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Fusion gene ID: 31400 |
FusionGeneSummary for RNF121_PPFIA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF121_PPFIA1 | Fusion gene ID: 31400 | Hgene | Tgene | Gene symbol | RNF121 | PPFIA1 | Gene ID | 55298 | 8500 |
| Gene name | ring finger protein 121 | PTPRF interacting protein alpha 1 | |
| Synonyms | - | LIP.1|LIP1|LIPRIN | |
| Cytomap | 11q13.4 | 11q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING finger protein 121 | liprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9H920 | Q13136 | |
| Ensembl transtripts involved in fusion gene | ENST00000361756, ENST00000533380, ENST00000393713, ENST00000490867, ENST00000545854, ENST00000530137, | ENST00000253925, ENST00000389547, ENST00000530548, | |
| Fusion gene scores | * DoF score | 14 X 4 X 7=392 | 14 X 13 X 7=1274 |
| # samples | 15 | 15 | |
| ** MAII score | log2(15/392*10)=-1.38589115361933 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1274*10)=-3.08633087176042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF121 [Title/Abstract] AND PPFIA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CQ-5323-01A | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361756 | ENST00000253925 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| In-frame | ENST00000361756 | ENST00000389547 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5CDS-3UTR | ENST00000361756 | ENST00000530548 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| Frame-shift | ENST00000533380 | ENST00000253925 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| Frame-shift | ENST00000533380 | ENST00000389547 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5CDS-3UTR | ENST00000533380 | ENST00000530548 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| Frame-shift | ENST00000393713 | ENST00000253925 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| Frame-shift | ENST00000393713 | ENST00000389547 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5CDS-3UTR | ENST00000393713 | ENST00000530548 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 3UTR-3CDS | ENST00000490867 | ENST00000253925 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 3UTR-3CDS | ENST00000490867 | ENST00000389547 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 3UTR-3UTR | ENST00000490867 | ENST00000530548 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5UTR-3CDS | ENST00000545854 | ENST00000253925 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5UTR-3CDS | ENST00000545854 | ENST00000389547 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5UTR-3UTR | ENST00000545854 | ENST00000530548 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| Frame-shift | ENST00000530137 | ENST00000253925 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| Frame-shift | ENST00000530137 | ENST00000389547 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
| 5CDS-3UTR | ENST00000530137 | ENST00000530548 | RNF121 | chr11 | 71640170 | + | PPFIA1 | chr11 | 70218318 | + |
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FusionProtFeatures for RNF121_PPFIA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF121 | PPFIA1 |
| May regulate the disassembly of focal adhesions. Maylocalize receptor-like tyrosine phosphatases type 2A at specificsites on the plasma membrane, possibly regulating theirinteraction with the extracellular environment and theirassociation with substrates. {ECO:0000269|PubMed:7796809}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 1021_1050 | 955 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 1021_1050 | 955 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 1051_1120 | 955 | 1597 | Domain | SAM 3 |
| Tgene | >PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 963_1027 | 955 | 1597 | Domain | SAM 2 |
| Tgene | >PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 1051_1120 | 955 | 1186 | Domain | SAM 3 |
