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Fusion gene ID: 31726 |
FusionGeneSummary for ROS1_FBXO9 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ROS1_FBXO9 | Fusion gene ID: 31726 | Hgene | Tgene | Gene symbol | ROS1 | FBXO9 | Gene ID | 6098 | 26268 |
Gene name | ROS proto-oncogene 1, receptor tyrosine kinase | F-box protein 9 | |
Synonyms | MCF3|ROS|c-ros-1 | FBX9|NY-REN-57|VCIA1|dJ341E18.2 | |
Cytomap | 6q22.1 | 6p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | F-box only protein 9F-box protein Fbx9cross-immune reaction antigen 1renal carcinoma antigen NY-REN-57 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P08922 | Q9UK97 | |
Ensembl transtripts involved in fusion gene | ENST00000368508, ENST00000368507, | ENST00000370939, ENST00000323557, ENST00000244426, ENST00000461222, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 4=64 |
# samples | 3 | 5 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ROS1 [Title/Abstract] AND FBXO9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
Hgene | ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
Hgene | ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
Tgene | FBXO9 | GO:0016567 | protein ubiquitination | 23263282 |
Tgene | FBXO9 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 23263282 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-64-1680-01A | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000368508 | ENST00000370939 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
Frame-shift | ENST00000368508 | ENST00000323557 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
Frame-shift | ENST00000368508 | ENST00000244426 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
5CDS-intron | ENST00000368508 | ENST00000461222 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
Frame-shift | ENST00000368507 | ENST00000370939 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
Frame-shift | ENST00000368507 | ENST00000323557 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
Frame-shift | ENST00000368507 | ENST00000244426 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
5CDS-intron | ENST00000368507 | ENST00000461222 | ROS1 | chr6 | 117724302 | - | FBXO9 | chr6 | 52962520 | + |
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FusionProtFeatures for ROS1_FBXO9 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ROS1 | FBXO9 |
Orphan receptor tyrosine kinase (RTK) that plays a rolein epithelial cell differentiation and regionalization of theproximal epididymal epithelium. May activate several downstreamsignaling pathways related to cell differentiation, proliferation,growth and survival including the PI3 kinase-mTOR signalingpathway. Mediates the phosphorylation of PTPN11, an activator ofthis pathway. May also phosphorylate and activate thetranscription factor STAT3 to control anchorage-independent cellgrowth. Mediates the phosphorylation and the activation of VAV3, aguanine nucleotide exchange factor regulating cell morphology. Mayactivate other downstream signaling proteins including AKT1,MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073,ECO:0000269|PubMed:16885344}. | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation of TTI1and TELO2 in a CK2-dependent manner, thereby directly regulatingmTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1and TELO2 when they are phosphorylated by CK2 following growthfactor deprivation, leading to their degradation. In contrast, theSCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 whenthey are part of the mTORC2 complex. As a consequence, mTORC1 isinactivated to restrain cell growth and protein translation, whilemTORC2 is activated due to the relief of feedback inhibition bymTORC1. {ECO:0000269|PubMed:23263282}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ROS1_FBXO9 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ROS1_FBXO9 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ROS1 | PTPN6, PTPN11, VAV3, IKBKG, GRB2 | FBXO9 | CALM1, CUL1, COPS5, HSP90AA1, GFOD1, SKP1, XPO1, EEF2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROS1_FBXO9 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROS1_FBXO9 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ROS1 | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
Hgene | ROS1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | ROS1 | C0025202 | melanoma | 1 | CTD_human |
Hgene | ROS1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | FBXO9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |