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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31628

FusionGeneSummary for RNMT_SNCAIP

check button Fusion gene summary
Fusion gene informationFusion gene name: RNMT_SNCAIP
Fusion gene ID: 31628
HgeneTgene
Gene symbol

RNMT

SNCAIP

Gene ID

8731

9627

Gene nameRNA guanine-7 methyltransferasesynuclein alpha interacting protein
SynonymsCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMetSYPH1|Sph1
Cytomap

18p11.21

5q23.2

Type of geneprotein-codingprotein-coding
DescriptionmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferasesynphilin-1
Modification date2018052320180519
UniProtAcc

O43148

Q9Y6H5

Ensembl transtripts involved in fusion geneENST00000383314, ENST00000592764, 
ENST00000262173, ENST00000591922, 
ENST00000543302, ENST00000535051, 
ENST00000589866, 
ENST00000542191, 
ENST00000261368, ENST00000379538, 
ENST00000379533, ENST00000379536, 
ENST00000261367, ENST00000414317, 
ENST00000503116, ENST00000504884, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNMT [Title/Abstract] AND SNCAIP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNMT

GO:0006370

7-methylguanosine mRNA capping

27422871

TgeneSNCAIP

GO:0008219

cell death

16595633

TgeneSNCAIP

GO:0042417

dopamine metabolic process

14506261

TgeneSNCAIP

GO:0046928

regulation of neurotransmitter secretion

14506261

TgeneSNCAIP

GO:0090083

regulation of inclusion body assembly

15603737


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A7EF-01ARNMTchr18

13726728

+SNCAIPchr5

121776324

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000383314ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000383314ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-3UTRENST00000383314ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000592764ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-3UTRENST00000592764ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000262173ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-3UTRENST00000262173ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000591922ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-3UTRENST00000591922ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000543302ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-3UTRENST00000543302ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-5UTRENST00000535051ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
5UTR-3UTRENST00000535051ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000542191RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000261368RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000379538RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000379533RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000379536RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000261367RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000414317RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-5UTRENST00000589866ENST00000503116RNMTchr18

13726728

+SNCAIPchr5

121776324

+
intron-3UTRENST00000589866ENST00000504884RNMTchr18

13726728

+SNCAIPchr5

121776324

+

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FusionProtFeatures for RNMT_SNCAIP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNMT

O43148

SNCAIP

Q9Y6H5

Catalytic subunit of the mRNA-capping methyltransferaseRNMT:RAMMET complex that methylates the N7 position of the addedguanosine to the 5'-cap structure of mRNAs (PubMed:9790902,PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306,PubMed:27422871). Binds RNA containing 5'-terminal GpppC(PubMed:11114884). {ECO:0000269|PubMed:10347220,ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306,ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270,ECO:0000269|PubMed:9790902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNMT_SNCAIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNMT_SNCAIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNMTRNGTT, CUL3, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, HECW2, KIF23, NFATC2IP, NTRK1, KPNA1, MCM2, FAM103A1, KPNA6, HSP90AB4P, TRPC4AP, KPNA5, BRCA1SNCAIPSNCA, GET4, SH2D3C, PTN, PARK2, SNCAIP, GSK3B, SIAH2, SIAH1, RNF19A, HERPUD1, NUDT21, C11orf58, PPP1CA, PSMC4, YWHAH, ARIH1, NUB1, PINK1, PPHLN1, CSNK2A1, PIN1, PPP1CC, KALRN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNMT_SNCAIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNMT_SNCAIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource