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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31927

FusionGeneSummary for RPL38_NCAPH2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL38_NCAPH2
Fusion gene ID: 31927
HgeneTgene
Gene symbol

RPL38

NCAPH2

Gene ID

6169

29781

Gene nameribosomal protein L38non-SMC condensin II complex subunit H2
SynonymsL38CAPH2
Cytomap

17q25.1

22q13.33

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L38large ribosomal subunit protein eL38condensin-2 complex subunit H2CAP-H2 subunit of the condensin II complexCTA-384D8.36chromosome-associated protein H2kleisin beta
Modification date2018052320180522
UniProtAcc

P63173

Q6IBW4

Ensembl transtripts involved in fusion geneENST00000439590, ENST00000311111, 
ENST00000584577, ENST00000534490, 
ENST00000533498, 		ENST00000420993, 
ENST00000395698, ENST00000395701, 
ENST00000299821, ENST00000520297, 
Fusion gene scores* DoF score17 X 15 X 4=10203 X 3 X 3=27
# samples 193
** MAII scorelog2(19/1020*10)=-2.42449782852791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPL38 [Title/Abstract] AND NCAPH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL38

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM810069RPL38chr17

72199954

-NCAPH2chr22

50962352

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000439590ENST00000420993RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000439590ENST00000395698RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000439590ENST00000395701RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000439590ENST00000299821RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000439590ENST00000520297RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000311111ENST00000420993RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000311111ENST00000395698RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000311111ENST00000395701RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000311111ENST00000299821RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000311111ENST00000520297RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000584577ENST00000420993RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000584577ENST00000395698RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000584577ENST00000395701RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000584577ENST00000299821RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000584577ENST00000520297RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000534490ENST00000420993RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000534490ENST00000395698RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000534490ENST00000395701RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000534490ENST00000299821RPL38chr17

72199954

-NCAPH2chr22

50962352

+
intron-intronENST00000534490ENST00000520297RPL38chr17

72199954

-NCAPH2chr22

50962352

+
5UTR-intronENST00000533498ENST00000420993RPL38chr17

72199954

-NCAPH2chr22

50962352

+
5UTR-intronENST00000533498ENST00000395698RPL38chr17

72199954

-NCAPH2chr22

50962352

+
5UTR-intronENST00000533498ENST00000395701RPL38chr17

72199954

-NCAPH2chr22

50962352

+
5UTR-intronENST00000533498ENST00000299821RPL38chr17

72199954

-NCAPH2chr22

50962352

+
5UTR-intronENST00000533498ENST00000520297RPL38chr17

72199954

-NCAPH2chr22

50962352

+

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FusionProtFeatures for RPL38_NCAPH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL38

P63173

NCAPH2

Q6IBW4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL38_NCAPH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL38_NCAPH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL38_NCAPH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL38_NCAPH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource