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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31622

FusionGeneSummary for RNH1_HRAS

check button Fusion gene summary
Fusion gene informationFusion gene name: RNH1_HRAS
Fusion gene ID: 31622
HgeneTgene
Gene symbol

RNH1

HRAS

Gene ID

246243

3265

Gene nameribonuclease H1HRas proto-oncogene, GTPase
SynonymsH1RNA|PEOB2|RNH1C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras
Cytomap

2p25.3

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionribonuclease H1ribonuclease H type IIGTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinc-ras-Ki-2 activated oncogenep19 H-RasIDX
Modification date2018052320180522
UniProtAcc

P13489

P01112

Ensembl transtripts involved in fusion geneENST00000534797, ENST00000397614, 
ENST00000397615, ENST00000397604, 
ENST00000533410, ENST00000438658, 
ENST00000354420, ENST00000356187, 
ENST00000533592, 		ENST00000397594, 
ENST00000397596, ENST00000451590, 
ENST00000417302, ENST00000311189, 
ENST00000468682, 
Fusion gene scores* DoF score6 X 2 X 5=602 X 2 X 2=8
# samples 62
** MAII scorelog2(6/60*10)=0log2(2/8*10)=1.32192809488736
Context

PubMed: RNH1 [Title/Abstract] AND HRAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHRAS

GO:0001934

positive regulation of protein phosphorylation

22065586

TgeneHRAS

GO:0007050

cell cycle arrest

9054499

TgeneHRAS

GO:0007093

mitotic cell cycle checkpoint

9054499

TgeneHRAS

GO:0007265

Ras protein signal transduction

23027131

TgeneHRAS

GO:0008284

positive regulation of cell proliferation

9765203

TgeneHRAS

GO:0008285

negative regulation of cell proliferation

9054499

TgeneHRAS

GO:0010629

negative regulation of gene expression

23027131

TgeneHRAS

GO:0010863

positive regulation of phospholipase C activity

11022048

TgeneHRAS

GO:0030335

positive regulation of cell migration

23027131

TgeneHRAS

GO:0034260

negative regulation of GTPase activity

23027131

TgeneHRAS

GO:0043406

positive regulation of MAP kinase activity

23027131

TgeneHRAS

GO:0043410

positive regulation of MAPK cascade

9765203

TgeneHRAS

GO:0043547

positive regulation of GTPase activity

23027131

TgeneHRAS

GO:0045944

positive regulation of transcription by RNA polymerase II

22065586|23027131

TgeneHRAS

GO:0046330

positive regulation of JNK cascade

22065586

TgeneHRAS

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneHRAS

GO:0071480

cellular response to gamma radiation

16213212

TgeneHRAS

GO:0090303

positive regulation of wound healing

23027131

TgeneHRAS

GO:0090398

cellular senescence

9054499

TgeneHRAS

GO:1900029

positive regulation of ruffle assembly

23027131

TgeneHRAS

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027131

TgeneHRAS

GO:2000630

positive regulation of miRNA metabolic process

23027131


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7382-01ARNH1chr11

507113

-HRASchr11

533944

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000534797ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000534797ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000534797ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000534797ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000534797ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
intron-5UTRENST00000534797ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397614ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397614ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397614ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397614ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397614ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
intron-5UTRENST00000397614ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397615ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397615ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397615ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397615ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000397615ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
intron-5UTRENST00000397615ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000397604ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000397604ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000397604ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000397604ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000397604ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
5UTR-5UTRENST00000397604ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000533410ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000533410ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000533410ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000533410ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000533410ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
5UTR-5UTRENST00000533410ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000438658ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000438658ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000438658ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000438658ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000438658ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
intron-5UTRENST00000438658ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000354420ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000354420ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000354420ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000354420ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000354420ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
5UTR-5UTRENST00000354420ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000356187ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000356187ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000356187ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000356187ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
5UTR-3CDSENST00000356187ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
5UTR-5UTRENST00000356187ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000533592ENST00000397594RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000533592ENST00000397596RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000533592ENST00000451590RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000533592ENST00000417302RNH1chr11

507113

-HRASchr11

533944

-
intron-3CDSENST00000533592ENST00000311189RNH1chr11

507113

-HRASchr11

533944

-
intron-5UTRENST00000533592ENST00000468682RNH1chr11

507113

-HRASchr11

533944

-

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FusionProtFeatures for RNH1_HRAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNH1

