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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31823

FusionGeneSummary for RPL18_TAGLN

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL18_TAGLN
Fusion gene ID: 31823
HgeneTgene
Gene symbol

RPL18

TAGLN

Gene ID

6141

6876

Gene nameribosomal protein L18transgelin
SynonymsL18SM22|SM22-alpha|SMCC|TAGLN1|WS3-10
Cytomap

19q13.33

11q23.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L18large ribosomal subunit protein eL18transgelin22 kDa actin-binding proteinsmooth muscle protein 22-alphatransgelin variant 2
Modification date2018052320180519
UniProtAcc

Q07020

Q01995

Ensembl transtripts involved in fusion geneENST00000549920, ENST00000550645, 
ENST00000552588, ENST00000549273, 
ENST00000392951, ENST00000530649, 
ENST00000532870, 
Fusion gene scores* DoF score20 X 12 X 6=14408 X 13 X 4=416
# samples 2116
** MAII scorelog2(21/1440*10)=-2.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/416*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL18 [Title/Abstract] AND TAGLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL18

GO:0002181

cytoplasmic translation

25957688

TgeneTAGLN

GO:0030855

epithelial cell differentiation

21492153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-VN-A88I-01ARPL18chr19

49118650

-TAGLNchr11

117070098

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000549920ENST00000392951RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000549920ENST00000530649RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000549920ENST00000532870RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-5UTRENST00000550645ENST00000392951RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000550645ENST00000530649RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000550645ENST00000532870RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-5UTRENST00000552588ENST00000392951RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000552588ENST00000530649RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000552588ENST00000532870RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-5UTRENST00000549273ENST00000392951RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000549273ENST00000530649RPL18chr19

49118650

-TAGLNchr11

117070098

+
intron-intronENST00000549273ENST00000532870RPL18chr19

49118650

-TAGLNchr11

117070098

+

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FusionProtFeatures for RPL18_TAGLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL18

Q07020

TAGLN

Q01995

Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. Actin cross-linking/gelling protein (By similarity).Involved in calcium interactions and contractile properties of thecell that may contribute to replicative senescence. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL18_TAGLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL18_TAGLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPL18FANCA, FANCC, ESR1, CD4, NOP56, DYRK2, ARRB2, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, RPL10A, RPL11, RPL12, RPL13, RPL15, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL24, RPL27A, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS13, RPS14, RPS15A, RPS16, RPS19, RPS23, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL23A, RPL14, RPL30, RPS24, RPS12, RPS20, RPS11, RPLP0, RPL36, RPL27, RPS9, RPL10, RPL35, RPS17, RPL38, RPL17, RPL32, RPS21, RPS27A, EEF2, EEF1A1, FBL, ILF3, HNRNPU, NCL, SLC25A5, ILF2, MYBBP1A, EEF1D, NHP2L1, ACTA2, HNRNPM, U2AF2, RPS27L, ATP5A1, MYL12A, RPL10L, RPLP0P6, NOP2, PTGES3, RPS10P5, ATP5B, HIST1H2AD, NIFK, HSP90AA5P, RHOA, TUBA1B, MRPL12, MAGOH, EIF4A3, PA2G4, FN1, VCAM1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CDKN1A, FBXO6, EEF1E1, FAU, IARS, NUDT21, RPA3, RPA2, RPA1, ZBTB1, STAU1, CEP250, TP53, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, RBM4B, NTRK1, HNRNPUL2, PABPC1, PABPC4, RPL13A, RPL26L1, RPL3L, RPLP1, RPS27, RPL26, RPL34, RPL35A, RPLP2, RPS10, RPS15, RPS18, LOC101929876, SFN, XPO1, NPM1, CENPQ, SKI, MCM2, NF2, RC3H1, ZNF746, CEBPZ, PDCD11, FNTB, VPRBP, UBE2O, NOC2L, RRP8, CNBP, NLE1, NSUN4, KIAA0020, MINA, GNL2, RRS1, EBNA1BP2, CENPC, REXO4, TTC19, RBM34, NOL8, NAP1L1, GTPBP4, RBM28, ZC3H10, SPTY2D1, DKC1, DDX10, C1QBP, FTSJ3, MRPL48, DDX27, FNTA, MECP2, BRIX1, NAP1L4, ZNF512, MRPS31, DDX51, ZNF22, ZC3HAV1, DDX24, DDX52, MRPL16, RRP7A, MRPS33, MRPL28, ZNF644, HERC5, MRPS9, FCF1, MRPL13, MRPS18C, MRPL32, MRPS35, RBM19, DDX54, NOC3L, RPL28, MRPL47, URB1, DDX56, DHX30, RRP1, ZNF771, BUD13, RPF2, PAK1IP1, MRPL27, MRPL24, NSA2, DDX18, C3orf17, MRPL20, PPAN-P2RY11, MRPL17, MRPS5, MRPL3, UTP3, GNL3, MRPS10, MRPL51, CYLD, INO80B, TRIM25, BRCA1, YAP1TAGLNS100A9, CFL1, GIPC1, ACTA1, ISG15, TINF2, ACD, POT1, RNF14, NDUFA7, SARNP, RBM27, MRPL53, SUGP1, SRPRB, SF1, BAG3, PIK3CD, NCF1, JAK1, DUSP6, ACAA2, ALDOA, ALDOC, EEF2, ENO1, ENO2, ENO3, FABP3, FABP5, FABP7, FKBP1A, FKBP1B, GPX4, HSPE1, NUTF2, PGD, PLS3, STIP1, FKBP2, GSTO1, HINT1, HSD17B10, NME1-NME2, NME2, PPIB, SNX12, SNX3, YKT6, UCHL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL18_TAGLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPL18Q07020DB11638Artenimol60S ribosomal protein L18small moleculeapproved|investigational

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RelatedDiseases for RPL18_TAGLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL18C0038356Stomach Neoplasms1CTD_human
TgeneTAGLNC0023794Lipoidosis3CTD_human
TgeneTAGLNC0009375Colonic Neoplasms1CTD_human
TgeneTAGLNC0014175Endometriosis1CTD_human
TgeneTAGLNC0022548Keloid1CTD_human
TgeneTAGLNC0279626Squamous cell carcinoma of esophagus1CTD_human