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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31599

FusionGeneSummary for RNF44_NXF3

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF44_NXF3
Fusion gene ID: 31599
HgeneTgene
Gene symbol

RNF44

NXF3

Gene ID

22838

56000

Gene namering finger protein 44nuclear RNA export factor 3
Synonyms--
Cytomap

5q35.2

Xq22.1

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 44nuclear RNA export factor 3TAP-like protein 3TAPL-3
Modification date2018052220180523
UniProtAcc

Q7L0R7

Q9H4D5

Ensembl transtripts involved in fusion geneENST00000274811, ENST00000537487, 
ENST00000509404, 
ENST00000395065, 
ENST00000425644, ENST00000425463, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 2 X 2=16
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF44 [Title/Abstract] AND NXF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNXF3

GO:0006406

mRNA export from nucleus

11545741


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-S3-A6ZF-01ARNF44chr5

175964732

-NXF3chrX

102339423

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000274811ENST00000395065RNF44chr5

175964732

-NXF3chrX

102339423

-
intron-5UTRENST00000274811ENST00000425644RNF44chr5

175964732

-NXF3chrX

102339423

-
intron-5UTRENST00000274811ENST00000425463RNF44chr5

175964732

-NXF3chrX

102339423

-
5UTR-3CDSENST00000537487ENST00000395065RNF44chr5

175964732

-NXF3chrX

102339423

-
5UTR-5UTRENST00000537487ENST00000425644RNF44chr5

175964732

-NXF3chrX

102339423

-
5UTR-5UTRENST00000537487ENST00000425463RNF44chr5

175964732

-NXF3chrX

102339423

-
intron-3CDSENST00000509404ENST00000395065RNF44chr5

175964732

-NXF3chrX

102339423

-
intron-5UTRENST00000509404ENST00000425644RNF44chr5

175964732

-NXF3chrX

102339423

-
intron-5UTRENST00000509404ENST00000425463RNF44chr5

175964732

-NXF3chrX

102339423

-

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FusionProtFeatures for RNF44_NXF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF44

Q7L0R7

NXF3

Q9H4D5

May function as a tissue-specific nuclear mRNA exportfactor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF44_NXF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF44_NXF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF44NXF3XPO1, NXT1, NXT2, NXF1, SKIL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF44_NXF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF44_NXF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource