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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31872

FusionGeneSummary for RPL30_KCTD18

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL30_KCTD18
Fusion gene ID: 31872
HgeneTgene
Gene symbol

RPL30

KCTD18

Gene ID

6156

130535

Gene nameribosomal protein L30potassium channel tetramerization domain containing 18
SynonymsL306530404F10Rik
Cytomap

8q22.2

2q33.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L30large ribosomal subunit protein eL30BTB/POZ domain-containing protein KCTD18potassium channel tetramerisation domain containing 18
Modification date2018052320180519
UniProtAcc

P62888

Q6PI47

Ensembl transtripts involved in fusion geneENST00000518164, ENST00000521291, 
ENST00000396070, ENST00000287038, 
ENST00000523172, 
ENST00000359878, 
ENST00000409157, ENST00000468413, 
Fusion gene scores* DoF score7 X 7 X 2=984 X 4 X 3=48
# samples 84
** MAII scorelog2(8/98*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL30 [Title/Abstract] AND KCTD18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL30

GO:0002181

cytoplasmic translation

25957688

HgeneRPL30

GO:0031640

killing of cells of other organism

15019208

HgeneRPL30

GO:0050829

defense response to Gram-negative bacterium

15019208

HgeneRPL30

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

15019208


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ221159RPL30chr8

99054945

-KCTD18chr2

201353840

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000518164ENST00000359878RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000518164ENST00000409157RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-intronENST00000518164ENST00000468413RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000521291ENST00000359878RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000521291ENST00000409157RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-intronENST00000521291ENST00000468413RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000396070ENST00000359878RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000396070ENST00000409157RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-intronENST00000396070ENST00000468413RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000287038ENST00000359878RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000287038ENST00000409157RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-intronENST00000287038ENST00000468413RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000523172ENST00000359878RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-3UTRENST00000523172ENST00000409157RPL30chr8

99054945

-KCTD18chr2

201353840

-
intron-intronENST00000523172ENST00000468413RPL30chr8

99054945

-KCTD18chr2

201353840

-

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FusionProtFeatures for RPL30_KCTD18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL30

P62888

KCTD18

Q6PI47


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL30_KCTD18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL30_KCTD18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL30_KCTD18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL30_KCTD18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource