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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31387

FusionGeneSummary for RNF115_PIAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF115_PIAS3
Fusion gene ID: 31387
HgeneTgene
Gene symbol

RNF115

PIAS3

Gene ID

27246

10401

Gene namering finger protein 115protein inhibitor of activated STAT 3
SynonymsBCA2|ZNF364ZMIZ5
Cytomap

1q21.1

1q21.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF115RING-type E3 ubiquitin transferase RNF115rabring 7zinc finger protein 364E3 SUMO-protein ligase PIAS3E3 SUMO-protein transferase PIAS3protein inhibitor of activated STAT protein 3zinc finger, MIZ-type containing 5
Modification date2018052320180519
UniProtAcc

Q9Y4L5

Q9Y6X2

Ensembl transtripts involved in fusion geneENST00000369291, ENST00000369299, 
ENST00000393045, ENST00000369298, 
Fusion gene scores* DoF score6 X 3 X 5=903 X 2 X 3=18
# samples 63
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF115 [Title/Abstract] AND PIAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF115

GO:0051865

protein autoubiquitination

16288031

TgenePIAS3

GO:0033234

negative regulation of protein sumoylation

24651376

TgenePIAS3

GO:0033235

positive regulation of protein sumoylation

17696781|21965678


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-77-7140-01ARNF115chr1

145611341

+PIAS3chr1

145578062

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369291ENST00000369299RNF115chr1

145611341

+PIAS3chr1

145578062

+
5CDS-5UTRENST00000369291ENST00000393045RNF115chr1

145611341

+PIAS3chr1

145578062

+
5CDS-5UTRENST00000369291ENST00000369298RNF115chr1

145611341

+PIAS3chr1

145578062

+

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FusionProtFeatures for RNF115_PIAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF115

Q9Y4L5

PIAS3

Q9Y6X2

E3 ubiquitin-protein ligase that mediates E2-dependent,'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substratesand may play a role in diverse biological processes. Through theirpolyubiquitination, may play a role in the endosomal traffickingand degradation of membrane receptors including EGFR, FLT3, METand CXCR4. {ECO:0000269|PubMed:16288031,ECO:0000269|PubMed:18819927, ECO:0000303|PubMed:23418353}. Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway and the steroid hormone signalingpathway. Involved in regulating STAT3 signaling via inhibitingSTAT3 DNA-binding and suppressing cell growth. Enhances thesumoylation of MTA1 and may participate in its paralog-selectivesumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2which promotes its interaction with SIRT1 (PubMed:25406032).Diminishes the sumoylation of ZFHX3 by preventing thecolocalization of ZFHX3 with SUMO1 in the nucleus(PubMed:24651376). {ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032,ECO:0000269|PubMed:9388184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF115_PIAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF115_PIAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF115UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2W, ELAVL1, RAD23A, SFN, ATN1, CDK10, CST3, DOCK4, FOLR3, MFAP4, IGHA1, HRAS, UBE2I, RPL18A, UBC, RNF115, AKT1, RAB7A, RAB7B, APP, UBE2N, EGFR, PFDN5, MYC, TTR, MDM4, DAZAP2, YWHAB, DNAJB2, HERC2, FBXW11, BAG6, TAX1BP1, PSEN2, GABRD, KDELR1, H2AFX, RAD51PIAS3MITF, RELA, GFI1, SMAD2, SMAD3, SMAD4, EP300, CREBBP, HMGA2, STAT3, AR, TRIM32, SIAH2, SIAH1, ZMIZ2, ZMIZ1, UBE2I, SREBF2, GLUL, HABP4, TRIM27, SATB1, CARHSP1, UBA1, PSMC1, C19orf60, TRIM8, RAC1, PPP1CA, ELAVL1, ERBB4, SUMO1, SUMO2, SERBP1, HNRNPK, ZFHX3, PRPF40A, SKIL, NCOA2, CREM, SERPINA10, GEMIN4, SUMO3, CBS, TAB2, TRIM63, TRIM55, HIC1, BCL11A, SMURF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF115_PIAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF115_PIAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF115C1458155Mammary Neoplasms1CTD_human
TgenePIAS3C0007873Uterine Cervical Neoplasm1CTD_human