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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 31532

FusionGeneSummary for RNF213_TBCD

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF213_TBCD
Fusion gene ID: 31532
HgeneTgene
Gene symbol

RNF213

TBCD

Gene ID

57674

6904

Gene namering finger protein 213tubulin folding cofactor D
SynonymsALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57PEBAT|SSD-1|tfcD
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterintubulin-specific chaperone Dbeta-tubulin cofactor D
Modification date2018052720180523
UniProtAcc

Q63HN8

Q9BTW9

Ensembl transtripts involved in fusion geneENST00000508628, ENST00000456466, 
ENST00000582970, ENST00000319921, 
ENST00000336301, ENST00000427003, 
ENST00000355528, ENST00000397466, 
ENST00000539345, ENST00000576691, 
Fusion gene scores* DoF score22 X 22 X 12=58088 X 7 X 8=448
# samples 309
** MAII scorelog2(30/5808*10)=-4.27500704749987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/448*10)=-2.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF213 [Title/Abstract] AND TBCD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF213

GO:0016567

protein ubiquitination

21799892

HgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

HgeneRNF213

GO:0051865

protein autoubiquitination

21799892

TgeneTBCD

GO:0006457

protein folding

20740604

TgeneTBCD

GO:0007021

tubulin complex assembly

28158450

TgeneTBCD

GO:0007023

post-chaperonin tubulin folding pathway

11847227

TgeneTBCD

GO:0031115

negative regulation of microtubule polymerization

10831612|20740604


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-XV-AAZV-01ARNF213chr17

78237577

+TBCDchr17

80828100

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000508628ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000508628ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000508628ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000508628ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000456466ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000456466ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000456466ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000456466ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000582970ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000582970ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000582970ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000582970ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000319921ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000319921ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
In-frameENST00000319921ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
5CDS-intronENST00000319921ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000336301ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000336301ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000336301ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-intronENST00000336301ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000427003ENST00000355528RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000427003ENST00000397466RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-3CDSENST00000427003ENST00000539345RNF213chr17

78237577

+TBCDchr17

80828100

+
intron-intronENST00000427003ENST00000576691RNF213chr17

78237577

+TBCDchr17

80828100

+

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FusionProtFeatures for RNF213_TBCD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF213

Q63HN8

TBCD

Q9BTW9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTBCDchr17:78237577chr17:80828100ENST00000355528+1239557_5944391193RepeatNote=HEAT 2
TgeneTBCDchr17:78237577chr17:80828100ENST00000355528+1239596_6324391193RepeatNote=HEAT 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78237577chr17:80828100ENST00000319921+217343_374321064Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828100ENST00000508628+269343_374325257Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828100ENST00000582970+268343_374325208Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78237577chr17:80828100ENST00000319921+2173997_4036321064Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828100ENST00000508628+2693997_4036325257Zinc fingerRING-type
HgeneRNF213chr17:78237577chr17:80828100ENST00000582970+2683997_4036325208Zinc fingerRING-type
TgeneTBCDchr17:78237577chr17:80828100ENST00000355528+1239361_3994391193RepeatNote=HEAT 1


Top

FusionGeneSequence for RNF213_TBCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_786aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_291aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQPCICSWGLMSPESKAE

>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_824aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_786aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_291aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQPCICSWGLMSPESKAE

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_824aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_786aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_291aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQPCICSWGLMSPESKAE

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_824aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_786aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKT

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_291aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQPCICSWGLMSPESKAE

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_824aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIAVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARATEPQELKPFVTAISSALVIA
AVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADTFAVGNRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARAL
HNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLTDRQLYRGLGGQLMR
QAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSETYMKEPGEADPAIQEELITQYLAELRNP
EEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMD
DYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEK
LFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNE
RVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLVCVGTVQMYAHTHLRLGAPGPHCAHG
SALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2358nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAG
ATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACC
ACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGAC
ACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCC

>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_873nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAA

>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2472nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCA
AGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGA
TCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCAC
CGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGAC
GAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGC

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2358nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAG
ATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACC
ACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGAC
ACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCC

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_873nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAA

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2472nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCA
AGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGA
TCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCAC
CGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGAC
GAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGC

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2358nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAG
ATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACC
ACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGAC
ACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCC

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_873nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAA

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2472nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCA
AGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGA
TCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCAC
CGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGAC
GAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGC

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2358nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAG
ATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACC
ACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGAC
ACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCC

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_873nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAA

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2472nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCC
TGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCT
GCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGT
ATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCT
GAGTACACGCAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTG
CACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATG
AGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTG
GACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGA
CAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATA
AATGACACTTTGAGACATCTCCATCTCATCTCAAGTCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGC
AGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCC
GAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGT
TTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAG
ACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGAC
GACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCT
CGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTC
CGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAG
CTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACC
TACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAG
TACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAG
AGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTT
GCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCA
AGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGA
TCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCAC
CGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGAC
GAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2888nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACT
TTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAG
TCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGA
TCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTT
GGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGT
AAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGC
TGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCAC
CTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTG
TGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCT
GCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTG
GAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTC
CCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCT
GGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCA
CGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAAT
CAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGC
CCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTA
CAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGA
GCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCC
ATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGG
GTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTT
CACTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGA
AAGGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCC

>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_1018nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAG

>In-frame_RNF213_ENST00000508628_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2863nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGAC
CTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGA
GCCTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGC
AGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGT
CGGTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTAC
CATGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGC
CACGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGC
TTACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCA
CCAGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACT
TTCCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAG
TCACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGA
TCCCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTT
GGGCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGT
AAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGC
TGTGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCAC
CTGGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTG
TGAGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCT
GCACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTG
GAGTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTC
CCTGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCT
GGGCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCA
CGTGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAAT
CAAGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGAT
GTACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTT
CCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCA
GGTGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGA
CGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGC
CTGCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCAC
AGTGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTG

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2886nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCC
TCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACA
GTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGC
AGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCAT
ACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGT
AGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCA
CTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAA
GGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCT

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_1016nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGAC

>In-frame_RNF213_ENST00000456466_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2861nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGT
ACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCC
CCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGG
TGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACG
CGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCT
GCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAG
TGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGAC

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2886nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCC
TCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACA
GTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGC
AGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCAT
ACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGT
AGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCA
CTTGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAA
GGCTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCT

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_1016nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGAC

>In-frame_RNF213_ENST00000582970_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2861nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCT
ACGACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGC
CTCAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAG
CCTCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCG
GTAACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCA
TGAAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCA
CGCAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTT
ACGCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACC
AGCAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTT
CCAAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTC
ACTCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATC
CCGCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGG
GCGCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAA
GTTTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTG
TGTGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCT
GGGTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTG
AGCGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGC
ACTTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGA
GTGCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCC
TGGGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGG
GCAGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACG
TGCTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCA
AGAATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGT
ACGCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCC
CCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGG
TGTACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACG
CGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCT
GCTGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAG
TGGTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGAC

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000355528_chr17_80828100_+_2884nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCC
AAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCC
GCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGT
TTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGG
GTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCAC
TTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTG
GGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTG
CTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAGTTCCCCGGCGACGTGAGGAGGCAGGCCCTC
CTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGT
GACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCGGAGCTTGCAGTGGTGAGAGAGCAG
CGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGAAGCCAGTCCTGGAGCCCATAC
CTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTGGTGCCTCCAGCTGTTGAAGGGTAG
CGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTTGGGGTGGACGCCTCTGCCTTCACT
TGAACACAAATGTGCTTCCTATAAAATCATGTACCAAGAAGTTCCTGCCTTTTGTCTCTGAGCCTGATGTGTGTAGGGGTGATGGAAAGG
CTCACTGCCCAGGGGTCAGCCAGAGGGGAGGTGGGCTGCACTCCTCCTGCCTGGAGACCAGGCCCCCTTCTTGCCTGGTGCTGTCCCTGC

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000397466_chr17_80828100_+_1014nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCCGTGCATCTGCAGCTGGGGTCTGATGTCTCCTGAAAGTAAAGCAGAATTTTGTGTGTGCGTCTGTCGGATTTCTCTGGGGAGACAG

