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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31655

FusionGeneSummary for ROBO1_ACKR3

check button Fusion gene summary
Fusion gene informationFusion gene name: ROBO1_ACKR3
Fusion gene ID: 31655
HgeneTgene
Gene symbol

ROBO1

ACKR3

Gene ID

6091

57007

Gene nameroundabout guidance receptor 1atypical chemokine receptor 3
SynonymsDUTT1|SAX3CMKOR1|CXC-R7|CXCR-7|CXCR7|GPR159|RDC-1|RDC1
Cytomap

3p12.3

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionroundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 1atypical chemokine receptor 3C-X-C chemokine receptor type 7G protein-coupled receptorG-protein coupled receptor 159G-protein coupled receptor RDC1 homologchemokine (C-X-C motif) receptor 7chemokine orphan receptor 1
Modification date2018051920180523
UniProtAcc

Q9Y6N7

P25106

Ensembl transtripts involved in fusion geneENST00000464233, ENST00000436010, 
ENST00000495273, ENST00000467549, 
ENST00000466906, 
ENST00000272928, 
Fusion gene scores* DoF score11 X 11 X 5=6053 X 3 X 2=18
# samples 113
** MAII scorelog2(11/605*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ROBO1 [Title/Abstract] AND ACKR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROBO1

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

HgeneROBO1

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneROBO1

GO:0050772

positive regulation of axonogenesis

12504588

HgeneROBO1

GO:0050925

negative regulation of negative chemotaxis

11748139


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE836744ROBO1chr3

78987881

+ACKR3chr2

237481611

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000464233ENST00000272928ROBO1chr3

78987881

+ACKR3chr2

237481611

+
intron-intronENST00000436010ENST00000272928ROBO1chr3

78987881

+ACKR3chr2

237481611

+
intron-intronENST00000495273ENST00000272928ROBO1chr3

78987881

+ACKR3chr2

237481611

+
intron-intronENST00000467549ENST00000272928ROBO1chr3

78987881

+ACKR3chr2

237481611

+
intron-intronENST00000466906ENST00000272928ROBO1chr3

78987881

+ACKR3chr2

237481611

+

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FusionProtFeatures for ROBO1_ACKR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROBO1

Q9Y6N7

ACKR3

P25106

Receptor for SLIT1 and SLIT2 that mediates cellularresponses to molecular guidance cues in cellular migration,including axonal navigation at the ventral midline of the neuraltube and projection of axons to different regions during neuronaldevelopment (PubMed:10102268, PubMed:24560577). Interaction withthe intracellular domain of FLRT3 mediates axon attraction towardscells expressing NTN1 (PubMed:24560577). In axon growth cones, thesilencing of the attractive effect of NTN1 by SLIT2 may requirethe formation of a ROBO1-DCC complex (By similarity). Plays a rolein the regulation of cell migration via its interaction withMYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPaseactivity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development(By similarity). {ECO:0000250|UniProtKB:O89026,ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577,ECO:0000269|PubMed:26529257, ECO:0000305}. Atypical chemokine receptor that controls chemokinelevels and localization via high-affinity chemokine binding thatis uncoupled from classic ligand-driven signal transductioncascades, resulting instead in chemokine sequestration,degradation, or transcytosis. Also known as interceptor(internalizing receptor) or chemokine-scavenging receptor orchemokine decoy receptor. Acts as a receptor for chemokines CXCL11and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestinrecruitment, leading to ligand internalization and activation ofMAPK signaling pathway. Required for regulation of CXCR4 proteinlevels in migrating interneurons, thereby adapting their chemokineresponsiveness. In glioma cells, transduces signals via MEK/ERKpathway, mediating resistance to apoptosis. Promotes cell growthand survival. Not involved in cell migration, adhesion orproliferation of normal hematopoietic progenitors but activated byCXCL11 in malignant hemapoietic cells, leading to phosphorylationof ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration.Plays a regulatory role in CXCR4-mediated activation of cellsurface integrins by CXCL12. Required for heart valve development.Acts as coreceptor with CXCR4 for a restricted number of HIVisolates. {ECO:0000269|PubMed:16107333,ECO:0000269|PubMed:16940167, ECO:0000269|PubMed:17804806,ECO:0000269|PubMed:18653785, ECO:0000269|PubMed:19255243,ECO:0000269|PubMed:19380869, ECO:0000269|PubMed:19641136,ECO:0000269|PubMed:20018651, ECO:0000269|PubMed:20161793,ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389,ECO:0000269|PubMed:22300987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ROBO1_ACKR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ROBO1_ACKR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROBO1_ACKR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROBO1_ACKR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneROBO1C0001418Adenocarcinoma1CTD_human
HgeneROBO1C0004352Autistic Disorder1CTD_human
HgeneROBO1C0024121Lung Neoplasms1CTD_human
TgeneACKR3C0003873Rheumatoid Arthritis1CTD_human
TgeneACKR3C0009404Colorectal Neoplasms1CTD_human
TgeneACKR3C0022658Kidney Diseases1CTD_human
TgeneACKR3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneACKR3C0027627Neoplasm Metastasis1CTD_human