FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31922

FusionGeneSummary for RPL38_DONSON

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL38_DONSON
Fusion gene ID: 31922
HgeneTgene
Gene symbol

RPL38

DONSON

Gene ID

6169

29980

Gene nameribosomal protein L38downstream neighbor of SON
SynonymsL38B17|C21orf60|MIMIS|MISSLA
Cytomap

17q25.1

21q22.11

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L38large ribosomal subunit protein eL38protein downstream neighbor of Son
Modification date2018052320180523
UniProtAcc

P63173

Q9NYP3

Ensembl transtripts involved in fusion geneENST00000439590, ENST00000311111, 
ENST00000584577, ENST00000534490, 
ENST00000533498, 
ENST00000303113, 
ENST00000453626, ENST00000303071, 
ENST00000432378, 
Fusion gene scores* DoF score17 X 15 X 4=10207 X 7 X 1=49
# samples 198
** MAII scorelog2(19/1020*10)=-2.42449782852791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/49*10)=0.707218250772154
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPL38 [Title/Abstract] AND DONSON [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL38

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE797621RPL38chr17

72206008

+DONSONchr21

35281514

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000439590ENST00000303113RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000439590ENST00000453626RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000439590ENST00000303071RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000439590ENST00000432378RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000311111ENST00000303113RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000311111ENST00000453626RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000311111ENST00000303071RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000311111ENST00000432378RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000584577ENST00000303113RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000584577ENST00000453626RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000584577ENST00000303071RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000584577ENST00000432378RPL38chr17

72206008

+DONSONchr21

35281514

-
intron-intronENST00000534490ENST00000303113RPL38chr17

72206008

+DONSONchr21

35281514

-
intron-intronENST00000534490ENST00000453626RPL38chr17

72206008

+DONSONchr21

35281514

-
intron-intronENST00000534490ENST00000303071RPL38chr17

72206008

+DONSONchr21

35281514

-
intron-intronENST00000534490ENST00000432378RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000533498ENST00000303113RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000533498ENST00000453626RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000533498ENST00000303071RPL38chr17

72206008

+DONSONchr21

35281514

-
3UTR-intronENST00000533498ENST00000432378RPL38chr17

72206008

+DONSONchr21

35281514

-

Top

FusionProtFeatures for RPL38_DONSON


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL38

P63173

DONSON

Q9NYP3

Replisome component that maintains genome stability byprotecting stalled or damaged replication forks. After theinduction of replication stress, required for the stabilization ofstalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance ofgenome stability. {ECO:0000269|PubMed:28191891}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPL38_DONSON


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPL38_DONSON


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPL38_DONSON


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RPL38_DONSON


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource