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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31376

FusionGeneSummary for RNF111_TCF12

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF111_TCF12
Fusion gene ID: 31376
HgeneTgene
Gene symbol

RNF111

TCF12

Gene ID

54778

6938

Gene namering finger protein 111transcription factor 12
SynonymsARK|hRNF111CRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64
Cytomap

15q22.1-q22.2

15q21.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase Arkadiatranscription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4
Modification date2018052320180523
UniProtAcc

Q6ZNA4

Q99081

Ensembl transtripts involved in fusion geneENST00000348370, ENST00000434298, 
ENST00000559209, ENST00000557998, 
ENST00000561186, ENST00000560080, 
ENST00000438423, ENST00000267811, 
ENST00000452095, ENST00000333725, 
ENST00000557843, ENST00000560764, 
ENST00000543579, ENST00000537840, 
ENST00000343827, ENST00000559710, 
ENST00000559703, 
Fusion gene scores* DoF score7 X 3 X 6=12610 X 10 X 5=500
# samples 710
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/500*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF111 [Title/Abstract] AND TCF12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-EP-A2KA-01ARNF111chr15

59280267

+TCF12chr15

57565228

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000348370ENST00000438423RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000348370ENST00000267811RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000348370ENST00000452095RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000348370ENST00000333725RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000348370ENST00000557843RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000348370ENST00000560764RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000348370ENST00000543579RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000348370ENST00000537840RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000348370ENST00000343827RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000348370ENST00000559710RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000348370ENST00000559703RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000434298ENST00000438423RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000434298ENST00000267811RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000434298ENST00000452095RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000434298ENST00000333725RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000434298ENST00000557843RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000434298ENST00000560764RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000434298ENST00000543579RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000434298ENST00000537840RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000434298ENST00000343827RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000434298ENST00000559710RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000434298ENST00000559703RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000559209ENST00000438423RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000559209ENST00000267811RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000559209ENST00000452095RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000559209ENST00000333725RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-3CDSENST00000559209ENST00000557843RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000559209ENST00000560764RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000559209ENST00000543579RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000559209ENST00000537840RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000559209ENST00000343827RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000559209ENST00000559710RNF111chr15

59280267

+TCF12chr15

57565228

+
5UTR-intronENST00000559209ENST00000559703RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000557998ENST00000438423RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000557998ENST00000267811RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000557998ENST00000452095RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000557998ENST00000333725RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000557998ENST00000557843RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000557998ENST00000560764RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000557998ENST00000543579RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000557998ENST00000537840RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000557998ENST00000343827RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000557998ENST00000559710RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000557998ENST00000559703RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000561186ENST00000438423RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000561186ENST00000267811RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000561186ENST00000452095RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000561186ENST00000333725RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000561186ENST00000557843RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000561186ENST00000560764RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000561186ENST00000543579RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000561186ENST00000537840RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000561186ENST00000343827RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000561186ENST00000559710RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000561186ENST00000559703RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000560080ENST00000438423RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000560080ENST00000267811RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000560080ENST00000452095RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000560080ENST00000333725RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-3CDSENST00000560080ENST00000557843RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000560080ENST00000560764RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000560080ENST00000543579RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000560080ENST00000537840RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000560080ENST00000343827RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000560080ENST00000559710RNF111chr15

59280267

+TCF12chr15

57565228

+
intron-intronENST00000560080ENST00000559703RNF111chr15

59280267

+TCF12chr15

57565228

+

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FusionProtFeatures for RNF111_TCF12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF111

Q6ZNA4

TCF12

Q99081

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Activates transcription by binding tothe E box (5'-CANNTG-3').

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RNF111_TCF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RNF111_TCF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF111SMAD3, SMAD6, SMAD7, SKIL, SMAD2, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2G2, UBE2W, UBE2I, UBE2M, UBE2V1, UBE2K, UBE2E2, UBE2Q2, TSG101, CREB1, SKI, RB1CC1, SUMO2, SUMO1, FHL2, RNF111, HSP90AA1, SMURF2, PML, UBE2N, XPC, DTX3L, TRIM21, ANAPC11, LRSAM1, MARCH7, PHF7, TRIM8, TRAF5, CSNK2A2, CTBP1, MVP, ACTN3, CSNK2A1, KRTAP5-9, EDARADD, LCE4A, SUMO3, NR4A1, AXIN2, UBC, ESRP2, ESRP1, SETD7, FAM189B, UBXN7, TPX2, DCUN1D5, TTC9C, SUGP1, CGGBP1, RBM27, GNAQ, ADD3, C21orf59, SPASTTCF12ID2, ASCL4, TCF23, OLIG3, PRSS23, TAL1, ID1, ID3, TAL2, RUNX1T1, CREBBP, EP300, TAF4, TBP, RUNX1, TRIM33, ELAVL1, SMAD2, SMAD3, TCF3, FOXH1, NOTCH1, MYC, SOX2, TCF21, BMF, DGCR6, CDKN2C, MLLT6, PSMA1, QARS, RNASEL, SRI, STAT5A, TSNAX, STK16, MAPKBP1, ARMC8, EDRF1, CRCP, OSGIN1, NEUROG3, VPS28, SPG21, C1orf109, NAGK, HOPX, C16orf45, TWIST2, MORN4, HEXIM2, C6orf165, LYSMD1, TRIM72, SHMT2, MOV10, NXF1, MYOG, CCDC101, NEUROD1, MESP2, NTRK1, TCF12, FRMD6, MYF6, XPO1, ZWINT, STRN3, TCF4, NFATC2, ATOH1, FERD3L, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RNF111_TCF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF111_TCF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCF12C3715051CRANIOSYNOSTOSIS 32UNIPROT
TgeneTCF12C0010278Craniosynostosis1CTD_human;HPO