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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3168

FusionGeneSummary for ATG14_MED6

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG14_MED6
Fusion gene ID: 3168
HgeneTgene
Gene symbol

ATG14

MED6

Gene ID

22863

10001

Gene nameautophagy related 14mediator complex subunit 6
SynonymsATG14L|BARKOR|KIAA0831ARC33|NY-REN-28
Cytomap

14q22.3

14q24.2

Type of geneprotein-codingprotein-coding
Descriptionbeclin 1-associated autophagy-related key regulatorATG14 autophagy related 14 homologBeclin 1-Interacting proteinautophagy-related protein 14-like proteinmediator of RNA polymerase II transcription subunit 6CTD-2540L5.5activator-recruited cofactor 33 kDa componentrenal carcinoma antigen NY-REN-28
Modification date2018052320180525
UniProtAcc

Q6ZNE5

O75586

Ensembl transtripts involved in fusion geneENST00000247178, ENST00000554963, 
ENST00000256379, ENST00000430055, 
ENST00000440435, ENST00000556044, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ATG14 [Title/Abstract] AND MED6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATG14

GO:0016240

autophagosome membrane docking

25686604

HgeneATG14

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

21062745

TgeneMED6

GO:0045944

positive regulation of transcription by RNA polymerase II

12037571


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-XF-AAMW-01AATG14chr14

55852577

-MED6chr14

71051660

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000247178ENST00000554963ATG14chr14

55852577

-MED6chr14

71051660

-
Frame-shiftENST00000247178ENST00000256379ATG14chr14

55852577

-MED6chr14

71051660

-
Frame-shiftENST00000247178ENST00000430055ATG14chr14

55852577

-MED6chr14

71051660

-
Frame-shiftENST00000247178ENST00000440435ATG14chr14

55852577

-MED6chr14

71051660

-
5CDS-intronENST00000247178ENST00000556044ATG14chr14

55852577

-MED6chr14

71051660

-

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FusionProtFeatures for ATG14_MED6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG14

Q6ZNE5

MED6

O75586

Required for both basal and inducible autophagy.Determines the localization of the autophagy-specific PI3-kinasecomplex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a rolein autophagosome formation and MAP1LC3/LC3 conjugation tophosphatidylethanolamine (PubMed:19270696, PubMed:20713597).Promotes BECN1 translocation from the trans-Golgi network toautophagosomes (PubMed:20713597). Enhances PIK3C3 activity in aBECN1-dependent manner. Essential for the autophagy-dependentphosphorylation of BECN1 (PubMed:23878393). Stimulates thephosphorylation of BECN1, but suppresses the phosphorylationPIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8interaction to promote autophagosome-endolysosome fusion(PubMed:25686604). Modulates the hepatic lipid metabolism (Bysimilarity). {ECO:0000250|UniProtKB:Q8CDJ3,ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071,ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597,ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25686604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATG14_MED6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATG14_MED6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATG14BECN1, PIK3C3, PIK3R4, NRBF2, ELAVL1, EXOC1, EXOC8, EXOC2, RALB, DACT1, RNF2, CHAF1A, USP18, IRGM, DVL2, LRRC58, RAD50, CETN2, MAP4K4, MTFR1, PDLIM5, PCM1MED6MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED15, CDK8, MED30, MED21, MED14, THRA, VDR, ESR1, ESR2, MED1, EHMT2, PARP1, SMAD1, SMAD2, SMAD3, RARA, SREBF1, MED12, MED18, ZC3H13, OBFC1, TADA2A, CTDP1, SKP1, CUL1, SMARCA4, BCL6, SUZ12, MED4, MED11, MED7, FBXW7, MED23, CCNC, CDK19, TARDBP, MED16, MED17, MED24, MED27, MED13, MED13L, MED20, MED8, CSNK2A2, EGR1, POLR2G, KIF15, BIRC5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATG14_MED6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATG14_MED6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource