
GTAAAGGTGCTGCAATGATGTTAGCTGTGGCCACTGTGGATTTTTCGCAAGAACATTAATAAACTAAAAACTTCATGTGTCTGGTTGTTT

>In-frame_RPS23_ENST00000507980_chr5_81573514_-_RPS24_ENST00000435275_chr10_79799960_+_319nt
CTCTTTCGCTCAGGCCCGTGGCGCCGACAGGATGGGCAAGTGTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCA
GAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAAT
CGTGCTGGAAAAAGTCAGTGAGCTGGAGATTGGATCACAGCCGAAGGAGTAAAGGTGCTGCAATGATGTTAGCTGTGGCCACTGTGGATT


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FusionGenePPI for RPS23_RPS24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPS23POU5F1, MME, HDGF, SIRT7, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RPL5, RPL10A, RPL10, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL23, RPL24, RPL27, RPL31, RPL37A, RPL3, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS11, RPS12, RPS13, RPS14, RPS16, RPS19, RPS20, RPS25, RPS28, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPS17, RPS2, RPS15A, RPL4, RPS24, RPL22, RPLP2, RPS26, RPL30, RPLP0, RPLP1, RPS9, RPS15, RPL17, RPL29, RPL32, RPS21, RPS27A, FAU, EEF2, EEF1A1, RPS29, HNRNPU, SLC25A5, ILF2, TUFM, HNRNPM, ILF3, MYBBP1A, ACTA2, DDX21, NHP2L1, NCL, NOLC1, HSP90AB1, RPL10L, RPS10P5, RPLP0P6, RPS27L, HNRNPR, VASN, SAMM50, HIST1H2AD, MRPL55, MRPS11, PSMB1, ESR1, FN1, PAN2, CD81, IGSF8, ICAM1, TARDBP, EIF3A, EIF3CL, EIF3E, PNO1, RPS18, DDX3X, DYNC1LI2, KIAA0368, EIF2A, FLNA, RPL28, RPS10, RPS27, SERBP1, TSR1, WIBG, ZBTB1, CEP250, CEP57, CEP76, TUBG1, HUWE1, EED, WDR76, RPL13A, RPL27A, MRPL17, RPL34, RPL35, RPL36, RPL38, RPL3L, LOC101929876, MDM2, XPO1, AHSA1, KIF11, NPM1, MCM2, ZNF746, CYLD, TRIM25, UBE2A, BRCA1, G3BP1RPS24DCC, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, RPL10A, RPL11, RPL12, RPL14, RPL30, RPL31, RPL6, RPS13, RPS14, RPS17, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS8, RPSA, RPL7, RPS7, RPL5, RPL18, RPL19, RPL18A, RPL7A, RPS15A, RPS23, RPL27, RPS11, RPL23, RPS16, RPS10, RPL10, RPS26, RPL4, RPL15, RPS19, RPLP2, RPL21, RPS2, RPL24, RPL23A, RPL37A, RPLP0, RPS12, RPL9, RPLP1, RPL22, RPL35, RPS9, RPS25, RPS15, RPL36, RPL3, RPS27A, RPL17, RPS21, RPL29, EEF2, EEF1A1, NCL, EIF3C, DDX21, ILF2, ILF3, NHP2L1, FBL, HNRNPU, HNRNPM, NOP58, NOP56, MYBBP1A, TUFM, U2AF1, DHX9, SLC25A5, U2AF2, GNL3, MOV10, EIF6, EIF4A3, RPLP0P6, RPL10L, SF3B6, MSH2, PRPF6, PSIP1, NFIA, RPS10P5, HP1BP3, PPP1CA, MOGS, RPS27L, NDUFAF2, NIFK, LOC255308, HIST1H2AD, PRPF19, ESR1, MAGOH, SMURF1, FN1, VCAM1, UBL4A, ITGA4, PAN2, PNISR, STK17B, PAH, PCBD1, TAF9, TARDBP, NUP188, PNO1, RPS18, RPS20, DYNC1H1, EIF2A, EIF3CL, FAU, PRUNE2, RPS28, RPS29, SERBP1, SPTAN1, WDR26, RPS27, TSR1, WIBG, TP53, HUWE1, EED, RNF2, RPL8, NPM1, RC3H1, ZNF746, RRS1, E4F1, CYLD, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS23_RPS24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS23_RPS24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource