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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31938

FusionGeneSummary for RPL3_SOX8

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL3_SOX8
Fusion gene ID: 31938
HgeneTgene
Gene symbol

RPL3

SOX8

Gene ID

6122

30812

Gene nameribosomal protein L3SRY-box 8
SynonymsASC-1|L3|TARBP-B-
Cytomap

22q13.1

16p13.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L3HIV-1 TAR RNA-binding protein Blarge ribosomal subunit protein uL3transcription factor SOX-8SRY (sex determining region Y)-box 8
Modification date2018052320180523
UniProtAcc

P39023

P57073

Ensembl transtripts involved in fusion geneENST00000216146, ENST00000465618, 
ENST00000401609, 
ENST00000293894, 
Fusion gene scores* DoF score4 X 4 X 1=161 X 1 X 1=1
# samples 41
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: RPL3 [Title/Abstract] AND SOX8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSOX8

GO:0045944

positive regulation of transcription by RNA polymerase II

10662550


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA242792RPL3chr22

39711373

-SOX8chr16

1036443

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000216146ENST00000293894RPL3chr22

39711373

-SOX8chr16

1036443

+
5UTR-3UTRENST00000465618ENST00000293894RPL3chr22

39711373

-SOX8chr16

1036443

+
5CDS-3UTRENST00000401609ENST00000293894RPL3chr22

39711373

-SOX8chr16

1036443

+

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FusionProtFeatures for RPL3_SOX8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL3

P39023

SOX8

P57073

The L3 protein is a component of the large subunit ofcytoplasmic ribosomes. {ECO:0000305|PubMed:12962325}. May play a role in central nervous system, limb andfacial development. May be involved in male sex determination.Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL3_SOX8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL3_SOX8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL3_SOX8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPL3P39023DB04865Omacetaxine mepesuccinate60S ribosomal protein L3small moleculeapproved|investigational
HgeneRPL3P39023DB09092Xanthinol60S ribosomal protein L3small moleculeapproved|withdrawn

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RelatedDiseases for RPL3_SOX8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL3C0024667Animal Mammary Neoplasms1CTD_human
HgeneRPL3C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSOX8C0031117Peripheral Neuropathy1CTD_human