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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 31466

FusionGeneSummary for RNF168_PCYT1A

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF168_PCYT1A
Fusion gene ID: 31466
HgeneTgene
Gene symbol

RNF168

PCYT1A

Gene ID

165918

5130

Gene namering finger protein 168phosphate cytidylyltransferase 1, choline, alpha
SynonymshRNF168CCTA|CT|CTA|CTPCT|PCYT1|SMDCRD
Cytomap

3q29

3q29

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF168RING-type E3 ubiquitin transferase RNF168ring finger protein 168, E3 ubiquitin protein ligasecholine-phosphate cytidylyltransferase ACCT ACCT-alphaCT ACTP:phosphocholine cytidylyltransferase Aphosphorylcholine transferase A
Modification date2018051920180523
UniProtAcc

Q8IYW5

P49585

Ensembl transtripts involved in fusion geneENST00000318037, ENST00000419333, 
ENST00000292823, ENST00000431016, 
ENST00000491544, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 6 X 5=180
# samples 56
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF168 [Title/Abstract] AND PCYT1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF168

GO:0006302

double-strand break repair

19203578|19203579|22980979

HgeneRNF168

GO:0006511

ubiquitin-dependent protein catabolic process

22373579

HgeneRNF168

GO:0006974

cellular response to DNA damage stimulus

19500350|20550933|22373579|22508508|22980979

HgeneRNF168

GO:0010212

response to ionizing radiation

19203578|19203579

HgeneRNF168

GO:0016567

protein ubiquitination

22373579

HgeneRNF168

GO:0035518

histone H2A monoubiquitination

22980979

HgeneRNF168

GO:0036351

histone H2A-K13 ubiquitination

22980979

HgeneRNF168

GO:0036352

histone H2A-K15 ubiquitination

22980979

HgeneRNF168

GO:0045739

positive regulation of DNA repair

19203578|19203579

HgeneRNF168

GO:0070534

protein K63-linked ubiquitination

22266820

HgeneRNF168

GO:0070535

histone H2A K63-linked ubiquitination

19203578|19203579|19500350


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-WY-A859-01ARNF168chr3

196229744

-PCYT1Achr3

195984758

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318037ENST00000419333RNF168chr3

196229744

-PCYT1Achr3

195984758

-
In-frameENST00000318037ENST00000292823RNF168chr3

196229744

-PCYT1Achr3

195984758

-
In-frameENST00000318037ENST00000431016RNF168chr3

196229744

-PCYT1Achr3

195984758

-
5CDS-5UTRENST00000318037ENST00000491544RNF168chr3

196229744

-PCYT1Achr3

195984758

-

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FusionProtFeatures for RNF168_PCYT1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF168

Q8IYW5

PCYT1A

P49585

E3 ubiquitin-protein ligase required for accumulation ofrepair proteins to sites of DNA damage. Acts with UBE2N/UBC13 toamplify the RNF8-dependent histone ubiquitination. Recruited tosites of DNA damage at double-strand breaks (DSBs) by binding toubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrateubiquitinated histones H2A and H2AX at DNA lesions to thethreshold required for recruitment of TP53BP1 and BRCA1. Alsorecruited at DNA interstrand cross-links (ICLs) sites and promotesaccumulation of 'Lys-63'-linked ubiquitination of histones H2A andH2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia(FA) complex, followed by interstrand cross-link repair. H2Aubiquitination also mediates the ATM-dependent transcriptionalsilencing at regions flanking DSBs in cis, a mechanism to avoidcollision between transcription and repair intermediates. Alsoinvolved in class switch recombination in immune system, via itsrole in regulation of DSBs repair. Following DNA damage, promotesthe ubiquitination and degradation of JMJD2A/KDM4A incollaboration with RNF8, leading to unmask H4K20me2 mark andpromote the recruitment of TP53BP1 at DNA damage sites. Not ableto initiate 'Lys-63'-linked ubiquitination in vitro; possibly dueto partial occlusion of the UBE2N/UBC13-binding region. Catalyzesmonoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histoneH2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578,ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933,ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371,ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833,ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478}. Controls phosphatidylcholine synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-1616_55100572Zinc fingerRING-type
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210168_16939368Nucleotide bindingCTP
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210196_20039368Nucleotide bindingCTP
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-21084_9239368Nucleotide bindingCTP
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19168_16939368Nucleotide bindingCTP
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19196_20039368Nucleotide bindingCTP
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-1984_9239368Nucleotide bindingCTP
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210228_28739368RegionAmphipathic
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210256_28839368RegionNote=3 X 11 AA approximate tandem repeats
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210319_34839368RegionNote=3 X repeats
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19228_28739368RegionAmphipathic
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19256_28839368RegionNote=3 X 11 AA approximate tandem repeats
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19319_34839368RegionNote=3 X repeats
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210319_32439368RepeatNote=1
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210329_33339368RepeatNote=2%3B approximate
TgenePCYT1Achr3:196229744chr3:195984758ENST00000292823-210343_34839368RepeatNote=3
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19319_32439368RepeatNote=1
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19329_33339368RepeatNote=2%3B approximate
TgenePCYT1Achr3:196229744chr3:195984758ENST00000431016-19343_34839368RepeatNote=3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-16115_177100572Compositional biasGlu-rich
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-16110_128100572MotifLR motif 1
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-16143_151100572MotifUMI motif
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-16168_191100572MotifMIU motif 1
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-16439_462100572MotifMIU motif 2
HgeneRNF168chr3:196229744chr3:195984758ENST00000318037-16466_477100572MotifLR motif 2


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FusionGeneSequence for RNF168_PCYT1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000419333_chr3_195984758_-_442aa
MALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHTPRECKL
RASGQESEEVGLTATSSFF__N_S_L__ALCQGNTGRSQQRNSL_ATCESLCRWNI_LISLWSRPSSDASEEPFP_YVPHCGSLQ__AHT
QLQRLHGDERE_AL_RSPALPLRG_GGEECALDADTRVPGRTPD_FCSP__TSLFICWQ__CL_AHQGGRHVCSNTEDRRTLHIRHHHPN
CAGL_CVCEAEPAEGLHSKGAQCQLTQREEIPLAGEG_QSKEESERCGGKVKRICSEGGGKKH_PHSEVGGEVPRIHWKFSGNVWSGRST

>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000292823_chr3_195984758_-_429aa
MALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHTPRECKL
RASGQESEEVGLTATSSFF__N_S_L__ALCQGNTGRSQQRNSL_ATCESLCRWNI_LISLWSRPSSDASEEPFP_YVPHCGSLQ__AHT
QLQRLHGDERE_AL_RSPALPLRG_GGEECALDADTRVPGRTPD_FCSP__TSLFICWQ__CL_AHQGGRHVCSNTEDRRTLHIRHHHPN
CAGL_CVCEAEPAEGLHSKGAQCQLTQREEIPLAGEG_QSKEESERCGGKVKRICSEGGGKKH_PHSEVGGEVPRIHWKFSGNVWSGRST

>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000431016_chr3_195984758_-_429aa
MALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHTPRECKL
RASGQESEEVGLTATSSFF__N_S_L__ALCQGNTGRSQQRNSL_ATCESLCRWNI_LISLWSRPSSDASEEPFP_YVPHCGSLQ__AHT
QLQRLHGDERE_AL_RSPALPLRG_GGEECALDADTRVPGRTPD_FCSP__TSLFICWQ__CL_AHQGGRHVCSNTEDRRTLHIRHHHPN
CAGL_CVCEAEPAEGLHSKGAQCQLTQREEIPLAGEG_QSKEESERCGGKVKRICSEGGGKKH_PHSEVGGEVPRIHWKFSGNVWSGRST


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000419333_chr3_195984758_-_1327nt
ATGGCTCTACCCAAAGACGCCATCCCCTCGCTGTCCGAGTGCCAGTGCGGGATCTGCATGGAAATCCTCGTGGAGCCCGTCACCCTCCCG
TGTAACCACACGCTGTGTAAACCGTGCTTCCAGTCGACCGTCGAAAAGGCGAGTTTATGCTGTCCCTTCTGTCGCCGCCGGGTATCGTCG
TGGACTCGGTACCATACCCGAAGAAATTCTCTCGTCAACGTGGAACTGTGGACGATAATTCAAAAACACTATCCCAGGGAGTGCAAGCTT
AGAGCGTCTGGCCAAGAATCAGAGGAAGTGGGGCTTACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTA
TGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAACTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCA
CTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGAACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACA
CAACTTCAAAGGCTTCACGGTGATGAACGAGAATGAGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGC
GCCCTGGACGCTGACACCCGAGTTCCTGGCCGAACACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGA
TGATGTTTATAAGCACATCAAGGAGGCAGGCATGTTTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAAT
TGTGCGGGATTATGATGTGTATGCGAGGCGGAACCTGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAA
ATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGAAGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGA
AAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGAAGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACT
GAAACATATGCTGAAAGAGGGGAAGGGCCGGATGCTGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTC
CCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCAAGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTA

>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000292823_chr3_195984758_-_1288nt
ATGGCTCTACCCAAAGACGCCATCCCCTCGCTGTCCGAGTGCCAGTGCGGGATCTGCATGGAAATCCTCGTGGAGCCCGTCACCCTCCCG
TGTAACCACACGCTGTGTAAACCGTGCTTCCAGTCGACCGTCGAAAAGGCGAGTTTATGCTGTCCCTTCTGTCGCCGCCGGGTATCGTCG
TGGACTCGGTACCATACCCGAAGAAATTCTCTCGTCAACGTGGAACTGTGGACGATAATTCAAAAACACTATCCCAGGGAGTGCAAGCTT
AGAGCGTCTGGCCAAGAATCAGAGGAAGTGGGGCTTACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTA
TGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAACTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCA
CTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGAACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACA
CAACTTCAAAGGCTTCACGGTGATGAACGAGAATGAGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGC
GCCCTGGACGCTGACACCCGAGTTCCTGGCCGAACACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGA
TGATGTTTATAAGCACATCAAGGAGGCAGGCATGTTTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAAT
TGTGCGGGATTATGATGTGTATGCGAGGCGGAACCTGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAA
ATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGAAGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGA
AAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGAAGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACT
GAAACATATGCTGAAAGAGGGGAAGGGCCGGATGCTGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTC
CCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCAAGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTA

>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000431016_chr3_195984758_-_1288nt
ATGGCTCTACCCAAAGACGCCATCCCCTCGCTGTCCGAGTGCCAGTGCGGGATCTGCATGGAAATCCTCGTGGAGCCCGTCACCCTCCCG
TGTAACCACACGCTGTGTAAACCGTGCTTCCAGTCGACCGTCGAAAAGGCGAGTTTATGCTGTCCCTTCTGTCGCCGCCGGGTATCGTCG
TGGACTCGGTACCATACCCGAAGAAATTCTCTCGTCAACGTGGAACTGTGGACGATAATTCAAAAACACTATCCCAGGGAGTGCAAGCTT
AGAGCGTCTGGCCAAGAATCAGAGGAAGTGGGGCTTACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTA
TGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAACTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCA
CTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGAACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACA
CAACTTCAAAGGCTTCACGGTGATGAACGAGAATGAGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGC
GCCCTGGACGCTGACACCCGAGTTCCTGGCCGAACACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGA
TGATGTTTATAAGCACATCAAGGAGGCAGGCATGTTTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAAT
TGTGCGGGATTATGATGTGTATGCGAGGCGGAACCTGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAA
ATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGAAGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGA
AAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGAAGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACT
GAAACATATGCTGAAAGAGGGGAAGGGCCGGATGCTGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTC
CCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCAAGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000419333_chr3_195984758_-_2094nt
GCTTGTCCGGTGGCTGCTGCGCTGCCGCAACGAATAGGGTTTCTGGCTGCGTAGGAGGGACGGGGGCGCGGAGCTCTGGGAAACTGCGCC
AGGCGCCCGAAAGGTGAACACGGGAGTCGCGCGTCTCCCCCGCAGCAGCGGTAAAGCGGAAGTTATGCTGCAGCCGGAGCCCGGGCTTCC
TCCCGGAGCCGCGTCCCGGGGCCCGGCTGCCCCGAGCTGAGCGGAGCATCCTTTCCGGGTGAGGGGAGGAGAGGACTTGGCGCGTTCCCC
TCGCTGCCCCGGGAGCCGCAGCCGCGGTGTTCATGCCGCGGAGCAGCCAGGCTCCTCCGACGAAAACCTGCATTTATTTGCTGGCGGGAC
GTTTGCCTTGAAAATGGACAAAGACGCCGCCCTCCGGGGTATTCCTGTTTGCCTGACCCTGAGAGCGCCTTTTTGCTTCAAGACGTGTTG
GATGCTCCTGTTCTCCGAATTCTGATACGCTTCTGGGCATAATACTGAAACACAAAACTGCTTTTGCTCTCTCTGTGGTTGGCCGAAAAT
AGGATTCTTTTTCGTGCAGGTGTCGTTGTTTAGTCGGCTTTACTAACATATTGAAATGGCTCTACCCAAAGACGCCATCCCCTCGCTGTC
CGAGTGCCAGTGCGGGATCTGCATGGAAATCCTCGTGGAGCCCGTCACCCTCCCGTGTAACCACACGCTGTGTAAACCGTGCTTCCAGTC
GACCGTCGAAAAGGCGAGTTTATGCTGTCCCTTCTGTCGCCGCCGGGTATCGTCGTGGACTCGGTACCATACCCGAAGAAATTCTCTCGT
CAACGTGGAACTGTGGACGATAATTCAAAAACACTATCCCAGGGAGTGCAAGCTTAGAGCGTCTGGCCAAGAATCAGAGGAAGTGGGGCT
TACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTATGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAA
CTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCACTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGA
ACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACACAACTTCAAAGGCTTCACGGTGATGAACGAGAATG
AGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGCGCCCTGGACGCTGACACCCGAGTTCCTGGCCGAAC
ACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGATGATGTTTATAAGCACATCAAGGAGGCAGGCATGT
TTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAATTGTGCGGGATTATGATGTGTATGCGAGGCGGAACC
TGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAAATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGA
AGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGAAAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGA
AGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACTGAAACATATGCTGAAAGAGGGGAAGGGCCGGATGC
TGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCA
AGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTATGATATCAGGTATAGTTACCTGGAACAGAGCAAAT
TTGGCTCCCATGTTCTGCTCACCCAGGTGTAGCCTGGCTTGACGGGAAATGATGCCCAGGGTCCAGAGAGCCAGCAGTGTGGACACGCCA
AGGAAAGTGTTGATCCATAGAGCTGTGCTCCCCTCAGAAATCTGGTGGCAACAGAAAGTAGTCAGTGAGGCAGGCAAGCTCTCTCTCTCT

