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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31514

FusionGeneSummary for RNF213_BAIAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF213_BAIAP2
Fusion gene ID: 31514
HgeneTgene
Gene symbol

RNF213

BAIAP2

Gene ID

57674

10458

Gene namering finger protein 213BAI1 associated protein 2
SynonymsALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57BAP2|FLAF3|IRSP53
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterinbrain-specific angiogenesis inhibitor 1-associated protein 2IRS-58IRSp53/58fas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate protein of 53 kDa
Modification date2018052720180523
UniProtAcc

Q63HN8

Q9UQB8

Ensembl transtripts involved in fusion geneENST00000508628, ENST00000456466, 
ENST00000582970, ENST00000319921, 
ENST00000336301, ENST00000427003, 
ENST00000392411, ENST00000321280, 
ENST00000428708, ENST00000575712, 
ENST00000575245, ENST00000435091, 
ENST00000321300, ENST00000573894, 
ENST00000416299, 
Fusion gene scores* DoF score22 X 22 X 12=580810 X 7 X 6=420
# samples 3010
** MAII scorelog2(30/5808*10)=-4.27500704749987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF213 [Title/Abstract] AND BAIAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF213

GO:0016567

protein ubiquitination

21799892

HgeneRNF213

GO:0051260

protein homooligomerization

24658080|26126547

HgeneRNF213

GO:0051865

protein autoubiquitination

21799892


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A3IQ-01ARNF213chr17

78272318

+BAIAP2chr17

79058632

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000508628ENST00000392411RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000508628ENST00000321280RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000508628ENST00000428708RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000508628ENST00000575712RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000508628ENST00000575245RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000508628ENST00000435091RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000508628ENST00000321300RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-3UTRENST00000508628ENST00000573894RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-intronENST00000508628ENST00000416299RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000392411RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000321280RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000428708RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000575712RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000575245RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000435091RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000456466ENST00000321300RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-3UTRENST00000456466ENST00000573894RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-intronENST00000456466ENST00000416299RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000392411RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000321280RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000428708RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000575712RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000575245RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000435091RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000582970ENST00000321300RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-3UTRENST00000582970ENST00000573894RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-intronENST00000582970ENST00000416299RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000392411RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000321280RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000428708RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000575712RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000575245RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000435091RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-5UTRENST00000319921ENST00000321300RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-3UTRENST00000319921ENST00000573894RNF213chr17

78272318

+BAIAP2chr17

79058632

+
5CDS-intronENST00000319921ENST00000416299RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000392411RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000321280RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000428708RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000575712RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000575245RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000435091RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000336301ENST00000321300RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-3UTRENST00000336301ENST00000573894RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-intronENST00000336301ENST00000416299RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000392411RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000321280RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000428708RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000575712RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000575245RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000435091RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-5UTRENST00000427003ENST00000321300RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-3UTRENST00000427003ENST00000573894RNF213chr17

78272318

+BAIAP2chr17

79058632

+
intron-intronENST00000427003ENST00000416299RNF213chr17

78272318

+BAIAP2chr17

79058632

+

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FusionProtFeatures for RNF213_BAIAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF213

Q63HN8

BAIAP2

Q9UQB8

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of theactin cytoskeleton by WASF family members and the Arp2/3 complex.Plays a role in neurite growth. Acts syngeristically with ENAH topromote filipodia formation. Plays a role in the reorganization ofthe actin cytoskeleton in response to bacterial infection.Participates in actin bundling when associated with EPS8,promoting filopodial protrusions. {ECO:0000269|PubMed:11130076,ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106,ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF213_BAIAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF213_BAIAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF213UBC, CBX2, CBX4, CBX6, EGFR, PLAC9, RNF213, TRIM23, GOLGA2, REL, TRIM27, TRIP6, UBXN11, KRT40, CD244, SCN2B, IFI16, PTPN1, MRPL50, RNASEH2B, GAN, MCM2, ATOH1, DLK2, SIGLECL1, SDC2, LAMP3, CYLDBAIAP2NCKIPSD, EPS8, YWHAG, C14orf1, SHANK1, CDC42, ENAH, ATN1, WASF1, WASF2, RAC1, PAK1, NEDD4, BRD4, APP, RHOA, YWHAE, RTN4, WASL, SRPK2, YWHAB, HECW2, KDM1A, WWOX, MARK2, TP53BP2, SF3B4, BAIAP2, PRR13, C19orf25, ZDHHC17, EGFR, NCK2, NCKAP1, CYFIP2, CYFIP1, BAIAP2L1, RAP1GDS1, KIAA1522, ABI1, GRB10, PCM1, NIN, CRY1, CSNK1E, DECR1, MPZL1, RAB11FIP2, PPIL2, TFB1M, RBM26, CHMP6, RAB11FIP1, BAI1, CDH1, PTPRA, PTPRE, KCTD3, KIF13B, ZBTB21, KSR1, CBY1, RAB3IP, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF213_BAIAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF213_BAIAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF213C1846689MOYAMOYA DISEASE 23UNIPROT