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Fusion gene ID: 31674 |
FusionGeneSummary for ROCK1_ABHD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK1_ABHD3 | Fusion gene ID: 31674 | Hgene | Tgene | Gene symbol | ROCK1 | ABHD3 | Gene ID | 6093 | 171586 |
| Gene name | Rho associated coiled-coil containing protein kinase 1 | abhydrolase domain containing 3 | |
| Synonyms | P160ROCK|ROCK-I | LABH3 | |
| Cytomap | 18q11.1 | 18q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35 | phospholipase ABHD3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13464 | Q8WU67 | |
| Ensembl transtripts involved in fusion gene | ENST00000399799, | ENST00000289119, ENST00000580981, ENST00000578270, ENST00000579875, | |
| Fusion gene scores | * DoF score | 21 X 11 X 11=2541 | 4 X 5 X 5=100 |
| # samples | 23 | 7 | |
| ** MAII score | log2(23/2541*10)=-3.46569060910898 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ROCK1 [Title/Abstract] AND ABHD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK1 | GO:0007159 | leukocyte cell-cell adhesion | 12082081 |
| Hgene | ROCK1 | GO:0022614 | membrane to membrane docking | 12082081 |
| Hgene | ROCK1 | GO:0032091 | negative regulation of protein binding | 18573880 |
| Hgene | ROCK1 | GO:0032956 | regulation of actin cytoskeleton organization | 25911094 |
| Hgene | ROCK1 | GO:0050900 | leukocyte migration | 12082081 |
| Hgene | ROCK1 | GO:0050901 | leukocyte tethering or rolling | 12082081 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A12P-01A | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19283708 | - |
| TCGA | RV | LUSC | TCGA-85-8048-01A | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19244191 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000399799 | ENST00000289119 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19283708 | - |
| In-frame | ENST00000399799 | ENST00000580981 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19283708 | - |
| 5CDS-5UTR | ENST00000399799 | ENST00000578270 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19283708 | - |
| 5CDS-5UTR | ENST00000399799 | ENST00000579875 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19283708 | - |
| In-frame | ENST00000399799 | ENST00000289119 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19244191 | - |
| 5CDS-intron | ENST00000399799 | ENST00000580981 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19244191 | - |
| 5CDS-5UTR | ENST00000399799 | ENST00000578270 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19244191 | - |
| 5CDS-5UTR | ENST00000399799 | ENST00000579875 | ROCK1 | chr18 | 18690779 | - | ABHD3 | chr18 | 19244191 | - |
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FusionProtFeatures for ROCK1_ABHD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK1 | ABHD3 |
| Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2,MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and actssynergistically with it to promote SRC-dependent non-apoptoticplasma membrane blebbing. Phosphorylates JIP3 and regulates therecruitment of JNK to JIP3 upon UVB-induced stress. Acts as asuppressor of inflammatory cell migration by regulating PTENphosphorylation and stability. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Required forcentrosome positioning and centrosome-dependent exit from mitosis.Plays a role in terminal erythroid differentiation. May regulateclosure of the eyelids and ventral body wall by inducing theassembly of actomyosin bundles. Promotes keratinocyte terminaldifferentiation. Involved in osteoblast compaction through thefibronectin fibrillogenesis cell-mediated matrix assembly process,essential for osteoblast mineralization.{ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353,ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607,ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880,ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714,ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057,ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. | Phospholipase that may play a role in phospholipidsremodeling. May selectively cleave myristate (C14)-containingphosphatidylcholines through its predominant phospholipase 1activity, cleaving preferentially acyl groups in sn1 position. Inparallel, may have a minor phospholipase 2 activity acting on acylgroups in position sn2. In addition to (C14)-containingphosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.{ECO:0000269|PubMed:21926997}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ABHD3 | chr18:18690779 | chr18:19283708 | ENST00000289119 | - | 0 | 9 | 140_233 | 54 | 410 | Domain | AB hydrolase-1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 1011_1102 | 31 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 422_692 | 31 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 1011_1102 | 31 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 422_692 | 31 | 1355 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 636_980 | 31 | 1355 | Compositional bias | Note=Glu-rich |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 636_980 | 31 | 1355 | Compositional bias | Note=Glu-rich |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 1118_1317 | 31 | 1355 | Domain | PH |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 341_409 | 31 | 1355 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 479_556 | 31 | 1355 | Domain | REM-1 |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 76_338 | 31 | 1355 | Domain | Protein kinase |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 949_1015 | 31 | 1355 | Domain | RhoBD |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 1118_1317 | 31 | 1355 | Domain | PH |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 341_409 | 31 | 1355 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 479_556 | 31 | 1355 | Domain | REM-1 |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 76_338 | 31 | 1355 | Domain | Protein kinase |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 949_1015 | 31 | 1355 | Domain | RhoBD |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 82_90 | 31 | 1355 | Nucleotide binding | ATP |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 82_90 | 31 | 1355 | Nucleotide binding | ATP |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 1115_1354 | 31 | 1355 | Region | Note=Auto-inhibitory |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 998_1010 | 31 | 1355 | Region | Note=RHOA binding |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 1115_1354 | 31 | 1355 | Region | Note=Auto-inhibitory |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 998_1010 | 31 | 1355 | Region | Note=RHOA binding |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 1228_1281 | 31 | 1355 | Zinc finger | Phorbol-ester/DAG-type |
| Hgene | >ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 1228_1281 | 31 | 1355 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | ABHD3 | chr18:18690779 | chr18:19244191 | ENST00000289119 | - | 3 | 9 | 140_233 | 185 | 410 | Domain | AB hydrolase-1 |
| Tgene | ABHD3 | chr18:18690779 | chr18:19244191 | ENST00000289119 | - | 3 | 9 | 26_46 | 185 | 410 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | ABHD3 | chr18:18690779 | chr18:19283708 | ENST00000289119 | - | 0 | 9 | 26_46 | 54 | 410 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for ROCK1_ABHD3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19283708_-_387aa MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIK TADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIH HVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMD HVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIW >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000580981_chr18_19283708_-_334aa MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIK TADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSE SLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDD >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19244191_-_256aa MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAAT FSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19283708_-_1161nt ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG CTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTCAAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACG GTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCACTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAA ACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACAGTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTA TTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATATGATCCATCTTAGTGAAGAATTAGGATACAGATGTGTGGTT TTTAACAACAGAGGAGTGGCGGGGGAGAATCTCTTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCAC CATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATT GGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAAC TGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGAT CATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACT GATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCT ATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGG >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000580981_chr18_19283708_-_1002nt ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG CTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTCAAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACG GTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCACTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAA ACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACAGTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTA TTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATATGATCCATCTTAGTGAAGAATTAGGATACAGAATGCTGCTT CTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAG TCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTT GTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAA ACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGAT GTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATT GGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACAT >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19244191_-_768nt ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTG CTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTC CTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACT TTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGC CTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTT GATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTA GGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAAT GTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19283708_-_2796nt GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTC AAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACGGTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCA CTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAAACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACA GTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTATTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATA TGATCCATCTTAGTGAAGAATTAGGATACAGATGTGTGGTTTTTAACAACAGAGGAGTGGCGGGGGAGAATCTCTTGACGCCAAGGACTT ATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTT CAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGA ACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTA ATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTT CAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGT GTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTA CTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAG CCATGGTTGAGCATGGACATGAACTCTCTTAACATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAATTGTGAAGGCAGCTCAGCTTA GTGCACAAATTTTAACTGTTGTATATAAAGCAAATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGATATGCAAAAACTACTTTTTAGA GAAACAAAACAACTTTGTAGCAACAAATTAAATATAGTATTAGATTGTTACTTACGTAGATTTTATTTTTACTATGCCTTACCAAGTACA TCCTTAAACAAAGTAGTATGTACATGAAATTGCACTTAACCAAAACTATTGTGTAAAACAAATTTTAATTCCTCAGGGTTTTAATTTAAA CTAGTATTTTTTTAGATTATTTGTTTTAGGTGATTTAATGGTACTTTAATAACTACTAAGAAATATTGGCTATTTCAATGTAAGTTATAA GGTGGTACATTCCTAAGGGTATTTATAGTTGATGATAACATGAAAACTGAAATAAGATAAAATACAACGTGCTAAATCTTTTATGTATTC TAACTTTAAAAGACAAGTGCAACAAAGTTAGACTGACTTCTATATGTGCTCTTTTACTCTGATAATATTAAATTAGGACTAACTTATGTT TTATAATGATTATAATTTACATGCTTATTTTTAAAATAGTATATGTGGACACATATATATCATTATATTAAAATAAATTCTACCATTTTA >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000580981_chr18_19283708_-_2606nt GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTC AAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACGGTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCA CTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAAACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACA GTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTATTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATA TGATCCATCTTAGTGAAGAATTAGGATACAGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTG CAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAA CCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAG AGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGT CAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATC CTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTG TCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACATGAACTCTCTTAACATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAA TTGTGAAGGCAGCTCAGCTTAGTGCACAAATTTTAACTGTTGTATATAAAGCAAATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGAT ATGCAAAAACTACTTTTTAGAGAAACAAAACAACTTTGTAGCAACAAATTAAATATAGTATTAGATTGTTACTTACGTAGATTTTATTTT TACTATGCCTTACCAAGTACATCCTTAAACAAAGTAGTATGTACATGAAATTGCACTTAACCAAAACTATTGTGTAAAACAAATTTTAAT TCCTCAGGGTTTTAATTTAAACTAGTATTTTTTTAGATTATTTGTTTTAGGTGATTTAATGGTACTTTAATAACTACTAAGAAATATTGG CTATTTCAATGTAAGTTATAAGGTGGTACATTCCTAAGGGTATTTATAGTTGATGATAACATGAAAACTGAAATAAGATAAAATACAACG TGCTAAATCTTTTATGTATTCTAACTTTAAAAGACAAGTGCAACAAAGTTAGACTGACTTCTATATGTGCTCTTTTACTCTGATAATATT >In-frame_ROCK1_ENST00000399799_chr18_18690779_-_ABHD3_ENST00000289119_chr18_19244191_-_2403nt GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAG TTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGG GCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAAC CACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTG ATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATT ATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCA GTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGG GAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACATGAACTCTCTTAAC ATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAATTGTGAAGGCAGCTCAGCTTAGTGCACAAATTTTAACTGTTGTATATAAAGCAA ATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGATATGCAAAAACTACTTTTTAGAGAAACAAAACAACTTTGTAGCAACAAATTAAAT ATAGTATTAGATTGTTACTTACGTAGATTTTATTTTTACTATGCCTTACCAAGTACATCCTTAAACAAAGTAGTATGTACATGAAATTGC ACTTAACCAAAACTATTGTGTAAAACAAATTTTAATTCCTCAGGGTTTTAATTTAAACTAGTATTTTTTTAGATTATTTGTTTTAGGTGA TTTAATGGTACTTTAATAACTACTAAGAAATATTGGCTATTTCAATGTAAGTTATAAGGTGGTACATTCCTAAGGGTATTTATAGTTGAT GATAACATGAAAACTGAAATAAGATAAAATACAACGTGCTAAATCTTTTATGTATTCTAACTTTAAAAGACAAGTGCAACAAAGTTAGAC TGACTTCTATATGTGCTCTTTTACTCTGATAATATTAAATTAGGACTAACTTATGTTTTATAATGATTATAATTTACATGCTTATTTTTA |
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FusionGenePPI for ROCK1_ABHD3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ROCK1 | CDC25A, PFN2, RHOA, RND3, GAB1, CFL1, LIMK2, HNRNPA1, ITSN2, ARRB1, TSG101, NOTCH1, SMURF1, SMAD2, CASP3, CASP7, CDK15, ANKFY1, MON2, FAM21A, KIAA1033, IKBKB, LMO2, MAGEB4, POLR3C, C6orf165, FAM124A, NXF1, NTRK1, MED23, XRCC5, NEIL3, TRIM15, HGS, SLC9A1, UBE2T, CDKN3, TENC1, ROCK2, ADD2, IL20RA, CYLD | ABHD3 | KLK15, ATP1B3, HTR3C, MAS1, HTR3A, IL17RC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ROCK1 | chr18:18690779 | chr18:19244191 | ENST00000399799 | - | 1 | 33 | 368_727 | 31 | 1355 | FHOD1 |
| Hgene | ROCK1 | chr18:18690779 | chr18:19283708 | ENST00000399799 | - | 1 | 33 | 368_727 | 31 | 1355 | FHOD1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROCK1_ABHD3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROCK1_ABHD3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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