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Fusion gene ID: 31599 |
FusionGeneSummary for RNF44_NXF3 |
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Fusion gene information | Fusion gene name: RNF44_NXF3 | Fusion gene ID: 31599 | Hgene | Tgene | Gene symbol | RNF44 | NXF3 | Gene ID | 22838 | 56000 |
Gene name | ring finger protein 44 | nuclear RNA export factor 3 | |
Synonyms | - | - | |
Cytomap | 5q35.2 | Xq22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | RING finger protein 44 | nuclear RNA export factor 3TAP-like protein 3TAPL-3 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q7L0R7 | Q9H4D5 | |
Ensembl transtripts involved in fusion gene | ENST00000274811, ENST00000537487, ENST00000509404, | ENST00000395065, ENST00000425644, ENST00000425463, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 2 X 2=16 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RNF44 [Title/Abstract] AND NXF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NXF3 | GO:0006406 | mRNA export from nucleus | 11545741 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-S3-A6ZF-01A | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000274811 | ENST00000395065 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
intron-5UTR | ENST00000274811 | ENST00000425644 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
intron-5UTR | ENST00000274811 | ENST00000425463 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
5UTR-3CDS | ENST00000537487 | ENST00000395065 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
5UTR-5UTR | ENST00000537487 | ENST00000425644 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
5UTR-5UTR | ENST00000537487 | ENST00000425463 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
intron-3CDS | ENST00000509404 | ENST00000395065 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
intron-5UTR | ENST00000509404 | ENST00000425644 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
intron-5UTR | ENST00000509404 | ENST00000425463 | RNF44 | chr5 | 175964732 | - | NXF3 | chrX | 102339423 | - |
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FusionProtFeatures for RNF44_NXF3 |
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Hgene | Tgene |
RNF44 | NXF3 |
May function as a tissue-specific nuclear mRNA exportfactor. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF44_NXF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF44_NXF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RNF44 | NXF3 | XPO1, NXT1, NXT2, NXF1, SKIL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF44_NXF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF44_NXF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |