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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31710

FusionGeneSummary for ROR1_SNAP25

check button Fusion gene summary
Fusion gene informationFusion gene name: ROR1_SNAP25
Fusion gene ID: 31710
HgeneTgene
Gene symbol

ROR1

SNAP25

Gene ID

6095

6616

Gene nameRAR related orphan receptor Asynaptosome associated protein 25
SynonymsNR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRACMS18|RIC-4|RIC4|SEC9|SNAP|SNAP-25|SUP|bA416N4.2|dJ1068F16.2
Cytomap

15q22.2

20p12.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4transynaptosomal-associated protein 25resistance to inhibitors of cholinesterase 4 homologsynaptosomal-associated protein, 25kDasynaptosome associated protein 25kDa
Modification date2018052320180523
UniProtAcc

Q01973

P60880

Ensembl transtripts involved in fusion geneENST00000371080, ENST00000371079, 
ENST00000482426, ENST00000545203, 
ENST00000254976, ENST00000304886, 
ENST00000495883, 
Fusion gene scores* DoF score4 X 4 X 4=646 X 7 X 2=84
# samples 47
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROR1 [Title/Abstract] AND SNAP25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROR1

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneROR1

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneROR1

GO:0036315

cellular response to sterol

19965867

HgeneROR1

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneROR1

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW899942ROR1chr1

64286029

+SNAP25chr20

10287852

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000371080ENST00000254976ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000371080ENST00000304886ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000371080ENST00000495883ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000371079ENST00000254976ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000371079ENST00000304886ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000371079ENST00000495883ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000482426ENST00000254976ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000482426ENST00000304886ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000482426ENST00000495883ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000545203ENST00000254976ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000545203ENST00000304886ROR1chr1

64286029

+SNAP25chr20

10287852

-
intron-3UTRENST00000545203ENST00000495883ROR1chr1

64286029

+SNAP25chr20

10287852

-

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FusionProtFeatures for ROR1_SNAP25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROR1

Q01973

SNAP25

P60880

Has very low kinase activity in vitro and is unlikely tofunction as a tyrosine kinase in vivo (PubMed:25029443). Receptorfor ligand WNT5A which activate downstream NFkB signaling pathwayand may result in the inhibition of WNT3A-mediated signaling(PubMed:25029443, PubMed:27162350). In inner ear, crucial forspiral ganglion neurons to innervate auditory hair cells(PubMed:27162350). {ECO:0000269|PubMed:25029443,ECO:0000269|PubMed:27162350}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ROR1_SNAP25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ROR1_SNAP25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROR1_SNAP25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSNAP25P60880DB00083Botulinum Toxin Type ASynaptosomal-associated protein 25biotechapproved|investigational

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RelatedDiseases for ROR1_SNAP25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneROR1C0005586Bipolar Disorder1PSYGENET
TgeneSNAP25C0005586Bipolar Disorder4CTD_human;PSYGENET
TgeneSNAP25C0011581Depressive disorder2CTD_human;PSYGENET
TgeneSNAP25C0011570Mental Depression1PSYGENET
TgeneSNAP25C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneSNAP25C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSNAP25C0033975Psychotic Disorders1CTD_human
TgeneSNAP25C0278076Behavioral tic1CTD_human
TgeneSNAP25C0752252Neuromuscular Manifestations1CTD_human
TgeneSNAP25C4225364MYASTHENIC SYNDROME, CONGENITAL, 181UNIPROT