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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31919

FusionGeneSummary for RPL38_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL38_BCAS3
Fusion gene ID: 31919
HgeneTgene
Gene symbol

RPL38

BCAS3

Gene ID

6169

54828

Gene nameribosomal protein L38BCAS3, microtubule associated cell migration factor
SynonymsL38GAOB1|MAAB
Cytomap

17q25.1

17q23.2

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L38large ribosomal subunit protein eL38breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

P63173

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000439590, ENST00000311111, 
ENST00000584577, ENST00000534490, 
ENST00000533498, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score17 X 15 X 4=102026 X 15 X 15=5850
# samples 1941
** MAII scorelog2(19/1020*10)=-2.42449782852791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL38 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL38

GO:0002181

cytoplasmic translation

25957688

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-7479-01ARPL38chr17

72200329

+BCAS3chr17

58979981

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000439590ENST00000589222RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000439590ENST00000407086RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000439590ENST00000390652RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000439590ENST00000408905RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000439590ENST00000588462RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000439590ENST00000585744RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000439590ENST00000588874RPL38chr17

72200329

+BCAS3chr17

58979981

+
5CDS-intronENST00000439590ENST00000585812RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000589222RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000407086RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000390652RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000408905RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000588462RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000585744RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000311111ENST00000588874RPL38chr17

72200329

+BCAS3chr17

58979981

+
5CDS-intronENST00000311111ENST00000585812RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000589222RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000407086RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000390652RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000408905RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000588462RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000585744RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000584577ENST00000588874RPL38chr17

72200329

+BCAS3chr17

58979981

+
5CDS-intronENST00000584577ENST00000585812RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000589222RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000407086RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000390652RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000408905RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000588462RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000585744RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000534490ENST00000588874RPL38chr17

72200329

+BCAS3chr17

58979981

+
5CDS-intronENST00000534490ENST00000585812RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000589222RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000407086RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000390652RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000408905RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000588462RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000585744RPL38chr17

72200329

+BCAS3chr17

58979981

+
Frame-shitENST00000533498ENST00000588874RPL38chr17

72200329

+BCAS3chr17

58979981

+
5CDS-intronENST00000533498ENST00000585812RPL38chr17

72200329

+BCAS3chr17

58979981

+

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FusionProtFeatures for RPL38_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL38

P63173

BCAS3

Q9H6U6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL38_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL38_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPL38TFE3, RIPK2, NME2, RUVBL2, MEPCE, AGO4, DCC, SIRT7, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, CAND1, CHMP5, RPS6, RPS12, RPS28, RPL23A, RPS15A, RPS19, RPS25, RPL5, RPL14, RPL8, RPL30, RPL3, RPL7, RPS13, RPS2, RPL36, RPL18, RPL10, RPL11, RPL35, RPL7A, RPL21, RPL17, RPL29, SRPRB, RPL10L, NDUFA7, NDUFA2, SLIRP, MRPL53, RBMS1, DUT, RRBP1, VCAM1, UBL4A, ITGA4, PAN2, AP2M1, EHD4, HNRNPA1, IARS, IGF2BP3, NMT1, PLCG1, RIC8A, ZC3HC1, ASB3, ASB10, ASB12, AURKA, CEP57, HAUS2, CEP76, LGALS3BP, NEDD1, TUBGCP4, RNF2, EGFR, EEF1G, PES1, RPL10A, RPL13, RPL13A, RPL15, RPL19, RPL22, RPL26, RPL27, RPL27A, RPL34, RPL37A, RPL12, RPL18A, RPL23, RPL24, RPL28, RPL31, RPL6, RPL9, RPS10, RPS11, RPS16, RPS20, RPS3, RPS3A, RPS5, RPS8, RPS9, RPSA, SLC1A2, RPL4, RPLP0, RPLP1, RPLP2, RPS14, RPS18, RPS23, LOC101929876, RPS26, RPS27, RPS4X, RPS7, SFN, PTEN, AHSA1, NPM1, SOX17, MCM2, NANOG, POU5F1, RC3H1, MRPL34, TRIM25BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL38_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL38_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource