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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31770

FusionGeneSummary for RPL10_POLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL10_POLA2
Fusion gene ID: 31770
HgeneTgene
Gene symbol

RPL10

POLA2

Gene ID

6134

23649

Gene nameribosomal protein L10DNA polymerase alpha 2, accessory subunit
SynonymsAUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QM-
Cytomap

Xq28

11q13.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QMDNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)
Modification date2018052320180523
UniProtAcc

P27635

Q14181

Ensembl transtripts involved in fusion geneENST00000369817, ENST00000479366, 
ENST00000424325, ENST00000406022, 
ENST00000265465, ENST00000541089, 
ENST00000534785, 
Fusion gene scores* DoF score10 X 8 X 2=1607 X 6 X 5=210
# samples 107
** MAII scorelog2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL10 [Title/Abstract] AND POLA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC015618RPL10chrX

153628152

-POLA2chr11

65029451

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369817ENST00000265465RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-5UTRENST00000369817ENST00000541089RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-intronENST00000369817ENST00000534785RPL10chrX

153628152

-POLA2chr11

65029451

+
intron-5UTRENST00000479366ENST00000265465RPL10chrX

153628152

-POLA2chr11

65029451

+
intron-5UTRENST00000479366ENST00000541089RPL10chrX

153628152

-POLA2chr11

65029451

+
intron-intronENST00000479366ENST00000534785RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-5UTRENST00000424325ENST00000265465RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-5UTRENST00000424325ENST00000541089RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-intronENST00000424325ENST00000534785RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-5UTRENST00000406022ENST00000265465RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-5UTRENST00000406022ENST00000541089RPL10chrX

153628152

-POLA2chr11

65029451

+
5CDS-intronENST00000406022ENST00000534785RPL10chrX

153628152

-POLA2chr11

65029451

+

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FusionProtFeatures for RPL10_POLA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL10

P27635

POLA2

Q14181

Component of the large ribosomal subunit(PubMed:26290468). Plays a role in the formation of activelytranslating ribosomes (PubMed:26290468). May play a role in theembryonic brain development (PubMed:25316788).{ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468,ECO:0000305|PubMed:12962325}. May play an essential role at the early stage ofchromosomal DNA replication by coupling the polymerasealpha/primase complex to the cellular replication machinery.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPL10_POLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPL10_POLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPL10_POLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPL10P27635DB11638Artenimol60S ribosomal protein L10 {ECO:0000305}small moleculeapproved|investigational
TgenePOLA2Q14181DB00851DacarbazineDNA polymerase alpha subunit Bsmall moleculeapproved|investigational

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RelatedDiseases for RPL10_POLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPL10C3275438AUTISM, SUSCEPTIBILITY TO, X-LINKED 52UNIPROT
HgeneRPL10C0004352Autistic Disorder1CTD_human
HgeneRPL10C0033578Prostatic Neoplasms1CTD_human
HgeneRPL10C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human