P13489

HRAS

P01112

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 andANG. May play a role in redox homeostasis.{ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218,ECO:0000269|PubMed:17292889}. Involved in the activation of Ras protein signaltransduction (PubMed:22821884). Ras proteins bind GDP/GTP andpossess intrinsic GTPase activity (PubMed:12740440,PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440,ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884,ECO:0000269|PubMed:9020151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNH1_HRAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNH1_HRAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNH1ANG, TNFAIP3, USP32P2, G3BP2, SLX4IP, MYC, SIRT7, DSTN, PRDX1, UBQLN2, ADSS, PRR12, COL1A1, FN1, IQCB1, NPM1, SOX2, PTGES3, ERO1L, LSM2, RAB1B, SDCBP, RNASE7, NTRK1, CEP19, CDC20, LMO7, PSMD2, MAP4K4, FBXL12, MCM2, CDC73, RNASE3, RNASE1, PRPF3, PRPF4, ALYREF, FOXA1, G3BP1HRASRAP1GDS1, BRAF, RASGRF1, RAF1, RGL4, RIN1, RALGDS, RASIP1, RGL2, PIK3CA, TTC1, GPSM2, SOS1, ARHGEF1, RASSF1, SHOC2, PDE6D, TIAM1, RASSF5, MLLT4, PIK3CD, INSR, RHEB, MAP2K1, DGKZ, IKZF3, NF1, PIK3R1, PLAU, ERBB2IP, PIK3CG, RASA1, LGALS1, SNRPE, ZHX2, RGL1, DEAF1, BTRC, SPRY2, CBL, SH3KBP1, RABGEF1, BRAP, RNF115, PPP1R13B, LATS2, TP53, TPR, SLC9A3R2, NEDD8, PSMB2, KRT18, DAB2IP, ABL2, MOV10, SNX17, PHF19, SLC25A41, CD27, HOXB5, RABGGTB, TMEM185A, FAM213B, CYP51A1, DHCR24, BLID, CXCL1, GREB1, IL24, PRSS50, MAPK8, FAM129B, PLA2G16, DUSP12, DUSP22, DUSP9, CYP2S1, ATG3, VDAC3, MGST3, PLCXD2, TIGD5, SGK1, MTHFD2, MED21, PCDHGC3, C1QL4, S1PR1, DUS4L, DEFB104A, GJB7, HDHD2, PMS1, NTRK3, SDC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNH1_HRAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNH1_HRAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHRASC0587248Costello syndrome (disorder)13CTD_human;ORPHANET;UNIPROT
TgeneHRASC0037286Skin Neoplasms7CTD_human
TgeneHRASC0023903Liver neoplasms5CTD_human
TgeneHRASC0024121Lung Neoplasms5CTD_human
TgeneHRASC0007621Neoplastic Cell Transformation4CTD_human
TgeneHRASC1458155Mammary Neoplasms4CTD_human
TgeneHRASC0005695Bladder Neoplasm3CTD_human
TgeneHRASC0023904Liver Neoplasms, Experimental3CTD_human
TgeneHRASC0027659Neoplasms, Experimental3CTD_human
TgeneHRASC2239176Liver carcinoma3CTD_human
TgeneHRASC0007137Squamous cell carcinoma2CTD_human
TgeneHRASC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneHRASC0027819Neuroblastoma2CTD_human
TgeneHRASC0038356Stomach Neoplasms2CTD_human
TgeneHRASC4225426THYROID CANCER, NONMEDULLARY, 22UNIPROT
TgeneHRASC0004352Autistic Disorder1CTD_human
TgeneHRASC0007138Carcinoma, Transitional Cell1CTD_human
TgeneHRASC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneHRASC0018923Hemangiosarcoma1CTD_human
TgeneHRASC0024667Animal Mammary Neoplasms1CTD_human
TgeneHRASC0026640Mouth Neoplasms1CTD_human
TgeneHRASC0027626Neoplasm Invasiveness1CTD_human
TgeneHRASC0028326Noonan Syndrome1CTD_human
TgeneHRASC0030354Papilloma1CTD_human;HPO
TgeneHRASC0030849Penile Neoplasms1CTD_human
TgeneHRASC0032927Precancerous Conditions1CTD_human
TgeneHRASC0036631Seminoma1CTD_human
TgeneHRASC0037999Splenic Neoplasms1CTD_human
TgeneHRASC0040136Thyroid Neoplasm1CTD_human
TgeneHRASC0040411Tongue Neoplasms1CTD_human
TgeneHRASC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneHRASC0206669Hepatocellular Adenoma1CTD_human
TgeneHRASC1275081Cardio-facio-cutaneous syndrome1CTD_human
TgeneHRASC3854181Nevus sebaceous1CTD_human;HPO;ORPHANET;UNIPROT