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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31914

FusionGeneSummary for RPL37_CFLAR

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL37_CFLAR
Fusion gene ID: 31914
HgeneTgene
Gene symbol

RPL37

CFLAR

Gene ID

6167

8837

Gene nameribosomal protein L37CASP8 and FADD like apoptosis regulator
SynonymsL37CASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS
Cytomap

5p13.1

2q33.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L3760S ribosomal protein L37aG1.16large ribosomal subunit protein eL37CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
Modification date2018052320180523
UniProtAcc

P61927

O15519

Ensembl transtripts involved in fusion geneENST00000274242, ENST00000509877, 
ENST00000504562, ENST00000508493, 
ENST00000309955, ENST00000443227, 
ENST00000341222, ENST00000340870, 
ENST00000355558, ENST00000341582, 
ENST00000342795, ENST00000395148, 
ENST00000423241, ENST00000490965, 
ENST00000440180, ENST00000457277, 
ENST00000494258, ENST00000479953, 
Fusion gene scores* DoF score5 X 5 X 3=759 X 6 X 6=324
# samples 510
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL37 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCFLAR

GO:0060544

regulation of necroptotic process

21737330

TgeneCFLAR

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

TgeneCFLAR

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

9208847


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW136069RPL37chr5

40832612

+CFLARchr2

201981714

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000274242ENST00000309955RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000443227RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000341222RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000340870RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000355558RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000341582RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000342795RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000395148RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000423241RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000490965RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000440180RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000457277RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000494258RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000274242ENST00000479953RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000309955RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000443227RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000341222RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000340870RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000355558RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000341582RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000342795RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000395148RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000423241RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000490965RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000440180RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000457277RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000494258RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000509877ENST00000479953RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000309955RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000443227RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000341222RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000340870RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000355558RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000341582RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000342795RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000395148RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000423241RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000490965RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000440180RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000457277RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000494258RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000504562ENST00000479953RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000309955RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000443227RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000341222RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000340870RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000355558RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000341582RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000342795RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000395148RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000423241RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000490965RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000440180RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000457277RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000494258RPL37chr5

40832612

+CFLARchr2

201981714

-
intron-intronENST00000508493ENST00000479953RPL37chr5

40832612

+CFLARchr2

201981714

-

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FusionProtFeatures for RPL37_CFLAR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL37

P61927

CFLAR

O15519

Binds to the 23S rRNA. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL37_CFLAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL37_CFLAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL37_CFLAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL37_CFLAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCFLARC0019829Hodgkin Disease1CTD_human
TgeneCFLARC0023418leukemia1CTD_human
TgeneCFLARC0030297Pancreatic Neoplasm1CTD_human
TgeneCFLARC1955906Lymphoma, Extranodal NK-T-Cell1CTD_human
TgeneCFLARC3463824MYELODYSPLASTIC SYNDROME1CTD_human