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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31887

FusionGeneSummary for RPL32_PPP2R1A

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL32_PPP2R1A
Fusion gene ID: 31887
HgeneTgene
Gene symbol

RPL32

PPP2R1A

Gene ID

6161

5518

Gene nameribosomal protein L32protein phosphatase 2 scaffold subunit Aalpha
SynonymsL32|PP9932MRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65A
Cytomap

3p25.2

19q13.41

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L32large ribosomal subunit protein eL32serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (P
Modification date2018052320180526
UniProtAcc

P62910

P30153

Ensembl transtripts involved in fusion geneENST00000429711, ENST00000396957, 
ENST00000273223, ENST00000435983, 
ENST00000396953, 
ENST00000322088, 
ENST00000444322, ENST00000477989, 
ENST00000462990, ENST00000473455, 
Fusion gene scores* DoF score5 X 5 X 3=757 X 8 X 3=168
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL32 [Title/Abstract] AND PPP2R1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL32

GO:0002181

cytoplasmic translation

25957688

TgenePPP2R1A

GO:0007059

chromosome segregation

16580887


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W48816RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000429711ENST00000322088RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000429711ENST00000444322RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000429711ENST00000477989RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000429711ENST00000462990RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000429711ENST00000473455RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000396957ENST00000322088RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000396957ENST00000444322RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000396957ENST00000477989RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000396957ENST00000462990RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000396957ENST00000473455RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000273223ENST00000322088RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000273223ENST00000444322RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000273223ENST00000477989RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000273223ENST00000462990RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000273223ENST00000473455RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000435983ENST00000322088RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000435983ENST00000444322RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000435983ENST00000477989RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000435983ENST00000462990RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000435983ENST00000473455RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000396953ENST00000322088RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-3CDSENST00000396953ENST00000444322RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000396953ENST00000477989RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000396953ENST00000462990RPL32chr3

12877645

+PPP2R1Achr19

52719874

-
intron-intronENST00000396953ENST00000473455RPL32chr3

12877645

+PPP2R1Achr19

52719874

-

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FusionProtFeatures for RPL32_PPP2R1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL32

P62910

PPP2R1A

P30153

The PR65 subunit of protein phosphatase 2A serves as ascaffolding molecule to coordinate the assembly of the catalyticsubunit and a variable regulatory B subunit. Upon interaction withGNA12 promotes dephosphorylation of microtubule associated proteinTAU/MAPT (PubMed:15525651). Required for proper chromosomesegregation and for centromeric localization of SGO1 in mitosis(PubMed:16580887). {ECO:0000269|PubMed:15525651,ECO:0000269|PubMed:16580887}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL32_PPP2R1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL32_PPP2R1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL32_PPP2R1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL32_PPP2R1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPP2R1AC4225352MENTAL RETARDATION, AUTOSOMAL DOMINANT 362ORPHANET;UNIPROT
TgenePPP2R1AC0029408Degenerative polyarthritis1CTD_human
TgenePPP2R1AC0038356Stomach Neoplasms1CTD_human