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Fusion gene ID: 31587 |
FusionGeneSummary for RNF41_MSRB3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF41_MSRB3 | Fusion gene ID: 31587 | Hgene | Tgene | Gene symbol | RNF41 | MSRB3 | Gene ID | 10193 | 253827 |
| Gene name | ring finger protein 41 | methionine sulfoxide reductase B3 | |
| Synonyms | FLRF|NRDP1|SBBI03 | DFNB74 | |
| Cytomap | 12q13.3 | 12q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase NRDP1RING-type E3 ubiquitin transferase NRDP1fetal liver ring fingerneuregulin receptor degradation protein-1ring finger protein 41, E3 ubiquitin protein ligase | methionine-R-sulfoxide reductase B3methionine-R-sulfoxide reductase B3, mitochondrial | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q9H4P4 | Q8IXL7 | |
| Ensembl transtripts involved in fusion gene | ENST00000345093, ENST00000394013, ENST00000552656, ENST00000552244, | ENST00000355192, ENST00000308259, ENST00000540804, ENST00000535664, ENST00000538725, | |
| Fusion gene scores | * DoF score | 6 X 3 X 6=108 | 11 X 6 X 6=396 |
| # samples | 6 | 10 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/396*10)=-1.98550043030488 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF41 [Title/Abstract] AND MSRB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF41 | GO:0000209 | protein polyubiquitination | 14765125|18541373 |
| Hgene | RNF41 | GO:0008285 | negative regulation of cell proliferation | 17145873 |
| Hgene | RNF41 | GO:0010498 | proteasomal protein catabolic process | 18541373 |
| Hgene | RNF41 | GO:0043408 | regulation of MAPK cascade | 17145873 |
| Hgene | RNF41 | GO:0051865 | protein autoubiquitination | 24105792 |
| Hgene | RNF41 | GO:0051896 | regulation of protein kinase B signaling | 17145873 |
| Hgene | RNF41 | GO:0097191 | extrinsic apoptotic signaling pathway | 14765125 |
| Tgene | MSRB3 | GO:0030091 | protein repair | 14699060 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-UY-A78L-01A | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000345093 | ENST00000355192 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-5UTR | ENST00000345093 | ENST00000308259 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-intron | ENST00000345093 | ENST00000540804 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-5UTR | ENST00000345093 | ENST00000535664 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-3UTR | ENST00000345093 | ENST00000538725 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5UTR-intron | ENST00000394013 | ENST00000355192 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5UTR-5UTR | ENST00000394013 | ENST00000308259 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5UTR-intron | ENST00000394013 | ENST00000540804 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5UTR-5UTR | ENST00000394013 | ENST00000535664 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5UTR-3UTR | ENST00000394013 | ENST00000538725 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-intron | ENST00000552656 | ENST00000355192 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-5UTR | ENST00000552656 | ENST00000308259 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-intron | ENST00000552656 | ENST00000540804 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-5UTR | ENST00000552656 | ENST00000535664 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-3UTR | ENST00000552656 | ENST00000538725 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-intron | ENST00000552244 | ENST00000355192 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-5UTR | ENST00000552244 | ENST00000308259 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-intron | ENST00000552244 | ENST00000540804 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-5UTR | ENST00000552244 | ENST00000535664 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
| 5CDS-3UTR | ENST00000552244 | ENST00000538725 | RNF41 | chr12 | 56607742 | - | MSRB3 | chr12 | 65702309 | + |
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FusionProtFeatures for RNF41_MSRB3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF41 | MSRB3 |
| Acts as E3 ubiquitin-protein ligase and regulates thedegradation of target proteins. Polyubiquitinates MYD88.Negatively regulates MYD88-dependent production of proinflammatorycytokines. Can promote TRIF-dependent production of type Iinterferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3.Involved in the ubiquitination of erythropoietin (EPO) andinterleukin-3 (IL-3) receptors. Thus, through maintaining basallevels of cytokine receptors, RNF41 is involved in the control ofhematopoietic progenitor cell differentiation into myeloerythroidlineages (By similarity). Contributes to the maintenance ofsteady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of theinhibitor of apoptosis BIRC6 and thus is an important regulator ofcell death by promoting apoptosis. Acts also as a PRKN modifierthat accelerates its degradation, resulting in a reduction of PRKNactivity, influencing the balance of intracellular redox state.The RNF41-PRKN pathway regulates autophagosome-lysosome fusionduring late mitophagy. Mitophagy is a selective form of autophagynecessary for mitochondrial quality control (PubMed:24949970).{ECO:0000250, ECO:0000250|UniProtKB:Q8BH75,ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:14765125,ECO:0000269|PubMed:15632191, ECO:0000269|PubMed:17210635,ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:19483718,ECO:0000269|PubMed:24949970}. | Catalyzes the reduction of free and protein-boundmethionine sulfoxide to methionine. Isoform 2 is essential forhearing. {ECO:0000269|PubMed:14699060,ECO:0000269|PubMed:21185009}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF41_MSRB3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF41_MSRB3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF41 | USP8, BIRC6, ERBB3, ERBB4, PARK2, UBE2U, UBE2Z, TSG101, UBE2K, H3F3A, TADA2A, MARK4, ELAVL1, LEPR, UBE2D3, APP, RNF41, RNF166, MNAT1, TRIM8, TRIM32, MARK2, ADRB2, CACYBP, SUGT1, TTC1, RFC4, VPS52, HOMER2, ARL6IP4, C1orf109, LZTS2, ISCA2, ASB6, IL23A, RCN1, CREB3, KIFC3, NPAT, P4HA1, SF1, EVI5, LPGAT1, N4BP3, MTCL1, CLEC16A, CLASP1, C1GALT1C1, ITSN2, RASIP1, CEP192, RFWD3, UPF3A, NAV1, SOGA1, CD247, ZAP70, UBASH3B, UBASH3A, LCP1, ENOPH1, GIP, TACC1, BHLHA15, ARHGAP19, IFIT5, ZNF517, MTNR1A, MTNR1B, VANGL1, DVL2, IRS4, MAGEL2, VANGL2, KDM3B | MSRB3 | GOLGA2, TCF4, TRIP6, PRDM4, MOV10, NXF1, AZIN1, GAPDH, MAPK8IP2, LNX2, KLHL7, RBP4, SPOP, DCUN1D4, C1QL1, BTBD9, STIM2, IFNA21 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF41_MSRB3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF41_MSRB3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RNF41 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | RNF41 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | RNF41 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | MSRB3 | C1384666 | hearing impairment | 1 | CTD_human |
| Tgene | MSRB3 | C2239351 | DEAFNESS, AUTOSOMAL RECESSIVE 74 | 1 | CTD_human;UNIPROT |
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