FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31373

FusionGeneSummary for RNF111_MAPKAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF111_MAPKAP1
Fusion gene ID: 31373
HgeneTgene
Gene symbol

RNF111

MAPKAP1

Gene ID

54778

79109

Gene namering finger protein 111mitogen-activated protein kinase associated protein 1
SynonymsARK|hRNF111JC310|MIP1|SIN1|SIN1b|SIN1g
Cytomap

15q22.1-q22.2

9q33.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase Arkadiatarget of rapamycin complex 2 subunit MAPKAP1MEKK2-interacting protein 1SAPK-interacting protein 1TORC2 subunit MAPKAP1mSIN1mitogen-activated protein kinase 2-associated protein 1ras inhibitor MGC2745stress-activated map kinase interacting protein
Modification date2018052320180523
UniProtAcc

Q6ZNA4

Q9BPZ7

Ensembl transtripts involved in fusion geneENST00000348370, ENST00000434298, 
ENST00000559209, ENST00000557998, 
ENST00000561186, ENST00000560080, 
ENST00000373511, ENST00000373498, 
ENST00000350766, ENST00000373503, 
ENST00000394063, ENST00000265960, 
ENST00000373497, ENST00000394060, 
ENST00000483937, 
Fusion gene scores* DoF score7 X 3 X 6=1266 X 6 X 5=180
# samples 76
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF111 [Title/Abstract] AND MAPKAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-SH-A9CU-01ARNF111chr15

59280267

+MAPKAP1chr9

128348006

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000348370ENST00000373511RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000348370ENST00000373498RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000348370ENST00000350766RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000348370ENST00000373503RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000348370ENST00000394063RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000348370ENST00000265960RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000348370ENST00000373497RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000348370ENST00000394060RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-intronENST00000348370ENST00000483937RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000434298ENST00000373511RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000434298ENST00000373498RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000434298ENST00000350766RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000434298ENST00000373503RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000434298ENST00000394063RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000434298ENST00000265960RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000434298ENST00000373497RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000434298ENST00000394060RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-intronENST00000434298ENST00000483937RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000559209ENST00000373511RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000559209ENST00000373498RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-3CDSENST00000559209ENST00000350766RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000559209ENST00000373503RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000559209ENST00000394063RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000559209ENST00000265960RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000559209ENST00000373497RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-5UTRENST00000559209ENST00000394060RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
5UTR-intronENST00000559209ENST00000483937RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000557998ENST00000373511RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000557998ENST00000373498RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000557998ENST00000350766RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000557998ENST00000373503RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000557998ENST00000394063RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000557998ENST00000265960RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000557998ENST00000373497RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000557998ENST00000394060RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-intronENST00000557998ENST00000483937RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000561186ENST00000373511RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000561186ENST00000373498RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000561186ENST00000350766RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000561186ENST00000373503RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000561186ENST00000394063RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000561186ENST00000265960RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000561186ENST00000373497RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000561186ENST00000394060RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-intronENST00000561186ENST00000483937RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000560080ENST00000373511RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000560080ENST00000373498RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-3CDSENST00000560080ENST00000350766RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000560080ENST00000373503RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000560080ENST00000394063RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000560080ENST00000265960RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000560080ENST00000373497RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-5UTRENST00000560080ENST00000394060RNF111chr15

59280267

+MAPKAP1chr9

128348006

-
intron-intronENST00000560080ENST00000483937RNF111chr15

59280267

+MAPKAP1chr9

128348006

-

Top

FusionProtFeatures for RNF111_MAPKAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RNF111

Q6ZNA4

MAPKAP1

Q9BPZ7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RNF111_MAPKAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RNF111_MAPKAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RNF111SMAD3, SMAD6, SMAD7, SKIL, SMAD2, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2G2, UBE2W, UBE2I, UBE2M, UBE2V1, UBE2K, UBE2E2, UBE2Q2, TSG101, CREB1, SKI, RB1CC1, SUMO2, SUMO1, FHL2, RNF111, HSP90AA1, SMURF2, PML, UBE2N, XPC, DTX3L, TRIM21, ANAPC11, LRSAM1, MARCH7, PHF7, TRIM8, TRAF5, CSNK2A2, CTBP1, MVP, ACTN3, CSNK2A1, KRTAP5-9, EDARADD, LCE4A, SUMO3, NR4A1, AXIN2, UBC, ESRP2, ESRP1, SETD7, FAM189B, UBXN7, TPX2, DCUN1D5, TTC9C, SUGP1, CGGBP1, RBM27, GNAQ, ADD3, C21orf59, SPASTMAPKAP1CDC42EP1, SFN, AKT1, MTOR, RICTOR, PRR5, RPL23, RPS6, RPS6KB1, PRKCA, PINK1, STK38, BRCA1, MAPK8, ECI1, ABCB1, PRR5L, NBN, XPO1, CTR9, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, RTKN, MAST3, ZNF638, DENND4C, PPM1H, CGN, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, FAM110B, USP21, FAM53C, ANKRD34A, HDAC4, FAM110A, NF1, CBY1, NADK, LPIN3, TIAM1, KIAA1804, PHLDB2, RASAL2, TBC1D25, CDC25C, CAMSAP2, GIGYF2, PLEKHA7, GAB2, MELK, KIF1C, NAV1, SH3RF3, INPP5E, RAB3IP, SGK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RNF111_MAPKAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RNF111_MAPKAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource