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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31293

FusionGeneSummary for RLBP1_RLBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RLBP1_RLBP1
Fusion gene ID: 31293
HgeneTgene
Gene symbol

RLBP1

RLBP1

Gene ID

6017

6017

Gene nameretinaldehyde binding protein 1retinaldehyde binding protein 1
SynonymsCRALBPCRALBP
Cytomap

15q26.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionretinaldehyde-binding protein 1cellular retinaldehyde-binding proteincellular retinaldehyde-binding protein-1retinaldehyde-binding protein 1cellular retinaldehyde-binding proteincellular retinaldehyde-binding protein-1
Modification date2018052720180527
UniProtAcc

P12271

P12271

Ensembl transtripts involved in fusion geneENST00000268125, ENST00000268125, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RLBP1 [Title/Abstract] AND RLBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W28826RLBP1chr15

89762220

+RLBP1chr15

89762292

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000268125ENST00000268125RLBP1chr15

89762220

+RLBP1chr15

89762292

-

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FusionProtFeatures for RLBP1_RLBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RLBP1

P12271

RLBP1

P12271

Soluble retinoid carrier essential the proper functionof both rod and cone photoreceptors. Participates in theregeneration of active 11-cis-retinol and 11-cis-retinaldehyde,from the inactive 11-trans products of the rhodopsin photocycleand in the de novo synthesis of these retinoids from 11-transmetabolic precursors. The cycling of retinoids betweenphotoreceptor and adjacent pigment epithelium cells is known asthe 'visual cycle'. {ECO:0000269|PubMed:19846785}. Soluble retinoid carrier essential the proper functionof both rod and cone photoreceptors. Participates in theregeneration of active 11-cis-retinol and 11-cis-retinaldehyde,from the inactive 11-trans products of the rhodopsin photocycleand in the de novo synthesis of these retinoids from 11-transmetabolic precursors. The cycling of retinoids betweenphotoreceptor and adjacent pigment epithelium cells is known asthe 'visual cycle'. {ECO:0000269|PubMed:19846785}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RLBP1_RLBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RLBP1_RLBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RLBP1_RLBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRLBP1P12271DB00162Vitamin ARetinaldehyde-binding protein 1small moleculeapproved|nutraceutical|vet_approved
TgeneRLBP1P12271DB00162Vitamin ARetinaldehyde-binding protein 1small moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for RLBP1_RLBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRLBP1C0311338Fundus Albipunctatus3CTD_human;ORPHANET;UNIPROT
HgeneRLBP1C0015398Eye Diseases, Hereditary1CTD_human
HgeneRLBP1C1843816Bothnia Retinal Dystrophy1CTD_human;ORPHANET;UNIPROT
TgeneRLBP1C0311338Fundus Albipunctatus3CTD_human;ORPHANET;UNIPROT
TgeneRLBP1C0015398Eye Diseases, Hereditary1CTD_human
TgeneRLBP1C1843816Bothnia Retinal Dystrophy1CTD_human;ORPHANET;UNIPROT