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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31436

FusionGeneSummary for RNF144A_CCNJL

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF144A_CCNJL
Fusion gene ID: 31436
HgeneTgene
Gene symbol

RNF144A

CCNJL

Gene ID

9781

79616

Gene namering finger protein 144Acyclin J like
SynonymsRNF144|UBCE7IP4|hUIP4-
Cytomap

2p25.1

5q33.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF144AUbcM4-interacting protein 4probable E3 ubiquitin-protein ligase RNF144Aring finger protein 144ubiquitin conjugating enzyme 7 interacting protein 4cyclin-J-like protein
Modification date2018052320180523
UniProtAcc

P50876

Q8IV13

Ensembl transtripts involved in fusion geneENST00000320892, ENST00000467276, 
ENST00000393977, ENST00000377503, 
ENST00000257536, ENST00000541762, 
ENST00000519673, ENST00000505287, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: RNF144A [Title/Abstract] AND CCNJL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE166383RNF144Achr2

7181704

-CCNJLchr5

159682603

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000320892ENST00000393977RNF144Achr2

7181704

-CCNJLchr5

159682603

-
3UTR-5UTRENST00000320892ENST00000377503RNF144Achr2

7181704

-CCNJLchr5

159682603

-
3UTR-5UTRENST00000320892ENST00000257536RNF144Achr2

7181704

-CCNJLchr5

159682603

-
3UTR-5UTRENST00000320892ENST00000541762RNF144Achr2

7181704

-CCNJLchr5

159682603

-
3UTR-5UTRENST00000320892ENST00000519673RNF144Achr2

7181704

-CCNJLchr5

159682603

-
3UTR-intronENST00000320892ENST00000505287RNF144Achr2

7181704

-CCNJLchr5

159682603

-
intron-3CDSENST00000467276ENST00000393977RNF144Achr2

7181704

-CCNJLchr5

159682603

-
intron-5UTRENST00000467276ENST00000377503RNF144Achr2

7181704

-CCNJLchr5

159682603

-
intron-5UTRENST00000467276ENST00000257536RNF144Achr2

7181704

-CCNJLchr5

159682603

-
intron-5UTRENST00000467276ENST00000541762RNF144Achr2

7181704

-CCNJLchr5

159682603

-
intron-5UTRENST00000467276ENST00000519673RNF144Achr2

7181704

-CCNJLchr5

159682603

-
intron-intronENST00000467276ENST00000505287RNF144Achr2

7181704

-CCNJLchr5

159682603

-

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FusionProtFeatures for RNF144A_CCNJL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF144A

P50876

CCNJL

Q8IV13

E3 ubiquitin-protein ligase which accepts ubiquitin fromE2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form ofa thioester and then directly transfers the ubiquitin to targetedsubstrates. Mediates the ubiquitination and degradation of the DNAdamage kinase PRKDC. {ECO:0000250, ECO:0000269|PubMed:24979766}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF144A_CCNJL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF144A_CCNJL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF144A_CCNJL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF144A_CCNJL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource