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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 31674

FusionGeneSummary for ROCK1_ABHD3

check button Fusion gene summary
Fusion gene informationFusion gene name: ROCK1_ABHD3
Fusion gene ID: 31674
HgeneTgene
Gene symbol

ROCK1

ABHD3

Gene ID

6093

171586

Gene nameRho associated coiled-coil containing protein kinase 1abhydrolase domain containing 3
SynonymsP160ROCK|ROCK-ILABH3
Cytomap

18q11.1

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionrho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35phospholipase ABHD3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3
Modification date2018052720180523
UniProtAcc

Q13464

Q8WU67

Ensembl transtripts involved in fusion geneENST00000399799, ENST00000289119, 
ENST00000580981, ENST00000578270, 
ENST00000579875, 
Fusion gene scores* DoF score21 X 11 X 11=25414 X 5 X 5=100
# samples 237
** MAII scorelog2(23/2541*10)=-3.46569060910898
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROCK1 [Title/Abstract] AND ABHD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROCK1

GO:0007159

leukocyte cell-cell adhesion

12082081

HgeneROCK1

GO:0022614

membrane to membrane docking

12082081

HgeneROCK1

GO:0032091

negative regulation of protein binding

18573880

HgeneROCK1

GO:0032956

regulation of actin cytoskeleton organization

25911094

HgeneROCK1

GO:0050900

leukocyte migration

12082081

HgeneROCK1

GO:0050901

leukocyte tethering or rolling

12082081


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12P-01AROCK1chr18

18690779

-ABHD3chr18

19283708

-
TCGARVLUSCTCGA-85-8048-01AROCK1chr18

18690779

-ABHD3chr18

19244191

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000399799ENST00000289119ROCK1chr18

18690779

-ABHD3chr18

19283708

-
In-frameENST00000399799ENST00000580981ROCK1chr18

18690779

-ABHD3chr18

19283708

-
5CDS-5UTRENST00000399799ENST00000578270ROCK1chr18

18690779

-ABHD3chr18

19283708

-
5CDS-5UTRENST00000399799ENST00000579875ROCK1chr18

18690779

-ABHD3chr18

19283708

-
In-frameENST00000399799ENST00000289119ROCK1chr18

18690779

-ABHD3chr18

19244191

-
5CDS-intronENST00000399799ENST00000580981ROCK1chr18

18690779

-ABHD3chr18

19244191

-
5CDS-5UTRENST00000399799ENST00000578270ROCK1chr18

18690779

-ABHD3chr18

19244191

-
5CDS-5UTRENST00000399799ENST00000579875ROCK1chr18

18690779

-ABHD3chr18

19244191

-

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FusionProtFeatures for ROCK1_ABHD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROCK1

Q13464

ABHD3

Q8WU67

Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. Phospholipase that may play a role in phospholipidsremodeling. May selectively cleave myristate (C14)-containingphosphatidylcholines through its predominant phospholipase 1activity, cleaving preferentially acyl groups in sn1 position. Inparallel, may have a minor phospholipase 2 activity acting on acylgroups in position sn2. In addition to (C14)-containingphosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.{ECO:0000269|PubMed:21926997}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABHD3chr18:18690779chr18:19283708ENST00000289119-09140_23354410DomainAB hydrolase-1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-1331011_1102311355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133422_692311355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-1331011_1102311355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133422_692311355Coiled coilOntology_term=ECO:0000255
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133636_980311355Compositional biasNote=Glu-rich
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133636_980311355Compositional biasNote=Glu-rich
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-1331118_1317311355DomainPH
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133341_409311355DomainNote=AGC-kinase C-terminal
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133479_556311355DomainREM-1
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-13376_338311355DomainProtein kinase
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133949_1015311355DomainRhoBD
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-1331118_1317311355DomainPH
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133341_409311355DomainNote=AGC-kinase C-terminal
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133479_556311355DomainREM-1
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-13376_338311355DomainProtein kinase
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133949_1015311355DomainRhoBD
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-13382_90311355Nucleotide bindingATP
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-13382_90311355Nucleotide bindingATP
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-1331115_1354311355RegionNote=Auto-inhibitory
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133998_1010311355RegionNote=RHOA binding
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-1331115_1354311355RegionNote=Auto-inhibitory
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133998_1010311355RegionNote=RHOA binding
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-1331228_1281311355Zinc fingerPhorbol-ester/DAG-type
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-1331228_1281311355Zinc fingerPhorbol-ester/DAG-type
TgeneABHD3chr18:18690779chr18:19244191ENST00000289119-39140_233185410DomainAB hydrolase-1
TgeneABHD3chr18:18690779chr18:19244191ENST00000289119-3926_46185410TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneABHD3chr18:18690779chr18:19283708ENST00000289119-0926_4654410TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for ROCK1_ABHD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19283708_-_387aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIK
TADGGQISLDWFDNDNSTCTMDASTRPTILLLPGLTGTSKESTILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTTCCANTEDLETVIH
HVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYTLTTCLQSSVNKHRHMFVKQVDMD
HVMKAKSIREFDKRFTSVMFGYQTIDDTTTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSTGGHIGFLEGIW

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000580981_chr18_19283708_-_334aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIK
TADGGQISLDWFDNDNSTCTMDASTRPTILLLPGLTGTSKESTILHMIHLSEELGYRMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSE
SLEKPLNWLLFNYTLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDTTTDASPSPRLKSVGIPVLCLNSVDD

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19244191_-_256aa
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLTPRTTCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAAT
FSVGWNTFACSESLEKPLNWLLFNYTLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDTTTDASPSPRLKSV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19283708_-_1161nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTCAAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACG
GTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCACTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAA
ACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACAGTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTA
TTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATATGATCCATCTTAGTGAAGAATTAGGATACAGATGTGTGGTT
TTTAACAACAGAGGAGTGGCGGGGGAGAATCTCTTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCAC
CATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATT
GGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAAC
TGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGAT
CATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACT
GATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCT
ATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGG

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000580981_chr18_19283708_-_1002nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTCAAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACG
GTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCACTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAA
ACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACAGTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTA
TTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATATGATCCATCTTAGTGAAGAATTAGGATACAGAATGCTGCTT
CTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAG
TCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTT
GTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAA
ACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGAT
GTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATT
GGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACAT

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19244191_-_768nt
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG
CTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTC
CTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACT
TTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGC
CTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTT
GATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTA
GGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAAT
GTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19283708_-_2796nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTC
AAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACGGTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCA
CTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAAACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACA
GTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTATTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATA
TGATCCATCTTAGTGAAGAATTAGGATACAGATGTGTGGTTTTTAACAACAGAGGAGTGGCGGGGGAGAATCTCTTGACGCCAAGGACTT
ATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTT
CAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGA
ACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTA
ATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTT
CAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGT
GTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTA
CTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAG
CCATGGTTGAGCATGGACATGAACTCTCTTAACATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAATTGTGAAGGCAGCTCAGCTTA
GTGCACAAATTTTAACTGTTGTATATAAAGCAAATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGATATGCAAAAACTACTTTTTAGA
GAAACAAAACAACTTTGTAGCAACAAATTAAATATAGTATTAGATTGTTACTTACGTAGATTTTATTTTTACTATGCCTTACCAAGTACA
TCCTTAAACAAAGTAGTATGTACATGAAATTGCACTTAACCAAAACTATTGTGTAAAACAAATTTTAATTCCTCAGGGTTTTAATTTAAA
CTAGTATTTTTTTAGATTATTTGTTTTAGGTGATTTAATGGTACTTTAATAACTACTAAGAAATATTGGCTATTTCAATGTAAGTTATAA
GGTGGTACATTCCTAAGGGTATTTATAGTTGATGATAACATGAAAACTGAAATAAGATAAAATACAACGTGCTAAATCTTTTATGTATTC
TAACTTTAAAAGACAAGTGCAACAAAGTTAGACTGACTTCTATATGTGCTCTTTTACTCTGATAATATTAAATTAGGACTAACTTATGTT
TTATAATGATTATAATTTACATGCTTATTTTTAAAATAGTATATGTGGACACATATATATCATTATATTAAAATAAATTCTACCATTTTA

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000580981_chr18_19283708_-_2606nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTC
AAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACGGTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCA
CTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAAACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACA
GTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTATTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATA
TGATCCATCTTAGTGAAGAATTAGGATACAGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTG
CAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAA
CCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAG
AGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGT
CAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATC
CTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTG
TCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACATGAACTCTCTTAACATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAA
TTGTGAAGGCAGCTCAGCTTAGTGCACAAATTTTAACTGTTGTATATAAAGCAAATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGAT
ATGCAAAAACTACTTTTTAGAGAAACAAAACAACTTTGTAGCAACAAATTAAATATAGTATTAGATTGTTACTTACGTAGATTTTATTTT
TACTATGCCTTACCAAGTACATCCTTAAACAAAGTAGTATGTACATGAAATTGCACTTAACCAAAACTATTGTGTAAAACAAATTTTAAT
TCCTCAGGGTTTTAATTTAAACTAGTATTTTTTTAGATTATTTGTTTTAGGTGATTTAATGGTACTTTAATAACTACTAAGAAATATTGG
CTATTTCAATGTAAGTTATAAGGTGGTACATTCCTAAGGGTATTTATAGTTGATGATAACATGAAAACTGAAATAAGATAAAATACAACG
TGCTAAATCTTTTATGTATTCTAACTTTAAAAGACAAGTGCAACAAAGTTAGACTGACTTCTATATGTGCTCTTTTACTCTGATAATATT

>In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19244191_-_2403nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAG
TTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGG
GCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAAC
CACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTG
ATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATT
ATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCA
GTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGG
GAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACATGAACTCTCTTAAC
ATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAATTGTGAAGGCAGCTCAGCTTAGTGCACAAATTTTAACTGTTGTATATAAAGCAA
ATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGATATGCAAAAACTACTTTTTAGAGAAACAAAACAACTTTGTAGCAACAAATTAAAT
ATAGTATTAGATTGTTACTTACGTAGATTTTATTTTTACTATGCCTTACCAAGTACATCCTTAAACAAAGTAGTATGTACATGAAATTGC
ACTTAACCAAAACTATTGTGTAAAACAAATTTTAATTCCTCAGGGTTTTAATTTAAACTAGTATTTTTTTAGATTATTTGTTTTAGGTGA
TTTAATGGTACTTTAATAACTACTAAGAAATATTGGCTATTTCAATGTAAGTTATAAGGTGGTACATTCCTAAGGGTATTTATAGTTGAT
GATAACATGAAAACTGAAATAAGATAAAATACAACGTGCTAAATCTTTTATGTATTCTAACTTTAAAAGACAAGTGCAACAAAGTTAGAC
TGACTTCTATATGTGCTCTTTTACTCTGATAATATTAAATTAGGACTAACTTATGTTTTATAATGATTATAATTTACATGCTTATTTTTA


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FusionGenePPI for ROCK1_ABHD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ROCK1CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLDABHD3KLK15, ATP1B3, HTR3C, MAS1, HTR3A, IL17RC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneROCK1chr18:18690779chr18:19244191ENST00000399799-133368_727311355FHOD1
HgeneROCK1chr18:18690779chr18:19283708ENST00000399799-133368_727311355FHOD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROCK1_ABHD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROCK1_ABHD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource