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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3141

FusionGeneSummary for ATF7IP2_STYXL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF7IP2_STYXL1
Fusion gene ID: 3141
HgeneTgene
Gene symbol

ATF7IP2

STYXL1

Gene ID

80063

51657

Gene nameactivating transcription factor 7 interacting protein 2serine/threonine/tyrosine interacting like 1
SynonymsMCAF2DUSP24|MK-STYX|MKSTYX
Cytomap

16p13.2-p13.13

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionactivating transcription factor 7-interacting protein 2ATF7-interacting protein 2MBD1-containing chromatin associated factor 2serine/threonine/tyrosine-interacting-like protein 1dual specificity phosphatase 24 (putative)dual specificity phosphatase inhibitor MK-STYXdual specificity protein phosphatase 24map kinase phosphatase-like protein MK-STYX
Modification date2018051920180523
UniProtAcc

Q5U623

Q9Y6J8

Ensembl transtripts involved in fusion geneENST00000396560, ENST00000396559, 
ENST00000561932, ENST00000543967, 
ENST00000356427, ENST00000324570, 
ENST00000248600, ENST00000359697, 
ENST00000340062, ENST00000360591, 
ENST00000431581, ENST00000451157, 
ENST00000460184, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 4 X 5=120
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF7IP2 [Title/Abstract] AND STYXL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTYXL1

GO:0032515

negative regulation of phosphoprotein phosphatase activity

24709986


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1558-01AATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000396560ENST00000248600ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396560ENST00000359697ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396560ENST00000340062ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396560ENST00000360591ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396560ENST00000431581ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396560ENST00000451157ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-intronENST00000396560ENST00000460184ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396559ENST00000248600ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396559ENST00000359697ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396559ENST00000340062ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396559ENST00000360591ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396559ENST00000431581ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000396559ENST00000451157ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-intronENST00000396559ENST00000460184ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-3CDSENST00000561932ENST00000248600ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-3CDSENST00000561932ENST00000359697ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-3CDSENST00000561932ENST00000340062ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-3CDSENST00000561932ENST00000360591ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-3CDSENST00000561932ENST00000431581ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-3CDSENST00000561932ENST00000451157ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
3UTR-intronENST00000561932ENST00000460184ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000543967ENST00000248600ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000543967ENST00000359697ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000543967ENST00000340062ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000543967ENST00000360591ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000543967ENST00000431581ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-3CDSENST00000543967ENST00000451157ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
5UTR-intronENST00000543967ENST00000460184ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000356427ENST00000248600ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000356427ENST00000359697ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000356427ENST00000340062ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000356427ENST00000360591ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000356427ENST00000431581ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000356427ENST00000451157ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-intronENST00000356427ENST00000460184ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000324570ENST00000248600ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000324570ENST00000359697ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000324570ENST00000340062ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000324570ENST00000360591ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000324570ENST00000431581ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-3CDSENST00000324570ENST00000451157ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-
intron-intronENST00000324570ENST00000460184ATF7IP2chr16

10479979

+STYXL1chr7

75634722

-

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FusionProtFeatures for ATF7IP2_STYXL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF7IP2

Q5U623

STYXL1

Q9Y6J8

Recruiter that couples transcriptional factors togeneral transcription apparatus and thereby modulatestranscription regulation and chromatin formation. Can both act asan activator or a repressor depending on the context. MediatesMBD1-dependent transcriptional repression, probably by recruitingcomplexes containing SETDB1. The complex formed with MBD1 andSETDB1 represses transcription and probably couples DNAmethylation and histone H3 'Lys-9' trimethylation (H3K9me3)activity (Probable). {ECO:0000305}. Catalytically inactive phosphatase (PubMed:20180778,PubMed:23163895). By binding to G3BP1, inhibits the formation ofG3BP1-induced stress granules (PubMed:20180778, PubMed:23163895).Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity(PubMed:24709986). By inhibiting PTPMT1, positively regulatesintrinsic apoptosis (PubMed:21262771). May play a role in theformation of neurites during neuronal development(PubMed:29250526). {ECO:0000269|PubMed:20180778,ECO:0000269|PubMed:21262771, ECO:0000269|PubMed:23163895,ECO:0000269|PubMed:24709986, ECO:0000269|PubMed:29250526}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATF7IP2_STYXL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATF7IP2_STYXL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATF7IP2MBD1, SETDB1, SP1, EGFRSTYXL1AES, SMC1A, RPS29, ATXN10, EHD4, PSPH, ACTA1, MYO1B, MYO1C, SPTAN1, SPTBN1, VIM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATF7IP2_STYXL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATF7IP2_STYXL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource