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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31451

FusionGeneSummary for RNF149_PARP6

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF149_PARP6
Fusion gene ID: 31451
HgeneTgene
Gene symbol

RNF149

PARP6

Gene ID

284996

56965

Gene namering finger protein 149poly(ADP-ribose) polymerase family member 6
SynonymsDNAPTP2ARTD17|PARP-6-B1|PARP-6-C|pART17
Cytomap

2q11.2

15q23

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF149DNA polymerase-transactivated protein 2RING-type E3 ubiquitin transferase RNF149poly [ADP-ribose] polymerase 6ADP-ribosyltransferase diphtheria toxin-like 17PARP-6
Modification date2018052320180523
UniProtAcc

Q8NC42

Q2NL67

Ensembl transtripts involved in fusion geneENST00000485752, ENST00000295317, 
ENST00000569795, ENST00000413097, 
ENST00000260376, ENST00000287196, 
Fusion gene scores* DoF score5 X 5 X 2=504 X 5 X 5=100
# samples 76
** MAII scorelog2(7/50*10)=0.485426827170242
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF149 [Title/Abstract] AND PARP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW391383RNF149chr2

101893937

+PARP6chr15

72552614

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000485752ENST00000569795RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000485752ENST00000413097RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000485752ENST00000260376RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000485752ENST00000287196RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000295317ENST00000569795RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000295317ENST00000413097RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000295317ENST00000260376RNF149chr2

101893937

+PARP6chr15

72552614

+
intron-intronENST00000295317ENST00000287196RNF149chr2

101893937

+PARP6chr15

72552614

+

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FusionProtFeatures for RNF149_PARP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF149

Q8NC42

PARP6

Q2NL67

E3 ubiquitin-protein ligase. Ubiquitinates BRAF,inducing its proteasomal degradation.{ECO:0000269|PubMed:22628551}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF149_PARP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF149_PARP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF149_PARP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF149_PARP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource