FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32086

FusionGeneSummary for RPS21_PIAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS21_PIAS3
Fusion gene ID: 32086
HgeneTgene
Gene symbol

RPS21

PIAS3

Gene ID

6227

10401

Gene nameribosomal protein S21protein inhibitor of activated STAT 3
SynonymsHLDF|S21ZMIZ5
Cytomap

20q13.33

1q21.1

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S218.2 kDa differentiation factorhuman leukemia differentiation factorsmall ribosomal subunit protein eS21E3 SUMO-protein ligase PIAS3E3 SUMO-protein transferase PIAS3protein inhibitor of activated STAT protein 3zinc finger, MIZ-type containing 5
Modification date2018052320180519
UniProtAcc

P63220

Q9Y6X2

Ensembl transtripts involved in fusion geneENST00000343986, ENST00000492356, 
ENST00000370562, ENST00000450116, 
ENST00000369299, ENST00000393045, 
ENST00000369298, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 2 X 3=18
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS21 [Title/Abstract] AND PIAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS21

GO:0002181

cytoplasmic translation

25957688

TgenePIAS3

GO:0033234

negative regulation of protein sumoylation

24651376

TgenePIAS3

GO:0033235

positive regulation of protein sumoylation

17696781|21965678


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI275065RPS21chr20

60963482

-PIAS3chr1

145578714

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000343986ENST00000369299RPS21chr20

60963482

-PIAS3chr1

145578714

-
intron-3CDSENST00000343986ENST00000393045RPS21chr20

60963482

-PIAS3chr1

145578714

-
intron-3CDSENST00000343986ENST00000369298RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000492356ENST00000369299RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000492356ENST00000393045RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000492356ENST00000369298RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000370562ENST00000369299RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000370562ENST00000393045RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000370562ENST00000369298RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000450116ENST00000369299RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000450116ENST00000393045RPS21chr20

60963482

-PIAS3chr1

145578714

-
3UTR-3CDSENST00000450116ENST00000369298RPS21chr20

60963482

-PIAS3chr1

145578714

-

Top

FusionProtFeatures for RPS21_PIAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS21

P63220

PIAS3

Q9Y6X2

Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway and the steroid hormone signalingpathway. Involved in regulating STAT3 signaling via inhibitingSTAT3 DNA-binding and suppressing cell growth. Enhances thesumoylation of MTA1 and may participate in its paralog-selectivesumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2which promotes its interaction with SIRT1 (PubMed:25406032).Diminishes the sumoylation of ZFHX3 by preventing thecolocalization of ZFHX3 with SUMO1 in the nucleus(PubMed:24651376). {ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032,ECO:0000269|PubMed:9388184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPS21_PIAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPS21_PIAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPS21_PIAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RPS21_PIAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS21C0038356Stomach Neoplasms1CTD_human
TgenePIAS3C0007873Uterine Cervical Neoplasm1CTD_human