FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31715

FusionGeneSummary for RORA_ARNT2

check button Fusion gene summary
Fusion gene informationFusion gene name: RORA_ARNT2
Fusion gene ID: 31715
HgeneTgene
Gene symbol

RORA

ARNT2

Gene ID

6095

9915

Gene nameRAR related orphan receptor Aaryl hydrocarbon receptor nuclear translocator 2
SynonymsNR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRAWEDAS|bHLHe1
Cytomap

15q22.2

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4tranaryl hydrocarbon receptor nuclear translocator 2ARNT protein 2class E basic helix-loop-helix protein 1
Modification date2018052320180519
UniProtAcc

P35398

Q9HBZ2

Ensembl transtripts involved in fusion geneENST00000335670, ENST00000309157, 
ENST00000261523, ENST00000449337, 
ENST00000560004, 		ENST00000303329, 
ENST00000533983, ENST00000527771, 
ENST00000531595, 
Fusion gene scores* DoF score8 X 3 X 5=1204 X 4 X 3=48
# samples 84
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RORA [Title/Abstract] AND ARNT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRORA

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneRORA

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneRORA

GO:0036315

cellular response to sterol

19965867

HgeneRORA

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneRORA

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433

TgeneARNT2

GO:0001666

response to hypoxia

12239177

TgeneARNT2

GO:0006355

regulation of transcription, DNA-templated

11782478

TgeneARNT2

GO:0045944

positive regulation of transcription by RNA polymerase II

24465693


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0I9-01ARORAchr15

61521252

-ARNT2chr15

80885941

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000335670ENST00000303329RORAchr15

61521252

-ARNT2chr15

80885941

+
In-frameENST00000335670ENST00000533983RORAchr15

61521252

-ARNT2chr15

80885941

+
In-frameENST00000335670ENST00000527771RORAchr15

61521252

-ARNT2chr15

80885941

+
5CDS-intronENST00000335670ENST00000531595RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000309157ENST00000303329RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000309157ENST00000533983RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000309157ENST00000527771RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-intronENST00000309157ENST00000531595RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000261523ENST00000303329RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000261523ENST00000533983RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000261523ENST00000527771RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-intronENST00000261523ENST00000531595RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000449337ENST00000303329RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000449337ENST00000533983RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000449337ENST00000527771RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-intronENST00000449337ENST00000531595RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000560004ENST00000303329RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000560004ENST00000533983RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-3CDSENST00000560004ENST00000527771RORAchr15

61521252

-ARNT2chr15

80885941

+
intron-intronENST00000560004ENST00000531595RORAchr15

61521252

-ARNT2chr15

80885941

+

Top

FusionProtFeatures for RORA_ARNT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RORA

P35398

ARNT2

Q9HBZ2

Nuclear receptor that binds DNA as a monomer to RORresponse elements (RORE) containing a single core motif half-site5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulatorof embryonic development, cellular differentiation, immunity,circadian rhythm as well as lipid, steroid, xenobiotics andglucose metabolism. Considered to have intrinsic transcriptionalactivity, have some natural ligands like oxysterols that act asagonists (25-hydroxycholesterol) or inverse agonists (7-oxygenatedsterols), enhancing or repressing the transcriptional activity,respectively. Recruits distinct combinations of cofactors totarget genes regulatory regions to modulate their transcriptionalexpression, depending on the tissue, time and promoter contexts.Regulates genes involved in photoreceptor development includingOPN1SW, OPN1SM and ARR3 and skeletal muscle development withMYOD1. Required for proper cerebellum development, regulates SHHgene expression, among others, to induce granule cellsproliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expressionof several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 andCRY1. Competes with NR1D1 for binding to their shared DNA responseelement on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1itself, resulting in NR1D1-mediated repression or RORA-mediatedactivation of clock genes expression, leading to the circadianpattern of clock genes expression. Therefore influences the periodlength and stability of the clock. Regulates genes involved inlipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 andPPARG. In liver, has specific and redundant functions with RORC aspositive or negative modulator of expression of genes encodingphase I and phase II proteins involved in the metabolism oflipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1.Induces a rhythmic expression of some of these genes. In addition,interplays functionally with NR1H2 and NR1H3 for the regulation ofgenes involved in cholesterol metabolism. Also involved in theregulation of hepatic glucose metabolism through the modulation ofG6PC and PCK1. In adipose tissue, plays a role as negativeregulator of adipocyte differentiation, probably acting throughdual mechanisms. May suppress CEBPB-dependent adipogenesis throughdirect interaction and PPARG-dependent adipogenesis throughcompetition for DNA-binding. Downstream of IL6 and TGFB andsynergistically with RORC isoform 2, is implicated in the lineagespecification of uncommitted CD4(+) T-helper (T(H)) cells intoT(H)17 cells, antagonizing the T(H)1 program. Probably regulatesIL17 and IL17F expression on T(H) by binding to the essentialenhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17Flocus. Involved in hypoxia signaling by interacting with andactivating the transcriptional activity of HIF1A. May inhibit cellgrowth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. {ECO:0000269|PubMed:10478845,ECO:0000269|PubMed:11053433, ECO:0000269|PubMed:11252722,ECO:0000269|PubMed:11554739, ECO:0000269|PubMed:12467577,ECO:0000269|PubMed:14570920, ECO:0000269|PubMed:15781255,ECO:0000269|PubMed:15790933, ECO:0000269|PubMed:16462772,ECO:0000269|PubMed:17512500, ECO:0000269|PubMed:18005000,ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046,ECO:0000269|PubMed:19965867, ECO:0000269|PubMed:21499262,ECO:0000269|PubMed:7926749, ECO:0000269|PubMed:9328355,ECO:0000269|PubMed:9862959}. Transcription factor that plays a role in thedevelopment of the hypothalamo-pituitary axis, postnatal braingrowth, and visual and renal function (PubMed:24022475).Specifically recognizes the xenobiotic response element (XRE).{ECO:0000269|PubMed:24022475}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-112166_169-30557Compositional biasNote=Poly-Gln
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-111166_169-24549Compositional biasNote=Poly-Gln
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-111166_16955524Compositional biasNote=Poly-Gln
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-110166_169-42469Compositional biasNote=Poly-Gln
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-11273_138-30557DNA bindingNuclear receptor
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-11173_138-24549DNA bindingNuclear receptor
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-11173_13855524DNA bindingNuclear receptor
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-11073_138-42469DNA bindingNuclear receptor
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-112272_510-30557DomainNR LBD
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-111272_510-24549DomainNR LBD
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-111272_51055524DomainNR LBD
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-110272_510-42469DomainNR LBD
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-112506_523-30557MotifNote=AF-2
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-111506_523-24549MotifNote=AF-2
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-111506_52355524MotifNote=AF-2
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-110506_523-42469MotifNote=AF-2
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-112139_271-30557RegionNote=Hinge
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-111139_271-24549RegionNote=Hinge
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-111139_27155524RegionNote=Hinge
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-110139_271-42469RegionNote=Hinge
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-112109_133-30557Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000261523-11273_93-30557Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-111109_133-24549Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000309157-11173_93-24549Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-111109_13355524Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000335670-11173_9355524Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-110109_133-42469Zinc fingerNR C4-type
HgeneRORAchr15:61521252chr15:80885941ENST00000449337-11073_93-42469Zinc fingerNR C4-type
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+1719440_445685718Compositional biasNote=Poly-Gln
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+1719552_555685718Compositional biasNote=Poly-Ser
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+171973_76685718Compositional biasNote=Poly-Arg
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+1719440_445674707Compositional biasNote=Poly-Gln
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+1719552_555674707Compositional biasNote=Poly-Ser
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+171973_76674707Compositional biasNote=Poly-Arg
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+1820440_445674707Compositional biasNote=Poly-Gln
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+1820552_555674707Compositional biasNote=Poly-Ser
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+182073_76674707Compositional biasNote=Poly-Arg
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+1719134_209685718DomainPAS 1
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+1719323_393685718DomainPAS 2
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+1719398_441685718DomainNote=PAC
TgeneARNT2chr15:61521252chr15:80885941ENST00000303329+171963_116685718DomainbHLH
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+1719134_209674707DomainPAS 1
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+1719323_393674707DomainPAS 2
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+1719398_441674707DomainNote=PAC
TgeneARNT2chr15:61521252chr15:80885941ENST00000527771+171963_116674707DomainbHLH
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+1820134_209674707DomainPAS 1
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+1820323_393674707DomainPAS 2
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+1820398_441674707DomainNote=PAC
TgeneARNT2chr15:61521252chr15:80885941ENST00000533983+182063_116674707DomainbHLH


Top

FusionGeneSequence for RORA_ARNT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000303329_chr15_80885941_+_88aa

>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000533983_chr15_80885941_+_88aa

>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000527771_chr15_80885941_+_88aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000303329_chr15_80885941_+_265nt
ATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGGCGCGGACGCGGCCGCCGGCTCCAGGGAGACCCCG
CTGAACCAGGAATCCGCCCGCAAGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGACATGCTGCCCAT

>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000533983_chr15_80885941_+_265nt
ATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGGCGCGGACGCGGCCGCCGGCTCCAGGGAGACCCCG
CTGAACCAGGAATCCGCCCGCAAGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGACATGCTGCCCAT

>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000527771_chr15_80885941_+_265nt
ATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGGCGCGGACGCGGCCGCCGGCTCCAGGGAGACCCCG
CTGAACCAGGAATCCGCCCGCAAGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGACATGCTGCCCAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000303329_chr15_80885941_+_4605nt
TTTTTTTTTTTTTTTTGGTACCATAGAGTTGCTCTGAAAACAGAAGATAGAGGGAGTCTCGGAGCTCGCCATCTCCAGCGATCTCTACAT
TGGGAAAAAACATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGGCGCGGACGCGGCCGCCGGCTCCA
GGGAGACCCCGCTGAACCAGGAATCCGCCCGCAAGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGAC
ATGCTGCCCATGCCAGGAGATCCAACCCAGGGGACTGGCAACTATAACATCGAAGACTTTGCCGACCTGGGCATGTTTCCACCGTTTTCT
GAGTAGCTGCGGCCAGAGTGAGGCTCCTGCTGTACAGTGCCACCCATACTGTGATGTCGATGCCCATGTGAATGAGGCCCACCCTCGCCC
TGCTTGCCCTGCCGCAGGCCCCCCACCAGAAGCCATCTCCCCCGCTGTGTGTCCCCAGGCGCATCATTGCTCCACTCTCCCCTGCAGCCG
CGGCTGCTCGGCCACTGACCAGGGGCCCTGGCAGACATTAGGGGATCAGTTGTATTTATTGTATTTTATCTGTGTGTGCTCAGGAGGTGA
GCCTAGTGGGTCCTTAAGTTTGGTTGTGAATAATCTCTTGATAGACAATTTATACCCATGAAAGTTCAGCCAATGCCCAGAGTGACCAAG
CAGCACCAGCAGGCCTGCCCAGGATGCTGAAAGCAGATTTCTTCTTGATTTCACTTCTGATGGATGCATGGGGCTCTGGGGGAATGCTGG
GAAAATGGGCAAGCAGAGTGCACAGCCCTCGTTCTGCCAGCTGGAGCCAAGAAGCACAGAGACACAGAGGCGCCTGCCCCTCAGCTCCGC
TGGTCTGTCTGTGCATCCACTGTGCCGTGGGACATATGTAATTTGTGCAGTGTGACATGGACTTGCTGTCCTAATGGATGTGTTGTGCCT
TGTGTCTGTCATGTGTGGCCAGCGTGATTGTATAGAATCCAGAGTATGTAGAGAGCCAAAATGTGTGGCCCTGTCCCCAAGCTCAGCACC
ACCGGCCATGACCAGAGGTTGCTCGGCCCAGGGTCTGGGAGCTGGGCTAACAGGCTGACACTTCGGCAGGGTCACCAGGAGGCACAGCTA
GGGGCATGCTCACATGGGTAGGTCAGTTCTTTGGTCCAAGCCTCTGGTGCAGATTCAAGCTCCTCCTCTTAGAGGAAGCAGCTCCTTCCT
CCCACAGGAGCCCCAAGGGAGCACTCACCCTCCTCCCAATTGGATCTGAATAGCTGTGTTCCTGATCCCACATAAGCATGTCTCATCCTT
GCCCCACTGGTGAGAGGAGGACCTTGTGCCTGCCCAGAGCCTGCAGGACAGCACGCCTTGAGGTCAGAGGCCTGGCCCTTCTTTACAGAT
GTAGATAGCAGGGTAGGACGCCCAGGCCTTCTCACATGGGCACCATGAAACACTTTCTTCCAGGCCACCTGAGCCTTCGTTCTTCAGCCC
GACTGGAGGAACAGCAGCTCTGGGAGGCACAGAGTGCAGGTCTCAGGGGCAGAAGACATGGGTTCCAGTTCTGGTTCTGCCACACACCCA
CCGGCCTTGAATTTCTCTGGTGGTCTCAAGACAAGAACAAGAGCTGACTCTAGAATCTTCTGCCTGGCTGACCTCTGAGCCCATGATCCC
TGGCTTGCTGTGCTTCTCTTGGATTTGAGGAGAGTTTATGAATCCATCCCCCTGTTTTCAGGGACCTCTGCCTTCTCCCACACCCCTTAC
ACTAGTGAGGACTCCTTCGGCCTCTTGTGTTTCCTTCCTTTTGTGACCATTACGCCCCCTCCCTGTTTCTTATCACCAGCCCATCAGCCC
ACTGACTCCCATATGGTAGAAAAGGTACCGTGGCTGCTGCAGGGCACATGGAGGGACCTACCCTCTGGGAAAGCCCTTGTGTCCCTCCCA
GAGTCCTTCAGGTAGGCCCTCGCAGATGCTGCTTGCTCAGAAACAACCCGTGCATCCCTGCCCATGGATTCTGCAGGACCTAGAAGAGTG
GCATTGGTTCTAGGAACCTGAGAGTGGAGTGAGGCCAGCATGCAGGAAGGAGTTTGGAGAGAGTGTTTGCTGTGATCCATTGAAAGCTCC
ACATTAAACCCCAGCCCTGTCTGGCCAGGGAGATCCATGTGCTCAATGTTGCTGGGGGACCTACAAAAGTCAAACATTGCTCAGTAAAAT
GCCTTTGGCTGGTCGCCAGCTGTGCATGACTGCAGTTCCTAGACTCTAACTTAACCCCAACTTTGCAGTTTCTAGAGCTTTTTGTCTGTA
ATGGTGATTGGGTCTCCACTGTAGATGCATGCAGTGTTCACTCCAACCTCAGAGGCTTTCTTGCTTCTGGGGAAATGGCAGGTGGTTGAA
ACCCTGCACATCCTCCCAGGGCCAGCCCCAGAATGGGCCTTTCTCTGCCTGCCCTGCCCTTGGGGCCACCTCTGCCTCCAGCAGGCTTGA
GCTTGCCCCAGGCCTTGGGCATAATTATTTCCCCCCAAAAAAGGCACAAAAATAGGTTTTGGATCAAAGAAGTGTTTCTCAGTGAAATGA
AAACAGTCTTTTTATAGCCTTTAGCTTGTGAGTTTGGAAGTTTGGGGGGTCTTATGTTTGTTTTGCCTCTTCTGTTTCTTGGAGGAGAGT
TGAGGCTTTTCTTAGGTGCATACACAGACCCAGGTGAACACGCTGACTGTGAACCTGCCCTGTATCCGGAGCTGTGCTGGGCACTGAGGG
GATGCAACAAAATTAGGAGAGGATCCTTGCTCCCAACGTCTACTTCTCCTACCTCAACAGGGGTCCAGGGTGCAGTGAACTCAGTTCTTG
GCCCTTGGGTGAGGATTCATGGATGAATGAAAGCTAGACCTGATGGGGAGGCATTATGACTAAATAGGCCCAGCCTCCTTCCCTTCCAGC
TCTGTCCTAGGAGCATAGGCGGGAAATCTGAGTAGAGTCTGACTGCAGTTTTTGCTTATGATTTGTAAAAGCCGTCATGGGGTCAATAAG
AAAATAGGGGTGATGGAGGGGGAGAAGCCCAGGACTGGGAGAATCGCACATGCCCCAGGGGTTTTCACCAAGGATTTTCAAGACAAACTG
GAGTAAGAATTAAAGCCCCAGAGGATTTAATTATCCTGGTTTGCAAAAGAGCCTCCCATGCCAGTACCGCCCAGCCTTGGAGGCCGGAAT
GCTCATGGCCCCTGTGGTCTGCTTGTCCTTCAGCCCATGCCCAGCAGATACCTCTCTGACTGGAGACGGGCTCAAAGCTGGATTAGAAAG
GGGAGAGGCACTTGTGACTTTGTTTGACTCTGTGACTCACTTCCTCGCTCACACCTTGTTTGAACTACTGGACTTTCAACTGGCTTTCCT
TAGGTCAGGCAAGCAGACAGCTCCCCACTGAAGAGGTCTGTACAGTGACAACCCGGGCCGGCAGCAAGGACACAGATGCAGCCACAGTAA
GGCTCCATCAGGACTGGGTCAGTGATGGCAACAGGATGGCCAAGGATGGCTCTAGAACACTCTGTCCATGCGTCACTCCCCCCAGTTTTA
TTTTTAGCTTTGGCTTCAGGGAGTGACAGCCATCACAAATAGCCACATTCTGCTCTACTCTCCAACATACCAGATTCTACACTGTTGTTA
TTTCATGAGACGTGAATGTTGCAGAGAGTGGGGGGATTCTGGTTGTTAAGGAACTTACACTGGGGAGCTTTACTCTTCCGTGTCAACAAT
GTGACTACATGTTCTCCAGATTAGCCACACATGCAAACATCAGTGTCCTTCTAGCTTTAGCCGAGAAAGAAACCAGTCCCAGGGAATGAA
TGGTGGTCTCCCCACTCCCGGCAGCACTTTAGGCAGCCCATAAGCTATGCGAGAATGTGAACGCTCACCTTGCTCCGTCACGGTTCTGAC
CTACCACATAAACAGGAAGAAGCCAGTGACCGGAACAGCTCTAGGAATAACAAGTCAGAATAGAAGTGTCCTTTATATTACCAGAAAATA
TGGGCTTGGCCTAAGTCGCTGTCTCCTAACCTGCCGGGGTCATTCCCCACCAAACACCCCATACTAAGGAGCCATGAGCCACCTGGACAT
TCACCTTTTCTTTGACCATCTGGAGTCTGGGGCAACTTAAGGAGGCACCACACAGTGGTGCAGGCACATTTCCAAGCGTAGGTGTCCCTG
GCTTTTGTGGCCAAAGCTAGTGTTATGGTCAACAACAGGCCAGGGTCTGTGGGGCACTGACCTTGAAAGTGGCAAAATGGAGGTTTCACA
GGCTGTGCGGGAGCAGGACGGCTTGCTTCATCTAACAATCTCAGTTTCCTTTAAAAAAAGAAAGAAAGGAAAAGATTTCATAAGCAGGTG
TCAGTGGACAGTTTAAGTACTTAACCATTTCTCTTTCTTCTTATGGATGTGAACTGTGCTGTGGATAAATCATTTGTATTTCTTGAATGT
TCTCTATGACTAACAGTTATTAAGTCGGTTGTGTATATGTGTAACTAATGTAACTGCCTTTTAAAATTTCATTACAATAAAAATGACTTT

>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000533983_chr15_80885941_+_4596nt
TTTTTTTTTTTTTTTTGGTACCATAGAGTTGCTCTGAAAACAGAAGATAGAGGGAGTCTCGGAGCTCGCCATCTCCAGCGATCTCTACAT
TGGGAAAAAACATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGGCGCGGACGCGGCCGCCGGCTCCA
GGGAGACCCCGCTGAACCAGGAATCCGCCCGCAAGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGAC
ATGCTGCCCATGCCAGGAGATCCAACCCAGGGGACTGGCAACTATAACATCGAAGACTTTGCCGACCTGGGCATGTTTCCACCGTTTTCT
GAGTAGCTGCGGCCAGAGTGAGGCTCCTGCTGTACAGTGCCACCCATACTGTGATGTCGATGCCCATGTGAATGAGGCCCACCCTCGCCC
TGCTTGCCCTGCCGCAGGCCCCCCACCAGAAGCCATCTCCCCCGCTGTGTGTCCCCAGGCGCATCATTGCTCCACTCTCCCCTGCAGCCG
CGGCTGCTCGGCCACTGACCAGGGGCCCTGGCAGACATTAGGGGATCAGTTGTATTTATTGTATTTTATCTGTGTGTGCTCAGGAGGTGA
GCCTAGTGGGTCCTTAAGTTTGGTTGTGAATAATCTCTTGATAGACAATTTATACCCATGAAAGTTCAGCCAATGCCCAGAGTGACCAAG
CAGCACCAGCAGGCCTGCCCAGGATGCTGAAAGCAGATTTCTTCTTGATTTCACTTCTGATGGATGCATGGGGCTCTGGGGGAATGCTGG
GAAAATGGGCAAGCAGAGTGCACAGCCCTCGTTCTGCCAGCTGGAGCCAAGAAGCACAGAGACACAGAGGCGCCTGCCCCTCAGCTCCGC
TGGTCTGTCTGTGCATCCACTGTGCCGTGGGACATATGTAATTTGTGCAGTGTGACATGGACTTGCTGTCCTAATGGATGTGTTGTGCCT
TGTGTCTGTCATGTGTGGCCAGCGTGATTGTATAGAATCCAGAGTATGTAGAGAGCCAAAATGTGTGGCCCTGTCCCCAAGCTCAGCACC
ACCGGCCATGACCAGAGGTTGCTCGGCCCAGGGTCTGGGAGCTGGGCTAACAGGCTGACACTTCGGCAGGGTCACCAGGAGGCACAGCTA
GGGGCATGCTCACATGGGTAGGTCAGTTCTTTGGTCCAAGCCTCTGGTGCAGATTCAAGCTCCTCCTCTTAGAGGAAGCAGCTCCTTCCT
CCCACAGGAGCCCCAAGGGAGCACTCACCCTCCTCCCAATTGGATCTGAATAGCTGTGTTCCTGATCCCACATAAGCATGTCTCATCCTT
GCCCCACTGGTGAGAGGAGGACCTTGTGCCTGCCCAGAGCCTGCAGGACAGCACGCCTTGAGGTCAGAGGCCTGGCCCTTCTTTACAGAT
GTAGATAGCAGGGTAGGACGCCCAGGCCTTCTCACATGGGCACCATGAAACACTTTCTTCCAGGCCACCTGAGCCTTCGTTCTTCAGCCC
GACTGGAGGAACAGCAGCTCTGGGAGGCACAGAGTGCAGGTCTCAGGGGCAGAAGACATGGGTTCCAGTTCTGGTTCTGCCACACACCCA
CCGGCCTTGAATTTCTCTGGTGGTCTCAAGACAAGAACAAGAGCTGACTCTAGAATCTTCTGCCTGGCTGACCTCTGAGCCCATGATCCC
TGGCTTGCTGTGCTTCTCTTGGATTTGAGGAGAGTTTATGAATCCATCCCCCTGTTTTCAGGGACCTCTGCCTTCTCCCACACCCCTTAC
ACTAGTGAGGACTCCTTCGGCCTCTTGTGTTTCCTTCCTTTTGTGACCATTACGCCCCCTCCCTGTTTCTTATCACCAGCCCATCAGCCC
ACTGACTCCCATATGGTAGAAAAGGTACCGTGGCTGCTGCAGGGCACATGGAGGGACCTACCCTCTGGGAAAGCCCTTGTGTCCCTCCCA
GAGTCCTTCAGGTAGGCCCTCGCAGATGCTGCTTGCTCAGAAACAACCCGTGCATCCCTGCCCATGGATTCTGCAGGACCTAGAAGAGTG
GCATTGGTTCTAGGAACCTGAGAGTGGAGTGAGGCCAGCATGCAGGAAGGAGTTTGGAGAGAGTGTTTGCTGTGATCCATTGAAAGCTCC
ACATTAAACCCCAGCCCTGTCTGGCCAGGGAGATCCATGTGCTCAATGTTGCTGGGGGACCTACAAAAGTCAAACATTGCTCAGTAAAAT
GCCTTTGGCTGGTCGCCAGCTGTGCATGACTGCAGTTCCTAGACTCTAACTTAACCCCAACTTTGCAGTTTCTAGAGCTTTTTGTCTGTA
ATGGTGATTGGGTCTCCACTGTAGATGCATGCAGTGTTCACTCCAACCTCAGAGGCTTTCTTGCTTCTGGGGAAATGGCAGGTGGTTGAA
ACCCTGCACATCCTCCCAGGGCCAGCCCCAGAATGGGCCTTTCTCTGCCTGCCCTGCCCTTGGGGCCACCTCTGCCTCCAGCAGGCTTGA
GCTTGCCCCAGGCCTTGGGCATAATTATTTCCCCCCAAAAAAGGCACAAAAATAGGTTTTGGATCAAAGAAGTGTTTCTCAGTGAAATGA
AAACAGTCTTTTTATAGCCTTTAGCTTGTGAGTTTGGAAGTTTGGGGGGTCTTATGTTTGTTTTGCCTCTTCTGTTTCTTGGAGGAGAGT
TGAGGCTTTTCTTAGGTGCATACACAGACCCAGGTGAACACGCTGACTGTGAACCTGCCCTGTATCCGGAGCTGTGCTGGGCACTGAGGG
GATGCAACAAAATTAGGAGAGGATCCTTGCTCCCAACGTCTACTTCTCCTACCTCAACAGGGGTCCAGGGTGCAGTGAACTCAGTTCTTG
GCCCTTGGGTGAGGATTCATGGATGAATGAAAGCTAGACCTGATGGGGAGGCATTATGACTAAATAGGCCCAGCCTCCTTCCCTTCCAGC
TCTGTCCTAGGAGCATAGGCGGGAAATCTGAGTAGAGTCTGACTGCAGTTTTTGCTTATGATTTGTAAAAGCCGTCATGGGGTCAATAAG
AAAATAGGGGTGATGGAGGGGGAGAAGCCCAGGACTGGGAGAATCGCACATGCCCCAGGGGTTTTCACCAAGGATTTTCAAGACAAACTG
GAGTAAGAATTAAAGCCCCAGAGGATTTAATTATCCTGGTTTGCAAAAGAGCCTCCCATGCCAGTACCGCCCAGCCTTGGAGGCCGGAAT
GCTCATGGCCCCTGTGGTCTGCTTGTCCTTCAGCCCATGCCCAGCAGATACCTCTCTGACTGGAGACGGGCTCAAAGCTGGATTAGAAAG
GGGAGAGGCACTTGTGACTTTGTTTGACTCTGTGACTCACTTCCTCGCTCACACCTTGTTTGAACTACTGGACTTTCAACTGGCTTTCCT
TAGGTCAGGCAAGCAGACAGCTCCCCACTGAAGAGGTCTGTACAGTGACAACCCGGGCCGGCAGCAAGGACACAGATGCAGCCACAGTAA
GGCTCCATCAGGACTGGGTCAGTGATGGCAACAGGATGGCCAAGGATGGCTCTAGAACACTCTGTCCATGCGTCACTCCCCCCAGTTTTA
TTTTTAGCTTTGGCTTCAGGGAGTGACAGCCATCACAAATAGCCACATTCTGCTCTACTCTCCAACATACCAGATTCTACACTGTTGTTA
TTTCATGAGACGTGAATGTTGCAGAGAGTGGGGGGATTCTGGTTGTTAAGGAACTTACACTGGGGAGCTTTACTCTTCCGTGTCAACAAT
GTGACTACATGTTCTCCAGATTAGCCACACATGCAAACATCAGTGTCCTTCTAGCTTTAGCCGAGAAAGAAACCAGTCCCAGGGAATGAA
TGGTGGTCTCCCCACTCCCGGCAGCACTTTAGGCAGCCCATAAGCTATGCGAGAATGTGAACGCTCACCTTGCTCCGTCACGGTTCTGAC
CTACCACATAAACAGGAAGAAGCCAGTGACCGGAACAGCTCTAGGAATAACAAGTCAGAATAGAAGTGTCCTTTATATTACCAGAAAATA
TGGGCTTGGCCTAAGTCGCTGTCTCCTAACCTGCCGGGGTCATTCCCCACCAAACACCCCATACTAAGGAGCCATGAGCCACCTGGACAT
TCACCTTTTCTTTGACCATCTGGAGTCTGGGGCAACTTAAGGAGGCACCACACAGTGGTGCAGGCACATTTCCAAGCGTAGGTGTCCCTG
GCTTTTGTGGCCAAAGCTAGTGTTATGGTCAACAACAGGCCAGGGTCTGTGGGGCACTGACCTTGAAAGTGGCAAAATGGAGGTTTCACA
GGCTGTGCGGGAGCAGGACGGCTTGCTTCATCTAACAATCTCAGTTTCCTTTAAAAAAAGAAAGAAAGGAAAAGATTTCATAAGCAGGTG
TCAGTGGACAGTTTAAGTACTTAACCATTTCTCTTTCTTCTTATGGATGTGAACTGTGCTGTGGATAAATCATTTGTATTTCTTGAATGT
TCTCTATGACTAACAGTTATTAAGTCGGTTGTGTATATGTGTAACTAATGTAACTGCCTTTTAAAATTTCATTACAATAAAAATGACTTT

>In-frame_RORA_ENST00000335670_chr15_61521252_-_ARNT2_ENST00000527771_chr15_80885941_+_561nt
TTTTTTTTTTTTTTTTGGTACCATAGAGTTGCTCTGAAAACAGAAGATAGAGGGAGTCTCGGAGCTCGCCATCTCCAGCGATCTCTACAT
TGGGAAAAAACATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGGCGCGGACGCGGCCGCCGGCTCCA
GGGAGACCCCGCTGAACCAGGAATCCGCCCGCAAGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGAC
ATGCTGCCCATGCCAGGAGATCCAACCCAGGGGACTGGCAACTATAACATCGAAGACTTTGCCGACCTGGGCATGTTTCCACCGTTTTCT
GAGTAGCTGCGGCCAGAGTGAGGCTCCTGCTGTACAGTGCCACCCATACTGTGATGTCGATGCCCATGTGAATGAGGCCCACCCTCGCCC
TGCTTGCCCTGCCGCAGGCCCCCCACCAGAAGCCATCTCCCCCGCTGTGTGTCCCCAGGCGCATCATTGCTCCACTCTCCCCTGCAGCCG


Top

FusionGenePPI for RORA_ARNT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RORAPSMC5, EP300, MYOD1, CEBPB, RUVBL1, LRIF1, ZXDC, PROX1, PNRC1, NCOA1, COPS5, PNRC2, LMO3, NR0B1, EZH2, VPRBP, DDB1, PTBP1, SMARCD3, NSD1, GFAP, CSNK1E, BHLHE41ARNT2NPAS4, SIM2, EPAS1, BCL6, USP7, APP, SH3GL2, TAX1BP3, BZRAP1, NPAS2, CTBP1, ADAMTSL4, CALCOCO2, CCDC33, CDR2, CEP57L1, CEP63, DTX2, DYDC1, GOLGA2, HIF1A, IKZF3, KIFC3, LZTS2, MAGEA4, MEIS2, MEOX2, MIPOL1, MTUS2, NCOA3, PDE4DIP, PLSCR1, RBCK1, REL, RFX6, RIMBP3, RINT1, SORBS3, SPAG5, SSBP3, SSX2IP, SYCE1, TACC3, TADA2A, TFIP11, TRAF1, TRAF2, TRAF4, TRIM23, TRIM27, TRIM37, TRIM42, TRIP6, USHBP1, VPS52, ZNF341, DGCR6, NDE1, NPAS3, AHR, NPAS1, CLPP, FNTA, FNTB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RORA_ARNT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RORA_ARNT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRORAC0005586Bipolar Disorder5PSYGENET
HgeneRORAC0011581Depressive disorder3PSYGENET
HgeneRORAC0004352Autistic Disorder2CTD_human
HgeneRORAC0011570Mental Depression2PSYGENET
HgeneRORAC0038356Stomach Neoplasms1CTD_human
HgeneRORAC0085159Seasonal Affective Disorder1PSYGENET