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Fusion gene ID: 31544 |
FusionGeneSummary for RNF216_JAZF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF216_JAZF1 | Fusion gene ID: 31544 | Hgene | Tgene | Gene symbol | RNF216 | JAZF1 | Gene ID | 54476 | 221895 |
| Gene name | ring finger protein 216 | JAZF zinc finger 1 | |
| Synonyms | CAHH|TRIAD3|U7I1|UBCE7IP1|ZIN | TIP27|ZNF802 | |
| Cytomap | 7p22.1 | 7p15.2-p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF216RING-type E3 ubiquitin transferase RNF216triad domain-containing protein 3ubiquitin-conjugating enzyme 7-interacting protein 1zinc finger protein inhibiting NF-kappa-B | juxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9NWF9 | Q86VZ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000425013, ENST00000389902, ENST00000469375, | ENST00000283928, ENST00000466516, | |
| Fusion gene scores | * DoF score | 9 X 8 X 7=504 | 6 X 4 X 5=120 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/504*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF216 [Title/Abstract] AND JAZF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF216 | GO:0032648 | regulation of interferon-beta production | 19893624 |
| Hgene | RNF216 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19893624 |
| Hgene | RNF216 | GO:0050691 | regulation of defense response to virus by host | 19893624 |
| Hgene | RNF216 | GO:0070936 | protein K48-linked ubiquitination | 19893624 |
| Tgene | JAZF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15302918 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-69-7980-01A | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000425013 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5CDS-intron | ENST00000425013 | ENST00000466516 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| In-frame | ENST00000389902 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5CDS-intron | ENST00000389902 | ENST00000466516 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5UTR-3CDS | ENST00000469375 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5UTR-intron | ENST00000469375 | ENST00000466516 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
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FusionProtFeatures for RNF216_JAZF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF216 | JAZF1 |
| Isoform 1 acts as an E3 ubiquitin ligase, which acceptsubiquitin from specific E2 ubiquitin-conjugating enzymes, and thentransfers it to substrates promoting their degradation by theproteasome. Promotes degradation of TRAF3, TLR4 and TLR9.Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNBproduction. Isoform 3 inhibits TNF and IL-1 mediated activation ofNF-kappa-B. Promotes TNF and RIP mediated apoptosis.{ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}. | Acts as a transcriptional corepressor of orphan nuclearreceptor NR2C2 (PubMed:15302918). Inhibits expression of thegluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity(By similarity). Also involved in transcriptional activation ofNAMPT by promoting expression of PPARA and PPARD (By similarity).Plays a role in lipid metabolism by suppressing lipogenesis,increasing lipolysis and decreasing lipid accumulation in adiposetissue (By similarity). Plays a role in glucose homeostasis byimproving glucose metabolism and insulin sensitivity (Bysimilarity). {ECO:0000250|UniProtKB:Q80ZQ5,ECO:0000269|PubMed:15302918}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 475_491 | 794 | 924 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 737_763 | 794 | 924 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 475_491 | 737 | 867 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 515_566 | 794 | 924 | Zinc finger | Note=RING-type 1 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 583_648 | 794 | 924 | Zinc finger | Note=IBR-type |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 675_714 | 794 | 924 | Zinc finger | Note=RING-type 2 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 515_566 | 737 | 867 | Zinc finger | Note=RING-type 1 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 583_648 | 737 | 867 | Zinc finger | Note=IBR-type |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 675_714 | 737 | 867 | Zinc finger | Note=RING-type 2 |
| Tgene | >JAZF1 | chr7:5680785 | chr7:28031600 | ENST00000283928 | - | 0 | 5 | 173_198 | 38 | 244 | Zinc finger | Note=C2H2-type 2 |
| Tgene | >JAZF1 | chr7:5680785 | chr7:28031600 | ENST00000283928 | - | 0 | 5 | 208_230 | 38 | 244 | Zinc finger | Note=C2H2-type 3%3B degenerate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 737_763 | 737 | 867 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 769_862 | 794 | 924 | Compositional bias | Note=Pro-rich |
| Hgene | >RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 769_862 | 737 | 867 | Compositional bias | Note=Pro-rich |
| Tgene | JAZF1 | chr7:5680785 | chr7:28031600 | ENST00000283928 | - | 0 | 5 | 12_37 | 38 | 244 | Zinc finger | Note=C2H2-type 1 |
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FusionGeneSequence for RNF216_JAZF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RNF216_ENST00000425013_chr7_5680785_-_JAZF1_ENST00000283928_chr7_28031600_-_942aa MEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTEDDSEDDYGEFLDLGPPGISEFTK PSGQTEREPKPGPSHNQAANDIVNPRSEQKVIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHPYFQS LNQQPREITNQVVPQERQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQPAHPLGEFEDQQLASDDEEPGPAFPMQESQEPNLEN IWGQEAAEVDQELVELLVKETEARFPDVANGFIEEIIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKIDFFDY SKLTPLDQRCFIQAADLLMADFKVLSSQDIKWALHELKGHYAITRKALSDAIKKWQELSPETSGKRKKRKQMNQYSYIDFKFEQGDIKIE KRMFFLENKRRHCRSYDRRALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKEC LIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPHCRK ETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSP GAPCQECSRCSLWTDPTIQIHGFXKNKNYSSQPMLPXVTXIDSXQMLPAESRSPXRRRFSRSSRXLCPAQCLEGMCPLPHATAVEALLPP XPHPSPPPLHSAAALRQAASMTRRRWTMRSRTAMSPGPQRVPSAPKPSSAPCAXMEGKRSLLPAQFLDVKRDTRMXMAXSITLRMVTEHR >In-frame_RNF216_ENST00000389902_chr7_5680785_-_JAZF1_ENST00000283928_chr7_28031600_-_999aa MEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTETNKPQRSRPNLIKPAAQWQDLKR LGEERPKKSRAAFESDKSSYFSVCNNPLFDSGAQDDSEDDYGEFLDLGPPGISEFTKPSGQTEREPKPGPSHNQAANDIVNPRSEQKVII LEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHPYFQSLNQQPREITNQVVPQERQPEAELGRLLFQHEFP GPAFPRPEPQQGGISGPSSPQPAHPLGEFEDQQLASDDEEPGPAFPMQESQEPNLENIWGQEAAEVDQELVELLVKETEARFPDVANGFI EEIIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKVLSSQDIKWA LHELKGHYAITRKALSDAIKKWQELSPETSGKRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALLPAVQQEQEFYE QKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSEL EKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSI EEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTIQIHGFXKNKNYSSQP MLPXVTXIDSXQMLPAESRSPXRRRFSRSSRXLCPAQCLEGMCPLPHATAVEALLPPXPHPSPPPLHSAAALRQAASMTRRRWTMRSRTA MSPGPQRVPSAPKPSSAPCAXMEGKRSLLPAQFLDVKRDTRMXMAXSITLRMVTEHRFVSANHSSVAVGRVTRQLRACGTTQSISIPRCR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RNF216_ENST00000425013_chr7_5680785_-_JAZF1_ENST00000283928_chr7_28031600_-_2828nt ATGGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAACTTTCACTGCCATCGGGGACAAGAGTGGATCAATCTCCGAGATGGG CCCATCACCATATCTGACTCCTCAGATGAGGAAAGGATTCCAATGCTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGAT GATGATGTCATCCTGACAGAAGATGATTCTGAGGATGACTACGGTGAATTTCTGGATCTTGGGCCTCCTGGAATCTCTGAATTCACTAAG CCAAGTGGCCAAACAGAAAGAGAACCCAAGCCTGGACCGAGTCATAACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAA GTCATCATCTTGGAAGAAGGTAGCCTTCTTTACACAGAAAGCGATCCTTTGGAAACTCAGAACCAGTCATCCGAAGACTCAGAGACAGAG CTGTTATCAAATCTAGGAGAGTCAGCTGCTCTAGCAGATGATCAGGCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCT CTGAACCAACAGCCCCGTGAAATAACAAACCAGGTCGTTCCTCAGGAACGGCAGCCTGAAGCAGAACTGGGCCGCTTGTTGTTTCAGCAT GAATTCCCAGGGCCCGCTTTTCCAAGGCCGGAACCCCAGCAAGGTGGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGA GAGTTTGAAGACCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGTCCAGCCTTTCCAATGCAAGAATCTCAAGAGCCCAATTTGGAAAAC ATTTGGGGGCAAGAAGCTGCAGAGGTAGATCAAGAGCTCGTTGAACTACTAGTGAAAGAAACGGAAGCAAGATTTCCAGATGTAGCAAAT GGGTTTATTGAGGAAATAATTCATTTTAAGAATTATTATGATCTGAATGTACTTTGTAATTTTCTTCTGGAAAACCCAGATTATCCAAAG AGAGAAGACAGAATCATTATAAATCCCAGTAGCAGTCTGCTGGCCAGCCAAGATGAGACAAAGTTGCCTAAAATAGACTTTTTTGACTAT TCTAAATTGACCCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCTGACCTCCTCATGGCCGACTTCAAAGTGCTCAGTAGTCAGGACATC AAGTGGGCCCTGCACGAGCTCAAAGGACACTATGCAATCACCCGAAAGGCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCA GAAACCAGTGGAAAAAGGAAGAAGAGAAAACAAATGAACCAGTATTCTTACATTGATTTCAAGTTTGAACAAGGTGACATAAAAATAGAA AAGAGGATGTTCTTTCTTGAAAATAAGCGACGACATTGTAGGTCCTATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAG TTCTATGAGCAGAAAATCAAAGAGATGGCAGAGCATGAAGACTTTTTGCTTGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGC CAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGT CTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCTCAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACC AGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGAC GAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGATGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAG GAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGT ACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGC ATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCA GGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCACTATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGC AGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGC CGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCG TGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGT CGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGC CTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGA TTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCC >In-frame_RNF216_ENST00000389902_chr7_5680785_-_JAZF1_ENST00000283928_chr7_28031600_-_2999nt ATGGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAACTTTCACTGCCATCGGGGACAAGAGTGGATCAATCTCCGAGATGGG CCCATCACCATATCTGACTCCTCAGATGAGGAAAGGATTCCAATGCTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGAT GATGATGTCATCCTGACAGAAACAAATAAACCTCAGAGATCACGACCCAATCTCATCAAACCAGCTGCCCAGTGGCAAGATCTGAAAAGG TTGGGAGAAGAAAGGCCTAAAAAGTCTAGAGCAGCATTTGAATCAGATAAGAGCAGCTATTTTTCAGTGTGTAACAACCCATTGTTTGAT TCTGGGGCACAGGATGATTCTGAGGATGACTACGGTGAATTTCTGGATCTTGGGCCTCCTGGAATCTCTGAATTCACTAAGCCAAGTGGC CAAACAGAAAGAGAACCCAAGCCTGGACCGAGTCATAACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAAGTCATCATC TTGGAAGAAGGTAGCCTTCTTTACACAGAAAGCGATCCTTTGGAAACTCAGAACCAGTCATCCGAAGACTCAGAGACAGAGCTGTTATCA AATCTAGGAGAGTCAGCTGCTCTAGCAGATGATCAGGCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCTCTGAACCAA CAGCCCCGTGAAATAACAAACCAGGTCGTTCCTCAGGAACGGCAGCCTGAAGCAGAACTGGGCCGCTTGTTGTTTCAGCATGAATTCCCA GGGCCCGCTTTTCCAAGGCCGGAACCCCAGCAAGGTGGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGAGAGTTTGAA GACCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGTCCAGCCTTTCCAATGCAAGAATCTCAAGAGCCCAATTTGGAAAACATTTGGGGG CAAGAAGCTGCAGAGGTAGATCAAGAGCTCGTTGAACTACTAGTGAAAGAAACGGAAGCAAGATTTCCAGATGTAGCAAATGGGTTTATT GAGGAAATAATTCATTTTAAGAATTATTATGATCTGAATGTACTTTGTAATTTTCTTCTGGAAAACCCAGATTATCCAAAGAGAGAAGAC AGAATCATTATAAATCCCAGTAGCAGTCTGCTGGCCAGCCAAGATGAGACAAAGTTGCCTAAAATAGACTTTTTTGACTATTCTAAATTG ACCCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCTGACCTCCTCATGGCCGACTTCAAAGTGCTCAGTAGTCAGGACATCAAGTGGGCC CTGCACGAGCTCAAAGGACACTATGCAATCACCCGAAAGGCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCAGAAACCAGT GGAAAAAGGAAGAAGAGAAAACAAATGAACCAGTATTCTTACATTGATTTCAAGTTTGAACAAGGTGACATAAAAATAGAAAAGAGGATG TTCTTTCTTGAAAATAAGCGACGACATTGTAGGTCCTATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAGTTCTATGAG CAGAAAATCAAAGAGATGGCAGAGCATGAAGACTTTTTGCTTGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATT GAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGA TATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCTCAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTG GAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTC AGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGATGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGT AGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATT GAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGC CGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCT TGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCACTATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCT ATGTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCT CGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCAC CCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCG ATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCT GCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCC GCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RNF216_ENST00000425013_chr7_5680785_-_JAZF1_ENST00000283928_chr7_28031600_-_5280nt AGGGGGCGCTGTGCGCAGGCGCGAGGTGACGCCGCGGCAGGGCCGGAAGGAGTGCAGCGGCTGCCACGGAGCTCGCAGCTGCGGCTTCTG AGGAGTAAGCGGCGCGGTAGCGAAGGCCGCCGAACCTGCCTGGCTAGCCGGCGACTTGAGTGACGATTCTTTTGAAACAGATGGTCACCA TGTTTAGATATTAGCAGTCCCATATATGCATGTCTGCATTTGAAAATGGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAAC TTTCACTGCCATCGGGGACAAGAGTGGATCAATCTCCGAGATGGGCCCATCACCATATCTGACTCCTCAGATGAGGAAAGGATTCCAATG CTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGATGATGATGTCATCCTGACAGAAGATGATTCTGAGGATGACTACGGT GAATTTCTGGATCTTGGGCCTCCTGGAATCTCTGAATTCACTAAGCCAAGTGGCCAAACAGAAAGAGAACCCAAGCCTGGACCGAGTCAT AACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAAGTCATCATCTTGGAAGAAGGTAGCCTTCTTTACACAGAAAGCGAT CCTTTGGAAACTCAGAACCAGTCATCCGAAGACTCAGAGACAGAGCTGTTATCAAATCTAGGAGAGTCAGCTGCTCTAGCAGATGATCAG GCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCTCTGAACCAACAGCCCCGTGAAATAACAAACCAGGTCGTTCCTCAG GAACGGCAGCCTGAAGCAGAACTGGGCCGCTTGTTGTTTCAGCATGAATTCCCAGGGCCCGCTTTTCCAAGGCCGGAACCCCAGCAAGGT GGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGAGAGTTTGAAGACCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGT CCAGCCTTTCCAATGCAAGAATCTCAAGAGCCCAATTTGGAAAACATTTGGGGGCAAGAAGCTGCAGAGGTAGATCAAGAGCTCGTTGAA CTACTAGTGAAAGAAACGGAAGCAAGATTTCCAGATGTAGCAAATGGGTTTATTGAGGAAATAATTCATTTTAAGAATTATTATGATCTG AATGTACTTTGTAATTTTCTTCTGGAAAACCCAGATTATCCAAAGAGAGAAGACAGAATCATTATAAATCCCAGTAGCAGTCTGCTGGCC AGCCAAGATGAGACAAAGTTGCCTAAAATAGACTTTTTTGACTATTCTAAATTGACCCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCT GACCTCCTCATGGCCGACTTCAAAGTGCTCAGTAGTCAGGACATCAAGTGGGCCCTGCACGAGCTCAAAGGACACTATGCAATCACCCGA AAGGCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCAGAAACCAGTGGAAAAAGGAAGAAGAGAAAACAAATGAACCAGTAT TCTTACATTGATTTCAAGTTTGAACAAGGTGACATAAAAATAGAAAAGAGGATGTTCTTTCTTGAAAATAAGCGACGACATTGTAGGTCC TATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAGTTCTATGAGCAGAAAATCAAAGAGATGGCAGAGCATGAAGACTTT TTGCTTGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAG GAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTG GAGCTCAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTAC TATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGAC AGTGATGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGC CTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGC CACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTT TCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGAT CCCACTATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAG ATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATG TGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTC CGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCG AAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATG TGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACA AGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCTGAGATTATCAGGAAGATGCAGCAATAACATGCTG GTCATAACTGTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCACCTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAA AGAAAAAGAATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTATCTTTGTAGAGTTAATGATTTTGTACATTTGCACA TGTAATCATCATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGCTCTAGGTTCTTCAGCACATTTCCCCCAAAACAAA ATAAAATTGAGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTGGGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTT CAAGATTGTAATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACCAAAATAATACCTTCATTATCAAACTGGTTACCAT GCCTTACATAATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATATAAATAAGAAAGAATGTTTAACATAATATGCTAA AAATATTTTCATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATTATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGA AAATCTTGCCATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACAAAATAGTCTATTCAGTTCGTTCATTCATTTAACA CACATTGATTGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATCTGCGGACCAAGATACCCATTTAGTGAAATACTTT TTTCCCTGAAATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTGTGTGAAGTTTAGTTATATCTTCATCTTCAGATGA AGTTTTAAAGCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGCCAATTCTTGCAACCACTGCCCTACCAAACCTGTG GGTTGCAAATCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTAAGACCCCTATTGCCTCTTCTTCATGCTCATTTTT TACTTTTTTTAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCATTGGAAATGTCTGTTTAGCTTTATAAAACAAACAC TTTGCTGAAATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGTGGTCAAAGAAAAGCATGACTAATACGACCTATTA GAGTAATCTACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCATGCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCC TTAAACACGAGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATAGCTAACTGCCCATAAAACAAACTCAAATTGCTTA TAAAGTTTCTTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGGGAAGCAGGGGTCCCTCCTCAATTTTCAGACATTT TGAAAGGATGACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCTAAAATCCTTCATTATGAGGGATTCAAAGTATTTA TAAAAACACTGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGAATATACAGTGTTATCCTATGTTTAAAAGGGTGAT CCAGACATGAGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCATATCTACCTACAATTGACCAAAAAAAATTTTTTAG GCCAGCAATTATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGATCAGTAGTTCAACAGCTAAACAGTCATAAAATAGT CATTGTGCATGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATTTACTTATTCATTGTGACAGTATTACTAAACAGGT AAGGATGGGAATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGTGAAAACTGTGCTTTAAATTATATTTTCATATGTT TTGTTGGGGACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTGAAGGCAATTTAATCAAAATTCCTGTCAAGAAAAG >In-frame_RNF216_ENST00000389902_chr7_5680785_-_JAZF1_ENST00000283928_chr7_28031600_-_5494nt AGTACCCGGAGTGCCTCTATGGTTCTTCCTGTCCTTAGTCGGGAGGGGGCGCTGTGCGCAGGCGCGAGGTGACGCCGCGGCAGGGCCGGA AGGAGTGCAGCGGCTGCCACGGAGCTCGCAGCTGCGGCTTCTGAGGAGTAAGCGGCGCGGTAGCGAAGGCCGCCGAACCTGCCTGGCTAG CCGGCGACTTGAGTGACGATTCTTTTGAAACAGATGGTCACCATGTTTAGATATTAGCAGTCCCATATATGCATGTCTGCATTTGAAAAT GGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAACTTTCACTGCCATCGGGGACAAGAGTGGATCAATCTCCGAGATGGGCC CATCACCATATCTGACTCCTCAGATGAGGAAAGGATTCCAATGCTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGATGA TGATGTCATCCTGACAGAAACAAATAAACCTCAGAGATCACGACCCAATCTCATCAAACCAGCTGCCCAGTGGCAAGATCTGAAAAGGTT GGGAGAAGAAAGGCCTAAAAAGTCTAGAGCAGCATTTGAATCAGATAAGAGCAGCTATTTTTCAGTGTGTAACAACCCATTGTTTGATTC TGGGGCACAGGATGATTCTGAGGATGACTACGGTGAATTTCTGGATCTTGGGCCTCCTGGAATCTCTGAATTCACTAAGCCAAGTGGCCA AACAGAAAGAGAACCCAAGCCTGGACCGAGTCATAACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAAGTCATCATCTT GGAAGAAGGTAGCCTTCTTTACACAGAAAGCGATCCTTTGGAAACTCAGAACCAGTCATCCGAAGACTCAGAGACAGAGCTGTTATCAAA TCTAGGAGAGTCAGCTGCTCTAGCAGATGATCAGGCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCTCTGAACCAACA GCCCCGTGAAATAACAAACCAGGTCGTTCCTCAGGAACGGCAGCCTGAAGCAGAACTGGGCCGCTTGTTGTTTCAGCATGAATTCCCAGG GCCCGCTTTTCCAAGGCCGGAACCCCAGCAAGGTGGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGAGAGTTTGAAGA CCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGTCCAGCCTTTCCAATGCAAGAATCTCAAGAGCCCAATTTGGAAAACATTTGGGGGCA AGAAGCTGCAGAGGTAGATCAAGAGCTCGTTGAACTACTAGTGAAAGAAACGGAAGCAAGATTTCCAGATGTAGCAAATGGGTTTATTGA GGAAATAATTCATTTTAAGAATTATTATGATCTGAATGTACTTTGTAATTTTCTTCTGGAAAACCCAGATTATCCAAAGAGAGAAGACAG AATCATTATAAATCCCAGTAGCAGTCTGCTGGCCAGCCAAGATGAGACAAAGTTGCCTAAAATAGACTTTTTTGACTATTCTAAATTGAC CCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCTGACCTCCTCATGGCCGACTTCAAAGTGCTCAGTAGTCAGGACATCAAGTGGGCCCT GCACGAGCTCAAAGGACACTATGCAATCACCCGAAAGGCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCAGAAACCAGTGG AAAAAGGAAGAAGAGAAAACAAATGAACCAGTATTCTTACATTGATTTCAAGTTTGAACAAGGTGACATAAAAATAGAAAAGAGGATGTT CTTTCTTGAAAATAAGCGACGACATTGTAGGTCCTATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAGTTCTATGAGCA GAAAATCAAAGAGATGGCAGAGCATGAAGACTTTTTGCTTGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGA GTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATA TGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCTCAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGA GAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAG GTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGATGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAG GAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGA AGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCG CTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTG CCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCACTATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTAT GTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCG CTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCC ATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGAT GAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGC CCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGC AAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCT GAGATTATCAGGAAGATGCAGCAATAACATGCTGGTCATAACTGTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCAC CTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAAAGAAAAAGAATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTAT CTTTGTAGAGTTAATGATTTTGTACATTTGCACATGTAATCATCATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGC TCTAGGTTCTTCAGCACATTTCCCCCAAAACAAAATAAAATTGAGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTG GGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTTCAAGATTGTAATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACC AAAATAATACCTTCATTATCAAACTGGTTACCATGCCTTACATAATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATA TAAATAAGAAAGAATGTTTAACATAATATGCTAAAAATATTTTCATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATT ATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGAAAATCTTGCCATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACA AAATAGTCTATTCAGTTCGTTCATTCATTTAACACACATTGATTGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATC TGCGGACCAAGATACCCATTTAGTGAAATACTTTTTTCCCTGAAATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTG TGTGAAGTTTAGTTATATCTTCATCTTCAGATGAAGTTTTAAAGCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGC CAATTCTTGCAACCACTGCCCTACCAAACCTGTGGGTTGCAAATCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTA AGACCCCTATTGCCTCTTCTTCATGCTCATTTTTTACTTTTTTTAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCAT TGGAAATGTCTGTTTAGCTTTATAAAACAAACACTTTGCTGAAATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGT GGTCAAAGAAAAGCATGACTAATACGACCTATTAGAGTAATCTACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCAT GCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCCTTAAACACGAGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATA GCTAACTGCCCATAAAACAAACTCAAATTGCTTATAAAGTTTCTTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGG GAAGCAGGGGTCCCTCCTCAATTTTCAGACATTTTGAAAGGATGACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCT AAAATCCTTCATTATGAGGGATTCAAAGTATTTATAAAAACACTGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGA ATATACAGTGTTATCCTATGTTTAAAAGGGTGATCCAGACATGAGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCAT ATCTACCTACAATTGACCAAAAAAAATTTTTTAGGCCAGCAATTATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGAT CAGTAGTTCAACAGCTAAACAGTCATAAAATAGTCATTGTGCATGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATT TACTTATTCATTGTGACAGTATTACTAAACAGGTAAGGATGGGAATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGT GAAAACTGTGCTTTAAATTATATTTTCATATGTTTTGTTGGGGACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTG AAGGCAATTTAATCAAAATTCCTGTCAAGAAAAGCTGCTTATAAATGTAAATGAAATCACATTTAAAATAAACTGCCTCTGACCCAAAAA |
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FusionGenePPI for RNF216_JAZF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF216 | TLR3, TLR4, TLR5, TLR9, UBE2H, UBE2L3, UBE2C, UBE2L6, RNF216, RIPK1, TIRAP, TICAM1, KIR2DL4, TRAF3, BRCA1, RNF11, MOV10, NXF1, XPO1, BECN1, ARC, UBE2D3, TRIM25 | JAZF1 | NR2C2, PPARG, RXRA, YEATS4, TRRAP, MEAF6, RUVBL1, MYCL, HIST1H2BA, MORF4L2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF216_JAZF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF216_JAZF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RNF216 | C1859305 | Cerebellar Ataxia and Hypogonadotropic Hypogonadism | 1 | ORPHANET;UNIPROT |
| Tgene | JAZF1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | JAZF1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | JAZF1 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
| Tgene | JAZF1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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