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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32009

FusionGeneSummary for RPN2_RPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPN2_RPN2
Fusion gene ID: 32009
HgeneTgene
Gene symbol

RPN2

RPN2

Gene ID

6185

6185

Gene nameribophorin IIribophorin II
SynonymsRIBIIR|RPN-II|RPNII|SWP1RIBIIR|RPN-II|RPNII|SWP1
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptiondolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2
Modification date2018052320180523
UniProtAcc

P04844

P04844

Ensembl transtripts involved in fusion geneENST00000237530, ENST00000373622, 
ENST00000470352, 		ENST00000237530, 
ENST00000373622, ENST00000470352, 
Fusion gene scores* DoF score9 X 8 X 7=5047 X 8 X 4=224
# samples 119
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPN2 [Title/Abstract] AND RPN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE075537RPN2chr20

35842162

-RPN2chr20

35833209

+
ChiTaRS3.1BI051087RPN2chr20

35826836

-RPN2chr20

35833177

+
ChiTaRS3.1BG390108RPN2chr20

35857081

-RPN2chr20

35857114

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000237530ENST00000237530RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-3CDSENST00000237530ENST00000373622RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-intronENST00000237530ENST00000470352RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-3CDSENST00000373622ENST00000237530RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-3CDSENST00000373622ENST00000373622RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-intronENST00000373622ENST00000470352RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-3CDSENST00000470352ENST00000237530RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-3CDSENST00000470352ENST00000373622RPN2chr20

35842162

-RPN2chr20

35833209

+
intron-intronENST00000470352ENST00000470352RPN2chr20

35842162

-RPN2chr20

35833209

+
In-frameENST00000237530ENST00000237530RPN2chr20

35826836

-RPN2chr20

35833177

+
In-frameENST00000237530ENST00000373622RPN2chr20

35826836

-RPN2chr20

35833177

+
5CDS-intronENST00000237530ENST00000470352RPN2chr20

35826836

-RPN2chr20

35833177

+
intron-3CDSENST00000373622ENST00000237530RPN2chr20

35826836

-RPN2chr20

35833177

+
intron-3CDSENST00000373622ENST00000373622RPN2chr20

35826836

-RPN2chr20

35833177

+
intron-intronENST00000373622ENST00000470352RPN2chr20

35826836

-RPN2chr20

35833177

+
intron-3CDSENST00000470352ENST00000237530RPN2chr20

35826836

-RPN2chr20

35833177

+
intron-3CDSENST00000470352ENST00000373622RPN2chr20

35826836

-RPN2chr20

35833177

+
intron-intronENST00000470352ENST00000470352RPN2chr20

35826836

-RPN2chr20

35833177

+
In-frameENST00000237530ENST00000237530RPN2chr20

35857081

-RPN2chr20

35857114

+
In-frameENST00000237530ENST00000373622RPN2chr20

35857081

-RPN2chr20

35857114

+
5CDS-intronENST00000237530ENST00000470352RPN2chr20

35857081

-RPN2chr20

35857114

+
In-frameENST00000373622ENST00000237530RPN2chr20

35857081

-RPN2chr20

35857114

+
In-frameENST00000373622ENST00000373622RPN2chr20

35857081

-RPN2chr20

35857114

+
5CDS-intronENST00000373622ENST00000470352RPN2chr20

35857081

-RPN2chr20

35857114

+
intron-3CDSENST00000470352ENST00000237530RPN2chr20

35857081

-RPN2chr20

35857114

+
intron-3CDSENST00000470352ENST00000373622RPN2chr20

35857081

-RPN2chr20

35857114

+
intron-intronENST00000470352ENST00000470352RPN2chr20

35857081

-RPN2chr20

35857114

+

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FusionProtFeatures for RPN2_RPN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPN2

P04844

RPN2

P04844

Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. {ECO:0000250|UniProtKB:F1PCT7,ECO:0000305}. Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. {ECO:0000250|UniProtKB:F1PCT7,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPN2_RPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPN2_RPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPN2_RPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPN2_RPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPN2C0033578Prostatic Neoplasms1CTD_human
TgeneRPN2C0033578Prostatic Neoplasms1CTD_human