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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32021

FusionGeneSummary for RPP38_GPR158

check button Fusion gene summary
Fusion gene informationFusion gene name: RPP38_GPR158
Fusion gene ID: 32021
HgeneTgene
Gene symbol

RPP38

GPR158

Gene ID

10557

57512

Gene nameribonuclease P/MRP subunit p38G protein-coupled receptor 158
Synonyms--
Cytomap

10p13

10p12.1

Type of geneprotein-codingprotein-coding
Descriptionribonuclease P protein subunit p38RNaseP protein p38ribonuclease P/MRP 38kDa subunitprobable G-protein coupled receptor 158
Modification date2018052220180329
UniProtAcc

P78345

Q5T848

Ensembl transtripts involved in fusion geneENST00000451677, ENST00000378202, 
ENST00000378197, 
ENST00000376351, 
ENST00000490549, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RPP38 [Title/Abstract] AND GPR158 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRPTCGA-UZ-A9PQ-01ARPP38chr10

15153785

+GPR158chr10

25509981

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000451677ENST00000376351RPP38chr10

15153785

+GPR158chr10

25509981

+
3UTR-intronENST00000451677ENST00000490549RPP38chr10

15153785

+GPR158chr10

25509981

+
intron-3CDSENST00000378202ENST00000376351RPP38chr10

15153785

+GPR158chr10

25509981

+
intron-intronENST00000378202ENST00000490549RPP38chr10

15153785

+GPR158chr10

25509981

+
intron-3CDSENST00000378197ENST00000376351RPP38chr10

15153785

+GPR158chr10

25509981

+
intron-intronENST00000378197ENST00000490549RPP38chr10

15153785

+GPR158chr10

25509981

+

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FusionProtFeatures for RPP38_GPR158


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPP38

P78345

GPR158

Q5T848

Component of ribonuclease P, a protein complex thatgenerates mature tRNA molecules by cleaving their 5'-ends. RPP38may associate transiently with RNase P RNA as a factor involved inthe transport of H1 RNA to the putative site of its assembly inthe cell, the nucleolus. Orphan receptor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPP38_GPR158


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPP38_GPR158


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPP38POP1, POP4, POP7, HDGF, CAST, PSMA1, PSMA4, PSMA5, PSMB1, PSMB4, PSMB5, PSMB8, AKAP2, CDKN2A, PSMA6, VASP, NPM1, SPACA1, PCGF6, RBM4B, VSIG4, CBWD1, SIAE, CASQ2, RPP25, CEP164, HNRNPU, NR2C2, CDC23, CTR9, NCSTN, ING4, ATL2, PAPD5, ASPM, C3orf17, RPP30, RPP21, C18orf21, RBM4, C1orf85, TOR1AIP2GPR158


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPP38_GPR158


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPP38_GPR158


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPP38C0025202melanoma1CTD_human