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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31776

FusionGeneSummary for RPL11_CAMTA1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL11_CAMTA1
Fusion gene ID: 31776
HgeneTgene
Gene symbol

RPL11

CAMTA1

Gene ID

6135

23261

Gene nameribosomal protein L11calmodulin binding transcription activator 1
SynonymsDBA7|GIG34|L11|uL5CANPMR
Cytomap

1p36.11

1p36.31-p36.23

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L11CLL-associated antigen KW-12cell growth-inhibiting protein 34large ribosomal subunit protein uL5calmodulin-binding transcription activator 1
Modification date2018052320180523
UniProtAcc

P62913

Q9Y6Y1

Ensembl transtripts involved in fusion geneENST00000374550, ENST00000482370, 
ENST00000303635, ENST00000439411, 
ENST00000476163, ENST00000557126, 
ENST00000473578, ENST00000467404, 
ENST00000476864, 
Fusion gene scores* DoF score11 X 11 X 5=60515 X 13 X 5=975
# samples 1116
** MAII scorelog2(11/605*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL11 [Title/Abstract] AND CAMTA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL11

GO:0002181

cytoplasmic translation

25957688

HgeneRPL11

GO:0010628

positive regulation of gene expression

18560357

HgeneRPL11

GO:2000435

negative regulation of protein neddylation

18560357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1XZ-01ARPL11chr1

24022398

+CAMTA1chr1

7805905

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000374550ENST00000303635RPL11chr1

24022398

+CAMTA1chr1

7805905

+
5CDS-intronENST00000374550ENST00000439411RPL11chr1

24022398

+CAMTA1chr1

7805905

+
5CDS-intronENST00000374550ENST00000476163RPL11chr1

24022398

+CAMTA1chr1

7805905

+
5CDS-intronENST00000374550ENST00000557126RPL11chr1

24022398

+CAMTA1chr1

7805905

+
5CDS-intronENST00000374550ENST00000473578RPL11chr1

24022398

+CAMTA1chr1

7805905

+
5CDS-intronENST00000374550ENST00000467404RPL11chr1

24022398

+CAMTA1chr1

7805905

+
5CDS-intronENST00000374550ENST00000476864RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-3CDSENST00000482370ENST00000303635RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-intronENST00000482370ENST00000439411RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-intronENST00000482370ENST00000476163RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-intronENST00000482370ENST00000557126RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-intronENST00000482370ENST00000473578RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-intronENST00000482370ENST00000467404RPL11chr1

24022398

+CAMTA1chr1

7805905

+
3UTR-intronENST00000482370ENST00000476864RPL11chr1

24022398

+CAMTA1chr1

7805905

+

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FusionProtFeatures for RPL11_CAMTA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL11

P62913

CAMTA1

Q9Y6Y1

Component of the ribosome, a large ribonucleoproteincomplex responsible for the synthesis of proteins in the cell. Thesmall ribosomal subunit (SSU) binds messenger RNAs (mRNAs) andtranslates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) containsthe ribosomal catalytic site termed the peptidyl transferasecenter (PTC), which catalyzes the formation of peptide bonds,thereby polymerizing the amino acids delivered by tRNAs into apolypeptide chain. The nascent polypeptides leave the ribosomethrough a tunnel in the LSU and interact with protein factors thatfunction in enzymatic processing, targeting, and the membraneinsertion of nascent chains at the exit of the ribosomal tunnel.As part of the 5S RNP/5S ribonucleoprotein particle it is anessential component of the LSU, required for its formation and thematuration of rRNAs (PubMed:19061985, PubMed:12962325,PubMed:24120868). It also couples ribosome biogenesis to p53/TP53activation. As part of the 5S RNP it accumulates in thenucleoplasm and inhibits MDM2, when ribosome biogenesis isperturbed, mediating the stabilization and the activation of TP53(PubMed:24120868). Promotes nucleolar location of PML (Bysimilarity). {ECO:0000250|UniProtKB:Q9CXW4,ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985,ECO:0000269|PubMed:24120868}. Transcriptional activator. May act as a tumorsuppressor. {ECO:0000269|PubMed:11925432,ECO:0000269|PubMed:15709179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL11_CAMTA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL11_CAMTA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPL11PML, MDM2, CDKN2A, TP53, BLMH, RPL23, RPL5, MYC, AGO4, NOP56, RAD21, ARRB2, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPL10A, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL24, RPL27A, RPL31, RPL37A, RPL6, RPL7A, RPL7, RPL9, RPS11, RPS12, RPS13, RPS14, RPS15A, RPS16, RPS20, RPS23, RPS24, RPS25, RPS28, RPS2, RPS3, RPS4X, RPS6, RPS8, RPSA, RPL30, RPS3A, RPS5, RPS19, RPL4, RPS7, RPL22, RPS26, RPLP1, RPL36, RPL8, RPLP0, RPL3, RPS9, RPL10, RPL35, RPS10, RPL38, RPL17, RPS21, EEF1A1, RPS27A, EEF2, GNL3, FBL, ILF3, ILF2, SLC25A5, NCL, NHP2L1, TUFM, HNRNPM, NOP58, NAP1L1, NOLC1, RPS27L, NOP2, MRPL12, BTF3, ANXA2, RPL10L, RPLP0P6, RRS1, NIFK, UQCRB, NEMF, UPF1, RBM8A, ESR1, LIG4, FMNL1, PA2G4, FN1, VCAM1, UBL4A, ITGA4, PELP1, VHL, PAN2, CD81, IGSF8, ICAM1, MYEOV2, ARFGAP1, PAIP2, STAT3, HP, IGF1R, C12orf5, TARDBP, QRICH1, ZBTB1, AURKA, CEP57, CEP250, TUBGCP2, TUBGCP3, FUS, CAMK2B, KRT40, KRTAP10-7, CUL7, OBSL1, CCDC8, EED, SURF2, BRIX1, FAU, MRPL24, MRPS10, MRPS7, PAK1IP1, DDX18, DDX24, EBNA1BP2, KPNA6, KRR1, PABPC1, POLR1B, RPL13A, RPL27, RPLP2, RPS15, RPL32, RPL35A, RPL3L, RPS18, LOC101929876, RPS27, APP, HSPB2, AHSA1, HNRNPU, NPM1, TP73, MCM2, ZNF618, RC3H1, GRWD1, CDC73, CHIT1, CNBP, ALDH2, TUBA1A, CYLD, INO80B, TRIM25, HEY1, BRCA1, LMNA, MTF1CAMTA1ALB, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL11_CAMTA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPL11_CAMTA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL11C2675512Diamond-Blackfan Anemia 71CTD_human;UNIPROT