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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31866

FusionGeneSummary for RPL28_LASP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL28_LASP1
Fusion gene ID: 31866
HgeneTgene
Gene symbol

RPL28

LASP1

Gene ID

6158

3927

Gene nameribosomal protein L28LIM and SH3 protein 1
SynonymsL28Lasp-1|MLN50
Cytomap

19q13.42

17q12

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L28large ribosomal subunit protein eL28LIM and SH3 domain protein 1metastatic lymph node gene 50 protein
Modification date2018052520180522
UniProtAcc

P46779

Q14847

Ensembl transtripts involved in fusion geneENST00000344063, ENST00000431533, 
ENST00000428193, ENST00000558815, 
ENST00000560583, ENST00000560055, 
ENST00000559463, ENST00000558131, 
ENST00000558752, ENST00000458349, 
ENST00000318008, ENST00000433206, 
ENST00000435347, 
Fusion gene scores* DoF score9 X 9 X 2=16213 X 12 X 7=1092
# samples 1116
** MAII scorelog2(11/162*10)=-0.558490289359965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL28 [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE388585RPL28chr19

55897775

+LASP1chr17

37076280

+
ChiTaRS3.1BE387849RPL28chr19

55897775

+LASP1chr17

37076280

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000344063ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000344063ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000344063ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000431533ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000431533ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000431533ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000428193ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000428193ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000428193ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000558815ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000558815ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000558815ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000560583ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000560583ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000560583ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000560055ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000560055ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000560055ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000559463ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000559463ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000559463ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000558131ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000558131ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000558131ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000558752ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000558752ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000558752ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-3UTRENST00000458349ENST00000318008RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000458349ENST00000433206RPL28chr19

55897775

+LASP1chr17

37076280

+
5CDS-intronENST00000458349ENST00000435347RPL28chr19

55897775

+LASP1chr17

37076280

+

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FusionProtFeatures for RPL28_LASP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL28

P46779

LASP1

Q14847

Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL28_LASP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL28_LASP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL28_LASP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL28_LASP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL28C0043094Weight Gain1CTD_human
TgeneLASP1C0004352Autistic Disorder1CTD_human
TgeneLASP1C0036341Schizophrenia1PSYGENET