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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31707

FusionGeneSummary for ROPN1_PLXNB3

check button Fusion gene summary
Fusion gene informationFusion gene name: ROPN1_PLXNB3
Fusion gene ID: 31707
HgeneTgene
Gene symbol

ROPN1

PLXNB3

Gene ID

54763

5365

Gene namerhophilin associated tail protein 1plexin B3
SynonymsCT91|ODF6|RHPNAP1|ROPN1A|ropporinPLEXB3|PLEXR|PLXN6
Cytomap

3q21.1

Xq28

Type of geneprotein-codingprotein-coding
Descriptionropporin-1Acancer/testis antigen 91outer dense fiber of sperm tails 6rhophilin-associated protein 1Aropporin, rhophilin associated protein 1testis secretory sperm-binding protein Li 239wplexin-B3plexin 6
Modification date2018051920180523
UniProtAcc

Q9HAT0

Q9ULL4

Ensembl transtripts involved in fusion geneENST00000184183, ENST00000405845, 
ENST00000459660, ENST00000479867, 
ENST00000495093, ENST00000484329, 
ENST00000538966, ENST00000361971, 
ENST00000538543, ENST00000538776, 
ENST00000538282, ENST00000485980, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 1=9
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ROPN1 [Title/Abstract] AND PLXNB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLXNB3

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

16122393

TgenePLXNB3

GO:0007162

negative regulation of cell adhesion

15218527

TgenePLXNB3

GO:0010976

positive regulation of neuron projection development

16122393

TgenePLXNB3

GO:0050918

positive chemotaxis

15218527

TgenePLXNB3

GO:0060326

cell chemotaxis

15218527

TgenePLXNB3

GO:0071526

semaphorin-plexin signaling pathway

15218527


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW006913ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000184183ENST00000538966ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000184183ENST00000361971ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000184183ENST00000538543ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000184183ENST00000538776ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000184183ENST00000538282ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000184183ENST00000485980ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000405845ENST00000538966ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000405845ENST00000361971ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000405845ENST00000538543ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000405845ENST00000538776ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000405845ENST00000538282ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000405845ENST00000485980ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000459660ENST00000538966ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000459660ENST00000361971ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000459660ENST00000538543ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000459660ENST00000538776ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000459660ENST00000538282ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000459660ENST00000485980ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000479867ENST00000538966ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000479867ENST00000361971ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000479867ENST00000538543ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000479867ENST00000538776ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000479867ENST00000538282ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000479867ENST00000485980ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000495093ENST00000538966ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000495093ENST00000361971ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000495093ENST00000538543ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000495093ENST00000538776ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000495093ENST00000538282ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000495093ENST00000485980ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000484329ENST00000538966ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000484329ENST00000361971ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000484329ENST00000538543ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000484329ENST00000538776ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000484329ENST00000538282ROPN1chr3

123704491

-PLXNB3chrX

153302668

-
intron-intronENST00000484329ENST00000485980ROPN1chr3

123704491

-PLXNB3chrX

153302668

-

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FusionProtFeatures for ROPN1_PLXNB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROPN1

Q9HAT0

PLXNB3

Q9ULL4

Important for male fertility. With ROPN1L, involved infibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoacapacitation. {ECO:0000250|UniProtKB:Q9ESG2}. Receptor for SEMA5A that plays a role in axon guidance,invasive growth and cell migration. Stimulates neurite outgrowthand mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In gliomacells, SEMA5A stimulation of PLXNB3 results in the disassembly ofF-actin stress fibers, disruption of focal adhesions and cellularcollapse as well as inhibition of cell migration and invasionthrough ARHGDIA-mediated inactivation of RAC1.{ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765,ECO:0000269|PubMed:21706053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ROPN1_PLXNB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ROPN1_PLXNB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROPN1_PLXNB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROPN1_PLXNB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource