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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31403

FusionGeneSummary for RNF121_SF1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF121_SF1
Fusion gene ID: 31403
HgeneTgene
Gene symbol

RNF121

SF1

Gene ID

55298

7536

Gene namering finger protein 121splicing factor 1
Synonyms-BBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162
Cytomap

11q13.4

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 121splicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162
Modification date2018052320180526
UniProtAcc

Q9H920

Q15637

Ensembl transtripts involved in fusion geneENST00000361756, ENST00000533380, 
ENST00000393713, ENST00000490867, 
ENST00000545854, ENST00000530137, 
ENST00000377387, ENST00000377390, 
ENST00000377394, ENST00000227503, 
ENST00000334944, ENST00000422298, 
ENST00000433274, ENST00000489544, 
Fusion gene scores* DoF score14 X 4 X 7=3926 X 6 X 2=72
# samples 156
** MAII scorelog2(15/392*10)=-1.38589115361933
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF121 [Title/Abstract] AND SF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A576-01ARNF121chr11

71640170

+SF1chr11

64544098

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361756ENST00000377387RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000361756ENST00000377390RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000361756ENST00000377394RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000361756ENST00000227503RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000361756ENST00000334944RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000361756ENST00000422298RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000361756ENST00000433274RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-intronENST00000361756ENST00000489544RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000533380ENST00000377387RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000533380ENST00000377390RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000533380ENST00000377394RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000533380ENST00000227503RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000533380ENST00000334944RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000533380ENST00000422298RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000533380ENST00000433274RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-intronENST00000533380ENST00000489544RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000393713ENST00000377387RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000393713ENST00000377390RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000393713ENST00000377394RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000393713ENST00000227503RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000393713ENST00000334944RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000393713ENST00000422298RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000393713ENST00000433274RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-intronENST00000393713ENST00000489544RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-3CDSENST00000490867ENST00000377387RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-3CDSENST00000490867ENST00000377390RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-3CDSENST00000490867ENST00000377394RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-3CDSENST00000490867ENST00000227503RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-3CDSENST00000490867ENST00000334944RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-5UTRENST00000490867ENST00000422298RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-5UTRENST00000490867ENST00000433274RNF121chr11

71640170

+SF1chr11

64544098

-
3UTR-intronENST00000490867ENST00000489544RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-3CDSENST00000545854ENST00000377387RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-3CDSENST00000545854ENST00000377390RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-3CDSENST00000545854ENST00000377394RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-3CDSENST00000545854ENST00000227503RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-3CDSENST00000545854ENST00000334944RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-5UTRENST00000545854ENST00000422298RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-5UTRENST00000545854ENST00000433274RNF121chr11

71640170

+SF1chr11

64544098

-
5UTR-intronENST00000545854ENST00000489544RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000530137ENST00000377387RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000530137ENST00000377390RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000530137ENST00000377394RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000530137ENST00000227503RNF121chr11

71640170

+SF1chr11

64544098

-
Frame-shiftENST00000530137ENST00000334944RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000530137ENST00000422298RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-5UTRENST00000530137ENST00000433274RNF121chr11

71640170

+SF1chr11

64544098

-
5CDS-intronENST00000530137ENST00000489544RNF121chr11

71640170

+SF1chr11

64544098

-

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FusionProtFeatures for RNF121_SF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF121

Q9H920

SF1

Q15637


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF121_SF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF121_SF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF121NFKBIA, LPAR1, TRIM25SF1PLSCR1, TRIM23, DDX17, WWP2, RBPMS, U2AF2, EWSR1, FUS, TAF15, TCERG1, ZNF461, NCOR2, PML, PPARGC1A, NFKB1, HDAC5, HDAC4, SF3A2, CUL3, CIRBP, EFTUD2, VDAC1, MPLKIP, ZC3H11A, TMED4, TOMM40, SRPRB, VDAC3, STIM1, UBE2L3, VAMP2, TAGLN, ZFR, SORCS3, SBDS, SEPT11, SIN3A, STOM, NNT, SRP9, ATXN1, FN1, VCAM1, SF3A1, SF3B4, RBM17, RBM10, SF1, ILF3, BCAS2, WDR83, RBM7, HNRNPK, HNRNPUL1, RBM4, WDR77, HNRNPF, HNRNPH1, HNRNPH2, IL7R, METTL22, ITGA4, LMNA, ITCH, PRPF40A, WBP4, APBB1, GAS7, RANBP3, EIF4B, FAF1, FARSB, GART, GFPT1, HIRIP3, HIST1H4A, HSPH1, NARS, OSBP, PLOD2, RPL24, SAMHD1, SUPT5H, TROVE2, XPO7, XRCC5, CIAO1, PSMA3, MKRN3, FAM168A, TRIM69, KRTAP26-1, CUL7, OBSL1, CCDC8, SUZ12, EED, PRMT2, ACTL6A, ZFP41, CAB39, CCDC25, ALDOC, CNN2, HADH, HNRNPL, HSDL2, IREB2, PGK1, PLAA, PPID, TKT, UBE2N, NTRK1, NCOA1, CDC42, CSNK2A2, LLGL2, MAPK8, EMC2, RNF41, PARD6B, KLC3, NAGK, P4HA3, BCHE, CAPN13, HSPBP1, HAO2, SFPQ, FOXA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF121_SF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSF1Q15637DB11638ArtenimolSplicing factor 1small moleculeapproved|investigational

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RelatedDiseases for RNF121_SF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSF1C0025202melanoma1CTD_human