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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31986

FusionGeneSummary for RPLP2_BOD1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPLP2_BOD1L1
Fusion gene ID: 31986
HgeneTgene
Gene symbol

RPLP2

BOD1L1

Gene ID

6181

259282

Gene nameribosomal protein lateral stalk subunit P2biorientation of chromosomes in cell division 1 like 1
SynonymsD11S2243E|LP2|P2|RPP2BOD1L|FAM44A
Cytomap

11p15.5

4p15.33

Type of geneprotein-codingprotein-coding
Description60S acidic ribosomal protein P2acidic ribosomal phosphoprotein P2large ribosomal subunit protein P2renal carcinoma antigen NY-REN-44ribosomal protein, large, P2biorientation of chromosomes in cell division protein 1-like 1biorientation of chromosomes in cell division 1-likefamily with sequence similarity 44, member A
Modification date2018052220180519
UniProtAcc

P05387

Q8NFC6

Ensembl transtripts involved in fusion geneENST00000321153, ENST00000532004, 
ENST00000530797, 
ENST00000040738, 
Fusion gene scores* DoF score13 X 11 X 4=5722 X 2 X 1=4
# samples 132
** MAII scorelog2(13/572*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: RPLP2 [Title/Abstract] AND BOD1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBOD1L1

GO:0006974

cellular response to DNA damage stimulus

26166705

TgeneBOD1L1

GO:0031297

replication fork processing

26166705


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB355988RPLP2chr11

810294

-BOD1L1chr4

13601214

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000321153ENST00000040738RPLP2chr11

810294

-BOD1L1chr4

13601214

+
intron-3CDSENST00000532004ENST00000040738RPLP2chr11

810294

-BOD1L1chr4

13601214

+
In-frameENST00000530797ENST00000040738RPLP2chr11

810294

-BOD1L1chr4

13601214

+

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FusionProtFeatures for RPLP2_BOD1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPLP2

P05387

BOD1L1

Q8NFC6

Plays an important role in the elongation step ofprotein synthesis. Component of the fork protection machinery required toprotect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalledreplication forks and protecting RAD51 nucleofilaments from theantirecombinogenic activities of FBH1 and BLM (PubMed:26166705).Does not regulate spindle orientation (PubMed:26166705).{ECO:0000269|PubMed:26166705}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPLP2_BOD1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RPLP2_ENST00000321153_chr11_810294_-_BOD1L1_ENST00000040738_chr4_13601214_+_0aa

>In-frame_RPLP2_ENST00000530797_chr11_810294_-_BOD1L1_ENST00000040738_chr4_13601214_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RPLP2_ENST00000321153_chr11_810294_-_BOD1L1_ENST00000040738_chr4_13601214_+_0nt

>In-frame_RPLP2_ENST00000530797_chr11_810294_-_BOD1L1_ENST00000040738_chr4_13601214_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_RPLP2_ENST00000321153_chr11_810294_-_BOD1L1_ENST00000040738_chr4_13601214_+_0nt

>In-frame_RPLP2_ENST00000530797_chr11_810294_-_BOD1L1_ENST00000040738_chr4_13601214_+_0nt


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FusionGenePPI for RPLP2_BOD1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPLP2_BOD1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPLP2_BOD1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource