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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 31516

FusionGeneSummary for RNF213_CEP104

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF213_CEP104
Fusion gene ID: 31516
HgeneTgene
Gene symbol

RNF213

CEP104

Gene ID

57674

9731

Gene namering finger protein 213centrosomal protein 104
SynonymsALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57CFAP256|GlyBP|JBTS25|KIAA0562|ROC22
Cytomap

17q25.3

1p36.32

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterincentrosomal protein of 104 kDacentrosomal protein 104kDa
Modification date2018052720180519
UniProtAcc

Q63HN8

O60308

Ensembl transtripts involved in fusion geneENST00000508628, ENST00000456466, 
ENST00000582970, ENST00000319921, 
ENST00000336301, ENST00000427003, 
ENST00000378230, ENST00000460038, 
ENST00000378223, 
Fusion gene scores* DoF score22 X 22 X 12=58081 X 1 X 1=1
# samples 301
** MAII scorelog2(30/5808*10)=-4.27500704749987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: RNF213 [Title/Abstract] AND CEP104 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF213

GO:0016567

protein ubiquitination

21799892

HgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

HgeneRNF213

GO:0051865

protein autoubiquitination

21799892


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTGCTTCGA-VF-A8AE-01ARNF213chr17

78337114

+CEP104chr1

3732934

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000508628ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000508628ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000508628ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-3CDSENST00000456466ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000456466ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000456466ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
In-frameENST00000582970ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000582970ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000582970ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-3CDSENST00000319921ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000319921ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000319921ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
In-frameENST00000336301ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000336301ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
5CDS-intronENST00000336301ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-3CDSENST00000427003ENST00000378230RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000427003ENST00000460038RNF213chr17

78337114

+CEP104chr1

3732934

-
intron-intronENST00000427003ENST00000378223RNF213chr17

78337114

+CEP104chr1

3732934

-

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FusionProtFeatures for RNF213_CEP104


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF213

Q63HN8

CEP104

O60308

Required for ciliogenesis and for structural integrityat the ciliary tip. {ECO:0000269|PubMed:23970417}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78337114chr1:3732934ENST00000508628+4169343_37439055257Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78337114chr1:3732934ENST00000582970+4068343_37438565208Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST00000378223-07209_289-114245Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST00000378223-07677_725-114245Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST00000378223-07529_567-114245RepeatNote=HEAT 1
TgeneCEP104chr17:78337114chr1:3732934ENST00000378223-07604_640-114245RepeatNote=HEAT 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF213chr17:78337114chr1:3732934ENST00000319921+117343_374-471064Coiled coilOntology_term=ECO:0000255
HgeneRNF213chr17:78337114chr1:3732934ENST00000319921+1173997_4036-471064Zinc fingerRING-type
HgeneRNF213chr17:78337114chr1:3732934ENST00000508628+41693997_403639055257Zinc fingerRING-type
HgeneRNF213chr17:78337114chr1:3732934ENST00000582970+40683997_403638565208Zinc fingerRING-type
TgeneCEP104chr17:78337114chr1:3732934ENST00000378230-1922209_289857926Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST00000378230-1922677_725857926Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr17:78337114chr1:3732934ENST00000378230-1922529_567857926RepeatNote=HEAT 1
TgeneCEP104chr17:78337114chr1:3732934ENST00000378230-1922604_640857926RepeatNote=HEAT 2


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FusionGeneSequence for RNF213_CEP104


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RNF213_ENST00000508628_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_3974aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQEGAT
SEVLVDAAVDLISDEWEAANAIPSKRRKQDAAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGT
GPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVF
IRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVITNGESFETEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
WHQYTDIVTMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMITEGQAQLWTDLQY
REKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSW
FSLLPLSHLVMTMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRR
LVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
VITKSWPRTADNFNDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQ
LREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILELEEVTDTLTQPSYRKFIKLHQDLKSGEVTLA
EIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDP
SVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGITVIQAPKGGQKISPDTVLHLILPESP
GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVT
ELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVL
PAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLK
TIRLIDPQVDESRVLGALLPFLDAQTQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLTIVEILERRTSVPSRSS
SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQTLRRFNQNQDLDTFQTQEGSVEGTPEECLQHF
LFHCGVINPSWSELRNFARFLNTQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTL
GIPQATDPDKTTELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPL
RQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSTRKAIARFFPKPTDDSRLLLDEITRAQDLFLDGVPLRKT
IAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSD
ILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVL
LLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHTLDINTVLEKWQKSIVEEL
CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAE
WLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
CKILIFQTDFEDGIRSAQLIASAKTSVINEINKIRENEDRIFVTFITKLSRVGRGTATVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHV
TISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMIS
FIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDTLEELWVQAQYITD
AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRF
RSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKG

>In-frame_RNF213_ENST00000582970_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_3925aa
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK
KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM
AVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPY
KYVITNGESFETEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYTDIVTMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMITEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVV
EKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMTMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQD
VQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDS
VAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFNDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR
LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHL
IQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP
EEESERHILELEEVTDTLTQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLH
QAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE
LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVE
RSSLTLATAINQRGITVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS
QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLV
YLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE
TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHK
VYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF
NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQTQKVPVLFHLDVTSSVQTGIWVFL
FKLLILQYLMDINGKMWLRNPCHLTIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC
SETFQRPYQTLRRFNQNQDLDTFQTQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNTQLRDCEASLFCNPSFIGDTLRGFKKF
VVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKV
IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTTELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLI
KFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI
IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDEN
GTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK
DSTRKAIARFFPKPTDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPA
AYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG
FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKAS
NRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF
EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIV
IEEKDVVYKHFPIPLINRLEKHTLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR
ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDC
EILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKTSVINEINKIRENEDRIFVTFITKL
SRVGRGTATVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETE
SSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP
LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEM
AYIVVQNHMNLSENASNNVPFSWKIKDTLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST
EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMAWKAHLMGPAGCTM

>In-frame_RNF213_ENST00000336301_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_1998aa
MVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKN
VPLKTIRLIDPQVDESRVLGALLPFLDAQTQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLTIVEILERRTSVP
SRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQTLRRFNQNQDLDTFQTQEGSVEGTPEEC
LQHFLFHCGVINPSWSELRNFARFLNTQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREE
DLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERL
CLTLGIPQATDPDKTTELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREA
ENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLG
SIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKV
FRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSTRKAIARFFPKPTDDSRLLLDEITRAQDLFLDGVP
LRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCAR
FQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGI
CSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAK
CSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETG
KMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHTLDINTVLEKWQKSI
VEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGG
FAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLT
NTAKCKILIFQTDFEDGIRSAQLIASAKTSVINEINKIRENEDRIFVTFITKLSRVGRGTATVGFHGGLWQSVHIDDLRRSTLMVSDVTR
LQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGML
RDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLA
SMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDTLEELWVQAQ
YITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLA
YQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RNF213_ENST00000508628_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_11922nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGATTCTGAGAACAATAACTCCACAATGGCGTCGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGC
CCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAAACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAGGAGCTACA
TCAGAGGTTTTGGTAGATGCTGCTGTAGACCTCATATCCGATGAATGGGAAGCTGCTAATGCCATACCCAGCAAGAGAAGGAAGCAGGAT
GCAGCCCCGCTTGAGGCCGCCAGCGTGCCTTCTGCAGACTGTGAGCAGAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAG
TCCGCTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACA
GCCCTGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGAC
GGCCTCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAG
AGCAGCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACC
GGTCCCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCT
GAGCCCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCA
GTTAAAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAG
GAAGCTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAG
CCAGAGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGC
ACGCTGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTC
ATCAGAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTT
CTTGTTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAG
TATGAGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGAC
TGGCATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGAC
CTGGTGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGC
TTCTTCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTAC
AGGGAGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCT
GTGGACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTG
GACTGGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGC
TGGCGGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGT
ATGGAGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGG
GAACAAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGG
TTTAGTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGT
CTTTCAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTA
GAAATGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTG
CATGAAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTT
CTATCTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAA
AGGTGGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGGTCTGGAGGCGG
CTGGTGGAAATCCAATTCCCCGCGGAGCATGGCTGGAAGGAGTCGTTGCTGGGAGACATGGAATGGAGGCTCACAAAGGAGGAACCCCTC
TCCCAGATCACTGCCTACTGCAATAGTTGCTGGGACACCAAAGGCTTAGAGGACAGTGTGGCCAAGACCTTCGAGAAATGCATCATTGAA
GCCGTGAGCTCAGCCTGCCAGTCTCAGACCAGTATCCTTCAGGGGTTCTCTTACTCTGATTTGCGGAAATTTGGCATCGTCTTGTCTGCT
GTGATCACTAAGTCCTGGCCTAGGACCGCGGACAACTTCAATGACATTTTAAAGCATCTGCTCACGTTGGCAGATGTCAAGCACGTCTTC
AGATTGTGTGGAACCGACGAGAAAATACTAGCAAATGTCACAGAGGATGCCAAGAGGCTGATAGCTGTTGCCGACTCTGTGTTGACGAAA
GTTGTTGGTGACCTCCTAAGTGGCACGATTTTAGTTGGACAACTGGAGCTGATTATAAAGCACAAGAATCAGTTTCTTGACATCTGGCAA
CTGAGGGAAAAAAGTCTTTCACCCCAGGATGAACAATGTGCTGTGGAGGAAGCACTGGATTGGAGAAGGGAGGAACTGTTACTTCTAAAG
AAAGAGAAAAGATGTGTTGATAGTCTCCTGAAGATGTGTGGGAACGTGAAACATCTGATACAAGTGGACTTTGGAGTGCTTGCAGTAAGA
CACTCACAAGACCTCAGCAGTAAAAGATTAAATGACACCGTGACAGTGAGACTGTCCACCTCCTCGAACTCGCAGAGGGCAACGCATTAC
CACCTGAGCTCCCAGGTCCAAGAAATGGCTGGGAAGATAGACTTGCTCAGAGACAGCCACATCTTCCAGCTCTTCTGGCGGGAAGCCGCA
GAGCCGCTGAGTGAGCCTAAGGAGGACCAGGAAGCCGCAGAGTTGCTGAGTGAGCCCGAAGAAGAATCAGAAAGGCACATCCTTGAGCTT
GAAGAGGTGTATGACTATTTGTATCAGCCTTCTTACAGAAAGTTCATTAAGTTGCACCAGGATCTAAAGTCAGGAGAGGTCACCCTTGCA
GAGATTGATGTCATCTTCAAGGACTTTGTGAATAAATACACGGACCTGGATTCAGAACTTAAGATCATGTGCACCGTGGACCACCAGGAC
CAAAGAGATTGGATCAAGGACCGAGTCGAACAGATCAAGGAATACCATCACCTGCACCAGGCTGTCCACGCAGCCAAGGTCATCTTGCAG
GTCAAAGAGAGCCTGGGACTGAACGGTGACTTCAGTGTTCTCAACACTTTACTAAATTTTACTGATAACTTCGACGACTTTCGCCGTGAA
ACACTGGACCAGATCAACCAGGAGCTCATCCAGGCCAAAAAGCTGCTCCAGGACATCAGCGAGGCCCGGTGCAAGGGGCTGCAGGCTCTG
TCCCTGAGAAAGGAGTTCATCTGCTGGGTCCGGGAGGCTCTTGGAGGCATCAATGAGCTGAAGGTGTTTGTGGACCTGGCCTCCATCTCA
GCGGGGGAGAATGACATTGATGTGGACCGGGTGGCCTGCTTCCATGACGCTGTGCAGGGCTACGCATCCCTGCTATTTAAGCTGGACCCC
AGCGTGGACTTCAGTGCATTCATGAAGCATCTGAAAAAGCTGTGGAAGGCTCTGGATAAGGACCAGTACCTGCCCAGGAAACTGTGTGAC
TCCGCCAGGAACTTGGAATGGCTGAAGACTGTGAATGAGAGTCATGGGTCTGTGGAACGCTCATCCCTGACCCTGGCCACGGCCATCAAC
CAAAGAGGCATCTATGTGATCCAGGCGCCCAAAGGTGGCCAAAAGATTTCCCCAGACACGGTTCTGCACTTGATCCTTCCTGAGAGCCCT
GGCAGCCACGAGGAGTCACGAGAGTACTCTTTAGAGGAGGTGAAGGAGCTTTTGAACAAGTTGATGCTGATGTCTGGCAAGAAGGATCGT
AACAACACGGAAGTGGAGAGGTTTTCAGAGGTCTTCTGCAGTGTGCAGAGGCTCAGCCAGGCCTTCATCGACCTGCACTCTGCTGGGAAT
ATGCTGTTCAGGACGTGGATCGCCATGGCCTACTGCTCCCCCAAGCAGGGTGTGTCCCTCCAAATGGACTTTGGCTTGGACCTGGTGACG
GAGCTTAAAGAAGGTGGAGATGTCACTGAGCTGCTGGCAGCCCTCTGCAGGCAGATGGAGCACTTCCTTGACAGCTGGAAGAGATTTGTG
ACCCAGAAGCGAATGGAGCACTTTTACCTGAACTTCTACACGGCAGAGCAGCTGGTTTACCTGAGCACTGAGCTCAGGAAGCAGCCCCCG
AGTGATGCCGCCCTAACGATGCTATCCTTCATCAAAAGCAACTGCACCCTGAGGGATGTCTTAAGGGCCTCTGTGGGGTGTGGGAGTGAG
GCCGCCAGGTACCGCATGAGGAGAGTCATGGAAGAGCTCCCGCTGATGCTCTTATCAGAGTTCAGCCTGGTGGACAAGCTGAGGATCATC
ATGGAGCAGTCCATGAGGTGCCTTCCTGCCTTCCTGCCCGACTGCCTCGACCTAGAGACCCTTGGCCACTGTCTGGCTCACCTGGCAGGG
ATGGGTGGGTCTCCCGTGGAGCGTTGTCTCCCGAGAGGTCTGCAGGTCGGCCAGCCCAACCTCGTCGTCTGTGGCCACTCCGAGGTGTTG
CCAGCCGCCCTGGCTGTCTACATGCAAACCCCAAGCCAGCCCCTGCCCACTTACGATGAGGTGCTGCTCTGCACCCCGGCAACCACCTTT
GAGGAGGTGGCACTGTTGCTGCGCCGCTGCCTGACCCTGGGCTCCCTGGGGCACAAGGTCTACAGCCTGCTGTTCGCAGATCAGCTGAGC
TACGAGGTGGCACGCCAAGCGGAGGAGCTTTTCCACAATCTGTGCACGCAGCAGCACCGAGAAGACTACCAGCTCGTCATGGTCTGTGAT
GGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAGGCCATCCAAGCC
TACCTGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGGATCGTGGCCTCG
GAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAATGTGCCTCTGAAA
ACAATTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTATCAGAAGGTCCCC
GTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAATACTTAATGGAT
ATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCGTCGAGGAGCTCT
TCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAGGTGATAGACATG
GAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCTTACCAGTATTTA
AGACGATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGCCTCCAGCATTTC
CTGTTTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGAGATTGTGAGGCC
TCTCTCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTTATGGCAAGAGAT
TTTGCCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAAGATCTAGCGCCC
TTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTCATCGGCTTCCAT
CTGCAGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACCAGGGACCTGTAC
CAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTCTGCCTGACCTTA
GGGATCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAGATGCGGTTCCGG
TGTGGGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGGCGTGGTGGTACC
AATGCTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCTGAAAATGTGGCC
TTCGCCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGTATCAAAGAAGTC
CTGTGTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATACCGGAAGCACTCT
GAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGCTCCATTCCTCTG
AGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGACGTTGCTGAAAAG
CTCTACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAAGTCCTCTGCGCC
TCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTTTTCAGGTGGTTC
CACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAGAGAGATCCCGTC
CTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATCGCCAGGTTCTTT
CCGAAACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCTCTGAGGAAAACC
ATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTGGTGGGGAAGCCC
GGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGCAGCCTGAAGCAG
GTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGCTTTCAGCAGGGG
AAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTGAAGACTCTGCAC
CCGCTGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGGGCCCTTGACCCT
GCCAAGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATCTGCTCCTCAGAC
ATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGACAAGGAATTCTTC
GGGCTTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAAGACATTGCACAG
GCTGTCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAGTGCTCAGAGGAA
GTCAGCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCTGAGTCCCGCTAC
TTACTCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAGATTATTTTTGGT
TCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGCAAGATGGTGTTG
CTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAGTACGTGGACCTC
GGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTGTACAAACACTTT
CCCATCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATCGTGGAGGAGCTC
TGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTCTTCATCGGCTAC
CACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCACCAGAAGGTGTCT
GAGGAGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGGTTCGCAGCGGAG
TGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCAGACCTGGAGCGC
CACGCCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTCACAGGCAGGGCT
CCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACGAATACAGCCAAA
TGTAAAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCTGTTATAAATGAA
ATCAACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACAGCCTATGTGGGC
TTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGGCTGCAGCATGTC
ACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAGGCGATGGAGACG
GAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAGGAAACCTCTGAA
CTCGGAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTCAGAGACCAGAAC
GAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCTTTCTTGCGGGTA
TCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAAGCCTGCAACCAG
GACGCTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCGAGCATGATATCA
TTCATCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTTATTTTCAGTGAC
ACGATGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAACCACATGAACCTT
TCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAGTACATCACAGAC
GCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGAGAGCCGCAGCAG
GAACTTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTGCAGATGGCTCTG
TGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCCTACCAGCGTTTC
AGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGGAACCATGAGCTG
GCTGGATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATTCTGCAGAAGGCC
CCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCCACCCCGAAGGGC

>In-frame_RNF213_ENST00000582970_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_11775nt
ATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCC
ATAGCAGATTCTGAGAACAATAACTCCACAATGGCGTCGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGC
CCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAAACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAG
AAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTG
ACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCC
CCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGA
GAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCC
TCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAG
CTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATG
GCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCA
GCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAG
AATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAAC
CAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCAT
TTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTG
CACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTAC
AAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTG
TTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTC
ATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATC
CTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAA
GGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCA
TTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTG
GAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGT
GACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACC
TGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCC
GCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTG
CTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCAC
CTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGAT
GTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTG
TCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTA
TCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAA
ACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTC
ACATACGTCAAGGAAATTGAGGTCTGGAGGCGGCTGGTGGAAATCCAATTCCCCGCGGAGCATGGCTGGAAGGAGTCGTTGCTGGGAGAC
ATGGAATGGAGGCTCACAAAGGAGGAACCCCTCTCCCAGATCACTGCCTACTGCAATAGTTGCTGGGACACCAAAGGCTTAGAGGACAGT
GTGGCCAAGACCTTCGAGAAATGCATCATTGAAGCCGTGAGCTCAGCCTGCCAGTCTCAGACCAGTATCCTTCAGGGGTTCTCTTACTCT
GATTTGCGGAAATTTGGCATCGTCTTGTCTGCTGTGATCACTAAGTCCTGGCCTAGGACCGCGGACAACTTCAATGACATTTTAAAGCAT
CTGCTCACGTTGGCAGATGTCAAGCACGTCTTCAGATTGTGTGGAACCGACGAGAAAATACTAGCAAATGTCACAGAGGATGCCAAGAGG
CTGATAGCTGTTGCCGACTCTGTGTTGACGAAAGTTGTTGGTGACCTCCTAAGTGGCACGATTTTAGTTGGACAACTGGAGCTGATTATA
AAGCACAAGAATCAGTTTCTTGACATCTGGCAACTGAGGGAAAAAAGTCTTTCACCCCAGGATGAACAATGTGCTGTGGAGGAAGCACTG
GATTGGAGAAGGGAGGAACTGTTACTTCTAAAGAAAGAGAAAAGATGTGTTGATAGTCTCCTGAAGATGTGTGGGAACGTGAAACATCTG
ATACAAGTGGACTTTGGAGTGCTTGCAGTAAGACACTCACAAGACCTCAGCAGTAAAAGATTAAATGACACCGTGACAGTGAGACTGTCC
ACCTCCTCGAACTCGCAGAGGGCAACGCATTACCACCTGAGCTCCCAGGTCCAAGAAATGGCTGGGAAGATAGACTTGCTCAGAGACAGC
CACATCTTCCAGCTCTTCTGGCGGGAAGCCGCAGAGCCGCTGAGTGAGCCTAAGGAGGACCAGGAAGCCGCAGAGTTGCTGAGTGAGCCC
GAAGAAGAATCAGAAAGGCACATCCTTGAGCTTGAAGAGGTGTATGACTATTTGTATCAGCCTTCTTACAGAAAGTTCATTAAGTTGCAC
CAGGATCTAAAGTCAGGAGAGGTCACCCTTGCAGAGATTGATGTCATCTTCAAGGACTTTGTGAATAAATACACGGACCTGGATTCAGAA
CTTAAGATCATGTGCACCGTGGACCACCAGGACCAAAGAGATTGGATCAAGGACCGAGTCGAACAGATCAAGGAATACCATCACCTGCAC
CAGGCTGTCCACGCAGCCAAGGTCATCTTGCAGGTCAAAGAGAGCCTGGGACTGAACGGTGACTTCAGTGTTCTCAACACTTTACTAAAT
TTTACTGATAACTTCGACGACTTTCGCCGTGAAACACTGGACCAGATCAACCAGGAGCTCATCCAGGCCAAAAAGCTGCTCCAGGACATC
AGCGAGGCCCGGTGCAAGGGGCTGCAGGCTCTGTCCCTGAGAAAGGAGTTCATCTGCTGGGTCCGGGAGGCTCTTGGAGGCATCAATGAG
CTGAAGGTGTTTGTGGACCTGGCCTCCATCTCAGCGGGGGAGAATGACATTGATGTGGACCGGGTGGCCTGCTTCCATGACGCTGTGCAG
GGCTACGCATCCCTGCTATTTAAGCTGGACCCCAGCGTGGACTTCAGTGCATTCATGAAGCATCTGAAAAAGCTGTGGAAGGCTCTGGAT
AAGGACCAGTACCTGCCCAGGAAACTGTGTGACTCCGCCAGGAACTTGGAATGGCTGAAGACTGTGAATGAGAGTCATGGGTCTGTGGAA
CGCTCATCCCTGACCCTGGCCACGGCCATCAACCAAAGAGGCATCTATGTGATCCAGGCGCCCAAAGGTGGCCAAAAGATTTCCCCAGAC
ACGGTTCTGCACTTGATCCTTCCTGAGAGCCCTGGCAGCCACGAGGAGTCACGAGAGTACTCTTTAGAGGAGGTGAAGGAGCTTTTGAAC
AAGTTGATGCTGATGTCTGGCAAGAAGGATCGTAACAACACGGAAGTGGAGAGGTTTTCAGAGGTCTTCTGCAGTGTGCAGAGGCTCAGC
CAGGCCTTCATCGACCTGCACTCTGCTGGGAATATGCTGTTCAGGACGTGGATCGCCATGGCCTACTGCTCCCCCAAGCAGGGTGTGTCC
CTCCAAATGGACTTTGGCTTGGACCTGGTGACGGAGCTTAAAGAAGGTGGAGATGTCACTGAGCTGCTGGCAGCCCTCTGCAGGCAGATG
GAGCACTTCCTTGACAGCTGGAAGAGATTTGTGACCCAGAAGCGAATGGAGCACTTTTACCTGAACTTCTACACGGCAGAGCAGCTGGTT
TACCTGAGCACTGAGCTCAGGAAGCAGCCCCCGAGTGATGCCGCCCTAACGATGCTATCCTTCATCAAAAGCAACTGCACCCTGAGGGAT
GTCTTAAGGGCCTCTGTGGGGTGTGGGAGTGAGGCCGCCAGGTACCGCATGAGGAGAGTCATGGAAGAGCTCCCGCTGATGCTCTTATCA
GAGTTCAGCCTGGTGGACAAGCTGAGGATCATCATGGAGCAGTCCATGAGGTGCCTTCCTGCCTTCCTGCCCGACTGCCTCGACCTAGAG
ACCCTTGGCCACTGTCTGGCTCACCTGGCAGGGATGGGTGGGTCTCCCGTGGAGCGTTGTCTCCCGAGAGGTCTGCAGGTCGGCCAGCCC
AACCTCGTCGTCTGTGGCCACTCCGAGGTGTTGCCAGCCGCCCTGGCTGTCTACATGCAAACCCCAAGCCAGCCCCTGCCCACTTACGAT
GAGGTGCTGCTCTGCACCCCGGCAACCACCTTTGAGGAGGTGGCACTGTTGCTGCGCCGCTGCCTGACCCTGGGCTCCCTGGGGCACAAG
GTCTACAGCCTGCTGTTCGCAGATCAGCTGAGCTACGAGGTGGCACGCCAAGCGGAGGAGCTTTTCCACAATCTGTGCACGCAGCAGCAC
CGAGAAGACTACCAGCTCGTCATGGTCTGTGATGGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTC
ACCCCCCAGGCACCCCTCGAGGCCATCCAAGCCTACCTGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTC
AATGACCGGCTGTGTGTTGGGATCGTGGCCTCGGAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAG
ATGCAGTTAAACGTGAAAAATGTGCCTCTGAAAACAATTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTG
CCCTTCCTGGATGCGCAGTATCAGAAGGTCCCCGTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTT
TTCAAGCTCCTCATTTTACAATACTTAATGGATATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTG
GAAAGGAGGACGTCAGTGCCGTCGAGGAGCTCTTCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTC
ACCTGCAGGCCTCCCAAAGAGGTGATAGACATGGAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGC
AGCGAAACTTTCCAAAGACCTTACCAGTATTTAAGACGATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTC
GAAGGCACCCCGGAGGAATGCCTCCAGCATTTCCTGTTTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGG
TTCCTGAATTATCAGCTCAGAGATTGTGAGGCCTCTCTCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTC
GTGGTGACCTTCATGATCTTTATGGCAAGAGATTTTGCCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACC
ATGGATGGGGTTAGGGAAGAAGATCTAGCGCCCTTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGAC
GACCACACAACCATGACATTCATCGGCTTCCATCTGCAGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTC
ATCAAGAGAGACGTCATGACCAGGGACCTGTACCAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGA
CACAAGAAACTTGAGAGGCTCTGCCTGACCTTAGGGATCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATG
CTTAAAATCCTTGCCATCGAGATGCGGTTCCGGTGTGGGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATT
AAATTCCTTAGCGACCTGCGGCGTGGTGGTACCAATGCTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATC
TACTCCAGAGTCAGGGAGGCTGAAAATGTGGCCTTCGCCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAAC
ACAACGGAAGCTATAAGCTGTATCAAAGAAGTCCTGTGTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATT
ATAGCTGCCTGCAATCCATACCGGAAGCACTCTGAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAG
GAGACGGCCGACAGGCTGGGCTCCATTCCTCTGAGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGG
GACTTTGGACAACTGAGTGACGTTGCTGAAAAGCTCTACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAAC
GGGACTCGCGTGATCACAGAAGTCCTCTGCGCCTCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGAC
GTGGAGCGCTGTGTGAAAGTTTTCAGGTGGTTCCACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGC
GTCAGCAAAAATCACACCGAGAGAGATCCCGTCCTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAA
GACTCATATCGGAAAGCCATCGCCAGGTTCTTTCCGAAACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGAT
CTTTTTCTGGACGGCGTACCTCTGAGGAAAACCATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAG
CTGAAGATTCCCCTCTTCCTGGTGGGGAAGCCCGGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCT
GCCTACTCAGATCTCTTCCGCAGCCTGAAGCAGGTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGC
ACCTTCCGGCAGTGCGCCCGCTTTCAGCAGGGGAAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAA
GACTCACCCAAAATGCCCCTGAAGACTCTGCACCCGCTGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGC
TTCGTGGGCATCTCCAACTGGGCCCTTGACCCTGCCAAGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTC
ATAGAGAGCGCCAAGGGCATCTGCTCCTCAGACATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAA
ACGGTGTGTAAGCGCCAGGACAAGGAATTCTTCGGGCTTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCA
AATAGAAAGCCTTCCCCGCAAGACATTGCACAGGCTGTCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTG
GCCAATTTGCCCGAGGCCAAGTGCTCAGAGGAAGTCAGCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCG
GGTGGAGAGCAGGAAGATGCTGAGTCCCGCTACTTACTCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTC
GAGGGGGACCAGCAGCCGGAGATTATTTTTGGTTCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTG
AAGATCTGCATGGAAACAGGCAAGATGGTGTTGCTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTAC
GTCCACCTCGGCGGCCAGAAGTACGTGGACCTCGGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTC
ATTGAAGAGAAAGACGTCGTGTACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTG
GAGAAATGGCAGAAGAGCATCGTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCAC
AAATACAGCCCCTCTGACGTCTTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGG
GCCTTGACGGAGGAACTTCACCAGAAGGTGTCTGAGGAGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTG
AGCGCCTACTCGCTGGGCGGGTTCGCAGCGGAGTGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTT
CAGGCACACCTGCACACGGCAGACCTGGAGCGCCACGCCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGT
GAAATTTTAGAATCAGAGGTCACAGGCAGGGCTCCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAA
GAAGTCCGAAACTGTTTAACGAATACAGCCAAATGTAAAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTC
ATTGCCTCAGCTAAGTATTCTGTTATAAATGAAATCAACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTG
TCCCGGGTGGGAAGAGGAACAGCCTATGTGGGCTTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTC
ATGGTTTCTGATGTGACCAGGCTGCAGCATGTCACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGG
GCGGAAGACGGCCATGAGGAGGCGATGGAGACGGAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAA
AGTTCTGAGAAGGTGGGAAAGGAAACCTCTGAACTCGGAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTG
CAGAGCGCCGTGGGCATGCTCAGAGACCAGAACGAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAG
GATGACGCGTGCCACGCCTCTTTCTTGCGGGTATCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCT
CTGGAGTGGTTGGCAAGGGAAGCCTGCAACCAGGACGCTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGT
GCTGTCACCCCTCTGCTGGCGAGCATGATATCATTCATCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGG
GCAAGAGATCTTTGGATGTTTATTTTCAGTGACACGATGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATG
GCCTACATCGTGGTGCAGAACCACATGAACCTTTCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAG
GAGCTGTGGGTCCAGGCTCAGTACATCACAGACGCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGG
TTTCTTGCCCAGCTCCATGGAGAGCCGCAGCAGGAACTTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACG
GAGGAGGAATTAAAGTTTCTGCAGATGGCTCTGTGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCC
TTACCGTGGGTGCACCTTGCCTACCAGCGTTTCAGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCAC
AGCCTGATGGAAGCCCGTTGGAACCATGAGCTGGCTGGATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATG
AACCTGCGCAAGACACACATTCTGCAGAAGGCCCCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCA

>In-frame_RNF213_ENST00000336301_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_5994nt
ATGGTCTGTGATGGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAG
GCCATCCAAGCCTACCTGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGG
ATCGTGGCCTCGGAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAAT
GTGCCTCTGAAAACAATTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTAT
CAGAAGGTCCCCGTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAA
TACTTAATGGATATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCG
TCGAGGAGCTCTTCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAG
GTGATAGACATGGAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCT
TACCAGTATTTAAGACGATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGC
CTCCAGCATTTCCTGTTTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGA
GATTGTGAGGCCTCTCTCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTT
ATGGCAAGAGATTTTGCCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAA
GATCTAGCGCCCTTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTC
ATCGGCTTCCATCTGCAGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACC
AGGGACCTGTACCAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTC
TGCCTGACCTTAGGGATCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAG
ATGCGGTTCCGGTGTGGGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGG
CGTGGTGGTACCAATGCTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCT
GAAAATGTGGCCTTCGCCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGT
ATCAAAGAAGTCCTGTGTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATAC
CGGAAGCACTCTGAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGC
TCCATTCCTCTGAGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGAC
GTTGCTGAAAAGCTCTACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAA
GTCCTCTGCGCCTCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTT
TTCAGGTGGTTCCACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAG
AGAGATCCCGTCCTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATC
GCCAGGTTCTTTCCGAAACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCT
CTGAGGAAAACCATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTG
GTGGGGAAGCCCGGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGC
AGCCTGAAGCAGGTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGC
TTTCAGCAGGGGAAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTG
AAGACTCTGCACCCGCTGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGG
GCCCTTGACCCTGCCAAGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATC
TGCTCCTCAGACATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGAC
AAGGAATTCTTCGGGCTTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAA
GACATTGCACAGGCTGTCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAG
TGCTCAGAGGAAGTCAGCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCT
GAGTCCCGCTACTTACTCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAG
ATTATTTTTGGTTCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGC
AAGATGGTGTTGCTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAG
TACGTGGACCTCGGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTG
TACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATC
GTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTC
TTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCAC
CAGAAGGTGTCTGAGGAGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGG
TTCGCAGCGGAGTGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCA
GACCTGGAGCGCCACGCCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTC
ACAGGCAGGGCTCCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACG
AATACAGCCAAATGTAAAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCT
GTTATAAATGAAATCAACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACA
GCCTATGTGGGCTTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGG
CTGCAGCATGTCACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAG
GCGATGGAGACGGAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAG
GAAACCTCTGAACTCGGAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTC
AGAGACCAGAACGAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCT
TTCTTGCGGGTATCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAA
GCCTGCAACCAGGACGCTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCG
AGCATGATATCATTCATCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTT
ATTTTCAGTGACACGATGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAAC
CACATGAACCTTTCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAG
TACATCACAGACGCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGA
GAGCCGCAGCAGGAACTTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTG
CAGATGGCTCTGTGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCC
TACCAGCGTTTCAGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGG
AACCATGAGCTGGCTGGATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATT
CTGCAGAAGGCCCCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RNF213_ENST00000508628_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_15388nt
GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC
TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA
GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGC
GTCGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGA
AAACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAGGAGCTACATCAGAGGTTTTGGTAGATGCTGCTGTAGACCTCAT
ATCCGATGAATGGGAAGCTGCTAATGCCATACCCAGCAAGAGAAGGAAGCAGGATGCAGCCCCGCTTGAGGCCGCCAGCGTGCCTTCTGC
AGACTGTGAGCAGAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCGCTTCCTCAGAGCTGGCTTCCTTGCCCCTTTC
TCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCCTGCCCCACAGCCAAGCCCAGCAGAGTGGCCC
CACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCCTCTCCGCGCCCACCGAGGTTGGCGACAGCCC
CCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCAGCCCGCAATTCCAGGACCACACGGAAGGGGA
GGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTCCCCCCACCTCTGCTGGTGAAGGCCATTCTAG
GACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGCCCGGGACAGAACTGCAGACCACCGAGCAACA
GGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTAAAGGGGCCGGGAAGGAAATGAAAGAGAAGAC
CCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAGCTGAGACCAAGACCAAGGACGAGATGGCTGC
TGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAGAGGGGAAGAACAGAAGTGCAGCTGCTGTGAA
AAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGCTGAGCCCGGGTGGAGGAGTCACCGTGTTCTT
CCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCAGAGGAGGAGAAGAATTTGGGGAGTCAAAATG
GGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTGTTGAAGGCATTGTCTGCATTTCCAAGAAGCA
CCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATGAGTTCATTTACAAGCACCAGCAGAAGAAGGG
CGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGCATCAGTACTATGACATAGTTTATATGAAGCC
TCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGGTGAAGGGGAAGCAGATTGCCGCTGCGCTCAT
GCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCTTCACCCAGTTCGAGCAGTTTTGCTTTGTCCT
GCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGGAGAAAGAGGTGAAGAGATACCTGTGGCAACA
TCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGGACTGCCCAGTGAGGAGTAAACTGAAAACAGG
CCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACTGGTTGTGTCACCTCCTAACCTCAGATGCCAG
CTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGCGGCTGTACCTGGTGAACCTGTGCCAAAGATG
CATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGGAGCTGGCCCCGCGGCACAAGGATGCCTGGAG
ACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAACAAATGCTAGATACGAGTTCCCTACTTCAGTT
TATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTAGTCTGCTACCTCTGAGTCACCTGGTTATGTA
TATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTTCAGGGATTTACTACCGGCTTCCGGGACTTGA
GCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAATGCTGTTGCGACTCCTGGACACTTACCGGGA
CAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATGAAGCCATCTGCAGCAGCACAAAGCTACTTAA
GTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTATCTCTGGTGGATTCTGCAGGACAGAGAGATGA
AACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGTGGCTCCGAGAAGTTTTTACAAAGAACATGCT
CACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGGTCTGGAGGCGGCTGGTGGAAATCCAATTCCCCGCGGAGCATGGCTG
GAAGGAGTCGTTGCTGGGAGACATGGAATGGAGGCTCACAAAGGAGGAACCCCTCTCCCAGATCACTGCCTACTGCAATAGTTGCTGGGA
CACCAAAGGCTTAGAGGACAGTGTGGCCAAGACCTTCGAGAAATGCATCATTGAAGCCGTGAGCTCAGCCTGCCAGTCTCAGACCAGTAT
CCTTCAGGGGTTCTCTTACTCTGATTTGCGGAAATTTGGCATCGTCTTGTCTGCTGTGATCACTAAGTCCTGGCCTAGGACCGCGGACAA
CTTCAATGACATTTTAAAGCATCTGCTCACGTTGGCAGATGTCAAGCACGTCTTCAGATTGTGTGGAACCGACGAGAAAATACTAGCAAA
TGTCACAGAGGATGCCAAGAGGCTGATAGCTGTTGCCGACTCTGTGTTGACGAAAGTTGTTGGTGACCTCCTAAGTGGCACGATTTTAGT
TGGACAACTGGAGCTGATTATAAAGCACAAGAATCAGTTTCTTGACATCTGGCAACTGAGGGAAAAAAGTCTTTCACCCCAGGATGAACA
ATGTGCTGTGGAGGAAGCACTGGATTGGAGAAGGGAGGAACTGTTACTTCTAAAGAAAGAGAAAAGATGTGTTGATAGTCTCCTGAAGAT
GTGTGGGAACGTGAAACATCTGATACAAGTGGACTTTGGAGTGCTTGCAGTAAGACACTCACAAGACCTCAGCAGTAAAAGATTAAATGA
CACCGTGACAGTGAGACTGTCCACCTCCTCGAACTCGCAGAGGGCAACGCATTACCACCTGAGCTCCCAGGTCCAAGAAATGGCTGGGAA
GATAGACTTGCTCAGAGACAGCCACATCTTCCAGCTCTTCTGGCGGGAAGCCGCAGAGCCGCTGAGTGAGCCTAAGGAGGACCAGGAAGC
CGCAGAGTTGCTGAGTGAGCCCGAAGAAGAATCAGAAAGGCACATCCTTGAGCTTGAAGAGGTGTATGACTATTTGTATCAGCCTTCTTA
CAGAAAGTTCATTAAGTTGCACCAGGATCTAAAGTCAGGAGAGGTCACCCTTGCAGAGATTGATGTCATCTTCAAGGACTTTGTGAATAA
ATACACGGACCTGGATTCAGAACTTAAGATCATGTGCACCGTGGACCACCAGGACCAAAGAGATTGGATCAAGGACCGAGTCGAACAGAT
CAAGGAATACCATCACCTGCACCAGGCTGTCCACGCAGCCAAGGTCATCTTGCAGGTCAAAGAGAGCCTGGGACTGAACGGTGACTTCAG
TGTTCTCAACACTTTACTAAATTTTACTGATAACTTCGACGACTTTCGCCGTGAAACACTGGACCAGATCAACCAGGAGCTCATCCAGGC
CAAAAAGCTGCTCCAGGACATCAGCGAGGCCCGGTGCAAGGGGCTGCAGGCTCTGTCCCTGAGAAAGGAGTTCATCTGCTGGGTCCGGGA
GGCTCTTGGAGGCATCAATGAGCTGAAGGTGTTTGTGGACCTGGCCTCCATCTCAGCGGGGGAGAATGACATTGATGTGGACCGGGTGGC
CTGCTTCCATGACGCTGTGCAGGGCTACGCATCCCTGCTATTTAAGCTGGACCCCAGCGTGGACTTCAGTGCATTCATGAAGCATCTGAA
AAAGCTGTGGAAGGCTCTGGATAAGGACCAGTACCTGCCCAGGAAACTGTGTGACTCCGCCAGGAACTTGGAATGGCTGAAGACTGTGAA
TGAGAGTCATGGGTCTGTGGAACGCTCATCCCTGACCCTGGCCACGGCCATCAACCAAAGAGGCATCTATGTGATCCAGGCGCCCAAAGG
TGGCCAAAAGATTTCCCCAGACACGGTTCTGCACTTGATCCTTCCTGAGAGCCCTGGCAGCCACGAGGAGTCACGAGAGTACTCTTTAGA
GGAGGTGAAGGAGCTTTTGAACAAGTTGATGCTGATGTCTGGCAAGAAGGATCGTAACAACACGGAAGTGGAGAGGTTTTCAGAGGTCTT
CTGCAGTGTGCAGAGGCTCAGCCAGGCCTTCATCGACCTGCACTCTGCTGGGAATATGCTGTTCAGGACGTGGATCGCCATGGCCTACTG
CTCCCCCAAGCAGGGTGTGTCCCTCCAAATGGACTTTGGCTTGGACCTGGTGACGGAGCTTAAAGAAGGTGGAGATGTCACTGAGCTGCT
GGCAGCCCTCTGCAGGCAGATGGAGCACTTCCTTGACAGCTGGAAGAGATTTGTGACCCAGAAGCGAATGGAGCACTTTTACCTGAACTT
CTACACGGCAGAGCAGCTGGTTTACCTGAGCACTGAGCTCAGGAAGCAGCCCCCGAGTGATGCCGCCCTAACGATGCTATCCTTCATCAA
AAGCAACTGCACCCTGAGGGATGTCTTAAGGGCCTCTGTGGGGTGTGGGAGTGAGGCCGCCAGGTACCGCATGAGGAGAGTCATGGAAGA
GCTCCCGCTGATGCTCTTATCAGAGTTCAGCCTGGTGGACAAGCTGAGGATCATCATGGAGCAGTCCATGAGGTGCCTTCCTGCCTTCCT
GCCCGACTGCCTCGACCTAGAGACCCTTGGCCACTGTCTGGCTCACCTGGCAGGGATGGGTGGGTCTCCCGTGGAGCGTTGTCTCCCGAG
AGGTCTGCAGGTCGGCCAGCCCAACCTCGTCGTCTGTGGCCACTCCGAGGTGTTGCCAGCCGCCCTGGCTGTCTACATGCAAACCCCAAG
CCAGCCCCTGCCCACTTACGATGAGGTGCTGCTCTGCACCCCGGCAACCACCTTTGAGGAGGTGGCACTGTTGCTGCGCCGCTGCCTGAC
CCTGGGCTCCCTGGGGCACAAGGTCTACAGCCTGCTGTTCGCAGATCAGCTGAGCTACGAGGTGGCACGCCAAGCGGAGGAGCTTTTCCA
CAATCTGTGCACGCAGCAGCACCGAGAAGACTACCAGCTCGTCATGGTCTGTGATGGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTT
CAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAGGCCATCCAAGCCTACCTGGCAGGTCACTACCGGGTCCCGAAGCAGAC
CCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGGATCGTGGCCTCGGAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAA
GAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAATGTGCCTCTGAAAACAATTCGACTGATCGACCCTCAGGTGGATGAGAG
CCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTATCAGAAGGTCCCCGTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCA
GACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAATACTTAATGGATATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCA
TTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCGTCGAGGAGCTCTTCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTT
TCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAGGTGATAGACATGGAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGG
GATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCTTACCAGTATTTAAGACGATTCAATCAAAACCAAGACCTAGACACGTT
TCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGCCTCCAGCATTTCCTGTTTCACTGCGGGGTAATAAACCCATCCTGGTC
AGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGAGATTGTGAGGCCTCTCTCTTCTGCAATCCGAGTTTTATTGGCGACAC
ACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTTATGGCAAGAGATTTTGCCACACCATCACTCCACACCTCTGACCAAAG
CCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAAGATCTAGCGCCCTTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCA
CCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTCATCGGCTTCCATCTGCAGCCCAACATCAACGGCAGTGTCGATGCCAT
CAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACCAGGGACCTGTACCAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGT
CGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTCTGCCTGACCTTAGGGATCCCCCAGGCCACCGACCCCGACAAAACGTA
TGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAGATGCGGTTCCGGTGTGGGATCCCGGTTATCATCATGGGAGAAACTGG
CTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGGCGTGGTGGTACCAATGCTGACACCATAAAGCTGGTCAAGGTGCACGG
AGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCTGAAAATGTGGCCTTCGCCAATAAGGACCAACATCAGTTGGACACCAT
CTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGTATCAAAGAAGTCCTGTGTGATCATATGGTGGATGGCCAGCCTCTGGC
TGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATACCGGAAGCACTCTGAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTT
GGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGCTCCATTCCTCTGAGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCC
GAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGACGTTGCTGAAAAGCTCTACATCCAGCAGATTGTCCAGAGACTGGTTGA
GTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAAGTCCTCTGCGCCTCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTG
CAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTTTTCAGGTGGTTCCACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAA
TGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAGAGAGATCCCGTCCTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTA
CCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATCGCCAGGTTCTTTCCGAAACCGTATGACGACAGCAGGCTGCTTCTGGA
TGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCTCTGAGGAAAACCATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTT
CATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTGGTGGGGAAGCCCGGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGC
AGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGCAGCCTGAAGCAGGTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTC
CACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGCTTTCAGCAGGGGAAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTT
AGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTGAAGACTCTGCACCCGCTGCTGGAAGACGGATGCATTGAAGACGATCC
CGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGGGCCCTTGACCCTGCCAAGATGAACCGGGGCATTTTTGTGTCACGTGG
CAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATCTGCTCCTCAGACATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGC
GTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGACAAGGAATTCTTCGGGCTTCGTGACTACTACAGCCTCATCAAAATGGT
CTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAAGACATTGCACAGGCTGTCCTTAGGAACTTCAGTGGCAAGGATGACAT
CCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAGTGCTCAGAGGAAGTCAGCCCCATGCAGCTGATCAAACAGAACATCTT
TGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCTGAGTCCCGCTACTTACTCGTGCTGACCAAAAACTACGTGGCACTGCA
GATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAGATTATTTTTGGTTCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCT
CTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGCAAGATGGTGTTGCTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTA
CGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAGTACGTGGACCTCGGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCA
CCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTGTACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTA
TCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATCGTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGC
ACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTCTTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGT
CATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCACCAGAAGGTGTCTGAGGAGGCCAAATCGATCCTGCTGAACTGCGCTAC
GCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGGTTCGCAGCGGAGTGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCA
CAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCAGACCTGGAGCGCCACGCCATCTTCACAGAGATCACCACTTTCTCCAG
GCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTCACAGGCAGGGCTCCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGA
CACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACGAATACAGCCAAATGTAAAATCCTCATTTTTCAGACAGATTTTGAAGA
TGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCTGTTATAAATGAAATCAACAAAATACGAGAAAATGAGGACCGTATCTT
CGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACAGCCTATGTGGGCTTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGA
TGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGGCTGCAGCATGTCACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCC
TGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAGGCGATGGAGACGGAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGC
AGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAGGAAACCTCTGAACTCGGAGGCAGTGATGTGTCGATCCTGGACACCAC
CAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTCAGAGACCAGAACGAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCT
CCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCTTTCTTGCGGGTATCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCA
AGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAAGCCTGCAACCAGGACGCTCTCCAGGAGGCGGGCACATTCAGGCACAC
CCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCGAGCATGATATCATTCATCGACAGAGACGGCAACCTAGAGTTACTGAC
CAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTTATTTTCAGTGACACGATGCTTCTGAACATTCCTCTTGTGATGAATAA
TGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAACCACATGAACCTTTCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTG
GAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAGTACATCACAGACGCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTT
TCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGAGAGCCGCAGCAGGAACTTCTTCAGTGTTACTTGAAGGATTTCATTCT
CTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTGCAGATGGCTCTGTGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGA
AGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCCTACCAGCGTTTCAGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGAC
CATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGGAACCATGAGCTGGCTGGATGTGAGATGGCATGGAAAGCTCACCTGAT
GGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATTCTGCAGAAGGCCCCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGC
CGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCCACCCCGAAGGGCGGACTGAGCAAGAGCTCCAGCAGGACGTACGCCAA
GCGCTGACGCGGCGCTCGGGCTCCTTGGTCTCTGTGAGGGATGGAGCGGGTCTCCTGATTCTACACCATCTCTCCAGAACTCTCTGGCCT
TGGTGGCCCCATGCTCTGGCTGCTGTCCCCAGCTCCCCGCCGTGCACGCCTCTTACGCGTCTGTGCCGTCAGCTCTCGTGCAAACGATAT
GGATGCAGCTAACCAAAGATCCTGCGTGCAGTGCCAGGACCTGGCCGCACTGTACATTAAGCCTTCAGGGCTGTCTCAGGCCTTCCTTAG
AATCAGAGAAGGAAGCGTCCTGTTTGGAGAGAGCCAGAGAGCACCGCCGGGAGGCGCTCGCGCAAGGCCACGGTCAGCACAGGCACGGTC
CCGCTTTCCTTAGTGCTTGGAGCAATTTCCATAAAACATTCACCAGAAACCTTTTGCACATCGGTCTCTGCCACACGCAGTAGAATTTCC
GCAGGGCTGTGGCTCGGCCAGCAGCGGTTCCAGGAGAGTGGCGGTGCGCACGGGCCTCCAGCCGTGCCTTCCCCCTGCAGGCCCCGTCTG
CTGGGCCTGCTGCCCAGTGCACTCAGCCCCAGGTAGCAGAACTCACGTTCCCACTATAGCAAGAAATAAAGGCAAAAGAGAACATCTTTT
TTTTAATCGTAGTTTTTTTGAGAATTGGTCCCACCTCAGCCGCACCTTGCTGGATGCTTCTCCAGTAGTGCTGCCCCTGTGACAGGCATC
AGCTCCCTGCTGGAACTGAGGTAGACACAGGTGTGGGCCCTTCCCGTGCCTTTGCTCAGAGGCGCTTCACTTTCTCCACACTTTCGAATT
CCTAAAGACATGTGGAGGAAGTCACTGTTAAATGAATTTCCACCTGATCACCCTGTGTTCACAGCAGGCAGAAGCCCACTGGTATGGGCC
TCCCGCCCCTTCCACATCCATGTTGTGATTGGATCCATAAGTTTACTTTCTTCAAAGAGTTGATAGGATGTTTAAAACATCAACACATTG
CTTAAAATGATGAAACCAACCCTCAAAAAACAGTCTCCTAACCAGCCATCCCCTCCTGTGGGAGTGAGCTGGGGGTTTTGTCCATAGCTT
TGGTTGGGCCTGTGTCACATCCAGGCAGCCATGTGGAGGGAGTCAGGGTCTGTCTGGAAGCATCCACCCTCTCGCTGCCCCAGCCTGTGC
TCCCAGGGGCCTAGGCTACCATGGACTGAAGGGCAGTCCCCTCCCACCTGGTGCCCAGGGCTTCTGCTTGCCTCGCTGATGTTGCATGGG
CAGACTTCAAAAAGGATAGTTAGAAAGGTTTGGGTTGATGGAGTTTGCATTAATGCAATTAGTGTATAAATATGTTTTAATTGCCAACCG
TGTGAAACAACAAAATATCTAAAAACTAATCCCGATTTGAACAATGTACTCCCTGGCCTGGATACATTAATAACCATAAATTTGCATGAA
TTAATCTCCACGTTTGGTAAACTAATACCTCTGGTTGACTGAGAATACTGAGTAAGATATAAGACCTACCAGGAACCTTTAAGAATATGC
TCTGCTCAGTGTTGTTTGTCTGCTTGTTTGCGACGGAGTCTCACTGTGTCGCCCGGGCTGCAGTGCAATGGCGTGATCTTGGCTCACAGT
AACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGTGCACACCACCATGCTCGGCTAATT
TTTTCTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCGTGACCTCATAATCTGCCCACCTTGGCCTCCC
AAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGGTTAAATGTGTTTATAAGGAGAGAGGAGGCCAGGCGCGGTGGCTCACGCTGT
AATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGACCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTC
TACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAGGAAAATTGCTTGAACCCGGGAG
GTGGAGGTTGCATTGAGCCCACATCATGCCATTGCACTCCAGCCCAGGCGACAGAGCGAGACTCCGTCTCGAAAAAAAAAAAAAGTATAA
GGAGAGAAATAACTTTAAAGTTTATTAGACAAAACAGAGTATAGATGCCAAGATGTCTGTAAAATGATTTTTTCTGGTTTTAAAGAGATG
TTGGCCATTATTTTCTAATCCATTTTTAAAATACAGACAAAACACTTCTTTAAACAGAACAAGAATGAGAAAAGTTAACCAAGGAATTAT
TCTTTTCTCACCAATCAACACTTTTAAGAAATATATATATATATATACACACATATACACATGCCTTCTATATATTGTAACTTAAAGAAA
ATACTTATAAAAAGACTTCATTTTTAGTGATTGACAAGCAAACGGGTTCATTTAAAACAGGTTCCTCTTTTGTTAGTTACAGGGGGTTTT
TTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTGCGGGGGTGGTGGGGTTTGAGACGGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTG
GCGCGATCTTGGCCCCCTGCAACCTCCGCCTCCCGGGTTCGAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGT
GTCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTTGTG
ATCCACCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGGCATGAGCCACCGCGCCCGGCCCAATCATGTGTTTTTGTTGAAATGATCCT
ACCAGTGATTAGTGGCTATTGAGAGTTTTACAGGGTTATACATTGTTAAGGGACCAAGAATCAAGTACAAAAAATTAAAAAGGAACTGTA
AAATCCCTTGGTCATTCATAAATAAATATCTAAATTAGGAATACTAATTAATTGAATTTTCACTCATGAGTATGTTCTGAATATTTAATA
TTTATTTCTATTATTTTCATATGTTAAGATATTCCATTAAATCTAACTTAAAAGAATTGTATGTATAAATTGGCATTAGGATACAAATGT
AAATGTTTTTAATGAAATTTTGCAACTTTTTAATATTTTAACATAGTTTTCTATTTGTCTTTATTTCAAGTACCAGAATTACAAAATATC

>In-frame_RNF213_ENST00000582970_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_15239nt
CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG
CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG
AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGATTCTGAGAACAATAACTCCACAATGGCGT
CGGCCTCGGAGGGTGAAATGGAGTGTGGGCAGGAGCTGAAGGAGGAAGGGGGCCCGTGCTTGTTCCCGGGCTCAGACAGTTGGCAAGAAA
ACCCCGAGGAGCCCTGTTCCAAAGCCTCCTGGACCGTCCAAGAAAGCAAAAAGAAGAAAAGGAAGAAGAAAAAGAAGGGGAACAAGTCCG
CTTCCTCAGAGCTGGCTTCCTTGCCCCTTTCTCCTGCCAGCCCCTGTCACCTGACTTTGCTTTCAAACCCGTGGCCTCAGGACACAGCCC
TGCCCCACAGCCAAGCCCAGCAGAGTGGCCCCACTGGCCAGCCGAGCCAGCCCCCAGGCACAGCCACCACGCCACTGGAGGGTGACGGCC
TCTCCGCGCCCACCGAGGTTGGCGACAGCCCCCTGCAGGCCCAGGCTTTGGGAGAGGCAGGAGTGGCCACAGGAAGTGAGGCTCAGAGCA
GCCCGCAATTCCAGGACCACACGGAAGGGGAGGACCAGGACGCTTCCATCCCCTCTGGGGGCAGAGGCCTGTCCCAGGAGGGGACCGGTC
CCCCCACCTCTGCTGGTGAAGGCCATTCTAGGACTGAAGATGCTGCCCAGGAGCTCCTGTTGCCTGAGTCAAAAGGAGGCAGCTCTGAGC
CCGGGACAGAACTGCAGACCACCGAGCAACAGGCAGGGGCCTCAGCCTCTATGGCAGTTGATGCTGTAGCTGAGCCAGCCAATGCAGTTA
AAGGGGCCGGGAAGGAAATGAAAGAGAAGACCCAGAGAATGAAACAGCCACCAGCAACCACTCCTCCTTTCAAAACACACTGCCAGGAAG
CTGAGACCAAGACCAAGGACGAGATGGCTGCTGCTGAAGAAAAAGTCGGTAAGAATGAACAAGGGGAGCCTGAAGACCTCAAGAAGCCAG
AGGGGAAGAACAGAAGTGCAGCTGCTGTGAAAAACGAGAAGGAGCAAAAAAACCAGGAAGCAGATGTCCAGGAAGTGAAGGCAAGCACGC
TGAGCCCGGGTGGAGGAGTCACCGTGTTCTTCCACGCCATCATCTCTCTTCATTTCCCATTCAATCCTGACCTCCATAAAGTCTTCATCA
GAGGAGGAGAAGAATTTGGGGAGTCAAAATGGGACAGCAATATCTGTGAGCTGCACTACACCAGAGACTTGGGTCATGACCGCGTTCTTG
TTGAAGGCATTGTCTGCATTTCCAAGAAGCACCTAGATAAATACATTCCTTACAAGTACGTCATTTATAATGGGGAATCTTTTGAGTATG
AGTTCATTTACAAGCACCAGCAGAAGAAGGGCGAGTACGTCAACCGCTGTCTGTTCATAAAATCTTCACTTCTGGGCTCAGGAGACTGGC
ATCAGTACTATGACATAGTTTATATGAAGCCTCATGGGAGACTCCAGAAAGTCATGAACCACATCACAGACGGGCCGAGGAAGGACCTGG
TGAAGGGGAAGCAGATTGCCGCTGCGCTCATGCTGGACAGCACCTTCAGCATCCTGCAGACCTGGGACACCATCAACCTGAACAGCTTCT
TCACCCAGTTCGAGCAGTTTTGCTTTGTCCTGCAACAGCCTATGATTTATGAAGGACAGGCACAGCTGTGGACCGATTTGCAGTACAGGG
AGAAAGAGGTGAAGAGATACCTGTGGCAACATCTGAAAAAACACGTGGTACCATTGCCGGACGGAAAAAGCACGGACTTTTTGCCTGTGG
ACTGCCCAGTGAGGAGTAAACTGAAAACAGGCCTGATTGTCCTTTTTGTAGTGGAAAAAATTGAGCTTTTATTAGAAGGCAGCCTGGACT
GGTTGTGTCACCTCCTAACCTCAGATGCCAGCTCACCAGATGAGTTTCACCGTGACCTAAGCCACATCCTTGGGATACCTCAGAGCTGGC
GGCTGTACCTGGTGAACCTGTGCCAAAGATGCATGGACACAAGGACGTACACCTGGCTGGGCGCCCTGCCTGTCCTGCACTGCTGTATGG
AGCTGGCCCCGCGGCACAAGGATGCCTGGAGACAGCCTGAGGACACCTGGGCCGCTCTGGAGGGACTCTCCTTCTCACCGTTCCGGGAAC
AAATGCTAGATACGAGTTCCCTACTTCAGTTTATGAGAGAGAAGCAGCATTTGCTGAGCATAGACGAGCCTCTCTTCCGGTCCTGGTTTA
GTCTGCTACCTCTGAGTCACCTGGTTATGTATATGGAAAACTTCATTGAGCACCTGGGTCGTTTTCCTGCTCATATCCTGGACTGTCTTT
CAGGGATTTACTACCGGCTTCCGGGACTTGAGCAAGTCTTGAATACGCAGGATGTTCAGGATGTTCAGAACGTTCAGAACATTTTAGAAA
TGCTGTTGCGACTCCTGGACACTTACCGGGACAAGATTCCCGAGGAGGCCTTGTCACCATCCTACCTGACTGTGTGTCTGAAACTGCATG
AAGCCATCTGCAGCAGCACAAAGCTACTTAAGTTTTACGAGCTGCCAGCCTTATCTGCCGAGATTGTCTGCAGAATGATTAGACTTCTAT
CTCTGGTGGATTCTGCAGGACAGAGAGATGAAACTGGAAATAATTCAGTCCAAACAGTCTTCCAAGGGACCCTTGCTGCTACGAAAAGGT
GGCTCCGAGAAGTTTTTACAAAGAACATGCTCACATCTTCAGGTGCCTCATTCACATACGTCAAGGAAATTGAGGTCTGGAGGCGGCTGG
TGGAAATCCAATTCCCCGCGGAGCATGGCTGGAAGGAGTCGTTGCTGGGAGACATGGAATGGAGGCTCACAAAGGAGGAACCCCTCTCCC
AGATCACTGCCTACTGCAATAGTTGCTGGGACACCAAAGGCTTAGAGGACAGTGTGGCCAAGACCTTCGAGAAATGCATCATTGAAGCCG
TGAGCTCAGCCTGCCAGTCTCAGACCAGTATCCTTCAGGGGTTCTCTTACTCTGATTTGCGGAAATTTGGCATCGTCTTGTCTGCTGTGA
TCACTAAGTCCTGGCCTAGGACCGCGGACAACTTCAATGACATTTTAAAGCATCTGCTCACGTTGGCAGATGTCAAGCACGTCTTCAGAT
TGTGTGGAACCGACGAGAAAATACTAGCAAATGTCACAGAGGATGCCAAGAGGCTGATAGCTGTTGCCGACTCTGTGTTGACGAAAGTTG
TTGGTGACCTCCTAAGTGGCACGATTTTAGTTGGACAACTGGAGCTGATTATAAAGCACAAGAATCAGTTTCTTGACATCTGGCAACTGA
GGGAAAAAAGTCTTTCACCCCAGGATGAACAATGTGCTGTGGAGGAAGCACTGGATTGGAGAAGGGAGGAACTGTTACTTCTAAAGAAAG
AGAAAAGATGTGTTGATAGTCTCCTGAAGATGTGTGGGAACGTGAAACATCTGATACAAGTGGACTTTGGAGTGCTTGCAGTAAGACACT
CACAAGACCTCAGCAGTAAAAGATTAAATGACACCGTGACAGTGAGACTGTCCACCTCCTCGAACTCGCAGAGGGCAACGCATTACCACC
TGAGCTCCCAGGTCCAAGAAATGGCTGGGAAGATAGACTTGCTCAGAGACAGCCACATCTTCCAGCTCTTCTGGCGGGAAGCCGCAGAGC
CGCTGAGTGAGCCTAAGGAGGACCAGGAAGCCGCAGAGTTGCTGAGTGAGCCCGAAGAAGAATCAGAAAGGCACATCCTTGAGCTTGAAG
AGGTGTATGACTATTTGTATCAGCCTTCTTACAGAAAGTTCATTAAGTTGCACCAGGATCTAAAGTCAGGAGAGGTCACCCTTGCAGAGA
TTGATGTCATCTTCAAGGACTTTGTGAATAAATACACGGACCTGGATTCAGAACTTAAGATCATGTGCACCGTGGACCACCAGGACCAAA
GAGATTGGATCAAGGACCGAGTCGAACAGATCAAGGAATACCATCACCTGCACCAGGCTGTCCACGCAGCCAAGGTCATCTTGCAGGTCA
AAGAGAGCCTGGGACTGAACGGTGACTTCAGTGTTCTCAACACTTTACTAAATTTTACTGATAACTTCGACGACTTTCGCCGTGAAACAC
TGGACCAGATCAACCAGGAGCTCATCCAGGCCAAAAAGCTGCTCCAGGACATCAGCGAGGCCCGGTGCAAGGGGCTGCAGGCTCTGTCCC
TGAGAAAGGAGTTCATCTGCTGGGTCCGGGAGGCTCTTGGAGGCATCAATGAGCTGAAGGTGTTTGTGGACCTGGCCTCCATCTCAGCGG
GGGAGAATGACATTGATGTGGACCGGGTGGCCTGCTTCCATGACGCTGTGCAGGGCTACGCATCCCTGCTATTTAAGCTGGACCCCAGCG
TGGACTTCAGTGCATTCATGAAGCATCTGAAAAAGCTGTGGAAGGCTCTGGATAAGGACCAGTACCTGCCCAGGAAACTGTGTGACTCCG
CCAGGAACTTGGAATGGCTGAAGACTGTGAATGAGAGTCATGGGTCTGTGGAACGCTCATCCCTGACCCTGGCCACGGCCATCAACCAAA
GAGGCATCTATGTGATCCAGGCGCCCAAAGGTGGCCAAAAGATTTCCCCAGACACGGTTCTGCACTTGATCCTTCCTGAGAGCCCTGGCA
GCCACGAGGAGTCACGAGAGTACTCTTTAGAGGAGGTGAAGGAGCTTTTGAACAAGTTGATGCTGATGTCTGGCAAGAAGGATCGTAACA
ACACGGAAGTGGAGAGGTTTTCAGAGGTCTTCTGCAGTGTGCAGAGGCTCAGCCAGGCCTTCATCGACCTGCACTCTGCTGGGAATATGC
TGTTCAGGACGTGGATCGCCATGGCCTACTGCTCCCCCAAGCAGGGTGTGTCCCTCCAAATGGACTTTGGCTTGGACCTGGTGACGGAGC
TTAAAGAAGGTGGAGATGTCACTGAGCTGCTGGCAGCCCTCTGCAGGCAGATGGAGCACTTCCTTGACAGCTGGAAGAGATTTGTGACCC
AGAAGCGAATGGAGCACTTTTACCTGAACTTCTACACGGCAGAGCAGCTGGTTTACCTGAGCACTGAGCTCAGGAAGCAGCCCCCGAGTG
ATGCCGCCCTAACGATGCTATCCTTCATCAAAAGCAACTGCACCCTGAGGGATGTCTTAAGGGCCTCTGTGGGGTGTGGGAGTGAGGCCG
CCAGGTACCGCATGAGGAGAGTCATGGAAGAGCTCCCGCTGATGCTCTTATCAGAGTTCAGCCTGGTGGACAAGCTGAGGATCATCATGG
AGCAGTCCATGAGGTGCCTTCCTGCCTTCCTGCCCGACTGCCTCGACCTAGAGACCCTTGGCCACTGTCTGGCTCACCTGGCAGGGATGG
GTGGGTCTCCCGTGGAGCGTTGTCTCCCGAGAGGTCTGCAGGTCGGCCAGCCCAACCTCGTCGTCTGTGGCCACTCCGAGGTGTTGCCAG
CCGCCCTGGCTGTCTACATGCAAACCCCAAGCCAGCCCCTGCCCACTTACGATGAGGTGCTGCTCTGCACCCCGGCAACCACCTTTGAGG
AGGTGGCACTGTTGCTGCGCCGCTGCCTGACCCTGGGCTCCCTGGGGCACAAGGTCTACAGCCTGCTGTTCGCAGATCAGCTGAGCTACG
AGGTGGCACGCCAAGCGGAGGAGCTTTTCCACAATCTGTGCACGCAGCAGCACCGAGAAGACTACCAGCTCGTCATGGTCTGTGATGGGG
ACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAGGCCATCCAAGCCTACC
TGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGGATCGTGGCCTCGGAGC
GAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAATGTGCCTCTGAAAACAA
TTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTATCAGAAGGTCCCCGTGC
TCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAATACTTAATGGATATAA
ATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCGTCGAGGAGCTCTTCAG
CGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAGGTGATAGACATGGAGC
TGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCTTACCAGTATTTAAGAC
GATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGCCTCCAGCATTTCCTGT
TTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGAGATTGTGAGGCCTCTC
TCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTTATGGCAAGAGATTTTG
CCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAAGATCTAGCGCCCTTCT
CCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTCATCGGCTTCCATCTGC
AGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACCAGGGACCTGTACCAGG
GCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTCTGCCTGACCTTAGGGA
TCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAGATGCGGTTCCGGTGTG
GGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGGCGTGGTGGTACCAATG
CTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCTGAAAATGTGGCCTTCG
CCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGTATCAAAGAAGTCCTGT
GTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATACCGGAAGCACTCTGAGG
AGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGCTCCATTCCTCTGAGGC
AGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGACGTTGCTGAAAAGCTCT
ACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAAGTCCTCTGCGCCTCTC
AGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTTTTCAGGTGGTTCCACG
AGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAGAGAGATCCCGTCCTCT
GGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATCGCCAGGTTCTTTCCGA
AACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCTCTGAGGAAAACCATCG
CCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTGGTGGGGAAGCCCGGCA
GCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGCAGCCTGAAGCAGGTCC
ACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGCTTTCAGCAGGGGAAGG
ACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTGAAGACTCTGCACCCGC
TGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGGGCCCTTGACCCTGCCA
AGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATCTGCTCCTCAGACATCC
TCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGACAAGGAATTCTTCGGGC
TTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAAGACATTGCACAGGCTG
TCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAGTGCTCAGAGGAAGTCA
GCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCTGAGTCCCGCTACTTAC
TCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAGATTATTTTTGGTTCTG
GTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGCAAGATGGTGTTGCTTC
TCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAGTACGTGGACCTCGGTC
TGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTGTACAAACACTTTCCCA
TCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATCGTGGAGGAGCTCTGTG
CGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTCTTCATCGGCTACCACT
CGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCACCAGAAGGTGTCTGAGG
AGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGGTTCGCAGCGGAGTGGC
TGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCAGACCTGGAGCGCCACG
CCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTCACAGGCAGGGCTCCGA
AACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACGAATACAGCCAAATGTA
AAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCTGTTATAAATGAAATCA
ACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACAGCCTATGTGGGCTTCC
ACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGGCTGCAGCATGTCACCA
TCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAGGCGATGGAGACGGAGG
CCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAGGAAACCTCTGAACTCG
GAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTCAGAGACCAGAACGAGA
GCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCTTTCTTGCGGGTATCCA
AGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAAGCCTGCAACCAGGACG
CTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCGAGCATGATATCATTCA
TCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTTATTTTCAGTGACACGA
TGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAACCACATGAACCTTTCCG
AGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAGTACATCACAGACGCAG
AAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGAGAGCCGCAGCAGGAAC
TTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTGCAGATGGCTCTGTGGT
CCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCCTACCAGCGTTTCAGAA
GCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGGAACCATGAGCTGGCTG
GATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATTCTGCAGAAGGCCCCGG
CACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCCACCCCGAAGGGCGGAC
TGAGCAAGAGCTCCAGCAGGACGTACGCCAAGCGCTGACGCGGCGCTCGGGCTCCTTGGTCTCTGTGAGGGATGGAGCGGGTCTCCTGAT
TCTACACCATCTCTCCAGAACTCTCTGGCCTTGGTGGCCCCATGCTCTGGCTGCTGTCCCCAGCTCCCCGCCGTGCACGCCTCTTACGCG
TCTGTGCCGTCAGCTCTCGTGCAAACGATATGGATGCAGCTAACCAAAGATCCTGCGTGCAGTGCCAGGACCTGGCCGCACTGTACATTA
AGCCTTCAGGGCTGTCTCAGGCCTTCCTTAGAATCAGAGAAGGAAGCGTCCTGTTTGGAGAGAGCCAGAGAGCACCGCCGGGAGGCGCTC
GCGCAAGGCCACGGTCAGCACAGGCACGGTCCCGCTTTCCTTAGTGCTTGGAGCAATTTCCATAAAACATTCACCAGAAACCTTTTGCAC
ATCGGTCTCTGCCACACGCAGTAGAATTTCCGCAGGGCTGTGGCTCGGCCAGCAGCGGTTCCAGGAGAGTGGCGGTGCGCACGGGCCTCC
AGCCGTGCCTTCCCCCTGCAGGCCCCGTCTGCTGGGCCTGCTGCCCAGTGCACTCAGCCCCAGGTAGCAGAACTCACGTTCCCACTATAG
CAAGAAATAAAGGCAAAAGAGAACATCTTTTTTTTAATCGTAGTTTTTTTGAGAATTGGTCCCACCTCAGCCGCACCTTGCTGGATGCTT
CTCCAGTAGTGCTGCCCCTGTGACAGGCATCAGCTCCCTGCTGGAACTGAGGTAGACACAGGTGTGGGCCCTTCCCGTGCCTTTGCTCAG
AGGCGCTTCACTTTCTCCACACTTTCGAATTCCTAAAGACATGTGGAGGAAGTCACTGTTAAATGAATTTCCACCTGATCACCCTGTGTT
CACAGCAGGCAGAAGCCCACTGGTATGGGCCTCCCGCCCCTTCCACATCCATGTTGTGATTGGATCCATAAGTTTACTTTCTTCAAAGAG
TTGATAGGATGTTTAAAACATCAACACATTGCTTAAAATGATGAAACCAACCCTCAAAAAACAGTCTCCTAACCAGCCATCCCCTCCTGT
GGGAGTGAGCTGGGGGTTTTGTCCATAGCTTTGGTTGGGCCTGTGTCACATCCAGGCAGCCATGTGGAGGGAGTCAGGGTCTGTCTGGAA
GCATCCACCCTCTCGCTGCCCCAGCCTGTGCTCCCAGGGGCCTAGGCTACCATGGACTGAAGGGCAGTCCCCTCCCACCTGGTGCCCAGG
GCTTCTGCTTGCCTCGCTGATGTTGCATGGGCAGACTTCAAAAAGGATAGTTAGAAAGGTTTGGGTTGATGGAGTTTGCATTAATGCAAT
TAGTGTATAAATATGTTTTAATTGCCAACCGTGTGAAACAACAAAATATCTAAAAACTAATCCCGATTTGAACAATGTACTCCCTGGCCT
GGATACATTAATAACCATAAATTTGCATGAATTAATCTCCACGTTTGGTAAACTAATACCTCTGGTTGACTGAGAATACTGAGTAAGATA
TAAGACCTACCAGGAACCTTTAAGAATATGCTCTGCTCAGTGTTGTTTGTCTGCTTGTTTGCGACGGAGTCTCACTGTGTCGCCCGGGCT
GCAGTGCAATGGCGTGATCTTGGCTCACAGTAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGAT
TACAGGTGCACACCACCATGCTCGGCTAATTTTTTCTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCG
TGACCTCATAATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGGTTAAATGTGTTTATAAGGAG
AGAGGAGGCCAGGCGCGGTGGCTCACGCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGACCACCTGAGGTCAGGAGTTCGAGAC
CAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCCTGTAGTCCCAGCTACTTGAGAGG
CTGAGGCAGGAAAATTGCTTGAACCCGGGAGGTGGAGGTTGCATTGAGCCCACATCATGCCATTGCACTCCAGCCCAGGCGACAGAGCGA
GACTCCGTCTCGAAAAAAAAAAAAAGTATAAGGAGAGAAATAACTTTAAAGTTTATTAGACAAAACAGAGTATAGATGCCAAGATGTCTG
TAAAATGATTTTTTCTGGTTTTAAAGAGATGTTGGCCATTATTTTCTAATCCATTTTTAAAATACAGACAAAACACTTCTTTAAACAGAA
CAAGAATGAGAAAAGTTAACCAAGGAATTATTCTTTTCTCACCAATCAACACTTTTAAGAAATATATATATATATATACACACATATACA
CATGCCTTCTATATATTGTAACTTAAAGAAAATACTTATAAAAAGACTTCATTTTTAGTGATTGACAAGCAAACGGGTTCATTTAAAACA
GGTTCCTCTTTTGTTAGTTACAGGGGGTTTTTTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTGCGGGGGTGGTGGGGTTTGAGACGGAGT
CTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCGCGATCTTGGCCCCCTGCAACCTCCGCCTCCCGGGTTCGAGCAATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGATTACAGGCGTGTGTCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATATTG
GCCAGGCTGGTCTCAAACTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGGCATGAGCCACCGCGCCCGG
CCCAATCATGTGTTTTTGTTGAAATGATCCTACCAGTGATTAGTGGCTATTGAGAGTTTTACAGGGTTATACATTGTTAAGGGACCAAGA
ATCAAGTACAAAAAATTAAAAAGGAACTGTAAAATCCCTTGGTCATTCATAAATAAATATCTAAATTAGGAATACTAATTAATTGAATTT
TCACTCATGAGTATGTTCTGAATATTTAATATTTATTTCTATTATTTTCATATGTTAAGATATTCCATTAAATCTAACTTAAAAGAATTG
TATGTATAAATTGGCATTAGGATACAAATGTAAATGTTTTTAATGAAATTTTGCAACTTTTTAATATTTTAACATAGTTTTCTATTTGTC
TTTATTTCAAGTACCAGAATTACAAAATATCTAAGTAATATATTTTTGTTGTCGTTTTAGGGCTTAAGGGTTAATTCACCCAGAGTATAT

>In-frame_RNF213_ENST00000336301_chr17_78337114_+_CEP104_ENST00000378230_chr1_3732934_-_9315nt
ATGGTCTGTGATGGGGACTGGGAGCACTGCTACCTCCCCTCTGCCTTCAGCCAGCACAAGGTCTTCGTCACCCCCCAGGCACCCCTCGAG
GCCATCCAAGCCTACCTGGCAGGTCACTACCGGGTCCCGAAGCAGACCCTGTCGGCGGCAGCCGTGTTCAATGACCGGCTGTGTGTTGGG
ATCGTGGCCTCGGAGCGAGCAGGTGTTGGAAAGTCTCTGTACGTGAAGAGGTTGCACGACAAAATGAAGATGCAGTTAAACGTGAAAAAT
GTGCCTCTGAAAACAATTCGACTGATCGACCCTCAGGTGGATGAGAGCCGAGTCCTGGGCGCCCTGCTGCCCTTCCTGGATGCGCAGTAT
CAGAAGGTCCCCGTGCTCTTTCACCTGGACGTGACCTCCTCAGTGCAGACTGGAATTTGGGTGTTTCTTTTCAAGCTCCTCATTTTACAA
TACTTAATGGATATAAATGGGAAAATGTGGCTTCGGAACCCCTGCCATTTGTATATCGTTGAAATCCTGGAAAGGAGGACGTCAGTGCCG
TCGAGGAGCTCTTCAGCGCTGCGTACACGTGTACCCCAGTTCAGTTTTCTTGACATCTTCCCAAAAGTCACCTGCAGGCCTCCCAAAGAG
GTGATAGACATGGAGCTGAGTGCCCTGAGGAGTGACACAGAGCCTGGGATGGATCTGTGGGAGTTCTGCAGCGAAACTTTCCAAAGACCT
TACCAGTATTTAAGACGATTCAATCAAAACCAAGACCTAGACACGTTTCAGTATCAAGAAGGCTCTGTCGAAGGCACCCCGGAGGAATGC
CTCCAGCATTTCCTGTTTCACTGCGGGGTAATAAACCCATCCTGGTCAGAGCTTCGGAACTTTGCTCGGTTCCTGAATTATCAGCTCAGA
GATTGTGAGGCCTCTCTCTTCTGCAATCCGAGTTTTATTGGCGACACACTGAGGGGCTTCAAGAAGTTCGTGGTGACCTTCATGATCTTT
ATGGCAAGAGATTTTGCCACACCATCACTCCACACCTCTGACCAAAGCCCGGGGAAGCACATGGTCACCATGGATGGGGTTAGGGAAGAA
GATCTAGCGCCCTTCTCCCTCCGGAAGAGGTGGGAGTCGGAGCCTCACCCATACGTTTTCTTCAATGACGACCACACAACCATGACATTC
ATCGGCTTCCATCTGCAGCCCAACATCAACGGCAGTGTCGATGCCATCAGTCACTTGACTGGGAAGGTCATCAAGAGAGACGTCATGACC
AGGGACCTGTACCAGGGCCTGCTGCTCCAGAGGGTGCCCTTCAATGTCGACTTTGATAAACTGCCCAGACACAAGAAACTTGAGAGGCTC
TGCCTGACCTTAGGGATCCCCCAGGCCACCGACCCCGACAAAACGTATGAGCTCACAACCGACAATATGCTTAAAATCCTTGCCATCGAG
ATGCGGTTCCGGTGTGGGATCCCGGTTATCATCATGGGAGAAACTGGCTGTGGGAAAACCAGGCTTATTAAATTCCTTAGCGACCTGCGG
CGTGGTGGTACCAATGCTGACACCATAAAGCTGGTCAAGGTGCACGGAGGAACAACTGCAGACATGATCTACTCCAGAGTCAGGGAGGCT
GAAAATGTGGCCTTCGCCAATAAGGACCAACATCAGTTGGACACCATCTTGTTTTTTGATGAAGCCAACACAACGGAAGCTATAAGCTGT
ATCAAAGAAGTCCTGTGTGATCATATGGTGGATGGCCAGCCTCTGGCTGAGGACTCTGGCCTGCATATTATAGCTGCCTGCAATCCATAC
CGGAAGCACTCTGAGGAGATGATCTGCCGTTTGGAGTCAGCTGGTTTGGGCTACAGGGTTAGTATGGAGGAGACGGCCGACAGGCTGGGC
TCCATTCCTCTGAGGCAGCTGGTATACCGGGTCCATGCTCTGCCCCCGAGCCTGATTCCTCTGGTGTGGGACTTTGGACAACTGAGTGAC
GTTGCTGAAAAGCTCTACATCCAGCAGATTGTCCAGAGACTGGTTGAGTCCATCAGCCTAGATGAAAACGGGACTCGCGTGATCACAGAA
GTCCTCTGCGCCTCTCAGGGTTTCATGAGGAAAACAGAAGATGAGTGCAGCTTTGTCAGCCTCAGGGACGTGGAGCGCTGTGTGAAAGTT
TTCAGGTGGTTCCACGAGCACAGCGCGATGCTCTTAGCGCAGCTGAATGCCTTTCTCTCCAAGTCCAGCGTCAGCAAAAATCACACCGAG
AGAGATCCCGTCCTCTGGTCGTTGATGCTGGCCATCGGGGTGTGTTACCATGCCTCTTTAGAAAAGAAAGACTCATATCGGAAAGCCATC
GCCAGGTTCTTTCCGAAACCGTATGACGACAGCAGGCTGCTTCTGGATGAAATAACACGGGCACAGGATCTTTTTCTGGACGGCGTACCT
CTGAGGAAAACCATCGCCAAGAACTTGGCCTTGAAGGAGAACGTCTTCATGATGGTCGTCTGCATCGAGCTGAAGATTCCCCTCTTCCTG
GTGGGGAAGCCCGGCAGCTCCAAGTCTCTCGCCAAGACCATCGTGGCAGACGCCATGCAGGGCCCGGCTGCCTACTCAGATCTCTTCCGC
AGCCTGAAGCAGGTCCACCTGGTGTCCTTCCAGTGCAGCCCGCACTCCACCCCACAGGGCATCATCAGCACCTTCCGGCAGTGCGCCCGC
TTTCAGCAGGGGAAGGACCTGCAGCAGTACGTCTCTGTGGTGGTGTTAGATGAGGTGGGGCTGGCGGAAGACTCACCCAAAATGCCCCTG
AAGACTCTGCACCCGCTGCTGGAAGACGGATGCATTGAAGACGATCCCGCCCCCCACAAAAAGGTCGGCTTCGTGGGCATCTCCAACTGG
GCCCTTGACCCTGCCAAGATGAACCGGGGCATTTTTGTGTCACGTGGCAGCCCCAACGAGACAGAGCTCATAGAGAGCGCCAAGGGCATC
TGCTCCTCAGACATCCTCGTCCAGGACCGAGTCCAAGGGTACTTTGCGTCCTTTGCCAAAGCCTACGAAACGGTGTGTAAGCGCCAGGAC
AAGGAATTCTTCGGGCTTCGTGACTACTACAGCCTCATCAAAATGGTCTTTGCTGCAGCAAAGGCTTCAAATAGAAAGCCTTCCCCGCAA
GACATTGCACAGGCTGTCCTTAGGAACTTCAGTGGCAAGGATGACATCCAAGCTTTGGACATCTTTCTGGCCAATTTGCCCGAGGCCAAG
TGCTCAGAGGAAGTCAGCCCCATGCAGCTGATCAAACAGAACATCTTTGGGCCTTCTCAGAAGGTGCCGGGTGGAGAGCAGGAAGATGCT
GAGTCCCGCTACTTACTCGTGCTGACCAAAAACTACGTGGCACTGCAGATCCTGCAGCAGACATTCTTCGAGGGGGACCAGCAGCCGGAG
ATTATTTTTGGTTCTGGTTTCCCCAAGGACCAAGAGTACACCCAGCTCTGCAGAAACATCAATCGTGTGAAGATCTGCATGGAAACAGGC
AAGATGGTGTTGCTTCTCAACCTGCAGAACCTCTACGAGAGCCTCTACGACGCACTCAACCAGTACTACGTCCACCTCGGCGGCCAGAAG
TACGTGGACCTCGGTCTGGGGACCCACCGCGTCAAATGTCGGGTTCACCCCAACTTCCGCCTGATTGTCATTGAAGAGAAAGACGTCGTG
TACAAACACTTTCCCATCCCCCTCATTAACCGGCTGGAGAAGCACTATCTGGATATCAACACGGTGCTGGAGAAATGGCAGAAGAGCATC
GTGGAGGAGCTCTGTGCGTGGGTGGAGAAGTTCATCAATGTCAAAGCACATCATTTCCAGAAGAGGCACAAATACAGCCCCTCTGACGTC
TTCATCGGCTACCACTCGGACGCCTGCGCGTCTGTGGTGCTGCAGGTCATAGAGAGGCAGGGTCCCCGGGCCTTGACGGAGGAACTTCAC
CAGAAGGTGTCTGAGGAGGCCAAATCGATCCTGCTGAACTGCGCTACGCCCGATGCCGTGGTCCGGCTGAGCGCCTACTCGCTGGGCGGG
TTCGCAGCGGAGTGGCTGTCGCAGGAGTACTTTCACAGACAGAGGCACAACTCCTTTGCAGATTTCCTTCAGGCACACCTGCACACGGCA
GACCTGGAGCGCCACGCCATCTTCACAGAGATCACCACTTTCTCCAGGCTGCTAACAAGTCACGACTGTGAAATTTTAGAATCAGAGGTC
ACAGGCAGGGCTCCGAAACCCACACTCCTGTGGCTGCAGCAGTTTGACACCGAGTACTCATTCCTCAAAGAAGTCCGAAACTGTTTAACG
AATACAGCCAAATGTAAAATCCTCATTTTTCAGACAGATTTTGAAGATGGAATCCGTAGCGCCCAGCTCATTGCCTCAGCTAAGTATTCT
GTTATAAATGAAATCAACAAAATACGAGAAAATGAGGACCGTATCTTCGTCTATTTCATCACAAAACTGTCCCGGGTGGGAAGAGGAACA
GCCTATGTGGGCTTCCACGGAGGGCTGTGGCAGTCTGTCCACATCGATGACCTCCGGAGATCCACCCTCATGGTTTCTGATGTGACCAGG
CTGCAGCATGTCACCATCAGCCAGCTGTTCGCGCCCGGAGACTTGCCTGAGCTGGGCTTGGAACACCGGGCGGAAGACGGCCATGAGGAG
GCGATGGAGACGGAGGCCAGCACATCAGGGGAGGTGGCAGAGGTGGCAGAGGAGGCCATGGAAACAGAAAGTTCTGAGAAGGTGGGAAAG
GAAACCTCTGAACTCGGAGGCAGTGATGTGTCGATCCTGGACACCACCAGGCTGCTGAGAAGCTGTGTGCAGAGCGCCGTGGGCATGCTC
AGAGACCAGAACGAGAGCTGCACGCGCAATATGCGGAGGGTGGTGCTCCTCCTGGGCCTCTTGAATGAGGATGACGCGTGCCACGCCTCT
TTCTTGCGGGTATCCAAGATGCGCCTCAGTGTCTTTTTAAAGAAGCAAGAAGAGAGCCAGTTTCACCCTCTGGAGTGGTTGGCAAGGGAA
GCCTGCAACCAGGACGCTCTCCAGGAGGCGGGCACATTCAGGCACACCCTCTGGAAGCGGGTCCAAGGTGCTGTCACCCCTCTGCTGGCG
AGCATGATATCATTCATCGACAGAGACGGCAACCTAGAGTTACTGACCAGGCCAGATACTCCGCCCTGGGCAAGAGATCTTTGGATGTTT
ATTTTCAGTGACACGATGCTTCTGAACATTCCTCTTGTGATGAATAATGAAAGACATAAAGGTGAGATGGCCTACATCGTGGTGCAGAAC
CACATGAACCTTTCCGAGAACGCTTCCAACAACGTCCCTTTCAGCTGGAAAATCAAGGACTATCTGGAGGAGCTGTGGGTCCAGGCTCAG
TACATCACAGACGCAGAAGGACTGCCCAAGAAGTTCGTGGACATCTTTCAGCAGACTCCTCTGGGCAGGTTTCTTGCCCAGCTCCATGGA
GAGCCGCAGCAGGAACTTCTTCAGTGTTACTTGAAGGATTTCATTCTCTTGACCATGCGTGTGTCAACGGAGGAGGAATTAAAGTTTCTG
CAGATGGCTCTGTGGTCCTGCACTAGGAAACTGAAAGCGGCGTCAGAAGCGCCCGAGGAAGAGGTTTCCTTACCGTGGGTGCACCTTGCC
TACCAGCGTTTCAGAAGCCGTCTGCAGAACTTTTCCAGAATCCTGACCATCTACCCTCAGGTTCTCCACAGCCTGATGGAAGCCCGTTGG
AACCATGAGCTGGCTGGATGTGAGATGGCATGGAAAGCTCACCTGATGGGCCCAGCCGGCTGCACGATGAACCTGCGCAAGACACACATT
CTGCAGAAGGCCCCGGCACTGCAGCCAGGGAAAAGCTCAGCTGTGGCCGCATCAGGCCCCTTGGGGTCAAAGGCCGGAAGCAAGATCCCC
ACCCCGAAGGGCGGACTGAGCAAGAGCTCCAGCAGGACGTACGCCAAGCGCTGACGCGGCGCTCGGGCTCCTTGGTCTCTGTGAGGGATG
GAGCGGGTCTCCTGATTCTACACCATCTCTCCAGAACTCTCTGGCCTTGGTGGCCCCATGCTCTGGCTGCTGTCCCCAGCTCCCCGCCGT
GCACGCCTCTTACGCGTCTGTGCCGTCAGCTCTCGTGCAAACGATATGGATGCAGCTAACCAAAGATCCTGCGTGCAGTGCCAGGACCTG
GCCGCACTGTACATTAAGCCTTCAGGGCTGTCTCAGGCCTTCCTTAGAATCAGAGAAGGAAGCGTCCTGTTTGGAGAGAGCCAGAGAGCA
CCGCCGGGAGGCGCTCGCGCAAGGCCACGGTCAGCACAGGCACGGTCCCGCTTTCCTTAGTGCTTGGAGCAATTTCCATAAAACATTCAC
CAGAAACCTTTTGCACATCGGTCTCTGCCACACGCAGTAGAATTTCCGCAGGGCTGTGGCTCGGCCAGCAGCGGTTCCAGGAGAGTGGCG
GTGCGCACGGGCCTCCAGCCGTGCCTTCCCCCTGCAGGCCCCGTCTGCTGGGCCTGCTGCCCAGTGCACTCAGCCCCAGGTAGCAGAACT
CACGTTCCCACTATAGCAAGAAATAAAGGCAAAAGAGAACATCTTTTTTTTAATCGTAGTTTTTTTGAGAATTGGTCCCACCTCAGCCGC
ACCTTGCTGGATGCTTCTCCAGTAGTGCTGCCCCTGTGACAGGCATCAGCTCCCTGCTGGAACTGAGGTAGACACAGGTGTGGGCCCTTC
CCGTGCCTTTGCTCAGAGGCGCTTCACTTTCTCCACACTTTCGAATTCCTAAAGACATGTGGAGGAAGTCACTGTTAAATGAATTTCCAC
CTGATCACCCTGTGTTCACAGCAGGCAGAAGCCCACTGGTATGGGCCTCCCGCCCCTTCCACATCCATGTTGTGATTGGATCCATAAGTT
TACTTTCTTCAAAGAGTTGATAGGATGTTTAAAACATCAACACATTGCTTAAAATGATGAAACCAACCCTCAAAAAACAGTCTCCTAACC
AGCCATCCCCTCCTGTGGGAGTGAGCTGGGGGTTTTGTCCATAGCTTTGGTTGGGCCTGTGTCACATCCAGGCAGCCATGTGGAGGGAGT
CAGGGTCTGTCTGGAAGCATCCACCCTCTCGCTGCCCCAGCCTGTGCTCCCAGGGGCCTAGGCTACCATGGACTGAAGGGCAGTCCCCTC
CCACCTGGTGCCCAGGGCTTCTGCTTGCCTCGCTGATGTTGCATGGGCAGACTTCAAAAAGGATAGTTAGAAAGGTTTGGGTTGATGGAG
TTTGCATTAATGCAATTAGTGTATAAATATGTTTTAATTGCCAACCGTGTGAAACAACAAAATATCTAAAAACTAATCCCGATTTGAACA
ATGTACTCCCTGGCCTGGATACATTAATAACCATAAATTTGCATGAATTAATCTCCACGTTTGGTAAACTAATACCTCTGGTTGACTGAG
AATACTGAGTAAGATATAAGACCTACCAGGAACCTTTAAGAATATGCTCTGCTCAGTGTTGTTTGTCTGCTTGTTTGCGACGGAGTCTCA
CTGTGTCGCCCGGGCTGCAGTGCAATGGCGTGATCTTGGCTCACAGTAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCT
CCCTAGTAGCTGGGATTACAGGTGCACACCACCATGCTCGGCTAATTTTTTCTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAG
GCTGGTCTCGAACTCGTGACCTCATAATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGGTTAA
ATGTGTTTATAAGGAGAGAGGAGGCCAGGCGCGGTGGCTCACGCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGACCACCTGAG
GTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATGAGCCAGGCGTGGTGGCCTGTAGTC
CCAGCTACTTGAGAGGCTGAGGCAGGAAAATTGCTTGAACCCGGGAGGTGGAGGTTGCATTGAGCCCACATCATGCCATTGCACTCCAGC
CCAGGCGACAGAGCGAGACTCCGTCTCGAAAAAAAAAAAAAGTATAAGGAGAGAAATAACTTTAAAGTTTATTAGACAAAACAGAGTATA
GATGCCAAGATGTCTGTAAAATGATTTTTTCTGGTTTTAAAGAGATGTTGGCCATTATTTTCTAATCCATTTTTAAAATACAGACAAAAC
ACTTCTTTAAACAGAACAAGAATGAGAAAAGTTAACCAAGGAATTATTCTTTTCTCACCAATCAACACTTTTAAGAAATATATATATATA
TATACACACATATACACATGCCTTCTATATATTGTAACTTAAAGAAAATACTTATAAAAAGACTTCATTTTTAGTGATTGACAAGCAAAC
GGGTTCATTTAAAACAGGTTCCTCTTTTGTTAGTTACAGGGGGTTTTTTTGTTGTTTTTTTGTTTTTGTTTTTGTTTTGCGGGGGTGGTG
GGGTTTGAGACGGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCGCGATCTTGGCCCCCTGCAACCTCCGCCTCCCGGGTTCGAG
CAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGTCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACG
GGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCCTGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGGCAT
GAGCCACCGCGCCCGGCCCAATCATGTGTTTTTGTTGAAATGATCCTACCAGTGATTAGTGGCTATTGAGAGTTTTACAGGGTTATACAT
TGTTAAGGGACCAAGAATCAAGTACAAAAAATTAAAAAGGAACTGTAAAATCCCTTGGTCATTCATAAATAAATATCTAAATTAGGAATA
CTAATTAATTGAATTTTCACTCATGAGTATGTTCTGAATATTTAATATTTATTTCTATTATTTTCATATGTTAAGATATTCCATTAAATC
TAACTTAAAAGAATTGTATGTATAAATTGGCATTAGGATACAAATGTAAATGTTTTTAATGAAATTTTGCAACTTTTTAATATTTTAACA
TAGTTTTCTATTTGTCTTTATTTCAAGTACCAGAATTACAAAATATCTAAGTAATATATTTTTGTTGTCGTTTTAGGGCTTAAGGGTTAA


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FusionGenePPI for RNF213_CEP104


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF213UBC, CBX2, CBX4, CBX6, EGFR, PLAC9, RNF213, TRIM23, GOLGA2, REL, TRIM27, TRIP6, UBXN11, KRT40, CD244, SCN2B, IFI16, PTPN1, MRPL50, RNASEH2B, GAN, MCM2, ATOH1, DLK2, SIGLECL1, SDC2, LAMP3, CYLDCEP104CEP97, ADSL, AHCY, ALMS1, AP4E1, AP4S1, APBB1, ARPC3, CEP131, C21orf2, CACYBP, CALM2, CAMSAP1, CAMSAP2, CC2D1A, CCDC138, CCDC66, CCP110, CDC37, CEP162, CEP170, CEP290, CEP350, CEP76, CKAP2, CSPP1, DAPK3, DLG5, ERC1, FAM179B, GPATCH1, GRM5, HAUS3, HAUS6, HAUS7, HAUS8, HERC2, HSPH1, IRAK1, KIAA1524, KIAA1671, KIF14, LRRC49, LUZP1, MAP7D3, MAPRE1, MAPRE2, MB21D2, MPHOSPH9, MTUS1, NEDD1, NEK1, NME7, NUDCD2, NUDCD3, OFD1, P4HB, PCM1, PLK1, RPAP3, SKA3, SSX2IP, SUGT1, TCHP, TJP1, TNRC6B, TP53BP2, UPF1, UXT, WDR83, XRN1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF213_CEP104


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF213_CEP104


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF213C1846689MOYAMOYA DISEASE 23UNIPROT