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Fusion gene ID: 3187 |
FusionGeneSummary for ATG4C_NFIA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATG4C_NFIA | Fusion gene ID: 3187 | Hgene | Tgene | Gene symbol | ATG4C | NFIA | Gene ID | 84938 | 4774 |
| Gene name | autophagy related 4C cysteine peptidase | nuclear factor I A | |
| Synonyms | APG4-C|APG4C|AUTL1|AUTL3 | BRMUTD|CTF|NF-I/A|NF1-A|NFI-A|NFI-L | |
| Cytomap | 1p31.3 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine protease ATG4CAPG4 autophagy 4 homolog CATG4 autophagy related 4 homolog CAUT-like 1, cysteine endopeptidaseAUT-like 3 cysteine endopeptidaseautophagin-3autophagy-related cysteine endopeptidase 3autophagy-related protein 4 homolog C | nuclear factor 1 A-typeCCAAT-box-binding transcription factorTGGCA-binding protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96DT6 | Q12857 | |
| Ensembl transtripts involved in fusion gene | ENST00000371120, ENST00000317868, | ENST00000371191, ENST00000407417, ENST00000479364, ENST00000371189, ENST00000403491, ENST00000371187, ENST00000485903, ENST00000371185, ENST00000371184, ENST00000357977, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 11 X 13 X 6=858 |
| # samples | 4 | 15 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATG4C [Title/Abstract] AND NFIA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATG4C | GO:0006508 | proteolysis | 12446702 |
| Tgene | NFIA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17010934 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-20-1684-01A | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371120 | ENST00000371191 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| In-frame | ENST00000371120 | ENST00000407417 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000371120 | ENST00000479364 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000371120 | ENST00000371189 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000371120 | ENST00000403491 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000371120 | ENST00000371187 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000371120 | ENST00000485903 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000371120 | ENST00000371185 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-intron | ENST00000371120 | ENST00000371184 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-intron | ENST00000371120 | ENST00000357977 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| In-frame | ENST00000317868 | ENST00000371191 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| In-frame | ENST00000317868 | ENST00000407417 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000317868 | ENST00000479364 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000317868 | ENST00000371189 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000317868 | ENST00000403491 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000317868 | ENST00000371187 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000317868 | ENST00000485903 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-3UTR | ENST00000317868 | ENST00000371185 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-intron | ENST00000317868 | ENST00000371184 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
| 5CDS-intron | ENST00000317868 | ENST00000357977 | ATG4C | chr1 | 63270926 | + | NFIA | chr1 | 61798184 | + |
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FusionProtFeatures for ATG4C_NFIA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATG4C | NFIA |
| Cysteine protease required for the cytoplasm to vacuoletransport (Cvt) and autophagy. Is not essential for autophagydevelopment under normal conditions but is required for a properautophagic response under stressful conditions such as prolongedstarvation (By similarity). Cleaves the C-terminal amino acid ofATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminalglycine. Exposure of the glycine at the C-terminus is essentialfor ATG8 proteins conjugation to phosphatidylethanolamine (PE) andinsertion to membranes, which is necessary for autophagy. Has alsoan activity of delipidating enzyme for the PE-conjugated forms.{ECO:0000250, ECO:0000269|PubMed:21177865}. | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and inthe origin of replication of adenovirus type 2. These proteins areindividually capable of activating transcription and replication. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NFIA | chr1:63270926 | chr1:61798184 | ENST00000371187 | + | 2 | 10 | 1_194 | 208 | 499 | DNA binding | CTF/NF-I |
