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Fusion gene ID: 31495 |
FusionGeneSummary for RNF185_STEAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF185_STEAP2 | Fusion gene ID: 31495 | Hgene | Tgene | Gene symbol | RNF185 | STEAP2 | Gene ID | 91445 | 261729 |
| Gene name | ring finger protein 185 | STEAP2 metalloreductase | |
| Synonyms | - | IPCA1|PCANAP1|PUMPCn|STAMP1|STMP | |
| Cytomap | 22q12.2 | 7q21.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF185BSK65-MONO1BSK65-MONO2BSK65-PANC1BSK65-PANC2BSK65-TEST1BSK65-TEST2BSK65-TEST3RING-type E3 ubiquitin transferase RNF185 | metalloreductase STEAP2STEAP family member 2, metalloreductaseSixTransMembrane Protein of Prostate 1prostate cancer-associated protein 1protein up-regulated in metastatic prostate cancerprotein upregulated in metastatic prostate cancersix transmembr | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96GF1 | Q8NFT2 | |
| Ensembl transtripts involved in fusion gene | ENST00000426256, ENST00000326132, ENST00000266252, | ENST00000287908, ENST00000394626, ENST00000394622, ENST00000394632, ENST00000394621, ENST00000402625, ENST00000394629, | |
| Fusion gene scores | * DoF score | 10 X 6 X 7=420 | 3 X 3 X 1=9 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RNF185 [Title/Abstract] AND STEAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF185 | GO:0051865 | protein autoubiquitination | 24019521 |
| Tgene | STEAP2 | GO:0006893 | Golgi to plasma membrane transport | 12095985 |
| Tgene | STEAP2 | GO:0006897 | endocytosis | 12095985 |
| Tgene | STEAP2 | GO:0009725 | response to hormone | 12095985 |
| Tgene | STEAP2 | GO:0045055 | regulated exocytosis | 12095985 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA772562 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000426256 | ENST00000287908 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| intron-intron | ENST00000426256 | ENST00000394626 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| intron-3UTR | ENST00000426256 | ENST00000394622 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| intron-intron | ENST00000426256 | ENST00000394632 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| intron-intron | ENST00000426256 | ENST00000394621 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| intron-intron | ENST00000426256 | ENST00000402625 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| intron-intron | ENST00000426256 | ENST00000394629 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-3UTR | ENST00000326132 | ENST00000287908 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000326132 | ENST00000394626 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-3UTR | ENST00000326132 | ENST00000394622 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000326132 | ENST00000394632 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000326132 | ENST00000394621 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000326132 | ENST00000402625 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000326132 | ENST00000394629 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-3UTR | ENST00000266252 | ENST00000287908 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000266252 | ENST00000394626 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-3UTR | ENST00000266252 | ENST00000394622 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000266252 | ENST00000394632 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000266252 | ENST00000394621 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000266252 | ENST00000402625 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
| 3UTR-intron | ENST00000266252 | ENST00000394629 | RNF185 | chr22 | 31602924 | - | STEAP2 | chr7 | 89862813 | - |
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FusionProtFeatures for RNF185_STEAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF185 | STEAP2 |
| E3 ubiquitin-protein ligase that regulates selectivemitochondrial autophagy by mediating 'Lys-63'-linkedpolyubiquitination of BNIP1 (PubMed:21931693). Acts in theendoplasmic reticulum (ER)-associated degradation (ERAD) pathway,which targets misfolded proteins that accumulate in theendoplasmic reticulum (ER) for ubiquitination and subsequentproteasome-mediated degradation (PubMed:27485036). Protects cellsfrom ER stress-induced apoptosis (PubMed:27485036). Responsiblefor the cotranslational ubiquitination and degradation of CFTR inthe ERAD pathway (PubMed:24019521). Preferentially associates withthe E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521).{ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521,ECO:0000269|PubMed:27485036}. | Metalloreductase that has the ability to reduce bothFe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RNF185_STEAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RNF185_STEAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF185_STEAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF185_STEAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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