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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31726

FusionGeneSummary for ROS1_FBXO9

check button Fusion gene summary
Fusion gene informationFusion gene name: ROS1_FBXO9
Fusion gene ID: 31726
HgeneTgene
Gene symbol

ROS1

FBXO9

Gene ID

6098

26268

Gene nameROS proto-oncogene 1, receptor tyrosine kinaseF-box protein 9
SynonymsMCF3|ROS|c-ros-1FBX9|NY-REN-57|VCIA1|dJ341E18.2
Cytomap

6q22.1

6p12.1

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1F-box only protein 9F-box protein Fbx9cross-immune reaction antigen 1renal carcinoma antigen NY-REN-57
Modification date2018052320180523
UniProtAcc

P08922

Q9UK97

Ensembl transtripts involved in fusion geneENST00000368508, ENST00000368507, 
ENST00000370939, ENST00000323557, 
ENST00000244426, ENST00000461222, 
Fusion gene scores* DoF score3 X 3 X 1=94 X 4 X 4=64
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROS1 [Title/Abstract] AND FBXO9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROS1

GO:0001558

regulation of cell growth

16885344

HgeneROS1

GO:0006468

protein phosphorylation

16885344

HgeneROS1

GO:0032006

regulation of TOR signaling

16885344

TgeneFBXO9

GO:0016567

protein ubiquitination

23263282

TgeneFBXO9

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

23263282


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-64-1680-01AROS1chr6

117724302

-FBXO9chr6

52962520

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000368508ENST00000370939ROS1chr6

117724302

-FBXO9chr6

52962520

+
Frame-shitENST00000368508ENST00000323557ROS1chr6

117724302

-FBXO9chr6

52962520

+
Frame-shitENST00000368508ENST00000244426ROS1chr6

117724302

-FBXO9chr6

52962520

+
5CDS-intronENST00000368508ENST00000461222ROS1chr6

117724302

-FBXO9chr6

52962520

+
Frame-shitENST00000368507ENST00000370939ROS1chr6

117724302

-FBXO9chr6

52962520

+
Frame-shitENST00000368507ENST00000323557ROS1chr6

117724302

-FBXO9chr6

52962520

+
Frame-shitENST00000368507ENST00000244426ROS1chr6

117724302

-FBXO9chr6

52962520

+
5CDS-intronENST00000368507ENST00000461222ROS1chr6

117724302

-FBXO9chr6

52962520

+

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FusionProtFeatures for ROS1_FBXO9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROS1

P08922

FBXO9

Q9UK97

Orphan receptor tyrosine kinase (RTK) that plays a rolein epithelial cell differentiation and regionalization of theproximal epididymal epithelium. May activate several downstreamsignaling pathways related to cell differentiation, proliferation,growth and survival including the PI3 kinase-mTOR signalingpathway. Mediates the phosphorylation of PTPN11, an activator ofthis pathway. May also phosphorylate and activate thetranscription factor STAT3 to control anchorage-independent cellgrowth. Mediates the phosphorylation and the activation of VAV3, aguanine nucleotide exchange factor regulating cell morphology. Mayactivate other downstream signaling proteins including AKT1,MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073,ECO:0000269|PubMed:16885344}. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation of TTI1and TELO2 in a CK2-dependent manner, thereby directly regulatingmTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1and TELO2 when they are phosphorylated by CK2 following growthfactor deprivation, leading to their degradation. In contrast, theSCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 whenthey are part of the mTORC2 complex. As a consequence, mTORC1 isinactivated to restrain cell growth and protein translation, whilemTORC2 is activated due to the relief of feedback inhibition bymTORC1. {ECO:0000269|PubMed:23263282}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ROS1_FBXO9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ROS1_FBXO9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ROS1PTPN6, PTPN11, VAV3, IKBKG, GRB2FBXO9CALM1, CUL1, COPS5, HSP90AA1, GFOD1, SKP1, XPO1, EEF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROS1_FBXO9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROS1_FBXO9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneROS1C0007131Non-Small Cell Lung Carcinoma4CTD_human
HgeneROS1C0017638Glioma1CTD_human
HgeneROS1C0025202melanoma1CTD_human
HgeneROS1C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneFBXO9C0023893Liver Cirrhosis, Experimental1CTD_human