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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31578

FusionGeneSummary for RNF38_PAX5

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF38_PAX5
Fusion gene ID: 31578
HgeneTgene
Gene symbol

RNF38

PAX5

Gene ID

152006

5079

Gene namering finger protein 38paired box 5
Synonyms-ALL3|BSAP
Cytomap

9p13.2

9p13.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5
Modification date2018052220180520
UniProtAcc

Q9H0F5

Q02548

Ensembl transtripts involved in fusion geneENST00000259605, ENST00000353739, 
ENST00000357058, ENST00000350199, 
ENST00000377885, ENST00000377877, 
ENST00000491349, 
ENST00000358127, 
ENST00000523241, ENST00000520154, 
ENST00000377852, ENST00000377853, 
ENST00000522003, ENST00000520281, 
ENST00000414447, ENST00000523145, 
ENST00000446742, ENST00000377847, 
Fusion gene scores* DoF score8 X 5 X 8=3207 X 5 X 5=175
# samples 87
** MAII scorelog2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF38 [Title/Abstract] AND PAX5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF38

GO:0016567

protein ubiquitination

23973461


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GV-A3QI-01ARNF38chr9

36424610

-PAX5chr9

36923481

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000259605ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000259605ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-3CDSENST00000353739ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000353739ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-3CDSENST00000357058ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000357058ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-3CDSENST00000350199ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000350199ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-3CDSENST00000377885ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377885ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-3CDSENST00000377877ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000377877ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-3CDSENST00000491349ENST00000358127RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000523241RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000520154RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000377852RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000377853RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000522003RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000520281RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000414447RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000523145RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000446742RNF38chr9

36424610

-PAX5chr9

36923481

-
intron-intronENST00000491349ENST00000377847RNF38chr9

36424610

-PAX5chr9

36923481

-

Top

FusionProtFeatures for RNF38_PAX5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF38

Q9H0F5

PAX5

Q02548


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF38_PAX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF38_PAX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF38TP53, TP63, TP73, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2H, ELAVL1, LDB1, RNF114, DZIP3, DTX3, RNF38, ZDHHC17, UBC, TRIM25PAX5TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RNF38_PAX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RNF38_PAX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human;UNIPROT
TgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human