| Tgene | NFIA | chr1:63270926 | chr1:61798184 | ENST00000371189 | + | 3 | 12 | 1_194 | 253 | 555 | DNA binding | CTF/NF-I |
| Tgene | NFIA | chr1:63270926 | chr1:61798184 | ENST00000403491 | + | 2 | 11 | 1_194 | 208 | 510 | DNA binding | CTF/NF-I |
| Tgene | NFIA | chr1:63270926 | chr1:61798184 | ENST00000407417 | + | 2 | 11 | 1_194 | 200 | 502 | DNA binding | CTF/NF-I |
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FusionGeneSequence for ATG4C_NFIA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATG4C_ENST00000371120_chr1_63270926_+_NFIA_ENST00000371191_chr1_61798184_+_355aa MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFS LSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPS PSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQG >In-frame_ATG4C_ENST00000371120_chr1_63270926_+_NFIA_ENST00000407417_chr1_61798184_+_355aa MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFS LSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPS PSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQG >In-frame_ATG4C_ENST00000317868_chr1_63270926_+_NFIA_ENST00000371191_chr1_61798184_+_355aa MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFS LSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPS PSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQG >In-frame_ATG4C_ENST00000317868_chr1_63270926_+_NFIA_ENST00000407417_chr1_61798184_+_355aa MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGTGPNFS LSDLESSSYYSMSPGAMRRSLPSTSSTSSTKRLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSPS PSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATG4C_ENST00000371120_chr1_63270926_+_NFIA_ENST00000371191_chr1_61798184_+_1065nt ATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAA ACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAGGACATTTGGGCTTCCAGGAC AGTTTTGTCACATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCT CTCTCAGATTTGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACA AAGCGCCTCAAGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGT CAGTCAAGTGGATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCC CCTTCACAGACCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCA TCGACTCTTCATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACG CTGAAAGAATTTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGC AAGGTGCACAACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGAC ACAAAGCCTCCAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGA >In-frame_ATG4C_ENST00000371120_chr1_63270926_+_NFIA_ENST00000407417_chr1_61798184_+_1065nt ATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAA ACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAGGACATTTGGGCTTCCAGGAC AGTTTTGTCACATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCT CTCTCAGATTTGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACA AAGCGCCTCAAGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGT CAGTCAAGTGGATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCC CCTTCACAGACCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCA TCGACTCTTCATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACG CTGAAAGAATTTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGC AAGGTGCACAACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGAC ACAAAGCCTCCAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGA >In-frame_ATG4C_ENST00000317868_chr1_63270926_+_NFIA_ENST00000371191_chr1_61798184_+_1065nt ATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAA ACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAGGACATTTGGGCTTCCAGGAC AGTTTTGTCACATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCT CTCTCAGATTTGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACA AAGCGCCTCAAGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGT CAGTCAAGTGGATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCC CCTTCACAGACCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCA TCGACTCTTCATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACG CTGAAAGAATTTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGC AAGGTGCACAACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGAC ACAAAGCCTCCAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGA >In-frame_ATG4C_ENST00000317868_chr1_63270926_+_NFIA_ENST00000407417_chr1_61798184_+_1065nt ATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAA ACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAGGACATTTGGGCTTCCAGGAC AGTTTTGTCACATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCT CTCTCAGATTTGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACA AAGCGCCTCAAGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGT CAGTCAAGTGGATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCC CCTTCACAGACCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCA TCGACTCTTCATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACG CTGAAAGAATTTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGC AAGGTGCACAACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGAC ACAAAGCCTCCAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATG4C_ENST00000371120_chr1_63270926_+_NFIA_ENST00000371191_chr1_61798184_+_1429nt GTACCTGTAGCTGCGGCGCTGAGGTCGGAACGTCTGCGTGTGTGCGGGCTGGTTTTGTGGCGGCTGCTGCTAGAGCTGGAGCATTTGCCG GTCAGTATAAAAGATTAAACTCTACAGAAGAATGCAATCAAGTGATGGCTTTTCCTTTAGAATTTGAATATGGAGGCTACAGGAACAGAT GAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAAACAAAGACGTATTTTAGTAGA AATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAGGACATTTGGGCTTCCAGGACAGTTTTGTCACATCAGGTGTT TTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCTCTCTCAGATTTGGAAAGTTCT TCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACAAAGCGCCTCAAGTCTGTGGAG GATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGTCAGTCAAGTGGATGGCATGAA GTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCCCCTTCACAGACCTCCTCCCTG GGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCATCGACTCTTCATTTCCCGACA TCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACGCTGAAAGAATTTGTCCAACTT GTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGCAAGGTGCACAACCCATTCCTT CCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGACACAAAGCCTCCAACCACGTCA ACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGATTCGTCAGTGTTGGACCACGG GATCCAAGCTTTGTAAATATCCCTCAACAGACACAGTCCTGGTACCTGGGATAAAAGTTGCAGCGTCCCACCATCCACCAGACAGACCAC CTGACCCCTTCTCAACTCTGTAACATGGACGCAACCTCAACCCAGCGCAGTTACAACTTCACTATCAGCGGAAGGGGAGAAAAACCGATT >In-frame_ATG4C_ENST00000371120_chr1_63270926_+_NFIA_ENST00000407417_chr1_61798184_+_1489nt GTACCTGTAGCTGCGGCGCTGAGGTCGGAACGTCTGCGTGTGTGCGGGCTGGTTTTGTGGCGGCTGCTGCTAGAGCTGGAGCATTTGCCG GTCAGTATAAAAGATTAAACTCTACAGAAGAATGCAATCAAGTGATGGCTTTTCCTTTAGAATTTGAATATGGAGGCTACAGGAACAGAT GAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAAACAAAGACGTATTTTAGTAGA AATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAGGACATTTGGGCTTCCAGGACAGTTTTGTCACATCAGGTGTT TTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATAGCTGCAGGAACTGGCCCAAATTTTTCTCTCTCAGATTTGGAAAGTTCT TCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTACCCAGCACATCCTCTACGAGCTCCACAAAGCGCCTCAAGTCTGTGGAG GATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGCCAAGGGCGCTCCCCAGGAAGTGGCAGTCAGTCAAGTGGATGGCATGAA GTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCGGAGAAGTCTGGTTTCAGCAGCCCCTCCCCTTCACAGACCTCCTCCCTG GGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGACCCAGAGCAAGTCCGCATGCAACACCATCGACTCTTCATTTCCCGACA TCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCAGCCATCCGCTATCACCCTCAGGAGACGCTGAAAGAATTTGTCCAACTT GTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTCCTCAATCCCAATGGGAGCAGCCAAGGCAAGGTGCACAACCCATTCCTT CCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCCAGGCCTGTGCCTCTGCCGGTGCCAGACACAAAGCCTCCAACCACGTCA ACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCGACACCCAGCACCTCCCCCGCAAACCGATTCGTCAGTGTTGGACCACGG GATCCAAGCTTTGTAAATATCCCTCAACAGACACAGTCCTGGTACCTGGGATAAAAGTTGCAGCGTCCCACCATCCACCAGACAGACCAC CTGACCCCTTCTCAACTCTGTAACATGGACGCAACCTCAACCCAGCGCAGTTACAACTTCACTATCAGCGGAAGGGGAGAAAAACCGATT CAAATCAACTTGTACATGGAAACAGCAAGCATTATGGTCAAACAGCAAAGGCCATAACCTTTTGGGATTTTTTTTTTTTTAAAATACTTT >In-frame_ATG4C_ENST00000317868_chr1_63270926_+_NFIA_ENST00000371191_chr1_61798184_+_1477nt GTACCTGTAGCTGCGGCGCTGAGGTCGGAACGTCTGCGTGTGTGCGGGCTGGTTTTGTGGCGGCTGCTGCTAGAGCTGGAGCATTTGCCG GGTTGGTGGCTCCTGCACATTTTTACAGTTCTCCAGTCCTTCTCTTTCGTCAGTATAAAAGATTAAACTCTACAGAAGAATGCAATCAAG TGATGGCTTTTCCTTTAGAATTTGAATATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAAC AACATGAAATATAGTTGGGTGTTGAAAACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAA TATGAAGGACATTTGGGCTTCCAGGACAGTTTTGTCACATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATA GCTGCAGGAACTGGCCCAAATTTTTCTCTCTCAGATTTGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTA CCCAGCACATCCTCTACGAGCTCCACAAAGCGCCTCAAGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGC CAAGGGCGCTCCCCAGGAAGTGGCAGTCAGTCAAGTGGATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCG GAGAAGTCTGGTTTCAGCAGCCCCTCCCCTTCACAGACCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGA CCCAGAGCAAGTCCGCATGCAACACCATCGACTCTTCATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCA GCCATCCGCTATCACCCTCAGGAGACGCTGAAAGAATTTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTC CTCAATCCCAATGGGAGCAGCCAAGGCAAGGTGCACAACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCC AGGCCTGTGCCTCTGCCGGTGCCAGACACAAAGCCTCCAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCG ACACCCAGCACCTCCCCCGCAAACCGATTCGTCAGTGTTGGACCACGGGATCCAAGCTTTGTAAATATCCCTCAACAGACACAGTCCTGG TACCTGGGATAAAAGTTGCAGCGTCCCACCATCCACCAGACAGACCACCTGACCCCTTCTCAACTCTGTAACATGGACGCAACCTCAACC CAGCGCAGTTACAACTTCACTATCAGCGGAAGGGGAGAAAAACCGATTCAAATCAACTTGTACATGGAAACAGCAAGCATTATGGTCAAA >In-frame_ATG4C_ENST00000317868_chr1_63270926_+_NFIA_ENST00000407417_chr1_61798184_+_1537nt GTACCTGTAGCTGCGGCGCTGAGGTCGGAACGTCTGCGTGTGTGCGGGCTGGTTTTGTGGCGGCTGCTGCTAGAGCTGGAGCATTTGCCG GGTTGGTGGCTCCTGCACATTTTTACAGTTCTCCAGTCCTTCTCTTTCGTCAGTATAAAAGATTAAACTCTACAGAAGAATGCAATCAAG TGATGGCTTTTCCTTTAGAATTTGAATATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAAC AACATGAAATATAGTTGGGTGTTGAAAACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAA TATGAAGGACATTTGGGCTTCCAGGACAGTTTTGTCACATCAGGTGTTTTTAGTGTCACTGAGCTAGTAAGAGTGTCACAGACACCAATA GCTGCAGGAACTGGCCCAAATTTTTCTCTCTCAGATTTGGAAAGTTCTTCATACTACAGCATGAGTCCAGGAGCAATGAGGAGGTCTTTA CCCAGCACATCCTCTACGAGCTCCACAAAGCGCCTCAAGTCTGTGGAGGATGAAATGGACAGTCCTGGTGAGGAGCCATTTTATACAGGC CAAGGGCGCTCCCCAGGAAGTGGCAGTCAGTCAAGTGGATGGCATGAAGTGGAGCCAGGAATGCCATCTCCAACCACACTGAAGAAGTCG GAGAAGTCTGGTTTCAGCAGCCCCTCCCCTTCACAGACCTCCTCCCTGGGAACGGCGTTCACACAGCATCACCGACCTGTCATTACAGGA CCCAGAGCAAGTCCGCATGCAACACCATCGACTCTTCATTTCCCGACATCACCCATTATCCAGCAGCCTGGGCCTTACTTCTCACACCCA GCCATCCGCTATCACCCTCAGGAGACGCTGAAAGAATTTGTCCAACTTGTCTGCCCTGATGCTGGTCAGCAGGCTGGACAGGTGGGGTTC CTCAATCCCAATGGGAGCAGCCAAGGCAAGGTGCACAACCCATTCCTTCCCACCCCAATGTTGCCACCGCCACCGCCACCACCGATGGCC AGGCCTGTGCCTCTGCCGGTGCCAGACACAAAGCCTCCAACCACGTCAACAGAAGGAGGTGCAGCCTCCCCCACGTCACCAACCTACTCG ACACCCAGCACCTCCCCCGCAAACCGATTCGTCAGTGTTGGACCACGGGATCCAAGCTTTGTAAATATCCCTCAACAGACACAGTCCTGG TACCTGGGATAAAAGTTGCAGCGTCCCACCATCCACCAGACAGACCACCTGACCCCTTCTCAACTCTGTAACATGGACGCAACCTCAACC CAGCGCAGTTACAACTTCACTATCAGCGGAAGGGGAGAAAAACCGATTCAAATCAACTTGTACATGGAAACAGCAAGCATTATGGTCAAA CAGCAAAGGCCATAACCTTTTGGGATTTTTTTTTTTTTAAAATACTTTAGGGACTGTTGTAATTTCTCATATGGTGCTGGAAATGGTTGG |
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FusionGenePPI for ATG4C_NFIA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATG4C | SPTLC1, PSMD2, PSMC2, PSMC1, USP11, PRKDC, PSMC5, PSMC4, SMC1A, RAB3IL1, KLHL22, WASL, GSTA2 | NFIA | ELAVL1, TFAP4, SAP18, PCDHA2, NOP2, TRA2A, HNRNPU, TPBG, SRSF7, NOP56, RRS1, RPS13, SON, SRSF10, FTSJ3, RRP7A, UTP14A, ZNF326, RPS6, DDX21, RPS24, SURF4, DHX9, TRIM55, VTN, LUC7L3, RBM25, HP1BP3, ACIN1, ADNP, SRSF3, TRA2B, RPS11, RPL37A, SMAD4, SMAD2, SMAD3, XPO1, CREB1, RBPJ, FOXC2, NFIB, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATG4C_NFIA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATG4C_NFIA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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