| Tgene | >PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 963_1027 | 955 | 1186 | Domain | SAM 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 100_120 | 21 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 148_168 | 21 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 172_192 | 21 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 306_326 | 21 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 50_70 | 21 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 79_99 | 21 | 328 | Transmembrane | Helical |
| Hgene | >RNF121 | chr11:71640170 | chr11:70218318 | ENST00000361756 | + | 1 | 9 | 226_276 | 21 | 328 | Zinc finger | RING-type%3B atypical |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 176_214 | 955 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 249_521 | 955 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 34_141 | 955 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 623_669 | 955 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 847_871 | 955 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 176_214 | 955 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 249_521 | 955 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 34_141 | 955 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 623_669 | 955 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 847_871 | 955 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 17_25 | 955 | 1597 | Compositional bias | Note=Poly-Gly |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 17_25 | 955 | 1186 | Compositional bias | Note=Poly-Gly |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000253925 | + | 20 | 28 | 878_944 | 955 | 1597 | Domain | SAM 1 |
| Tgene | PPFIA1 | chr11:71640170 | chr11:70218318 | ENST00000389547 | + | 20 | 26 | 878_944 | 955 | 1186 | Domain | SAM 1 |
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FusionGeneSequence for RNF121_PPFIA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RNF121_ENST00000361756_chr11_71640170_+_PPFIA1_ENST00000253925_chr11_70218318_+_269aa MAAVVEVEVGGGAAGERELDETLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCL RRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREF >In-frame_RNF121_ENST00000361756_chr11_71640170_+_PPFIA1_ENST00000389547_chr11_70218318_+_252aa MAAVVEVEVGGGAAGERELDETLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCL RRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RNF121_ENST00000361756_chr11_71640170_+_PPFIA1_ENST00000253925_chr11_70218318_+_807nt ATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGACACTCGCCTATGGGGACATGAACCAC GAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCTG GACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCTG AGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGAT CGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTTA GATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATTT AACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTTT AGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTCT >In-frame_RNF121_ENST00000361756_chr11_71640170_+_PPFIA1_ENST00000389547_chr11_70218318_+_756nt ATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGACACTCGCCTATGGGGACATGAACCAC GAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCTG GACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCTG AGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGAT CGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTTA GATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATTT AACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTTT AGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RNF121_ENST00000361756_chr11_71640170_+_PPFIA1_ENST00000253925_chr11_70218318_+_2578nt ACGTCTCGCTCCTTGGAGCCCAGACTGAGGGAGCGTCGCGAAAGTTGCCCGTTTTGGAACGCTCCCATTTGGCTCTCCAAAGGGAAGAAT TGGTTAAATAGTTGCACTGAAAATAATGCGATTCAAATTTCTCATTTTCCAAGAACGCTCCCTTGCTGAAGCTTGCAAGGGCACGGTACT CCCCTCTCCTTGACCCTGAAACGTGCAGCAAGTAGATAACCTCCTGATCCCTGACAGTCTCCGCCTGTGTTGATGCCCCGCCCCCTCTGC TGGAGTCCGAGCCGCCGATTGGCTAGGAGCACTTGAGCAGCGGAAGCAGCTGGCTCGCGCGGGGACTGCGGTGAGGGGGCGAGCCGTGAA GATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGACACTCGCCTATGGGGACATGAACCA CGAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCT GGACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCT GAGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGA TCGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTT AGATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATT TAACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTT TAGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTC TATGCAGCCAAAGAAGATGCAGATGGACGGCAATGTATCAGGAACACAGAGGTTGGATTCTGCTACAGTCAGGACTTACTCCTGCTAAAG TCTCCTGTTGTTTACCCACACTACTTCTACAGATGATTATGCAGCATTTGAATCCAACAAAGACTACATTTTGGAATCCAGTGGAATCTT TAATCTTGTTAATACTTGTTATATGGACCCTAAGATATTTTATTACAGAGTTTTTAATTAGTGAAAAATTCATGAATACCATAGAGAAAA TATTTTAGAATTTAATGTTTCTTATATTTATGTAAACTTATGACTCTTCATTTATATAGTTACTTACTTTTTCATGTATATCCAGGCTAT AAATATCCTTTCAAATCATGTTCTTATACCTAATTTTAGTCTTTCAAATGAATGTACTGTAATGCTTGTATGTATAAATCCTATGAATAG AGGGCTTTTGTAAATTATGCATTTATTGTAATTATCATTAATTTTTTAATGATAAACCATGACAAAGGATTTTACGTTTATAAAATTATG ACAGAAGCCATGTGCATTATCCTTTACGGACGCAGCCTAGCTCTACAGCAATCATCCTGAAATAAGCATACCTAATTTCAAGCAATTGTT GTATTTTCATGACTGACCTTAACTGTACTTTTTCTAGCAAGAGATGCTTTATTCTGCAGCATGAACAGATTTAAAATGGCTGGTGTTAAA TATCAGCTCCTAATAAGATGTGGACTGAAAACACTATCACAACACTATGAGAAGCCCCTAGCACTGGTTAACGCTTTCCTAGCCTAGTCT CTGGATTTGGGGAGCTTGTCTTCAGTGGCTGAGACTGTGAGCTGGGAGCAGTTCTCTCAGCTGGAGAGACTCGGGATGGGGTAACCTGGG GACCAGTCTAGCCCCTGCACCCTCTTCCCTGCCTCTGCTCCTTGGGAGCGGGTGGAGAGACACCCATGTGGCTCCCCTTAGGGCCAGCAC CAAGCACCACGCTCTCATCCTGCAAGTCGGCGCACACAGTGGATGAAGGCAGGAGACCCAGAAAGCAGTGCAGTGCAGCTCTAATAAAGG CCTTATTTTTCTTATGTAAATCATCTTTTTACATTTGTTTGTAAACATGTTTAAAGAACGAACCTAGTGGGACATTTTTAGACTTTGATG CTCTAGCCATTTTGGATTGTGTAAGTTGCAGATGTGGCTTTTACTTTTTAAATGGCATATTAACAAGCCAGCAAAGTGTGTCAGACCATG GCGTGGTATTTATTGTGCAGCAGATCCAGAGACAGAGGCAGCCTGTCTTTTCAGTTGGTTTCTGCTTTTAATTTACTTGTACAATTCATT GTTACTGTTCTGTTTTTCTATTAATCTTTTGTCAACTTCCTGATTATGTAACAAAGTATGTACAGTCTACTTTTGAACTATTTTTATCAC >In-frame_RNF121_ENST00000361756_chr11_71640170_+_PPFIA1_ENST00000389547_chr11_70218318_+_1494nt ACGTCTCGCTCCTTGGAGCCCAGACTGAGGGAGCGTCGCGAAAGTTGCCCGTTTTGGAACGCTCCCATTTGGCTCTCCAAAGGGAAGAAT TGGTTAAATAGTTGCACTGAAAATAATGCGATTCAAATTTCTCATTTTCCAAGAACGCTCCCTTGCTGAAGCTTGCAAGGGCACGGTACT CCCCTCTCCTTGACCCTGAAACGTGCAGCAAGTAGATAACCTCCTGATCCCTGACAGTCTCCGCCTGTGTTGATGCCCCGCCCCCTCTGC TGGAGTCCGAGCCGCCGATTGGCTAGGAGCACTTGAGCAGCGGAAGCAGCTGGCTCGCGCGGGGACTGCGGTGAGGGGGCGAGCCGTGAA GATGGCGGCAGTGGTGGAGGTGGAGGTTGGAGGTGGTGCTGCTGGGGAACGGGAGCTGGATGAGACACTCGCCTATGGGGACATGAACCA CGAGTGGATCGGCAACGAGTGGCTCCCCAGCCTGGGCCTCCCCCAGTACCGCAGCTACTTCATGGAGTGCCTTGTAGACGCCAGGATGCT GGACCACTTGACCAAGAAAGACCTTCGAGGGCAGCTGAAAATGGTCGACAGTTTTCACAGAAACAGTTTCCAGTGTGGAATTATGTGCCT GAGAAGGTTAAATTATGACCGGAAAGAACTGGAAAGAAAAAGAGAAGAAAGTCAGAGTGAAATAAAAGACGTGCTTGTTTGGAGCAATGA TCGAGTGATTCGCTGGATCCTGTCAATTGGCCTTAAAGAATATGCAAACAATCTTATAGAGAGTGGTGTTCACGGAGCACTTCTGGCCTT AGATGAAACCTTCGACTTCAGTGCACTGGCACTGCTGTTACAGATCCCGACGCAGAACACACAGGCTCGTGCTGTCTTGGAAAGAGAATT TAACAACCTTTTGGTCATGGGGACTGATAGAAGGTTTGATGAAGATGATGATAAAAGCTTTAGGAGAGCACCTTCATGGAGAAAAAAGTT TAGACCAAAGGACATTCGTGGCTTAGCTGCTGGGTCAGCAGAGACTCTCCCTGCAAACTTCCGGGTGACTTCTTCTATGTCTTCCCCCTC TATGCAGCCAAAGAAGATGCAGATGGACGGTATGTGATGGGTCACACTAACCTGTCACTTGTTGGGAGCATGAGCAGCTTTCTGTCTGGA ACATTAATAATGATCTAAAACGGCCTATTTAATATGTTACAAGGCACTTGAGTATGGTTGCATGTCCAAATATAAATGTTTTTAAATTAA CTCTAACATTTGTTTATAAAAGTTTAACCATAATAATAGAATTTTTAAAACACGCTTGTCTGGTTGAATCTTAGCATATTTTTCCAACTA ATAAAGCTCAGTATTCGTCTGTGTTCTCAGAGAGAGACTGAGGCATACTTGTAAATTTGTGTCTGTGACAGGCCGTGCTAGAAAGCTCTT |
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FusionGenePPI for RNF121_PPFIA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RNF121 | NFKBIA, LPAR1, TRIM25 | PPFIA1 | GIT1, ERC2, PPP2R5D, TNNT1, MBIP, GRIP2, PTPRF, PTPRD, PTPRS, NCOA2, PPP2CA, PPP2R1A, PPFIA1, PPFIA2, ING4, PPP2CB, CUL2, AGTPBP1, CEP70, AMOT, LATS2, YWHAB, IKBKG, PSMC4, PSMD1, PSMD13, PSMD8, SPTAN1, DROSHA, NDN, AURKB, CDKN1A, CCNH, DTNB, FAM161A, TXLNA, BRCA1, GPS2, C16orf70, CYP4X1, NTRK1, OSBP, PPFIA3, PPFIBP1, PPFIBP2, CAGE1, TUBG1, XRCC1, GBA2, CDC5L, NF2, IL17RE, LLGL2, SERPINB2, STX11, EXOC8, TTC9B, CCDC120, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RNF121_PPFIA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RNF121_PPFIA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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