FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31577

FusionGeneSummary for RNF38_LMOD2

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF38_LMOD2
Fusion gene ID: 31577
HgeneTgene
Gene symbol

RNF38

LMOD2

Gene ID

152006

442721

Gene namering finger protein 38leiomodin 2
Synonyms-C-LMOD|CLMOD
Cytomap

9p13.2

7q31.32

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38leiomodin-2cardiac leiomodinleiomodin 2 (cardiac)
Modification date2018052220180523
UniProtAcc

Q9H0F5

Q6P5Q4

Ensembl transtripts involved in fusion geneENST00000259605, ENST00000353739, 
ENST00000357058, ENST00000350199, 
ENST00000377885, ENST00000377877, 
ENST00000491349, 
ENST00000458573, 
ENST00000456238, 
Fusion gene scores* DoF score8 X 5 X 8=3202 X 1 X 2=4
# samples 82
** MAII scorelog2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: RNF38 [Title/Abstract] AND LMOD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF38

GO:0016567

protein ubiquitination

23973461

TgeneLMOD2

GO:0030838

positive regulation of actin filament polymerization

26370058

TgeneLMOD2

GO:0045010

actin nucleation

20685966|26370058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A7B1-01ARNF38chr9

36400551

-LMOD2chr7

123301914

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000259605ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-intronENST00000259605ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-3CDSENST00000353739ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-intronENST00000353739ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+
5UTR-3CDSENST00000357058ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
5UTR-intronENST00000357058ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+
5UTR-3CDSENST00000350199ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
5UTR-intronENST00000350199ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-3CDSENST00000377885ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-intronENST00000377885ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+
5UTR-3CDSENST00000377877ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
5UTR-intronENST00000377877ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-3CDSENST00000491349ENST00000458573RNF38chr9

36400551

-LMOD2chr7

123301914

+
intron-intronENST00000491349ENST00000456238RNF38chr9

36400551

-LMOD2chr7

123301914

+

Top

FusionProtFeatures for RNF38_LMOD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF38

Q9H0F5

LMOD2

Q6P5Q4

Mediates nucleation of actin filaments and therebypromotes actin polymerization (PubMed:18403713, PubMed:26370058,PubMed:25250574, PubMed:26417072). Plays a role in the regulationof actin filament length (By similarity). Required for normalsarcomere organization in the heart, and for normal heart function(PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5,ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574,ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RNF38_LMOD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RNF38_LMOD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF38TP53, TP63, TP73, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2H, ELAVL1, LDB1, RNF114, DZIP3, DTX3, RNF38, ZDHHC17, UBC, TRIM25LMOD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RNF38_LMOD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RNF38_LMOD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLMOD2C0033975Psychotic Disorders1PSYGENET
TgeneLMOD2C0036341Schizophrenia1PSYGENET
TgeneLMOD2C0349204Nonorganic psychosis1PSYGENET