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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32079

FusionGeneSummary for RPS19_RPS4Y1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS19_RPS4Y1
Fusion gene ID: 32079
HgeneTgene
Gene symbol

RPS19

RPS4Y1

Gene ID

6223

6192

Gene nameribosomal protein S19ribosomal protein S4 Y-linked 1
SynonymsDBA|DBA1|S19|eS19RPS4Y|S4
Cytomap

19q13.2

Yp11.2

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S19small ribosomal subunit protein eS1940S ribosomal protein S4, Y isoform 140S ribosomal protein S4, Yribosomal protein S4, Y-linkedribosomal protein S4Ysmall ribosomal subunit protein eS4
Modification date2018052320180523
UniProtAcc

P39019

P22090

Ensembl transtripts involved in fusion geneENST00000598742, ENST00000221975, 
ENST00000593863, 
ENST00000250784, 
ENST00000477725, 
Fusion gene scores* DoF score6 X 3 X 4=725 X 5 X 3=75
# samples 66
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS19 [Title/Abstract] AND RPS4Y1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS19

GO:0002548

monocyte chemotaxis

11226885

HgeneRPS19

GO:0031640

killing of cells of other organism

15019208

HgeneRPS19

GO:0050829

defense response to Gram-negative bacterium

15019208

HgeneRPS19

GO:0051262

protein tetramerization

11226885

HgeneRPS19

GO:0060265

positive regulation of respiratory burst involved in inflammatory response

15750715

HgeneRPS19

GO:0060266

negative regulation of respiratory burst involved in inflammatory response

15750715

HgeneRPS19

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

15019208


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW300778RPS19chr19

42364325

-RPS4Y1chrY

2734859

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000598742ENST00000250784RPS19chr19

42364325

-RPS4Y1chrY

2734859

+
5UTR-3UTRENST00000598742ENST00000477725RPS19chr19

42364325

-RPS4Y1chrY

2734859

+
intron-3CDSENST00000221975ENST00000250784RPS19chr19

42364325

-RPS4Y1chrY

2734859

+
intron-3UTRENST00000221975ENST00000477725RPS19chr19

42364325

-RPS4Y1chrY

2734859

+
intron-3CDSENST00000593863ENST00000250784RPS19chr19

42364325

-RPS4Y1chrY

2734859

+
intron-3UTRENST00000593863ENST00000477725RPS19chr19

42364325

-RPS4Y1chrY

2734859

+

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FusionProtFeatures for RPS19_RPS4Y1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS19

P39019

RPS4Y1

P22090

Required for pre-rRNA processing and maturation of 40Sribosomal subunits. {ECO:0000269|PubMed:16990592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS19_RPS4Y1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS19_RPS4Y1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS19_RPS4Y1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPS19P39019DB11638Artenimol40S ribosomal protein S19small moleculeapproved|investigational

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RelatedDiseases for RPS19_RPS4Y1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS19C2676137Diamond-Blackfan Anemia 17UNIPROT
HgeneRPS19C0033578Prostatic Neoplasms1CTD_human
HgeneRPS19C0038356Stomach Neoplasms1CTD_human