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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31862

FusionGeneSummary for RPL28_EPB41L1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL28_EPB41L1
Fusion gene ID: 31862
HgeneTgene
Gene symbol

RPL28

EPB41L1

Gene ID

6158

2036

Gene nameribosomal protein L28erythrocyte membrane protein band 4.1 like 1
SynonymsL284.1N|MRD11
Cytomap

19q13.42

20q11.23

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L28large ribosomal subunit protein eL28band 4.1-like protein 1neuron-type nonerythroid protein 4.1neuronal protein 4.1
Modification date2018052520180523
UniProtAcc

P46779

Q9H4G0

Ensembl transtripts involved in fusion geneENST00000344063, ENST00000431533, 
ENST00000428193, ENST00000558815, 
ENST00000560583, ENST00000560055, 
ENST00000559463, ENST00000558131, 
ENST00000558752, ENST00000458349, 
ENST00000202028, ENST00000373950, 
ENST00000441639, ENST00000373946, 
ENST00000338074, ENST00000373941, 
ENST00000479336, 
Fusion gene scores* DoF score9 X 9 X 2=1629 X 8 X 7=504
# samples 1111
** MAII scorelog2(11/162*10)=-0.558490289359965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL28 [Title/Abstract] AND EPB41L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA776201RPL28chr19

55899611

-EPB41L1chr20

34776411

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000344063ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000344063ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000344063ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000344063ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000344063ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000344063ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000344063ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000431533ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000431533ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000431533ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000431533ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000431533ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000431533ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000431533ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000428193ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000428193ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000428193ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000428193ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000428193ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000428193ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000428193ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558815ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558815ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558815ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558815ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558815ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558815ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000558815ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-3CDSENST00000560583ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-3CDSENST00000560583ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-3CDSENST00000560583ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-3CDSENST00000560583ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-3CDSENST00000560583ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-3CDSENST00000560583ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
3UTR-intronENST00000560583ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000560055ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000560055ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000560055ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000560055ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000560055ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000560055ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000560055ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000559463ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000559463ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000559463ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000559463ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000559463ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000559463ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000559463ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558131ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558131ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558131ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558131ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558131ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558131ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000558131ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558752ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558752ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558752ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558752ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558752ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000558752ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000558752ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000458349ENST00000202028RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000458349ENST00000373950RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000458349ENST00000441639RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000458349ENST00000373946RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000458349ENST00000338074RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-3CDSENST00000458349ENST00000373941RPL28chr19

55899611

-EPB41L1chr20

34776411

-
intron-intronENST00000458349ENST00000479336RPL28chr19

55899611

-EPB41L1chr20

34776411

-

Top

FusionProtFeatures for RPL28_EPB41L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL28

P46779

EPB41L1

Q9H4G0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPL28_EPB41L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL28_EPB41L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL28_EPB41L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RPL28_EPB41L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL28C0043094Weight Gain1CTD_human
TgeneEPB41L1C3280285MENTAL RETARDATION, AUTOSOMAL DOMINANT 111UNIPROT