>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000292823_chr3_195984758_-_6203nt
GCTTGTCCGGTGGCTGCTGCGCTGCCGCAACGAATAGGGTTTCTGGCTGCGTAGGAGGGACGGGGGCGCGGAGCTCTGGGAAACTGCGCC
AGGCGCCCGAAAGGTGAACACGGGAGTCGCGCGTCTCCCCCGCAGCAGCGGTAAAGCGGAAGTTATGCTGCAGCCGGAGCCCGGGCTTCC
TCCCGGAGCCGCGTCCCGGGGCCCGGCTGCCCCGAGCTGAGCGGAGCATCCTTTCCGGGTGAGGGGAGGAGAGGACTTGGCGCGTTCCCC
TCGCTGCCCCGGGAGCCGCAGCCGCGGTGTTCATGCCGCGGAGCAGCCAGGCTCCTCCGACGAAAACCTGCATTTATTTGCTGGCGGGAC
GTTTGCCTTGAAAATGGACAAAGACGCCGCCCTCCGGGGTATTCCTGTTTGCCTGACCCTGAGAGCGCCTTTTTGCTTCAAGACGTGTTG
GATGCTCCTGTTCTCCGAATTCTGATACGCTTCTGGGCATAATACTGAAACACAAAACTGCTTTTGCTCTCTCTGTGGTTGGCCGAAAAT
AGGATTCTTTTTCGTGCAGGTGTCGTTGTTTAGTCGGCTTTACTAACATATTGAAATGGCTCTACCCAAAGACGCCATCCCCTCGCTGTC
CGAGTGCCAGTGCGGGATCTGCATGGAAATCCTCGTGGAGCCCGTCACCCTCCCGTGTAACCACACGCTGTGTAAACCGTGCTTCCAGTC
GACCGTCGAAAAGGCGAGTTTATGCTGTCCCTTCTGTCGCCGCCGGGTATCGTCGTGGACTCGGTACCATACCCGAAGAAATTCTCTCGT
CAACGTGGAACTGTGGACGATAATTCAAAAACACTATCCCAGGGAGTGCAAGCTTAGAGCGTCTGGCCAAGAATCAGAGGAAGTGGGGCT
TACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTATGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAA
CTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCACTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGA
ACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACACAACTTCAAAGGCTTCACGGTGATGAACGAGAATG
AGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGCGCCCTGGACGCTGACACCCGAGTTCCTGGCCGAAC
ACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGATGATGTTTATAAGCACATCAAGGAGGCAGGCATGT
TTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAATTGTGCGGGATTATGATGTGTATGCGAGGCGGAACC
TGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAAATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGA
AGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGAAAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGA
AGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACTGAAACATATGCTGAAAGAGGGGAAGGGCCGGATGC
TGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCA
AGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTATGATATCAGTGAGGATGAAGAAGACTAATGTTTCC
TCCCTCCTTTCCTGTCCTCCCTTTCTGTCCCATTACCTTCAGAAGCTCTCTGTTGAATTCCAAATTGTGACCCCAACACTAAACCTAAGG
ACAGCTACAAAGGAAAGACAACTGGGGAAAGAAGACCTAGGACTGGGGGAACCCAAACAGCCTGTCCTGCAAGTGACATCACTCACCCAC
ACGAAGGAGGGGGACTGCACCTTAGAAGCCTGCTCTGCATCCATTTACCCCCCCCCAAGGGCTTTGTTTCACTGTTTATGTTCACGTGAT
CTCAACAGGGAAATTGTCATTTTCATTAATTTTTTAAAAAATTCGTCTTTCAAATGTAGAACTAATTTTTTGCCCCTGAGGAGTGGGCAG
AAGAAGGAGGTAGTGTAATACGCAGAGGCCTTTTCTTCCCGGTATACTATAGCATTTGCCTTCCGTTCTGAAGCTATGTGGCTTGCCAAG
TCCTTCACGAAATGAGCCACGCTGATGGGTAATTTGTGGAGAAATATCTTAATTTTGATTTCCTTAAGGAAAAGCGAAAAGCAGAGTTAC
AGTCACAAATCCCCTGAACGTACTGCTGTCACCAGTGTCATTGTGGCTGCGGGAAGGAGATCTGAACCTAACTTTTCTTACTCCCTGAGG
AGTTTCTTGTTGGACCCAATGGGGTCCATGAAGACACTGATGGGGATGGAAGCAGACCCATGGCATCAACTGCAGTGTTTCTGCTGTGTT
CATCTTCTCAGAAAACTCTGTGACCCAGTTCTTTGGGAGCTTTTGTCAGTCTCTTTCGTGCCATCTACCTTCGAAGGAAGGAACACTTTT
AGAGTTACAATGATGAGGAGAGGAGCGGGACAATACTCAATCCTATACCAAGTCGATTGAGATTAGTTTCCTACTGGGAGTAAGTGCCTG
GCCCTGCTACTCCTATTTGAATGCTATTAATATTACCTAGCCTTTTACAAAGGATACTTTGTAAATGTCTGCTGTTGGAACTTGATGTTA
ATCCATTTTGGTCATAGCCATATTAGAGAGATTTGCACAGAATGTAAAGGCAAAAGCATAGGAAACACCTTCCTTTCTAAAGCAACAGCC
TTATCACCTTGACCTCTGTCCCTCTTCAGAACATTCTTCCCTGGAACCAGTGCTCCACATCTTTCTTTTCCTCTGAGAGCTGCAGCTGGC
AGGGACCTCCCTCTGCTGCTCCTCCAGCAAGCCACAGAGCATACCCTCACGTGACAAGAGTGTGGTAGGTTTTCTCCCCACTTTTCACAC
ACGCCTGGTGGTTGTGGTTCCATCTGCCTTGTTGGCTTGCCCGGGGGGATTCAACACTTGACTTTCAAATCAAAGAATGCTAATGCTTAG
CACTTGCTGTTGAGCATGCTCTAACTTTTAAAGCCCTGGCCTCCTGTCTCCTTAGCTGCTTAGCTACGCGGCCTAGCAGATCATCACCCA
TCAGTAATCCTGTGGCTAGATCCAGGGGAAAATTGCTTATGTCCAGGCCCCACCCCTGTCACTCATAAATACCCCTTGTGGGGGTGGAAT
TTTAGTGTTTTCAGCTAAGAAAACCACATTTTCTCTTTCCTTGCCTCTGCTAGGACTGTGAGCATCTCATAGTCCACTCCCTAAACACTT
TCTGGTAACACCTAGTTTTCCGCCTGAGGGTCAGAGGCTAGAATCATTGCCTGCACAGCAGGACTACCTTGGTTCTTAAAACTTGGATCA
CCCAGGCAAGGCGTGGTGGCTCACGCCTGTCATCTCAGCACTTTGGGAGACTGAGGCTGGTGGATCACTTGAGGCCACGAGTTTGAGACC
AGCCTGACCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCACCTGTAATCCCAGCTACTTG
GGAGGCTGAGGCAGGAGAATCCCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCAGAGATGGTGCCGCTGCAGTCCAGCCTGGGTGACAG
AGCGAGACTCTGTCTCCAAAACAAAACAAAAACCACACACACATACAGAAATAAAGAGAAATAATCAACTAGAAAAAAAACAAAACTTGG
ATCACCCAGAAAGAGCGTCACAGAGGCGAGGGAGAATGAAGCCTCTTGTTATCCTGATCGCCTATGACAACGACATTTCTAACTCTTCTT
TGAAGCGCAGTTCTTACTCTTAAATCTGGTCATACAAGCTTTGGCTTGGAATCCTGTCTGTCTTTGAAACAGCTGAAGTTAGTGTTTTCC
TGTGTTACCCAGTGTTACATAGTCTCATCTTTGAACTTTTCTGCGTCAGCCTTCTCTCTTTGGGAATGCTGCCTGTTTCTGTCTAACTTA
TTCTCCCTGGTGTGGTGTGGCAGTGAAGTCTGTGCTGAAGCCCATCTGCTTGGTTCCTCCAAGTGCACATTATGCAAGTGTATTTGGATA
GACAGGGAGATGCCCGGAACGTGGTTTTCCTCCTCCCTCCCTATTGGAGCCATACCTCCTAAATATATTGTCTGGGTCCCAAATGTTTGA
GCCCTCTTCCTCTGCTCTCAGTGGGCTGCTCTTGGCATGCCCTGTGCTTGGAACGGGACCTGCAGGCTGACAGGCCTCTGAGACTGCTAG
GGCCAGCAAACGTACATGTTATTGGGAAACTCCCTTTCCCCTTTTGGTGAGCTTCTACCACCTCAGTCTAATCGTTTTGACTGAAAGCTA
TTTGTCTGACTGAAAGCTAAAATCTTTTATAGTGTGGCCTGTTAGATACTTTGGGGTAAATGTGGTCTGAGGTGCTGGACTAGCACGGGT
AGATGGAGAAAGCTGTTGGGAAGTTGCATAATGTGGTCATCTGTGCCTAATTAAATGAGGTTAGAGGTGTGCACACCACCACAATGCCTG
GGATCTAAATCTTCAGATATTAACGTTTGAGGCTATGGAGCTGTTTCCCTGAATCACACACGAGAAAGCAGTCAACATGGGTGGGCCAAA
TGTGGCCAAGATGAGAGAGCCAGAAGTGTTGGCCTTAGAGCAGAGCCTCTGTGTGTGAGACATTAGAAGGCCAGAGCCGGGGAGGTGCCG
GCGCAGCCACTGCCTTCCGGTGGGCCGGACGGAAAGCTTGGTCTTATGCTAGATTCAGAAGCACTGAAGAATGGAGGTTGACACTTTAGA
GGACTAGGAAGGGATCATTTGTGCTCTTGCAGCTATTGCTGATAGCTAGAGCCAAAGACCATTATATTGCTGAGGCTTGGGTAAGAAAGT
TAGGGATGTGAGGAGGTTGAAAATCCTGAAGAAGAGAAAAAATATGAGGGAGGCTAAGGAAACTTAGCCACTTTCTGATCACTGATGACT
CCTTAGGCTGCACCTGAGTGATGGTGGTGTTTTTGGAGGCTGTACCTGAGTGATGGTGGTTTTTGGGGGGCTGCACCTGAGCGATAGTGA
TTTTTTTTTGGAGGCTGCACAGCTGGTCAGACCATCTCTAGATGTTCTTTCCACAGTGGTTCATAGGGCGTCATTCCCCCTTCCTGGATT
ATTTTGACTATGGGTAGCTTATTTTCAAGAGCTCTTTGCCTTTTTAATCCTGTTCCAGATCACTTATCCAAAATCTTTCCAAATCAATTA
TATTTTGCTGCTTTTCTTTAATTCCCTAAAAGCCATAGCTTCTAGATTTTCTATCAGCACACATTCTCACCAGAAGTTGAACCAATACAG
GTAGAAAAAGAAAGCCCCCTTAATGTTTTTAACTGATGATATTTTTTTAAGCTTACCAATATAAGTATTTTTAAAGGTTCTATTTTTCAA
AGTCATAACAATGATTGTTCTTGTTTTCTCTCATAGAATAGACTGCCATCGGATAAAGAGTGGTCCCTAGCTTCTATTTTTCCAAGTAAA
TAAGTAGAACATGTTCTTGGGATTATACCATTAAATGTTAATTTTCTTGAAGAAGAAAGATTGTTGTCTGCCAAGATTTTATGTTAGCGC
TCGGATTGAGGCAGAAAACGGAAGCACCAGGTTTAACACTGGGATGACTTGGGTTGTGTTCCTGGAGGTTTGAAGTGGGCCTTCCCGCCT
TTTGAGGGGGAAAACTGACTGTTTTGAACACATATCCTGGATTAGTTGGGTTGTTTTGTATTGAGGATCCCTAAAAGACAAAAGAGTCTT
GGAAAGGACTGCTGGCTTCGTCTTGAACGTTCGCCCCATCACCAGTGTGAGTCCGTGGGGAAGTCTTCCTCAAGTGGGGTTCAGTCTGTA

>In-frame_RNF168_ENST00000318037_chr3_196229744_-_PCYT1A_ENST00000431016_chr3_195984758_-_2020nt
GCTTGTCCGGTGGCTGCTGCGCTGCCGCAACGAATAGGGTTTCTGGCTGCGTAGGAGGGACGGGGGCGCGGAGCTCTGGGAAACTGCGCC
AGGCGCCCGAAAGGTGAACACGGGAGTCGCGCGTCTCCCCCGCAGCAGCGGTAAAGCGGAAGTTATGCTGCAGCCGGAGCCCGGGCTTCC
TCCCGGAGCCGCGTCCCGGGGCCCGGCTGCCCCGAGCTGAGCGGAGCATCCTTTCCGGGTGAGGGGAGGAGAGGACTTGGCGCGTTCCCC
TCGCTGCCCCGGGAGCCGCAGCCGCGGTGTTCATGCCGCGGAGCAGCCAGGCTCCTCCGACGAAAACCTGCATTTATTTGCTGGCGGGAC
GTTTGCCTTGAAAATGGACAAAGACGCCGCCCTCCGGGGTATTCCTGTTTGCCTGACCCTGAGAGCGCCTTTTTGCTTCAAGACGTGTTG
GATGCTCCTGTTCTCCGAATTCTGATACGCTTCTGGGCATAATACTGAAACACAAAACTGCTTTTGCTCTCTCTGTGGTTGGCCGAAAAT
AGGATTCTTTTTCGTGCAGGTGTCGTTGTTTAGTCGGCTTTACTAACATATTGAAATGGCTCTACCCAAAGACGCCATCCCCTCGCTGTC
CGAGTGCCAGTGCGGGATCTGCATGGAAATCCTCGTGGAGCCCGTCACCCTCCCGTGTAACCACACGCTGTGTAAACCGTGCTTCCAGTC
GACCGTCGAAAAGGCGAGTTTATGCTGTCCCTTCTGTCGCCGCCGGGTATCGTCGTGGACTCGGTACCATACCCGAAGAAATTCTCTCGT
CAACGTGGAACTGTGGACGATAATTCAAAAACACTATCCCAGGGAGTGCAAGCTTAGAGCGTCTGGCCAAGAATCAGAGGAAGTGGGGCT
TACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTATGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAA
CTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCACTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGA
ACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACACAACTTCAAAGGCTTCACGGTGATGAACGAGAATG
AGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGCGCCCTGGACGCTGACACCCGAGTTCCTGGCCGAAC
ACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGATGATGTTTATAAGCACATCAAGGAGGCAGGCATGT
TTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAATTGTGCGGGATTATGATGTGTATGCGAGGCGGAACC
TGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAAATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGA
AGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGAAAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGA
AGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACTGAAACATATGCTGAAAGAGGGGAAGGGCCGGATGC
TGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCA
AGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTATGATATCAGTGAGGATGAAGAAGACTAATGTTTCC
TCCCTCCTTTCCTGTCCTCCCTTTCTGTCCCATTACCTTCAGAAGCTCTCTGTTGAATTCCAAATTGTGACCCCAACACTAAACCTAAGG


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FusionGenePPI for RNF168_PCYT1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF168UBE2G2, HIST2H2AC, TP53BP1, H2AFX, UBE2N, HIST2H2AA3, HIST2H2BE, HERC2, KDM4A, UBC, KIAA0368, UBE2D3, UBE2E1, DDX1, POC1A, TAF15, EWSR1, DCTN1, KIF5B, SMARCA5, UBR5, TRIP12, LAPTM5, RNF11, KDM1A, JMJD1C, BCL10, RNF168, PSMD11, TBP, SRCAP, CCDC174, NUB1, RPRD1B, TACC3, FAM45A, USP7, SUMO2, SUMO3, HIST1H1C, UBE2D1, H2AFZ, HIST1H2AB, FOXM1, WBP2, PALB2, BRCA2, TOP2A, MKI67, SUMO1, UBB, TJP1, PCM1, PDCD11, NCL, HNRNPM, DDX21, RAI14, LIMA1, DHX9, DHX15, DBN1, PABPC4, USP10PCYT1ABARD1, PDIA6, S100A13, NMNAT1, CEP170, CEP170P1, GPRC5C, IP6K3, TMEM206, STX11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF168_PCYT1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePCYT1AP49585DB00122CholineCholine-phosphate cytidylyltransferase Asmall moleculeapproved|nutraceutical

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RelatedDiseases for RNF168_PCYT1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePCYT1AC1837073Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy2ORPHANET;UNIPROT
TgenePCYT1AC0080178Spina Bifida1CTD_human
TgenePCYT1AC4277682Chemical and Drug Induced Liver Injury1CTD_human