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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31992

FusionGeneSummary for RPLP2_MED15

check button Fusion gene summary
Fusion gene informationFusion gene name: RPLP2_MED15
Fusion gene ID: 31992
HgeneTgene
Gene symbol

RPLP2

MED15

Gene ID

6181

51586

Gene nameribosomal protein lateral stalk subunit P2mediator complex subunit 15
SynonymsD11S2243E|LP2|P2|RPP2ARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
Cytomap

11p15.5

22q11.21

Type of geneprotein-codingprotein-coding
Description60S acidic ribosomal protein P2acidic ribosomal phosphoprotein P2large ribosomal subunit protein P2renal carcinoma antigen NY-REN-44ribosomal protein, large, P2mediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
Modification date2018052220180523
UniProtAcc

P05387

Q96RN5

Ensembl transtripts involved in fusion geneENST00000321153, ENST00000532004, 
ENST00000530797, 
ENST00000425759, 
ENST00000292733, ENST00000542773, 
ENST00000263205, ENST00000406969, 
ENST00000382974, ENST00000541476, 
ENST00000478831, 
Fusion gene scores* DoF score13 X 11 X 4=57213 X 9 X 7=819
# samples 1315
** MAII scorelog2(13/572*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPLP2 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB193761RPLP2chr11

811645

+MED15chr22

20922848

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000321153ENST00000425759RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000321153ENST00000292733RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000321153ENST00000542773RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000321153ENST00000263205RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000321153ENST00000406969RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000321153ENST00000382974RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000321153ENST00000541476RPLP2chr11

811645

+MED15chr22

20922848

+
5CDS-3UTRENST00000321153ENST00000478831RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000425759RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000292733RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000542773RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000263205RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000406969RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000382974RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3CDSENST00000532004ENST00000541476RPLP2chr11

811645

+MED15chr22

20922848

+
3UTR-3UTRENST00000532004ENST00000478831RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000425759RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000292733RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000542773RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000263205RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000406969RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000382974RPLP2chr11

811645

+MED15chr22

20922848

+
Frame-shiftENST00000530797ENST00000541476RPLP2chr11

811645

+MED15chr22

20922848

+
5CDS-3UTRENST00000530797ENST00000478831RPLP2chr11

811645

+MED15chr22

20922848

+

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FusionProtFeatures for RPLP2_MED15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPLP2

P05387

MED15

Q96RN5

Plays an important role in the elongation step ofprotein synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPLP2_MED15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPLP2_MED15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPLP2_MED15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPLP2_MED15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMED15C0036341Schizophrenia2PSYGENET
TgeneMED15C0036337Schizoaffective Disorder1PSYGENET