>In-frame_RNF213_ENST00000319921_chr17_78237577_+_TBCD_ENST00000539345_chr17_80828100_+_2859nt
GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC
AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA
ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGTTGTCGCCGTGATCCTGAAGGCGCTGACCTAC
GACGAGAAGCGGGGTGCCTGCAGCGTGGGCACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTTGACCGAGACATAAACTGCAGAAGAGCAGCC
TCTGCCGCCTTCCAGGAGAATGTGGGGAGACAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACGCAGCCAATGATAGACCACCTGGTTACCATG
AAGATCAGCCACTGGGATGGGGTCATCCGAGAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGGTCGATTCTCGCCTGCGCAGAAGTTGCTTAC
GCCTTGTACAAACTTGCAGCCCAAGAGAACAGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTGTGTGTTTTAATAGAAAAGTTGTCACTTTCC
AAAATGCCCTTTAGAGGTGACACCGTAATTGATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATATTACATGAAGGAGCCGGGGGAGGCAGATCCC
GCAATTCAGGAGGAGCTGATCACGCAGTACCTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCAGTTACCCACACTTCCCCCGAGGACGTAAGT
TTTGCTGAGTCCAGGAGAGACGGCTTGAAGGCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACCACGGACAGCAGAGGGGACGTGGGCACCTGG
GTCCGCAAGGCCGCCATGACCAGTCTGATGGATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCACGCCGCCAGCGTGTTCCTGACGCTCCTGCAC
TTTGACAGCCCTCCCATCCCCCACGTGCCCCACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTACCACGTCCTGCTGGGGCTAGTCGTGTCCCTG
GGCGGCTTGACGGAGTCGACGATCCGGCACTCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCCGTGCCGCTGCTGAAGACGCTGGACCACGTG
CTCACCCACGGCTGCTTCGACATCTTCACCACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTTGACTTTCCAAGTGCGACACTCGTGTGTGTAGGCACAGTGCAGATGTAC
GCACACACACACCTCCGGCTTGGGGCCCCAGGCCCGCACTGTGCTCACGGATCTGCTCTGCCCAGGTTCTGCGAGATGGTGCAGTTCCCC
GGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGTTTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTG
TACGAGACATTGCTCACCTACAGTGACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGGGACGCG
GAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTACCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGC
TGAAGCCAGTCCTGGAGCCCATACCTCACCCCTGCCTGGTGAGGATGTCTTGTTCCTGAGGGAGGCCGGTGTGGAAAGCCTCGCACAGTG
GTGCCTCCAGCTGTTGAAGGGTAGCGCTGGCCCTTGGAGGCTGGCACTAGCTGACAGCTTTTCCTCTCTGCACCTGCGCTCTGGTGACTT


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FusionGenePPI for RNF213_TBCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF213UBC, CBX2, CBX4, CBX6, EGFR, PLAC9, RNF213, TRIM23, GOLGA2, REL, TRIM27, TRIP6, UBXN11, KRT40, CD244, SCN2B, IFI16, PTPN1, MRPL50, RNASEH2B, GAN, MCM2, ATOH1, DLK2, SIGLECL1, SDC2, LAMP3, CYLDTBCDPPP2CA, ARL2, XRCC6, TERF1, ACD, POT1, APP, SMAD9, POLR2I, APEH, HIST1H1C, NASP, NMI, SNX2, STAT3, ACBD3, ATG7, CUL3, GORASP2, GTF2A1, ME1, RPUSD2, SARS, SH3GLB2, STAT1, VPS25, TOM1, TSN, VPS29, WDR12, ABCE1, BSG, TUBB2A, TUBB2B, SCN2B, HTR6, PSMD5, TPM3, TPM4, NTRK1, KRAS, FAF2, TUBB, LRRC4, NCR3LG1, VSIG1, CRYL1, IL1R2, IL17RA, TCP11L1, ZNF146, ZNF836, MTNR1B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF213_TBCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF213_TBCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF213C1846689MOYAMOYA DISEASE 23UNIPROT