FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31550

FusionGeneSummary for RNF217_HDDC2

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF217_HDDC2
Fusion gene ID: 31550
HgeneTgene
Gene symbol

RNF217

HDDC2

Gene ID

154214

51020

Gene namering finger protein 217HD domain containing 2
SynonymsC6orf172|IBRDC1|OSTL|dJ84N20.1C6orf74|CGI-130|NS5ATP2|dJ167O5.2
Cytomap

6q22.31

6q22.31

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase RNF217IBR domain containing 1opposite STLHD domain-containing protein 2HCV NS5A-transactivated protein 2hepatitis C virus NS5A-transactivated protein 2testicular tissue protein Li 83
Modification date2018052320180523
UniProtAcc

Q8TC41

Q7Z4H3

Ensembl transtripts involved in fusion geneENST00000521654, ENST00000560949, 
ENST00000454842, ENST00000368414, 
ENST00000359704, ENST00000275184, 
ENST00000608456, ENST00000368377, 
ENST00000608295, ENST00000398153, 
ENST00000608284, 
Fusion gene scores* DoF score7 X 4 X 7=1963 X 3 X 2=18
# samples 103
** MAII scorelog2(10/196*10)=-0.970853654340483
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF217 [Title/Abstract] AND HDDC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-33-6737-01ARNF217chr6

125284572

+HDDC2chr6

125621805

-
TCGALDLUSCTCGA-68-A59J-01ARNF217chr6

125379252

+HDDC2chr6

125598386

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000521654ENST00000608456RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000521654ENST00000368377RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000521654ENST00000608295RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000521654ENST00000398153RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000521654ENST00000608284RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000560949ENST00000608456RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000560949ENST00000368377RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000560949ENST00000608295RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000560949ENST00000398153RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000560949ENST00000608284RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000454842ENST00000608456RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000454842ENST00000368377RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000454842ENST00000608295RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000454842ENST00000398153RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000454842ENST00000608284RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000368414ENST00000608456RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000368414ENST00000368377RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000368414ENST00000608295RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000368414ENST00000398153RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000368414ENST00000608284RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000359704ENST00000608456RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000359704ENST00000368377RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000359704ENST00000608295RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000359704ENST00000398153RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000359704ENST00000608284RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000275184ENST00000608456RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000275184ENST00000368377RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000275184ENST00000608295RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000275184ENST00000398153RNF217chr6

125284572

+HDDC2chr6

125621805

-
intron-intronENST00000275184ENST00000608284RNF217chr6

125284572

+HDDC2chr6

125621805

-
5CDS-intronENST00000521654ENST00000608456RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000521654ENST00000368377RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000521654ENST00000608295RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000521654ENST00000398153RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000521654ENST00000608284RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000560949ENST00000608456RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000560949ENST00000368377RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000560949ENST00000608295RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000560949ENST00000398153RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000560949ENST00000608284RNF217chr6

125379252

+HDDC2chr6

125598386

-
intron-intronENST00000454842ENST00000608456RNF217chr6

125379252

+HDDC2chr6

125598386

-
intron-intronENST00000454842ENST00000368377RNF217chr6

125379252

+HDDC2chr6

125598386

-
intron-3UTRENST00000454842ENST00000608295RNF217chr6

125379252

+HDDC2chr6

125598386

-
intron-3UTRENST00000454842ENST00000398153RNF217chr6

125379252

+HDDC2chr6

125598386

-
intron-intronENST00000454842ENST00000608284RNF217chr6

125379252

+HDDC2chr6

125598386

-
5UTR-intronENST00000368414ENST00000608456RNF217chr6

125379252

+HDDC2chr6

125598386

-
5UTR-intronENST00000368414ENST00000368377RNF217chr6

125379252

+HDDC2chr6

125598386

-
5UTR-3UTRENST00000368414ENST00000608295RNF217chr6

125379252

+HDDC2chr6

125598386

-
5UTR-3UTRENST00000368414ENST00000398153RNF217chr6

125379252

+HDDC2chr6

125598386

-
5UTR-intronENST00000368414ENST00000608284RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000359704ENST00000608456RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000359704ENST00000368377RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000359704ENST00000608295RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000359704ENST00000398153RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000359704ENST00000608284RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000275184ENST00000608456RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000275184ENST00000368377RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000275184ENST00000608295RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-3UTRENST00000275184ENST00000398153RNF217chr6

125379252

+HDDC2chr6

125598386

-
5CDS-intronENST00000275184ENST00000608284RNF217chr6

125379252

+HDDC2chr6

125598386

-

Top

FusionProtFeatures for RNF217_HDDC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF217

Q8TC41

HDDC2

Q7Z4H3

E3 ubiquitin-protein ligase which accepts ubiquitin fromE2 ubiquitin-conjugating enzymes in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RNF217_HDDC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RNF217_HDDC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF217KIAA0368, HAX1, POTEKP, ACTBL2, H1FNT, ACTA2HDDC2OTUD6B, DUSP1, DUSP12, DUSP19, DUSP23, DUSP6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RNF217_HDDC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RNF217_HDDC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource