FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31773

FusionGeneSummary for RPL10_SCLY

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL10_SCLY
Fusion gene ID: 31773
HgeneTgene
Gene symbol

RPL10

SCLY

Gene ID

6134

51540

Gene nameribosomal protein L10selenocysteine lyase
SynonymsAUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QMSCL|hSCL
Cytomap

Xq28

2q37.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QMselenocysteine lyase
Modification date2018052320180519
UniProtAcc

P27635

Q96I15

Ensembl transtripts involved in fusion geneENST00000369817, ENST00000479366, 
ENST00000424325, ENST00000406022, 
ENST00000254663, ENST00000373332, 
ENST00000555827, ENST00000409736, 
ENST00000422984, ENST00000429612, 
ENST00000480859, 
Fusion gene scores* DoF score10 X 8 X 2=1602 X 2 X 1=4
# samples 102
** MAII scorelog2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: RPL10 [Title/Abstract] AND SCLY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA813916RPL10chrX

153629200

-SCLYchr2

239007567

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000369817ENST00000254663RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000369817ENST00000373332RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-3UTRENST00000369817ENST00000555827RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000369817ENST00000409736RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000369817ENST00000422984RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000369817ENST00000429612RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000369817ENST00000480859RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-3UTRENST00000479366ENST00000254663RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-intronENST00000479366ENST00000373332RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-3UTRENST00000479366ENST00000555827RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-intronENST00000479366ENST00000409736RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-intronENST00000479366ENST00000422984RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-intronENST00000479366ENST00000429612RPL10chrX

153629200

-SCLYchr2

239007567

-
intron-intronENST00000479366ENST00000480859RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-3UTRENST00000424325ENST00000254663RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000424325ENST00000373332RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-3UTRENST00000424325ENST00000555827RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000424325ENST00000409736RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000424325ENST00000422984RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000424325ENST00000429612RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000424325ENST00000480859RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-3UTRENST00000406022ENST00000254663RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000406022ENST00000373332RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-3UTRENST00000406022ENST00000555827RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000406022ENST00000409736RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000406022ENST00000422984RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000406022ENST00000429612RPL10chrX

153629200

-SCLYchr2

239007567

-
3UTR-intronENST00000406022ENST00000480859RPL10chrX

153629200

-SCLYchr2

239007567

-

Top

FusionProtFeatures for RPL10_SCLY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL10

P27635

SCLY

Q96I15

Component of the large ribosomal subunit(PubMed:26290468). Plays a role in the formation of activelytranslating ribosomes (PubMed:26290468). May play a role in theembryonic brain development (PubMed:25316788).{ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468,ECO:0000305|PubMed:12962325}. Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPL10_SCLY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPL10_SCLY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPL10_SCLY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPL10P27635DB11638Artenimol60S ribosomal protein L10 {ECO:0000305}small moleculeapproved|investigational
TgeneSCLYQ96I15DB00114Pyridoxal PhosphateSelenocysteine lyasesmall moleculeapproved|investigational|nutraceutical

Top

RelatedDiseases for RPL10_SCLY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL10C3275438AUTISM, SUSCEPTIBILITY TO, X-LINKED 52UNIPROT
HgeneRPL10C0004352Autistic Disorder1CTD_human
HgeneRPL10C0033578Prostatic Neoplasms1CTD_human
HgeneRPL10C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human